Psoriatic Arthritis https://greenmedinfo.com/taxonomy/term/4073/all en Balneotherapy at the Dead Sea area appears to produce a statistically significant substantial improvement in the number of active joints and tender points in both male and female patients with fibromyalgia and psoriatic arthritis. https://greenmedinfo.com/article/balneotherapy-dead-sea-area-appears-produce-statistically-significant-substant PMID:  Isr Med Assoc J. 2001 Feb;3(2):147-50. PMID: 11344827 Abstract Title:  Balneotherapy at the Dead Sea area for patients with psoriatic arthritis and concomitant fibromyalgia. Abstract:  BACKGROUND: Balneotherapy has been successfully used to treat various rheumatic diseases, but has only recently been evaluated for the treatment of fibromyalgia. Since no effective treatment exists for this common rheumatic disease, complementary methods of treatment have been attempted. OBJECTIVES: To assess the effectiveness of balneotherapy at the Dead Sea area in the treatment of patients suffering from both fibromyalgia and psoriatic arthritis. METHODS: Twenty-eight patients with psoriatic arthritis and fibromyalgia were treated with various modalities of balneotherapy at the Dead Sea area. Clinical indices assessed were duration of morning stiffness, number of active joints, a point count of 18 fibrositic tender points, and determination of the threshold of tenderness in nine fibrositic and in four control points using a dolorimeter. RESULTS: The number of active joints was reduced from 18.4 +/- 10.9 to 9 +/- 8.2 (P https://greenmedinfo.com/article/balneotherapy-dead-sea-area-appears-produce-statistically-significant-substant#comments Fibromyalgia Psoriatic Arthritis Sea Salt: Dead Sea Balneotherapy Human Study Wed, 08 Dec 2010 21:26:36 +0000 greenmedinfo 59425 at https://greenmedinfo.com Balneotherapy, sunlight exposure and mud therapy at the Dead Sea have therapeutic effects in patients with psoriatic arthritis. https://greenmedinfo.com/article/balneotherapy-sunlight-exposure-and-mud-therapy-dead-sea-have-therapeutic-effe PMID:  Rheumatol Int. 2000;19(3):77-82. PMID: 10776684 Abstract Title:  Immediate and delayed effects of treatment at the Dead Sea in patients with psoriatic arthritis. Abstract:  The purpose of this study was to evaluate the immediate and delayed effects of balneotherapy at the Dead Sea on patients with psoriatic arthritis (PsA). A total of 42 patients with PsA were treated at the Dead Sea for 4 weeks. Patients were randomly allocated into two groups: group 1 (23 patients) and group 2 (19 patients). Both groups received daily exposure to sun ultraviolet rays and regular bathing at the Dead Sea. Group 1 was also treated with mud packs and sulfur baths. Patients were assessed by a dermatologist and a rheumatologist 3 days before arrival, at the end of treatment, and at weeks 8, 16, and 28 from the start of treatment. The clinical indices assessed were morning stiffness, right and left hand grip, number of tender joints, number of swollen joints, Schober test, distance from finger to floor when bending forward, patient&#039;s self-assessment of disease severity, inflammatory neck and back pain and psoriasis area and severity index (PASI) score. Comparison between groups disclosed a similar statistically significant improvement for variables such as PASI, morning stiffness, patient self-assessment, right and left grip, Schober test and distance from finger to floor when bending forward. For variables such as tender and swollen joints, and inflammatory neck and back pain, improvement over time was statistically significant in group 1. Addition of mud packs and sulfur baths to sun ultraviolet exposure and Dead Sea baths seems to prolong beneficial effects and improves inflammatory back pain. https://greenmedinfo.com/article/balneotherapy-sunlight-exposure-and-mud-therapy-dead-sea-have-therapeutic-effe#comments Psoriatic Arthritis Sea Salt: Dead Sea Balneotherapy Mud therapy Sunlight exposure Human Study Wed, 08 Dec 2010 21:31:06 +0000 greenmedinfo 59427 at https://greenmedinfo.com Dead sea salt has therapeutic value in the treatment of psoriatic arthritis. https://greenmedinfo.com/article/dead-sea-salt-has-therapeutic-value-treatment-psoriatic-arthritis PMID:  J Rheumatol. 