Lung Diseases https://greenmedinfo.com/taxonomy/term/3091/all en A combination of GAR and S-VACE can be a novel therapy for the management of lung diseases in humans. https://greenmedinfo.com/article/combination-gar-and-s-vace-can-be-novel-therapy-management-lung-diseases-human PMID:  Drug Metabol Personal Ther. 2016 Mar 1 ;31(1):47-54. PMID: 26943616 Abstract Title:  Garlic capsule and selenium-vitamins ACE combination therapy modulate key antioxidant proteins and cellular adenosine triphosphate in lisinopril-induced lung damage in rats. Abstract:  BACKGROUND: Garlic capsule (GAR) and/or selenium- vitamin A, C, E (S-VACE) might be useful in the treatment of lung diseases. The present study evaluated the toxicity of lisinopril (LIS) in the lungs of male rats and the reversal effect of GAR and/or selenium-vitamins A, C, and E (S-VACE).METHODS: Group I served as the control, whereas animals in groups II, III, IV, and V received 28 mg of LIS/kg body weight by gavage. Group III was co-treated with GAR at a therapeutic dosage of 250 mg/kg body weight per day. Group IV was co-treated with S-VACE at dosage of 500 mg/kg body weight per day. Lastly, group V was co-treated with GAR and S-VACE at dosages of 250 and 500 mg/kg body weight per day, respectively. The experiment lasted for 8 days (sub-acute exposure).RESULTS: Administration of therapeutic dose of LIS to male rats depleted enzymatic antioxidants (superoxide dismutase and catalase) and cellular adenosine triphosphate content with concomitant increase in lipid peroxidation. Histopathology examination showed damage to the epithelial cells of the airways. These effects were prevented by both single and combination treatment of GAR and S-VACE in male rats with LIS-induced lung toxicity.CONCLUSIONS: We therefore concluded that the combination of GAR and S-VACE can be a novel therapy for the management of lung diseases in humans. https://greenmedinfo.com/article/combination-gar-and-s-vace-can-be-novel-therapy-management-lung-diseases-human#comments Garlic Lung Damage Lung Diseases Selenium Vitamin A Vitamin C Vitamin E Antioxidants Lisinopril Animal Study Thu, 17 Mar 2016 05:15:19 +0000 greenmedinfo 124892 at https://greenmedinfo.com A review of carnosine and lung disease. https://greenmedinfo.com/article/review-carnosine-and-lung-disease PMID:  Curr Med Chem. 2019 Jul 12. Epub 2019 Jul 12. PMID: 31309876 Abstract Title:  Carnosine and Lung Disease. Abstract:  Carnosine (b-alanyl-L-histidine) is a small dipeptide with numerous activities, including antioxidant effects, metal ion chelation, proton buffering capacity, and inhibitory effects on protein carbonylation and glycation. Carnosine has been mostly studied in organs where it is abundant, including skeletal muscle, cerebral cortex, kidney, spleen, and plasma. Recently, the effect of supplementation with carnosine has been studied in organs with low levels of carnosine, such as the lung, in animal models of influenza virus- or lipopolysaccharide-induced acute lung injury and pulmonary fibrosis. Among the known protective effects of carnosine, its antioxidant effect has attracted increasing attention for potential use in treating lung disease. In this review, we describe the in vitro and in vivo biological and physiological actions of carnosine. We also report our recent study and discuss the roles of carnosine or its related compounds in organs where carnosine is present in only small amounts (especially the lung) and its protective mechanisms. <p><a href="https://greenmedinfo.com/article/review-carnosine-and-lung-disease" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-carnosine-and-lung-disease#comments Lipopolysaccharide-Induced Toxicity Lung Diseases Oxidative Stress Pulmonary Fibrosis Antioxidants Review Thu, 31 Oct 2019 22:50:33 +0000 greenmedinfo 200546 at https://greenmedinfo.com Açai Seeds administration was useful against lung disease by the reduction of NF-κB nuclear translocation. https://greenmedinfo.com/article/ai-seeds-administration-was-useful-against-lung-disease-reduction-nf-b-nuclear PMID:  Cell Physiol Biochem. 