Retinal Detachment https://greenmedinfo.com/taxonomy/term/4199/all en Flavonoid antioxidants may have therapeutic value in PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection. https://greenmedinfo.com/article/flavonoid-antioxidants-may-have-therapeutic-value-pvcrd-and-drd-purpose-improv PMID:  Inflamm Res. 2009 Aug;58(8):513-21. Epub 2009 Mar 11. PMID: 15384840 Abstract Title:  [The use of flavonoid antioxidants in the complex treatment of patients with peripheral vitreo-chorioretinal dystrophies and dystrophic retinal detachment]. Abstract:  Parameters of lipid peroxidation (LP) and antioxidant activity (AOA) of tear and blood plasma were examined in 22 healthy subjects (44 eyes) as well as in 33 patients with peripheral vitreochoreoretinal dystrophies (PVCRD--60 eyes), in 32 patients with non-operated dystrophic retinal detachment (DRD--34 eyes) and in 135 patients with operated retinal detachment, stable visual functions and with the postoperative period ranging from 4 months to 10 years (137 eyes). The results denoted a lower tear AOA (on the average by 35%) in patients with DRD and PVCRD, whereas, the blood plasma AOA or LP products&#039; content remained unchanged. It is indicative of a local nature of metabolic impairments, specifically, of impairments in the system of antioxidant protection of the eye. Flavonoid antioxidants (dikvertin and ginkgo biloba) reduced the content of LP products, and induced the AOA in tear and blood plasma in patients with PVCRD and retinal detachment; they also improved the visual functions in patients with operated retinal detachment. Therefore, the flavonoid antioxidants can be recommended for adding to the complex treatment of PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection. https://greenmedinfo.com/article/flavonoid-antioxidants-may-have-therapeutic-value-pvcrd-and-drd-purpose-improv#comments Dystrophic retinal detachment (DRD) Eye Diseases: Vitreous Disorders Flavonoids Ginkgo biloba Peripheral vitreochoreoretinal dystrophies (PVCRD) Retinal Detachment Antioxidants Human Study Fri, 03 Sep 2010 16:09:03 +0000 greenmedinfo 56072 at https://greenmedinfo.com Glutathione improves the antioxidant activity of vitamin C in human lens and retinal epithelial cells. https://greenmedinfo.com/article/glutathione-improves-antioxidant-activity-vitamin-c-human-lens-and-retinal-epi PMID:  Curr Eye Res. 2020 Aug 24:1-12. Epub 2020 Aug 24. PMID: 32838548 Abstract Title:  Glutathione Improves the Antioxidant Activity of Vitamin C in Human Lens and Retinal Epithelial Cells: Implications for Vitreous Substitutes. Abstract:  PURPOSE: Tissues in the eye are particularly susceptible to oxidative damage due to light exposure. While vitamin C (ascorbic acid) has been noted as a vital antioxidant in the vitreous humor, its physiological concentration (1-2 mM) has been shown to be toxic to retinal and lens epithelial cells incell culture. We have explored adding vitamin C to hydrogel vitreous substitutes as a potential therapeutic to prevent oxidative damage to intraocular tissues after vitrectomy. However, vitamin C degrades rapidly even when loaded at high concentrations, limiting its long-term effectiveness. Glutathione, another antioxidant found abundantly in the lens at concentrations of 2-10 mM, was proposed to be used in conjunction with vitamin C.METHODS: Cell viability and reactive oxygen species activity of human retinal and lens epithelial cells treated with various combinations of vitamin C, glutathione, hydrogen peroxide, and a hydrogel vitreous substitute were determined using CellTiter-Glo luminescent cell viability assay and dichlorofluorescein assay, respectively. The vitamin C remaining in hydrogel vitreous substitute or glutathione-vitamin C solutions was determined using a microplate reader at 265 nm wavelength, compared against standard solutions with known concentrations.RESULTS: Glutathione protected the lens and retinal cells from the negative effect of vitamin C on cell viability and prolonged the antioxidant effect of vitamin C. While the detected reading of pure vitamin C solution decreased rapidly from 100% to 10% by 3 days, glutathione provided a significant extension to vitamin C stability, with 70% remaining after 14 days when the glutathione was used at physiological concentrations found in the lens (2-10 mM).CONCLUSIONS: These results indicate glutathione might be an effective addition to vitamin C in intraocular implants, including potential vitreous substitutes, and warrants additional studies on the effectiveness of the vitamin C - glutathione combination in preventing oxidative stress post-vitrectomy. <p><a href="https://greenmedinfo.com/article/glutathione-improves-antioxidant-activity-vitamin-c-human-lens-and-retinal-epi" target="_blank">read more</a></p> https://greenmedinfo.com/article/glutathione-improves-antioxidant-activity-vitamin-c-human-lens-and-retinal-epi#comments Glutathione Retinal Degeneration: Light-Induced Retinal Detachment Vitamin C Antioxidants Natural Substance Synergy In Vitro Study Tue, 08 Sep 2020 21:58:23 +0000 greenmedinfo 226542 at https://greenmedinfo.com Neferine may be a potential candidate molecule in the treatment of proliferative vitreoretinopathy. https://greenmedinfo.com/article/neferine-may-be-potential-candidate-molecule-treatment-proliferative-vitreoret PMID:  Cutan Ocul Toxicol. 