Neuralgia: Post Herpetic https://greenmedinfo.com/taxonomy/term/3489/all en Intravenous administration of vitamin C has been reported effective in the treatment of herpetic neuralgia. https://greenmedinfo.com/article/intravenous-administration-vitamin-c-has-been-reported-effective-treatment-her PMID:  Gynecol Oncol. 2007 Apr;105(1):104-12. Epub 2006 Dec 15. PMID: 20424557 Abstract Title:  Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports. Abstract:  BACKGROUND: Acute herpetic neuralgia (AHN) due to a reactivated varicella zoster virus infection is a common problem. Furthermore, about 18% of all patients with confirmed herpes zoster (HZ) develop postherpetic neuralgia (PHN). The leading factors of the prognosis and persistence of symptoms are patient age and the size of the lesions. Animal studies came to a similar conclusions that in both AHN and PHN, inflammatory cytokines such as IL-6 and IL-8 could serve as predictive markers and that a positive influence of vitamin C administration, by modifying cytokine metabolism, could be demonstrated.CASE REPORT: Two patients (females aged 67 and 53 years) from an average and unselected patient group of a general practice with confirmed AHN were observed in the course of their illness. They received the basic analgesic (according to the WHO step scheme) and viral-static therapy. Furthermore, 15 g of vitamin C was administered intravenously every second day over a period of two weeks. Sudden and total remission of the neuropathic pain (measured on the basis of the visual analogous-scale, VAS) could be observed. Remission of the cutaneous lesions was noted within 10 days.CONCLUSIONS: The use of the vitamin C appears to be an interesting component of alternative therapeutic strategies in the treatment of HZ. Especially for therapy-resistant cases of PHN, vitamin C administration should be examined as an additional option. To test and confirm the clinical findings, randomized clinical studies concerning the use of vitamin C in the concomitant treatment of zoster-associated neuralgia should be performed. https://greenmedinfo.com/article/intravenous-administration-vitamin-c-has-been-reported-effective-treatment-her#comments Neuralgia: Post Herpetic Vitamin C Human: Case Report Sat, 26 Mar 2011 13:36:07 +0000 greenmedinfo 62863 at https://greenmedinfo.com Intravenously administered ascorbic acid is effective for reducing the incidence of postherpetic neuralgia. https://greenmedinfo.com/article/intravenously-administered-ascorbic-acid-effective-reducing-incidence-postherp PMID:  Ann Dermatol. 2016 Dec ;28(6):677-683. Epub 2016 Nov 23. PMID: 27904265 Abstract Title:  A Study of Intravenous Administration of Vitamin C in the Treatment of Acute Herpetic Pain and Postherpetic Neuralgia. Abstract:  BACKGROUND: Although there are several available management strategies for treatment of both acute pain of herpes zoster (HZ) and postherpetic neuralgia (PHN), it is difficult to treat them adequately.OBJECTIVE: The aim of this study was to evaluate the efficacy of intravenously administrated vitamin C on acute pain and its preventive effects on PHN in patients with HZ.METHODS: Between September 2011 and May 2013 eighty-seven patients who were admitted for HZ were assessed according to age, sex, underlying diseases, duration of pain and skin lesion, dermatomal distribution, and PHN. It was a randomized controlled study, in which 87 patients were randomly allocated into the ascorbic acid group and control group. Each patient received normal saline infusion with or without 5 g of ascorbic acid on days 1, 3, and 5 then answered questionnaires that included side effects and pain severity using visual analogue scale on days 1, 2, 3, 4, and 5. After discharge, the severity of pain was obtained at out-patient clinic or by telephone on weeks 2, 4, 8, and 16.RESULTS: There was no differences in severity of pain on patients&#039; age, sex, underlying diseases, duration of pain and skin lesion and dermatomal distribution between two groups (p&gt;0.05). Since 8th week, pain score in ascorbic acid treatment group was significantly lower than control group (p<p><a href="https://greenmedinfo.com/article/intravenously-administered-ascorbic-acid-effective-reducing-incidence-postherp" target="_blank">read more</a></p> https://greenmedinfo.com/article/intravenously-administered-ascorbic-acid-effective-reducing-incidence-postherp#comments Herpes Zoster Neuralgia: Post Herpetic Vitamin C: Intravenous Human Study Tue, 13 Dec 2016 00:20:46 +0000 greenmedinfo 140341 at https://greenmedinfo.com Melatonin had significant analgesic effects in the treatment of post herpetic neuralgia. https://greenmedinfo.com/article/melatonin-had-significant-analgesic-effects-treatment-post-herpetic-neuralgia PMID:  Int J Clin Exp Med. 2015 ;8(4):5004-9. Epub 2015 Apr 15. PMID: 26131073 Abstract Title:  