2022 May 13 ;56(S2):1-20. PMID: 35551733 Abstract Title:  Açaí(Euterpe Oleraceae Mart.) Seeds Regulate NF-κB and Nrf2/ARE Pathways Protecting Lung against Acute and Chronic Inflammation. Abstract:  BACKGROUND/AIMS: Respiratory diseases are the world&#039;s biggest cause of mortality and disability. Specific nutrients have been proposed to positively affect disease progression as novel therapy alternatives to glucocorticosteroids. There has been a lot of attention in the possible health advantages of dietary assumption of Açai Seeds, popular native fruit found in the Amazon region which is rich in bioactive compounds. Until today nobody investigated the beneficial property of Açai Seeds administration in lung disease.METHODS: In our study we use two model of lung disease: for acute lung disease we use an intrapleural injection of Carrageenan; for chronic disease we used an intratracheal instillation of bleomycin. Açai Seeds was administered orally dissolved in saline.RESULTS: We found that Açai Seeds was able to reduce histological alteration, cells infiltration, pro inflammatory cytokine release, inflammation, and oxidative stress in both acute and chronic model of lung disease.CONCLUSION: Our data clearly demonstrate for the first time that Açai Seeds administration was useful against lung disease by the reduction of NF-κB nuclear translocation and by the stimulation of Nrf2/ARE pathways promoting the physiological antioxidant defense. <p><a href="https://greenmedinfo.com/article/ai-seeds-administration-was-useful-against-lung-disease-reduction-nf-b-nuclear" target="_blank">read more</a></p> https://greenmedinfo.com/article/ai-seeds-administration-was-useful-against-lung-disease-reduction-nf-b-nuclear#comments Acai Inflammation Lung Diseases Lung Inflammation Anti-Inflammatory Agents Antioxidants NF-kappaB Inhibitor Nrf2 activation Plant Extracts In Vitro Study Sun, 15 Jan 2023 22:24:07 +0000 greenmedinfo 269434 at https://greenmedinfo.com Aerotoxic - An Inconvenient Truth of Flying https://greenmedinfo.com/blog/aerotoxic-inconvenient-truth-flying <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/AerotoxicAnInconvenienttruthofFlying.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><em><strong>A seven decade old cause of mysterious public ill health will eventually be solved with solutions which exist - today</strong></em></span></p> <p>Anybody lighting up a cigarette in an airliner these days would be rightly judged by society to be on the wrong side of the law - as it has finally been proven beyond reasonable doubt that exposure to toxic chemicals from <strong><a href="/toxic-ingredient/tobacco-smoking" rel="dofollow" target="_blank">tobacco smoke</a></strong> is dangerous.</p><p><a href="https://greenmedinfo.com/blog/aerotoxic-inconvenient-truth-flying" target="_blank">read more</a></p> https://greenmedinfo.com/blog/aerotoxic-inconvenient-truth-flying#comments Air Pollution Linked Toxicity Chronic Disease Fatigue Headache Lung Diseases Memory Loss Mood Disorders Respiratory Diseases Sleep Disorders Vomiting Chemical and Drug Toxicity Health Guide: Chemical Exposures Health Guide: Corruption in Science Jet fuel Petrochemical Industrial Byproducts/Pollution aerotoxic syndrome air travel safety corruption in science Fri, 23 Jun 2023 13:23:15 +0000 johnhoyte 165286 at https://greenmedinfo.com Air Pollution, Forest Fires, and Industrial Toxins: Your Best Detox Strategies https://greenmedinfo.com/blog/air-pollution-forest-fires-and-industrial-toxins-your-best-detox-strategies <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2018<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:20px;"><em><strong><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/AirPollutionForestFiresandIndustrialToxins.jpg" style="width: 600px; height: 315px;" /></strong></em></span></p> <p><span style="font-size:22px;"><em><strong>Poor air quality from industrial activities and the recent wildfires is a looming health risk for us all. Here are evidence-based strategies for removing toxic compounds from your body and mitigating the health risks of air pollution.