Childhood Poisoning https://greenmedinfo.com/taxonomy/term/40381/all en Chinese children are the populations at the high risk of dietary exposure to three mycotoxins. https://greenmedinfo.com/article/chinese-children-are-populations-high-risk-dietary-exposure-three-mycotoxins PMID:  Wei Sheng Yan Jiu. 2010 Nov ;39(6):709-14. PMID: 21351637 Abstract Title:  [Dietary exposure assessment of some important Fusarium toxins in cereal-based products in China]. Abstract:  OBJECTIVE: To elucidate the dietary exposure of Chinese populations to deoxynivalenol (DON), nivalenol (NIV) and zearalenone (ZEN).METHODS: Ten Fusarium toxins including DON, NIV, ZEN in domestic wheat flour and corn-based products harvested and collected in 2009 were analyzed by UPLC-MS/MS. Dietary intake assessments of human exposure to DON, NIV and ZEN were carried out in combination of national food consumption data with toxin concentration data by deterministic estimate method.RESULTS: (1) There are 2.5% adults and 10% children with the dietary exposure to DON exceeding the tolerable daily intake (TDI) on the basis of the average food consumption. At the 75th percentile food consumption level, the dietary exposure of populations to DON was higher than its TDI, 1.72 and 2.02 times (adults) as well as 1.19 and 1.09 times higher than TDI (children), respectively, based on the higher DON exposure (adults : P90 for wheat flour and P97. 5 for corn-based products, children: P50 for wheat flour and P75 for corn-based products). At the average toxin concentration, children with the high consumption level (90th, 97. 5th and 99th percentile) of either wheat flour or corn-based products, the dietary exposure to DON exceed the TDI, 1.81 to 3.17 times (wheat flour) and 1.47 - 3.97 times (corn-based products) higher than TDI, respectively. The dietary exposure of adults to ZEN exceed the TDI, based on the average food consumption data and higher ZEN level (P99), the 75th consumption data combined with P97. 5th toxin concentration, as well as 90th percentile of both food consumption data and ZEN concentration, respectively. There are 1%, 2.5%, 25%, 25% and 50% populations of children exposed ZEN higher than TDI, respectively at the 50th, 75th, 90th, 97. 5th and 99th percentile of food consumption data. (2) The level of concern (LOC) of DON in wheat flour calculated with high consumption data (90th, 97. 5th and 99th percentile) for all populations as well as DON and ZEN in corn-based products calculated with high consumption data (adults: 99th percentile, children: 97. 5th and 99th percentile) were lower than their average concentrations in above cereals. (3) No matter adults or children, the maximum daily safe intake of both wheat flour and corn-based products with high concentration of DON (97. 5th and 99th percentile, and 90th else for children) were lower than their own average food consumption data. For adults, the maximum daily safe intake of corn-based products with high ZEN contamination level (99th percentile) was lower than the average amount of corn-based products consumption. While, the maximum daily safe intake of both wheat flour and corn-based products derived from high ZEN concentration (97.5th and 99th percentile) for children were lower than their own average food consumption.CONCLUSIONS: Children dietary exposure to DON, NIV and ZEN was higher than adults. Children are the populations at the high risk of dietary exposure to these three mycotoxins. The risk to health caused by long-term consumption of wheat flour and corn-based products heavily contaminated with such high concentration of DON and ZEN was relatively high. The present tolerance limit for DON and ZEN in foods implemented in China should be revised on the basis of assessment results. https://greenmedinfo.com/article/chinese-children-are-populations-high-risk-dietary-exposure-three-mycotoxins#comments Childhood Poisoning Mycotoxicity Deoxynivalenol (DON) Mycotoxin Nivalenol (NIV) Zearalenone (ZEA) Human Study Thu, 29 Nov 2012 16:23:33 +0000 greenmedinfo 85672 at https://greenmedinfo.com Gut Biota Never Recover from Antibiotics: Damages Future Generations https://greenmedinfo.com/blog/gut-biota-never-recover-antibiotics-damages-future-generations <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2013<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><em><strong>The misuse of antibiotics is not only causing new, never-before known diseases like E. coli and MRSA, the flesh-eating bacteria, it's also destroying the gut biome with devastating effects on our ability to deal with infections and destroying our ability to absorb nutrients from food.</strong></em></p> <p class="rtecenter"><img alt="Gut Biota Never Recover from Antibiotics: Damages Future Generations" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/Immunocompromised.jpg" /></p> <p><em>by Heidi Stevenson</em>, originally published on <a href="http://gaia-health.com/gaia-blog/2013-04-13/gut-biota-never-recover-from-antibiotics-damages-future-generations/" target="_blank">Gaia Health</a>.