Gastric Polyposis https://greenmedinfo.com/taxonomy/term/40316/all en Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells. https://greenmedinfo.com/article/berberine-attenuates-intestinal-tumorigenesis-inhibiting-migration-and-invasio PMID:  Evid Based Complement Alternat Med. 2016 ;2016:5137505. Epub 2016 Jul 17. PMID: 27493671 Abstract Title:  Berberine Inhibits Intestinal Polyps Growth in Apc (min/+) Mice via Regulation of Macrophage Polarization. Abstract:  Antitumor effect of berberine has been reported in a wide spectrum of cancer, however, the mechanisms of which are not fully understood. The aim of this study was to investigate the hypothesis that berberine suppresses tumorigenesis in the familial adenomatous polyposis (FAP) by regulating the macrophage polarization in Apc (min/+) mouse model. Berberine was given to Apc (min/+) mice for 12 weeks. Primary macrophages were isolated; after berberine treatment, the change in signaling cascade was determined. The total number and size of polyps were reduced remarkably in berberine group, compared with control group. A significant decrease in protein levels of F4/80, mannose receptor (MR), and COX-2 in stroma of intestinal polyps and an increase in the level of iNOS were observed after berberine treatment. The mRNA level of MR and Arg-1 in berberine group was significantly lower than those in IL-10 or IL-4 group, while no significant difference in mRNA levels of iNOS and CXCL10 was observed. The migration and invasiveness assays in vitro showed that berberine could reduce the capability of migration and invasiveness. These findings suggest that berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells via regulation of macrophage polarization. https://greenmedinfo.com/article/berberine-attenuates-intestinal-tumorigenesis-inhibiting-migration-and-invasio#comments Berberine Colon Cancer: Prevention Gastric Polyposis Intestinal Polyps Anticarcinogenic Agents Chemopreventive Animal Study Tue, 23 Aug 2016 20:23:25 +0000 greenmedinfo 133725 at https://greenmedinfo.com Gastric polyposis has been reported due to treatment with proton pump inhibitors. https://greenmedinfo.com/article/gastric-polyposis-has-been-reported-due-treatment-proton-pump-inhibitors PMID:  Gastroenterol Hepatol. 2009 Feb;32(2):88-91. Epub 2009 Feb 5. PMID: 19231680 Abstract Title:  [Gastric polyposis due to treatment with proton pump inhibitors]. Abstract:  Fundic gland polyps can appear sporadically or in association with familial adenomatous polyposis syndrome. An association between fundic gland polyps and prolonged treatment with proton pump inhibitors has been described, as has their regression after withdrawal of these inhibitors. Dysplastic components are not usually associated. We describe four patients who were receiving chronic treatment with proton pump inhibitors. The results of prior endoscopic analysis were normal. The presence of multiple fundic gland polyps was detected as was their disappearance 6 months after treatment cessation. https://greenmedinfo.com/article/gastric-polyposis-has-been-reported-due-treatment-proton-pump-inhibitors#comments Fundic Gland Polyposis Gastric Polyposis Commentary Wed, 27 Oct 2010 13:52:38 +0000 greenmedinfo 58168 at https://greenmedinfo.com Proton pump inhibitors appear to be contributing to an emerging epidemic of gastric fundic gland polyposis. https://greenmedinfo.com/article/proton-pump-inhibitors-appear-be-contributing-emerging-epidemic-gastric-fundic PMID:  World J Gastroenterol. 2008 Mar 7;14(9):1318-20. PMID: 18322941 Abstract Title:  Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis. Abstract:  Fundic gland polyps are now commonly recognized during endoscopy. These polyps are benign, often multiple and usually detected in the gastric body and fundus. In the past, these polyps were sometimes associated with familial adenomatous polyposis. In recent years, it has become evident that increasing numbers of these polyps are being detected during endoscopic studies, particularly in patients treated with proton pump inhibitors for prolonged periods. In some, dysplastic changes in these polyps have also been reported. Recent studies have suggested that there may be no increase in risk of colon cancer with long-term proton pump inhibitor therapy. While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted. https://greenmedinfo.com/article/proton-pump-inhibitors-appear-be-contributing-emerging-epidemic-gastric-fundic#comments Fundic Gland Polyposis Gastric Polyposis Commentary Wed, 27 Oct 2010 13:53:34 +0000 greenmedinfo 58169 at https://greenmedinfo.com