&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/air-pollution-forest-fires-and-industrial-toxins-your-best-detox-strategies" target="_blank">read more</a></p> https://greenmedinfo.com/blog/air-pollution-forest-fires-and-industrial-toxins-your-best-detox-strategies#comments Airway Obstruction Autoimmune Diseases Berries: All Cinnamon Curcumin Fish Oil Fruit: All Green Leafy Vegetables Heart Disease Holy Basil Inflammation Lung Diseases Metabolic Diseases Olive Oil Vegetables: All Air Pollution: Ozone Chemical and Drug Toxicity Health Guide: Chemical Exposures Health Guides: Healing Foods Heavy Metals Hydrocarbons Nanoparticles air pollution Airborne Pollution chemical exposure Free Radicals healing foods industrial pollution Mon, 19 Nov 2018 17:54:51 +0000 AliLeVere 152982 at https://greenmedinfo.com Ambient air pollution could affect the progression from free of chronic lung disease to incident chronic lung disease, chronic lung multimorbidity and death. https://greenmedinfo.com/article/ambient-air-pollution-could-affect-progression-free-chronic-lung-disease-incid PMID:  Thorax. 2023 Feb 2. Epub 2023 Feb 2. PMID: 36732083 Abstract Title:  Air pollution associated with incidence and progression trajectory of chronic lung diseases: a population-based cohort study. Abstract:  BACKGROUND: No prior study has examined the effects of air pollution on the progression from healthy to chronic lung disease, subsequent chronic lung multimorbidity and further to death.METHODS: We used data from the UK Biobank of 265 506 adults free of chronic lung disease at recruitment. Chronic lung multimorbidity was defined as the coexistence of at least two chronic lung diseases, including asthma, chronic obstructive pulmonary disease and lung cancer. The concentrations of air pollutants were estimated using land-use regression models. Multistate models were applied to assess the effect of air pollution on the progression of chronic lung multimorbidity.RESULTS: During a median follow-up of 11.9 years, 13 863 participants developed at least one chronic lung disease, 1055 developed chronic lung multimorbidity and 12 772 died. We observed differential associations of air pollution with different trajectories of chronic lung multimorbidity. Fine particulate matter showed the strongest association with all five transitions, with HRs (95% CI) per 5 µg/mincrease of 1.31 (1.22 to 1.42) and 1.27 (1.01 to 1.57) for transitions from healthy to incident chronic lung disease and from incident chronic lung disease to chronic lung multimorbidity, and 1.32 (1.21 to 1.45), 1.24 (1.01 to 1.53) and 1.91 (1.14 to 3.20) for mortality risk from healthy, incident chronic lung disease and chronic lung multimorbidity, respectively.CONCLUSION: Our study provides the first evidence that ambient air pollution could affect the progression from free of chronic lung disease to incident chronic lung disease, chronic lung multimorbidity and death. <p><a href="https://greenmedinfo.com/article/ambient-air-pollution-could-affect-progression-free-chronic-lung-disease-incid" target="_blank">read more</a></p> https://greenmedinfo.com/article/ambient-air-pollution-could-affect-progression-free-chronic-lung-disease-incid#comments Air Pollution Linked Toxicity Lung Diseases Risk Factors Human Study Sat, 04 Feb 2023 02:57:28 +0000 greenmedinfo 270513 at https://greenmedinfo.com Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. https://greenmedinfo.com/article/clinical-and-experimental-effects-nigella-sativa-and-its-constituents-respirat PMID:  Avicenna J Phytomed. 