Marfan Syndrome https://greenmedinfo.com/taxonomy/term/3173/all en Ascorbic acid, riboflavin and pyridoxine may have therapeutic value in various heredietary connective tissue diseases. https://greenmedinfo.com/article/ascorbic-acid-riboflavin-and-pyridoxine-may-have-therapeutic-value-various-her PMID:  Vopr Med Khim. 1988 Sep-Oct;34(5):99-104. PMID: 2905846 Abstract Title:  [Effect of therapy with beta-adrenoblockers and vitamin complexes on indices of oxyproline excretion in various hereditary connective tissue diseases]. Abstract:  Excretion of hydroxyproline with urine was studied in 16 children (5-14 years old) with Marphan-Like syndrome and Marphan, Ehlers-Dunlos and Larson syndromes after therapy involving propranolol and a complex of vitamins (ascorbic acid, riboflavin and pyridoxine) and recommended on the basis of echocardiographic analyses. The therapeutic course appears to cause quantitative and qualitative correction of collagen and apparently of elastin fibrilles development. Depending on initial patterns of hydroxyproline excretion and the syndrome form the correction could be complete or partial, while positive effect of the treatment was stable or provisional. The data obtained suggest that the complex treatment developed might be applied as a preoperative therapy of the patients with Marphan-like syndrome as well as with syndromes of Marphan and Ehlers-Dunlos before thoracoplastics caused by hereditary chest deformation and by impairments of cardiovascular system. https://greenmedinfo.com/article/ascorbic-acid-riboflavin-and-pyridoxine-may-have-therapeutic-value-various-her#comments Connective Tissue Diseases Ehlers-Danlos Syndrome Larsen Syndrome Marfan Syndrome Riboflavin (Vitamin B-2) Vitamin B-6 Vitamin C Human Study Fri, 24 Sep 2010 16:32:31 +0000 greenmedinfo 57094 at https://greenmedinfo.com Oxidative stress in plasma from patients with Marfan syndrome is modulated by deodorized garlic preliminary findings. https://greenmedinfo.com/article/oxidative-stress-plasma-patients-marfan-syndrome-modulated-deodorized-garlic-p PMID:  Oxid Med Cell Longev. 2022 ;2022:5492127. Epub 2022 Jan 17. PMID: 35082968 Abstract Title:  Oxidative Stress in Plasma from Patients with Marfan Syndrome Is Modulated by Deodorized Garlic Preliminary Findings. Abstract:  Marfan syndrome (MFS) is a genetic disorder of connective tissue that affects the fibrillin-1 protein (FBN-1). It is associated with the formation of aneurysms, damage to the endothelium and oxidative stress (OS). Allium sativum (garlic) has antioxidant properties; therefore, the goal of this study was to show the antioxidant effect of deodorized garlic (DG) on antioxidant enzymes and OS markers in the plasma of patients with MFS. The activity of antioxidant enzymes such as extracellular superoxide dismutase (EcSOD), peroxidases, glutathione peroxidase (GPx), gluthatione-S-tranferase (GST), and thioredoxin reductase (TrxR) was quantified, and nonenzymatic antioxidant system markers including lipid peroxidation (LPO), carbonylation, nitrates/nitrites, GSH, and vitamin C in plasma were determined in patients with MFS before and after treatment with DG. The results show that DG increased the activity of the EcSOD, peroxidases, GPx, GST, TrxR (≤ 0.05) and decrease LPO, carbonylation, and nitrates/nitrites (≤ 0.01). However, glutathione was increased (= 0.01) in plasma from patients with MFS. This suggests that treatment with garlic could lower the OS threshold by increasing the activity of antioxidant enzymes and could help in the prevention and mitigation of adverse OS in patients with MFS. <p><a href="https://greenmedinfo.com/article/oxidative-stress-plasma-patients-marfan-syndrome-modulated-deodorized-garlic-p" target="_blank">read more</a></p> https://greenmedinfo.com/article/oxidative-stress-plasma-patients-marfan-syndrome-modulated-deodorized-garlic-p#comments Garlic: Aged Marfan Syndrome Oxidative Stress Antioxidants Human Study Mon, 14 Mar 2022 22:29:28 +0000 greenmedinfo 254724 at https://greenmedinfo.com