</p> <p>Emerging research shows that the harmful effects of antibiotics go much further than the development of drug resistant diseases. The beneficial bacteria lost to <strong><a href="/blog/reflection-antibiotics">antibiotics</a></strong>, along with disease-inducing bacteria, do not fully recover. Worse, flora lost by a mother is also lost to her babies. The missing <strong><a href="/substance/probiotics">beneficial gut bacteria</a></strong> are likely a major factor behind much of the chronic disease experienced today. The continuous use of antibiotics is resulting in each generation experiencing worse health than their parents.</p> <p>Martin Blaser, the author of a report in the prestigious journal <i>Nature</i> writes:</p> <blockquote> <div> <p>Antibiotics kill the bacteria we do want, as well as those we don't. These long-term changes to the beneficial bacteria within people's bodies may even increase our susceptibility to infections and disease.Overuse of antibiotics could be fuelling the dramatic increase in conditions such as obesity, type 1 diabetes, inflammatory bowel disease, allergies and asthma, which have more than doubled in many populations.</p> </div> </blockquote> <p>Without even considering the development of superbugs, we're now seeing clear documentation that the overall long term effects of antibiotics are devastatingly harmful to our health. Speaking to ABC News, Blaser said:</p> <blockquote> <p>Antibiotics are miraculous. They've changed health and medicine over the last 70 years. But when doctors prescribe antibiotics, it is based on the belief that there are no long-term effects. <b>We've seen evidence that suggests antibiotics may permanently change the beneficial bacteria that we're carrying.</b> [Emphasis my own.]</p> </blockquote> <p>Notice that term, <strong>permanent</strong>. Without factoring in the potential risks in the casual use of antibiotics, it now looks like conventional medicine is creating several pandemics of some of the worst chronic diseases known.</p> <p><a href="https://greenmedinfo.com/blog/gut-biota-never-recover-antibiotics-damages-future-generations" target="_blank">read more</a></p> https://greenmedinfo.com/blog/gut-biota-never-recover-antibiotics-damages-future-generations#comments Antibiotic Toxicity Childhood Chemical Exposures Childhood Infections Childhood Poisoning Dysbiosis Infection: Antibiotic Resistant MRSA Anti-Bacterial Agents Antibiotics Antibiotics Antibiotics: Intrapartum Antimicrobial Iatrogenic Disease Wed, 05 Jun 2013 12:00:00 +0000 GaiaHealth 100169 at https://greenmedinfo.com Paraphenylene diamine (PPD) intoxication is a life-threatening condition with significant morbidity and mortality in children. https://greenmedinfo.com/article/paraphenylene-diamine-ppd-intoxication-life-threatening-condition-significant- PMID:  Ann Trop Paediatr. 2009 Sep;29(3):191-6. PMID: 19689860 Abstract Title:  Acute renal failure owing to paraphenylene diamine hair dye poisoning in Sudanese children. Abstract:  INTRODUCTION: Paraphenylene diamine (PPD) has traditionally been used as a dark-coloured hair dye. In Sudan, it is used by women to colour their hair and as a body dye when added to henna (Lawasonia alba). Accidental or deliberate ingestion causes severe systemic toxicity. Although a wide variety of complications has been described, there are few reports in children. AIM: To describe the clinical features, management and outcome of PPD intoxication in Sudanese children. METHODS: Data for a 3-year period (2006-2008) were extracted from the medical records of the Paediatric Nephrology Unit, Soba University Hospital. Information included the circumstances of poisoning, gender, age distribution, clinical presentation, biochemical findings and outcome. RESULTS: Over the 3-year period, 17 children (16 female) were admitted to the Paediatric Nephrology Unit with PPD intoxication. Mean age was 13.8 yrs (range 2-18). Thirteen (76.4%) had attempted suicide, three (17.6%) were poisoned as a result of attempted murder and one poisoning (5.8%) was accidental. Eight children (47%) required tracheostomy for severe angioneurotic oedema. Of 12 (71%) who developed acute renal failure (ARF), nine required dialysis and three were managed conservatively. Two children (12%) died and the other 15 recovered with normal renal function. CONCLUSION: PPD intoxication is a life-threatening condition with significant morbidity and mortality in children. Clinical manifestations and outcome are similar to those in adults. Mortality can be reduced by early recognition, prompt referral and aggressive supportive treatment. https://greenmedinfo.com/article/paraphenylene-diamine-ppd-intoxication-life-threatening-condition-significant-#comments Childhood Poisoning Kidney Failure: Acute Paraphenylenediamine (Hair Dye Ingredient) Human Study Thu, 28 Oct 2010 17:43:50 +0000 greenmedinfo 58194 at https://greenmedinfo.com