1994 Jul;21(7):1305-9. PMID: 7966074 Abstract Title:  Treatment of psoriatic arthritis at the Dead Sea. Abstract:  OBJECTIVE: To evaluate the effectiveness of balneotherapy (mud packs and sulfur baths) on patients with psoriasis and psoriatic arthritis (PsA). METHODS: One hundred and sixty-six patients with psoriasis and PsA were treated at the Dead Sea for a period of 3 weeks. The patients were divided into 2 groups. Both groups had the regular regimen of bathing in Dead Sea water and exposure to the sun&#039;s ultraviolet rays. The study group, which consisted of 146 patients also was treated with mud packs and sulfur baths. The control group, which had no additional therapy, consisted of 20 patients. The main clinical variables assessed were duration of morning stiffness, grip strength, activities of daily living, subjective patient assessment of disease severity, number of active joints, number of effluent joints. Ritchie index, psoriasis area and severity index score, cervical, thoracic, and lumbar spine pain and limitations of movement. RESULTS: Statistically significant improvement was found in most variables in both groups. However, better results were observed in the study group. In 2 variables, reduction of spinal pain and range of movement in the lumbar spine, significant improvement (p https://greenmedinfo.com/article/dead-sea-salt-has-therapeutic-value-treatment-psoriatic-arthritis#comments Psoriatic Arthritis Sea Salt: Dead Sea Balneotherapy Human Study Wed, 08 Dec 2010 21:29:04 +0000 greenmedinfo 59426 at https://greenmedinfo.com Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease. https://greenmedinfo.com/article/delphinidin-diminishes-vitro-interferon-and-interleukin-17-producing-cells-pat PMID:  Immunol Res. 2021 Nov 25. Epub 2021 Nov 25. PMID: 34825313 Abstract Title:  Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease. Abstract:  The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin&#039;s in vitro immunomodulatory effect on ex vivo stimulated peripheral blood mononuclear cells (PBMCs) from 50 individuals [26 with psoriasis, 10 with psoriatic arthritis (PsA) and 14 healthy controls (HCs)]. Cells were either left untreated or stimulated with PMA plus ionomycin in the presence or absence of delphinidin. Intracellular production of interferon-γ (IFNγ), interleukin-17A (IL-17A), and interleukin-10 (IL-10) was measured flow cytometrically. Delphinidin dose-dependently reduced IFNγT cells from patients and HCs. The mean IFNγ decrease in CD4T subpopulations was 42.5 ± 28% for psoriasis patients, 51.8 ± 21.5% for PsA patients and 49 ± 17% for HCs (p <p><a href="https://greenmedinfo.com/article/delphinidin-diminishes-vitro-interferon-and-interleukin-17-producing-cells-pat" target="_blank">read more</a></p> https://greenmedinfo.com/article/delphinidin-diminishes-vitro-interferon-and-interleukin-17-producing-cells-pat#comments Delphinidin Psoriatic Arthritis Immunomodulatory: Th17 downregulation Animal Study In Vitro Study Sun, 19 Dec 2021 23:22:29 +0000 greenmedinfo 250457 at https://greenmedinfo.com EPA and DHA may have a therapeutic effect in patients with psoriasis and psoriatic arthritis. https://greenmedinfo.com/article/epa-and-dha-may-have-therapeutic-effect-patients-psoriasis-and-psoriatic-arthr PMID:  J Int Med Res. 1990 Jan-Feb;18(1):68-73. PMID: 2139859 Abstract Title:  Effects of dietary supplementation with polyunsaturated ethyl ester lipids (Angiosan) in patients with psoriasis and psoriatic arthritis. Abstract:  A total of 80 patients with chronic, stable psoriasis, 34 of whom also had psoriatic arthritis, were treated with 1122 mg/day