2019 May-Jun;9(3):195-212. PMID: 31143688 Abstract Title:  Clinical and experimental effects ofand its constituents on respiratory and allergic disorders. Abstract:  Objective: Black cumin or() seed has been widely used traditionally as a medicinal natural product because of its therapeutic effects. In this review, the medicinal properties ofas a healing remedy for the treatment of respiratory and allergic diseases, were evaluated.Material and Methods: Keywords including, black seed, thymoquinone, respiratory, pulmonary, lung and allergic diseases were searched in medical and nonmedical databases (i.e. PubMed, Science Direct, Scopus, and Google Scholar). Preclinical studies and clinical trials published between 1993 and 2018 were selected.Results: In experimental and clinical studies, antioxidant, immunomodulatory, anti-inflammatory, antihistaminic, antiallergic, antitussive and bronchodilatory properties ofdifferent extracts, extracts fractions and constituents were demonstrated. Clinical studies also showed bronchodilatory and preventive properties of the plant in asthmatic patients. The extract ofshowed a preventive effect on lung disorders caused by sulfur mustard exposure. The therapeutic effects of the plant and its constituents on various allergic disorders were also demonstrated.Conclusion: Therefore,and its constituents may be considered effective remedies for treatment of allergic and obstructive lung diseases as well as other respiratory diseases. <p><a href="https://greenmedinfo.com/article/clinical-and-experimental-effects-nigella-sativa-and-its-constituents-respirat" target="_blank">read more</a></p> https://greenmedinfo.com/article/clinical-and-experimental-effects-nigella-sativa-and-its-constituents-respirat#comments Allergies Cough Hypersensitivity: Respiratory Lung Diseases Nigella sativa (aka Black Seed) Thymoquinone Anti-Allergic Agents Anti-Inflammatory Agents Antitussive Agents Review Mon, 03 Jun 2019 00:31:40 +0000 greenmedinfo 188600 at https://greenmedinfo.com DHA increases resistance to Pseudomonas aeruginosa infection. https://greenmedinfo.com/article/dha-increases-resistance-pseudomonas-aeruginosa-infection PMID:  Biochem J. 2009 Apr 1;419(1):193-200. PMID: 19105793 Abstract Title:  Membrane-targeted synergistic activity of docosahexaenoic acid and lysozyme against Pseudomonas aeruginosa. Abstract:  Antimicrobial polypeptides, including lysozymes, have membrane perturbing activity and are well-documented effector molecules of innate immunity. In cystic fibrosis, a hereditary disease with frequent lung infection with Pseudomonas aeruginosa, the non-esterified fatty acid DA (docosahexaenoic acid), but not OA (oleic acid), is decreased, and DA supplementation has been shown to improve the clinical condition in these patients. We hypothesized that DA may, either alone or in conjunction with lysozyme, exert antibacterial action against Ps. aeruginosa. We found that DA and lysozyme synergistically inhibit the metabolic activity of Ps. aeruginosa, in contrast with OA. Electron microscopy and equilibrium dialysis suggest that DA accumulates in the bacterial membrane in the presence of lysozyme. Surface plasmon resonance with live bacteria and differential scanning calorimetry studies with bacterial model membranes reveal that, initially, DA facilitates lysozyme incorporation into the membrane, which in turn allows influx of more DA, leading to bacterial cell death. The present study elucidates a molecular basis for the synergistic action of non-esterified fatty acids and antimicrobial polypeptides, which may be dysfunctional in cystic fibrosis. https://greenmedinfo.com/article/dha-increases-resistance-pseudomonas-aeruginosa-infection#comments Cystic Fibrosis DHA (Docosahexaenoic Acid) Lung Diseases Pseudomonas aeruginosa Pseudomonas Infections Sun, 30 Aug 2009 21:25:46 +0000 greenmedinfo 46718 at https://greenmedinfo.com Ellagic acid may have the potential to be used as a medication for the prevention or attenuation of lung diseases. https://greenmedinfo.com/article/ellagic-acid-may-have-potential-be-used-medication-prevention-or-attenuation-l PMID:  Environ Sci Pollut Res Int. 2019 Dec 29. Epub 2019 Dec 29. PMID: 31885062 Abstract Title:  Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities. Abstract:  Phytochemicals is considered one of the most effective and safe alternative therapy against oxidative linked lung diseases. Ellagic acid (EA), an important component of fruits, nuts, and vegetables, are partly responsible for their beneficial health effects against oxidation-related diseases. In the present study, we investigated the ameliorative effect of EA on lung damage induced by carbon tetrachloride (CCl) in Wistar male