Analgesic effects of melatonin on post-herpetic neuralgia. Abstract:  OBJECTIVE: This study aims to explore the analgesic effects of melatonin on post-herpetic neuralgia and its possible mechanism.METHODS: A total of 48 PHN Wistar rats were divided into 4 groups randomly: Normal, PHN, PHN+MT and naloxone, 4P-PDOT or L-arginine+120 mg/kg MT (C). Heat pain latency was determined after MT injection for 20 min, 40 min, 80 min and 120 min respectively. The expression levels ofδ receptor and MT2 receptor in different tissues of rats were detected by RT-PCR method. NO content was determined.RESULTS: Heat pain latency in PHN rats were lower than that of control group (P https://greenmedinfo.com/article/melatonin-had-significant-analgesic-effects-treatment-post-herpetic-neuralgia#comments Melatonin Neuralgia: Post Herpetic Analgesics Animal Study Tue, 04 Aug 2015 19:07:07 +0000 greenmedinfo 119543 at https://greenmedinfo.com Peppermint oil has been used to successfully treat post-herpetic neuralgia. https://greenmedinfo.com/article/peppermint-oil-has-been-used-successfully-treat-post-herpetic-neuralgia PMID:  Clin J Pain. 2002 May-Jun;18(3):200-2 PMID: 12048423 Abstract Title:  A novel treatment of postherpetic neuralgia using peppermint oil. Abstract:  BACKGROUND: Postherpetic neuralgia remains a difficult problem to treat. A number of therapies have been shown to be effective, but some patients have intractable pain. PATIENT: The case of a 76-year-old woman whose pain had been resistant to standard therapies is described. The pattern of quantitative sensory testing results for this patient led the authors to believe that she had an &quot;irritable nociceptor&quot; type of pathophysiology. INTERVENTION: The patient was instructed to apply neat peppermint oil (containing 10% menthol) to her skin, resulting in an almost immediate improvement in her pain. This pain relief persisted for 4-6 hours after application of the oil. RESULTS: The patient was successfully treated with topical peppermint oil. During 2 months of follow-up she has had only a minor side effect, with continuing analgesia. The authors believe this is the first evidence of peppermint oil (or menthol) having a strong analgesic effect on neuropathic pain. The possible mechanisms of action of peppermint oil are discussed. https://greenmedinfo.com/article/peppermint-oil-has-been-used-successfully-treat-post-herpetic-neuralgia#comments Herpes Zoster Neuralgia: Post Herpetic Peppermint Shingles Human: Case Report Mon, 20 Apr 2009 06:11:37 +0000 greenmedinfo 42067 at https://greenmedinfo.com Plasma vitamin C status plays a role in postherptetic neuralgia (PHN), and intravenous ascorbate helps relieve spontaneous pain in PHN https://greenmedinfo.com/article/plasma-vitamin-c-status-plays-role-postherptetic-neuralgia-phn-and-intravenous PMID:  Clin J Pain. 2009 Sep;25(7):562-9. PMID: 19692796 Abstract Title:  Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. Abstract:  OBJECTIVES: Plasma vitamin C concentrations have been suggested to be related to pain modulation in postherpetic neuralgia (PHN), an intractable neuropathic pain syndrome. In this study, we first compared plasma concentrations of vitamin C between healthy volunteers and PHN patients and then designed a symptom-based and mechanism-based approach to assess the analgesic effect of intravenous vitamin C on spontaneous and brush-evoked pain.METHODS: Study 1 was cross-sectional that enrolled 39 healthy volunteers and 38 PHN patients. Study 2 was a double-blinded, placebo-controlled intervention study, which comprised 41 patients randomly allocated into the ascorbate group and placebo. Each patient received normal saline infusion with or without ascorbate on days 1, 3, and 5 and answered questionnaires that included side effects; numeric rating pain scale (NRS) on spontaneous and brush-evoked pain on days 1, 3, 5, and 7; and patient global impression of change on spontaneous and brush-evoked pain on day 7.RESULTS: Study 1 revealed that plasma concentrations of vitamin C were significantly lower in patients with PHN than in healthy volunteers (P https://greenmedinfo.com/article/plasma-vitamin-c-status-plays-role-postherptetic-neuralgia-phn-and-intravenous#comments Neuralgia: Post Herpetic Vitamin C Analgesics Antioxidants Human Study Sat, 26 Mar 2011 13:38:05 +0000 greenmedinfo 62864 at https://greenmedinfo.com Post-herpetic neuralgia may be relieved through the use of SCENAR technology. https://greenmedinfo.com/article/post-herpetic-neuralgia-may-be-relieved-through-use-scenar-technology PMID:  Hawaii Med J. 2007 Sep;66(9):232, 234. PMID: 20879466 Abstract Title:  The use of electronic biofeedback for the management of post-herpetic neuralgia--a report of 3 cases. Abstract:  The purpose of these case reports is to describe treatment of three consecutive patients with post-herpetic