eicosapentaenoic acid ethyl ester and 756 mg/day docosahexaenoic acid ethyl ester. Before the study and after 4 and 8 weeks of treatment a Psoriatic Association scoring index (PASI) score was assessed. Before treatment the mean PASI score was 3.56, after 4 weeks 1.98 and after 8 weeks 1.24; the decrease in the score was highly significant (P less than 0.001). The degree of pruritus decreased most rapidly, followed by scaling and induration of the plaques, and erythema was most persistent. At the end of the trial, seven patients were completely healed and in 13 other patients more than 75% healing was observed but in 14 patients the result was poor. The majority of patients with psoriatic arthritis reported a subjective improvement in joint pain during the study. It is concluded that polyunsaturated ethyl ester lipids may be useful for the treatment of psoriasis and psoriatic arthritis and may provide an important adjuvant to standard therapy of both conditions. https://greenmedinfo.com/article/epa-and-dha-may-have-therapeutic-effect-patients-psoriasis-and-psoriatic-arthr#comments DHA (Docosahexaenoic Acid) EPA (Eicosapentaenoic Acid) Psoriasis Psoriatic Arthritis Human Study Wed, 08 Dec 2010 21:35:55 +0000 greenmedinfo 59428 at https://greenmedinfo.com Seal oil rich in the essential fatty acid EPA results in subjective improvement in patients with psoriatic arthritis. https://greenmedinfo.com/article/seal-oil-rich-essential-fatty-acid-epa-results-subjective-improvement-patients PMID:  J Rheumatol. 2006 Feb;33(2):307-10. PMID: 16465662 Abstract Title:  Subjective improvement in patients with psoriatic arthritis after short-term oral treatment with seal oil. A pilot study with double blind comparison to soy oil. Abstract:  OBJECTIVE: To investigate effects of short-term oral treatment with seal oil in patients with psoriatic arthritis (PsA). METHODS: Forty-three patients with polyarticular PsA were randomized to receive oral treatment for 2 weeks with either seal oil or soy oil in a double blind controlled trial. Clinical and biochemical variables were assessed at baseline, after treatment, and 4 weeks post-treatment. Patients were allowed to continue nonsteroidal antiinflammatory drugs (NSAID) and disease modifying antirheumatic drugs (DMARD) during the study. RESULTS: Forty patients completed the study, 20 in each treatment group. Patients in the seal oil group reported a significant improvement in global assessment of the disease 4 weeks post- treatment (p https://greenmedinfo.com/article/seal-oil-rich-essential-fatty-acid-epa-results-subjective-improvement-patients#comments Eicosapentaenoic acid (EPA) Psoriatic Arthritis Seal Oil Anti-Inflammatory Agents Human Study Wed, 08 Dec 2010 21:20:30 +0000 greenmedinfo 59423 at https://greenmedinfo.com Vitamin D generates significant improvement in psoriatic arthritis. https://greenmedinfo.com/article/vitamin-d-generates-significant-improvement-psoriatic-arthritis PMID:  Arthritis Rheum. 1990 Nov;33(11):1723-7. PMID: 2242069 Abstract Title:  Treatment of psoriatic arthritis with oral 1,25-dihydroxyvitamin D3: a pilot study. Abstract:  We conducted a 6-month open-label trial in which 10 patients with active psoriatic arthritis received 2 micrograms of oral 1,25-dihydroxyvitamin D3 daily. Statistically significant improvement was noted in the tender joint count and physician global impression. Of these 10 patients, 4 had substantial (greater than or equal to 50%) improvement, and 3 had moderate (greater than or equal to 25%) improvement in the tender joint count. Two patients were unable to receive therapeutic doses because of hypercalciuria. High-dose vitamin D may be a useful therapeutic agent for psoriatic arthritis.&quot; https://greenmedinfo.com/article/vitamin-d-generates-significant-improvement-psoriatic-arthritis#comments Psoriatic Arthritis Vitamin D Human Study Mon, 20 Apr 2009 06:13:41 +0000 greenmedinfo 42530 at https://greenmedinfo.com