albino rats. Thirty-six male rats (n = 36, 8-week old) were divided into 4 groups, each with 9 rats. The groups were: Control group: received standard diet; EA group: administered with EA (10 mg/kg body weight, intraperitoneal); CClgroup: administered with CCl(1.5 mg/kg body weight, intraperitoneal); EA+CClgroup: administered with EA and CCl. . The rats were decapitated at the end of experimental period of 8 weeks and the lung tissues were examined. CCl-induced rats showed elevation in the expressions of inflammatory proteins, nuclear factor kappa b (NF-κB), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α); and the indicator of lipid peroxidation, malondialdehyde (MDA). Intraperitoneal administration of EA significantly reduced the levels of these markers. EA administration increased the protein expression levels of nuclear factor erythroid 2-related factor 2 (Nrf-2) and enhanced the activity of glutathione (GSH) and catalase enzyme (CAT). In addition, EA administration increased the expression levels of the executioner protein of apoptosis, caspase-3, and decreasing pro-survival protein, B cell lymphoma-2 (Bcl-2). In conclusion, these results establishes the protective role of EA in the treatment of lung damage and that in the future, this may have the potential to be used as a medication for the prevention or attenuation of lung diseases. Graphical abstract. <p><a href="https://greenmedinfo.com/article/ellagic-acid-may-have-potential-be-used-medication-prevention-or-attenuation-l" target="_blank">read more</a></p> https://greenmedinfo.com/article/ellagic-acid-may-have-potential-be-used-medication-prevention-or-attenuation-l#comments Ellagic Acid Lung Diseases Anti-Inflammatory Agents Antioxidants Cyclooxygenase 2 Inhibitors Malondialdehyde Down-regulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Fri, 10 Jan 2020 15:00:23 +0000 greenmedinfo 207573 at https://greenmedinfo.com Flying Should Come with a Health Warning https://greenmedinfo.com/blog/flying-should-come-health-warning <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/FlyingShouldComeWithaHealthWarning.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><em style="letter-spacing: 0px;"><strong>Did you know that the air you breathe on a commercial airliner comes directly from the engine, complete with engine oil, lubricants and hydraulic fluid? A study confirms the link between contaminated cabin air and aerotoxic syndrome. Learn what you can do to protect yourself and your family</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/flying-should-come-health-warning" target="_blank">read more</a></p> https://greenmedinfo.com/blog/flying-should-come-health-warning#comments Aerotoxic Syndrome Dizziness Fatigue Lung Diseases Nausea Vision Disorders Chemical and Drug Toxicity Crude Oil/Petroleum Hydrocarbons Jet fuel Wi-Fi Radiation air pollution air travel air travel safety aircraft oil Neurological Conditions Sat, 15 Jul 2017 19:20:04 +0000 Biraalo 150494 at https://greenmedinfo.com Glyphosate-rich air samples from farms as well as pure glyphosate to induce type 2 airway inflammation. https://greenmedinfo.com/article/glyphosate-rich-air-samples-farms-well-pure-glyphosate-induce-type-2-airway-in PMID:  Toxicology. 2014 Nov 5 ;325:42-51. Epub 2014 Aug 27. PMID: 25172162 Abstract Title:  Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation. Abstract:  Several low weight molecules have often been implicated in the induction of occupational asthma. Glyphosate, a small molecule herbicide, is widely used in the world. There is a controversy regarding a role of glyphosate in developing asthma and rhinitis among farmers, the mechanism of which is unexplored. The aim of this study was to explore the mechanisms of glyphosate induced pulmonary pathology by utilizing murine models and real environmental samples. C57BL/6, TLR4-/-, and IL-13-/- mice inhaled extracts of glyphosate-rich air samples collected on farms during spraying of herbicides or inhaled different doses of glyphosate and ovalbumin. The cellular response, humoral response, and lung function of exposed mice were evaluated. Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5. In contrast, in vivo systemic IL-4 production was not increased. Co-administration of ovalbumin with glyphosate did not substantially change the inflammatory immune response. However, IL-13-deficiency resulted in diminished inflammatory response but did not have a significant effect on airway resistance upon methacholine challenge after 7 or 21 days of glyphosate exposure. Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone. This study, for the first time, provides evidence for the mechanism of glyphosate-induced occupational lung disease. https://greenmedinfo.com/article/glyphosate-rich-air-samples-farms-well-pure-glyphosate-induce-type-2-airway-in#comments Asthma Glyphosate Toxicity Lung Diseases Glyphosate Inflammatory Airborne Pollution Animal Study Tue, 19 Jan 2016 22:08:53 +0000 greenmedinfo 123268 at https://greenmedinfo.com Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. https://greenmedinfo.com/article/improved-glutathione-status-young-adult-patients-cystic-fibrosis-supplemented- PMID:  J Cyst Fibros. 2003 Dec;2(4):195-8. PMID: 15463873 Abstract Title:  Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. Abstract:  BACKGROUND: The lung disease of cystic fibrosis is associated with a chronic inflammatory reaction and an over abundance of oxidants relative to antioxidants. Glutathione functions as a major frontline defense against the build-up of oxidants in the lung. This increased demand for glutathione (GSH) in cystic fibrosis may be limiting if nutritional status is compromised. We sought to increase glutathione levels in stable patients with cystic fibrosis by supplementation with a whey-based protein. METHODS: Twenty-one patients who were in stable condition were randomly assigned to take a whey protein isolate (Immunocal, 10 g twice a day) or casein placebo for 3 months. Peripheral lymphocyte GSH was used as a marker of lung GSH. Values were compared with nutritional status and lung parameters. RESULTS: At baseline there were no significant differences in age, height, weight, percent ideal body weight or percent body fat. Lymphocyte GSH was similar in the two groups. After supplementation, we observed a 46.6% increase from baseline (P https://greenmedinfo.com/article/improved-glutathione-status-young-adult-patients-cystic-fibrosis-supplemented-#comments Cystic Fibrosis Lung Diseases Oxidative Stress Whey Antioxidants Glutathione Upregulation Human Study Thu, 28 Oct 2010 18:11:18 +0000 greenmedinfo 58208 at https://greenmedinfo.com Inhaled resveratrol treatments could slow ageing-related degenerative changes in mouse lung. https://greenmedinfo.com/article/inhaled-resveratrol-treatments-could-slow-ageing-related-degenerative-changes- PMID:  Thorax. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28070015 Abstract Title:  Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung. Abstract:  BACKGROUND: Lung ageing, a significant risk factor for chronic human lung diseases such as COPD and emphysema, is characterised by airspace enlargement and decreasing lung function. Likewise, in prematurely ageing telomerase null (terc-/-) mice, p53 stabilisation within diminishing numbers of alveolar epithelial type 2 cells (AEC2) accompanies reduced lung function. Resveratrol (RSL) is a plant phytoalexin that has previously showed efficacy in enhancing invertebrate longevity and supporting mammalian muscle metabolism when delivered orally. Here, we tested whether inhaled RSL could protect young, terc-/- mice from accelerated ageing of the lung.METHODS: terc-/- mice aged 2 months inhaled 1 mg/kg RSL that was instilled intratracheally once per month for 3 months. One month after the last inhalation, whole lung function, structure and cellular DNA damage were evaluated and AEC2 survival was assessed by western blotting for survival pathway gene expression.RESULTS: RSL treatments delayed the loss of lung compliance (p<p><a href="https://greenmedinfo.com/article/inhaled-resveratrol-treatments-could-slow-ageing-related-degenerative-changes-" target="_blank">read