neuralgia using a bioelectronical device (SCENAR). The instrument is approved as a Class II device in the United States. The electrode of the device was stroked gently over the involved skin area for up to 15 minutes per session. No more than 5 sessions over a 3-week period was required. All patients experienced substantial relief of pain from the first treatment. One patient required only 1 treatment lasting 10 minutes. The other 2 patients required 4 to 5 treatments over a 3-week period. One patient required a treatment for skin itch after one year with a follow up period of 6 months to 24 months. An electronic biofeedback device (SCENAR) may be successfully utilized in the management of post-herpetic neuralgia. https://greenmedinfo.com/article/post-herpetic-neuralgia-may-be-relieved-through-use-scenar-technology#comments Neuralgia: Post Herpetic SCENAR Therapy (electronic biofeedback) Human: Case Report Wed, 04 May 2011 17:37:10 +0000 greenmedinfo 63557 at https://greenmedinfo.com Pricking blood therapy combined with ultraviolet irradiation has rapid therapeutic effect, effectively shortens duration of illness, decreases the incidence rate of post herpetic neuralgia and it is a safe remedy for treatment of herpes zoster. https://greenmedinfo.com/article/pricking-blood-therapy-combined-ultraviolet-irradiation-has-rapid-therapeutic- PMID:  Zhongguo Zhen Jiu. 2009 Apr;29(4):285-8. PMID: 19565736 Abstract Title:  [Pricking blood therapy combined with ultraviolet irradiation for treatment of acute herpes zoster]. Abstract:  OBJECTIVE: To evaluate clinical therapeutic effect and the safety of pricking blood therapy combined with ultraviolet irradiation for treatment of acute herpes zoster. METHODS: One hundred and thirty cases were randomly divided into an observation group and a control group, 65 cases in each group. The observation group was treated with pricking blood therapy combined with ultraviolet irradiation. Firstly, the affected parts were heavily taped with a plum-blossom needle and then cupping. After the cup was removed, with the body surface-dividing field method, ultraviolet irradiation was given at the skin injury area and the nerve root area corresponding to paraspinal vertebra, and the control group was treated with Aciclovir and other western medicine. Seven days constituted one course. Their therapeutic effects and adverse reactions were observed. RESULTS: After treatment of 7 days, the cured rate of 76.9% and the total effective rate of 90.8% in the observation group were significantly higher than 38.5% and 66.2% in the control group, respectively (both P https://greenmedinfo.com/article/pricking-blood-therapy-combined-ultraviolet-irradiation-has-rapid-therapeutic-#comments Herpes Zoster Neuralgia: Post Herpetic Shingles Antiviral Agents Light Therapy Prickling Blood Therapy Human Study Thu, 04 Feb 2010 22:56:32 +0000 greenmedinfo 50852 at https://greenmedinfo.com Vitamin D may be therapeutic in the treatment of post herpetic neuralgia. https://greenmedinfo.com/article/vitamin-d-may-be-therapeutic-treatment-post-herpetic-neuralgia PMID:  Med Hypotheses. 2009 Jul 25. PMID: 19635651 Abstract Title:  Post herpetic neuralgia, schwann cell activation and vitamin D. Abstract:  While the underlying pathophysiology of herpes zoster infection has been well characterised, many of the mechanisms relating to the subsequent development of post herpetic neuralgia (PHN) remain uncertain. The dorsal horn atrophy and reduction in skin innervation seen in PHN patients does not adequately explain many clinical features or the efficacy of a number of topical treatments. In the central nervous system the glia, their receptors and their secreted signalling factors are now known to have a major influence on neural function. In the peripheral nervous system, schwann cell activation in response to infection and trauma releases a number of neuroexcitatory substances. Activation of the nervi nervorum in the peripheral nervous system also leads to the release of calcitonin gene related peptide, substance P and nitric oxide. Schwann cell and/or nervi nervorum activation could be an additional mechanism of pain generation in PHN. Such a paradigm shift would mean that drugs useful in the treatment of glial cell activation such as naloxone, naltrexone, minocycline, pentoxifyllline, propentofylline, AV411 (ibudilast) and interleukin 10 could be useful in PHN. These drugs could be used systemically or even topically. High dose topical vitamin D would appear to offer particular promise because vitamin D has the ability to both reduce glial inflammation and reduce nitric oxide production. https://greenmedinfo.com/article/vitamin-d-may-be-therapeutic-treatment-post-herpetic-neuralgia#comments Neuralgia: Post Herpetic Vitamin D Commentary Wed, 05 Aug 2009 21:25:05 +0000 greenmedinfo 46463 at https://greenmedinfo.com