Pheochromocytoma https://greenmedinfo.com/taxonomy/term/3875/all en Bisphenol S can trigger the migration and invasion of Pheochromocytoma cells. https://greenmedinfo.com/article/bisphenol-s-can-trigger-migration-and-invasion-pheochromocytoma-cells PMID:  J Mol Neurosci. 2018 Oct ;66(2):188-196. Epub 2018 Aug 23. PMID: 30140998 Abstract Title:  Bisphenol S Triggers the Migration and Invasion of Pheochromocytoma PC12 Cells via Estrogen-Related Receptorα. Abstract:  Pheochromocytoma (PCC) is a tumor of the adrenal medulla for which surgical resection is the only therapy approach. Risk factors responsible for the tumorigenesis and progression of PCC are not well illustrated. Our present study revealed that an industrial chemical, bisphenol S (BPS), can promote the migration and invasion of PCC PC12 cells, which was evidenced by the upregulation of fibronectin (FN) and matrix metalloproteinases (MMP-2 and MMP-9). The inhibitor of estrogen-related receptorα (ERRα), while not estrogen receptor α/β (ERα/β) or G protein-coupled estrogen receptor (GPER), can attenuate BPS-induced cell migration. Mechanically, BPS can increase the binding between ERRα and promoter of FN1 and then induce the expression of FN in PC12 cells. Further, BPS can induce the expression of miR-10b in PC12 cells via ERRα. The upregulated miR-10b inhibited the expression of KLF4, which can suppress the migration and invasion of cancer cells. BPS can trigger the mRNA and protein expression of ERRα in PC12 cells via a time-dependent manner. Collectively, our study revealed that nanomolar BPS can trigger the migration and invasion of PC12 cells via activation and upregulation of ERRα. <p><a href="https://greenmedinfo.com/article/bisphenol-s-can-trigger-migration-and-invasion-pheochromocytoma-cells" target="_blank">read more</a></p> https://greenmedinfo.com/article/bisphenol-s-can-trigger-migration-and-invasion-pheochromocytoma-cells#comments Bisphenol Toxicity Pheochromocytoma Bisphenol S In Vitro Study Thu, 18 Oct 2018 18:28:05 +0000 greenmedinfo 172611 at https://greenmedinfo.com Pheochromocytoma: Extra-Adrenal https://greenmedinfo.com/disease/pheochromocytoma-extra-adrenal <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="360" alt="" src="//cdn.greenmedinfo.com/sites/default/files/AdrenalGland_13.jpg?1484867799" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_alila&#039;&gt;alila / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Pheochromocytoma Tue, 14 Apr 2009 07:24:22 +0000 greenmedinfo 21539 at https://greenmedinfo.com Piperlongumine a promising potential candidate for use as a therapeutic option for patients with PHEO/PGL and SDHB mutations. https://greenmedinfo.com/article/piperlongumine-promising-potential-candidate-use-therapeutic-option-patients-p PMID:  Oncotarget. 2016 May 26. Epub 2016 May 26. PMID: 27244895 Abstract Title:  Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models. Abstract:  Hypoxia is a common feature of solid tumors that activates a plethora of pathways, resulting in proliferation and resistance of cancer cells to radio- and chemotherapy. Pheochromocytomas/paragangliomas (PHEOs/PGLs) with mutations in the gene coding for the subunit B of succinate dehydrogenase (SDHB) are the most aggressive forms of the disease, which is partially due to their pseudohypoxic character, metabolic abnormalities, and elevated reactive oxygen species (ROS) levels. We investigated the effect of piperlongumine (PL), a natural product with cytotoxic properties restricted to cancer cells by significantly increasing intracellular ROS levels, on PHEO cells. Here we report for the first time that PL mediates PHEO cell death by activating both apoptosis and necroptosis in vitro and in vivo. This effect is magnified in hypoxic conditions, making PL a promising potential candidate for use as a therapeutic option for patients with PHEO/PGL, including those with SDHB mutations. https://greenmedinfo.com/article/piperlongumine-promising-potential-candidate-use-therapeutic-option-patients-p#comments Cancers: All Liver Cancer Neuroblastoma Pheochromocytoma Piperlongumine Angiogenesis Inhibitors Anti-metastatic Antiproliferative Apoptotic Selective Cytotoxicity Animal Study In Vitro Study Sat, 13 Aug 2016 20:25:27 +0000 greenmedinfo 132798 at https://greenmedinfo.com Tanshinone IIA has an inhibitory effect on the proliferation of pheochromocytoma cells. https://greenmedinfo.com/article/tanshinone-iia-has-inhibitory-effect-proliferation-pheochromocytoma-cells PMID:  Int J Mol Sci. 2018 Sep 12 ;19(9). Epub 2018 Sep 12. PMID: 30213025 Abstract Title:  Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways. Abstract:  The insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) facilitate tumor proliferation and progression. Tanshinone IIA (TSN) is an active diterpene quinone isolated from the roots of the herbal plant. TSN inhibits the proliferation of various types of cancer cells but its role in the IGF-1R-induced proliferation of pheochromocytoma (PC12) cells and the potential mechanisms are largely unknown. This study aims to investigate the anti-proliferative effect of TSN in PC12 cells and its role on IGF-1R signaling transduction. PC12 cells were treated with IGF-1 with or without TSN, methyl thiazolytetrazolium (MTT) assay, and cell counting kit-8 and flow cytometry were used to evaluate the proliferation of PC12 cells. The role of TSN on the apoptosis of PC12 cells were detected by flow cytometry as well. The effects of TSN and IGF-1 on the phosphorylation of IGF-1R, protein kinase B (Akt), extracellular-signal related kinase 1/2 (ERK1/2) and other downstream targets were analyzed by Western blotting analysis. Our results showed that IGF-1 promoted the growth of PC12 cells in a dose-dependent manner and increased the phosphorylation of IGF-1R, whereas TSN attenuated the effect of IGF-1. Interestingly, TSN did not induce cell apoptosis in PC12 cells. Moreover, TSN attenuated the phosphorylation of Akt and ERK1/2 induced by IGF-1, and the phosphorylation of glycogen synthase kinase-3β, forkhead box O3a (FOXO3a) and c-Raf were also inhibited by TSN. Furthermore, TSN inhibited cell growth induced by IGF-1 and blocked the activation of IGF-1R in SH-SY5Y cells. Taken together, TSN has an inhibitory effect on the proliferation of PC12 cells via down-regulation of the phosphorylatedIGF-1R and its downstream signaling. <p><a href="https://greenmedinfo.com/article/tanshinone-iia-has-inhibitory-effect-proliferation-pheochromocytoma-cells" target="_blank">read more</a></p> https://greenmedinfo.com/article/tanshinone-iia-has-inhibitory-effect-proliferation-pheochromocytoma-cells#comments Pheochromocytoma Tanshinone IIA Antiproliferative Apoptotic In Vitro Study Mon, 15 Apr 2019 20:17:48 +0000 greenmedinfo 185096 at https://greenmedinfo.com