more</a></p> https://greenmedinfo.com/article/inhaled-resveratrol-treatments-could-slow-ageing-related-degenerative-changes-#comments Lung Diseases Resveratrol Gene Expression Regulation Animal Study Thu, 12 Jan 2017 00:06:05 +0000 greenmedinfo 141888 at https://greenmedinfo.com Lactobacillus brevis BGZLS10-17 and Lb. plantarum BGPKM22 balance immune response in lungs and replenish diminished lung microbiota in chronic lung diseases. https://greenmedinfo.com/article/lactobacillus-brevis-bgzls10-17-and-lb-plantarum-bgpkm22-balance-immune-respon PMID:  Int J Mol Sci. 2022 May 16 ;23(10). Epub 2022 May 16. PMID: 35628361 Abstract Title:  BGZLS10-17 andBGPKM22 Exhibit Anti-Inflammatory Effect by Attenuation of NF-κB and MAPK Signaling in Human Bronchial Epithelial Cells. Abstract:  Bronchial epithelial cells are exposed to environmental influences, microbiota, and pathogens and also serve as a powerful effector that initiate and propagate inflammation by the release of pro-inflammatory mediators. Recent studies suggested that lung microbiota differ between inflammatory lung diseases and healthy lungs implicating their contribution in the modulation of lung immunity. Lactic acid bacteria (LAB) are natural inhabitants of healthy human lungs and also possess immunomodulatory effects, but so far, there are no studies investigating their anti-inflammatory potential in respiratory cells. In this study, we investigated immunomodulatory features of 21 natural LAB strains in lipopolysaccharide (LPS)-stimulated human bronchial epithelial cells (BEAS-2B). Our results show that several LAB strains reduced the expression of pro-inflammatory cytokine and chemokine genes. We also demonstrated that two LAB strains,BGZLS10-17 andBGPKM22, effectively attenuated LPS-induced nuclear factor-κB (NF-κB) nuclear translocation. Moreover, BGZLS10-17 and BGPKM22 reduced the activation of p38, extracellular signal-related kinase (ERK), and c-Jun amino-terminal kinase (JNK) signaling cascade resulting in a reduction of pro-inflammatory mediator expressions in BEAS-2B cells. Collectively, theLAB strains BGZLS10-17 and BGPKM22 exhibited anti-inflammatory effects in BEAS-2B cells and could be employed to balance immune response in lungs and replenish diminished lung microbiota in chronic lung diseases. <p><a href="https://greenmedinfo.com/article/lactobacillus-brevis-bgzls10-17-and-lb-plantarum-bgpkm22-balance-immune-respon" target="_blank">read more</a></p> https://greenmedinfo.com/article/lactobacillus-brevis-bgzls10-17-and-lb-plantarum-bgpkm22-balance-immune-respon#comments Lactobacillus Brevis Lactobacillus plantarum Lipopolysaccharide-Induced Toxicity Lung Diseases Anti-Inflammatory Agents NF-kappaB Inhibitor In Vitro Study Fri, 03 Jun 2022 19:47:48 +0000 greenmedinfo 258489 at https://greenmedinfo.com OB/GYN Docs in U.S. Want COVID-19 Vaccines Tested on Pregnant Women https://greenmedinfo.com/blog/obgyn-docs-us-want-covid-19-vaccines-tested-pregnant-women <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/OB-GYN_Docs_in_US_Want_COVID-19_Vaccines_Tested_on_Pregnant_Women-GreenMedInfo(1).jpg" style="width: 600px; height: 315px;" /><br /> <span style="font-size:12px;"><strong>Originally published on&nbsp;<a href="https://thevaccinereaction.org/2020/07/ob-gyn-docs-in-u-s-want-covid-19-vaccines-tested-on-pregnant-women/">www.thevaccinereaction.org</a></strong></span></p> <p><span style="font-size:18px;"><em><strong>OB/GYN Docs in U.S. Want COVID-19 Vaccines Tested on Pregnant Women</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/obgyn-docs-us-want-covid-19-vaccines-tested-pregnant-women" target="_blank">read more</a></p> https://greenmedinfo.com/blog/obgyn-docs-us-want-covid-19-vaccines-tested-pregnant-women#comments Cardiovascular Disease Coronavirus Disease Coronavirus Infection Diarrhea Fever Headache Lung Diseases SARS Vaccination: All Health Guide: Chemical Exposures Health Guide: Corruption in Science Infant and Children's Heatlh Vaccine Adjuvants Vaccine Effects Vaccine Rights Women's Health dishonesty technology viral infections Tue, 07 Jul 2020 19:43:23 +0000 VaccineReaction 223208 at https://greenmedinfo.com