2020 Jun ;39(2):97-105. Epub 2020 Mar 9. PMID: 32064963 Abstract Title:  Neferine inhibits epidermal growth factor-induced proliferation and migration of retinal pigment epithelial cells through downregulating p38 MAPK and PI3K/AKT signalling. Abstract:  Proliferative vitreoretinopathy (PVR) occurs in approximately 5-10% of patients after retinal detachment surgery. Neferine is a bis-benzylisoquinoline alkaloid found in the green seed embryos () of the lotus flower and has various properties, such as being antithrombotic, antioxidant, neuroprotective, anticancerous, and anti-inflammatory. Although the effects of neferine on the proliferation and migration of cancer cells have been partially shown, their possible role and the mechanism of action on PVR remain unclear.To mimic a PVR model, retinal pigment epithelial (RPE) cells were exposed to epidermal growth factor (EGF) and treated with various concentrations of neferine. Cell viability was determined by MTT test. Cell-cycle phase distribution and cell migration were examined by image-based cytometry and wound healing test, respectively. Messenger RNA (mRNA) and protein expression were determined by RT-qPCR and Western blotting, respectively.Stimulation of the cells with EGF significantly increased the rate of proliferation, whilst treatment with low concentrations of neferine-reduced proliferation to a level equal to that seen in untreated cells. Neferine significantly downregulated EGF-increased cell viability, and survivin mRNA expression was depressed to the basal level. In addition, neferine treatment contributed to cell proliferation loss by upregulating p21 and p27 expression leading to cycle arrest at the G1 phase. The treatment significantly inhibited cell migration by upregulating the expression of epithelial markers, such as E-cadherin and occludin, and decreased MMP2, MMP9,α-SMA, and vimentin. Neferine treatment markedly reduced phosphotidyl inositol 3-kinase (PI3K), AKT, p-p38 mitogen-activated protein kinase (MAPK), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) protein expression.It can be considered that neferine may be a potential candidate molecule in the treatment of PVR by inhibiting cell proliferation and the migration of EGF-induced RPE cells through the modulation of various transcriptional activities. <p><a href="https://greenmedinfo.com/article/neferine-may-be-potential-candidate-molecule-treatment-proliferative-vitreoret" target="_blank">read more</a></p> https://greenmedinfo.com/article/neferine-may-be-potential-candidate-molecule-treatment-proliferative-vitreoret#comments Lotus Retinal Detachment Antiproliferative Matrix metalloproteinase-2 (MMP-2) inhibitor Matrix metalloproteinase-9 (MMP-9) inhibitor P21 Activation In Vitro Study Thu, 25 Jun 2020 21:56:46 +0000 greenmedinfo 222569 at https://greenmedinfo.com Resveratrol may have a therapeutic role in retinopathy of prematurity. https://greenmedinfo.com/article/resveratrol-may-have-therapeutic-role-retinopathy-prematurity PMID:  Korean J Ophthalmol. 2010 Apr;24(2):108-18. Epub 2010 Apr 6. PMID: 20379461 Abstract Title:  Retinal protective effects of resveratrol via modulation of nitric oxide synthase on oxygen-induced retinopathy. Abstract:  PURPOSE: Retinopathy of prematurity (ROP) is one of the leading causes of blindness, with retinal detachment occurring due to oxygen toxicity in preterm infants. Recently, advances in neonatal care have led to improved survival rates for preterm infants, and ROP has increased in incidence. In the present study, we aimed to determine whether or not resveratrol exhibits protective effects in an animal model of ROP and in primary retinal cell cultures of neonatal rat via nitric oxide (NO)-modulating actions using western blotting and real-time PCR with inducible nitric oxide synthase (iNOS), endothelial NOS (eNOS) and neuronal NOS (nNOS) antibodies and mRNAs. METHODS: In an in vivo oxygen-induced retinopathy (OIR) model, cyclic hyperoxia was induced with 80% O(2) for one day and 21% O(2) for one day from P1 to P14 in newborn Sprague-Dawley (SD) rats. Resveratrol was injected intravitreally for seven days and rats were sacrificed at P21. In vitro OIR primary retinal cell culture was performed using P0-2 SD rats. Hyperoxia injuries were induced through 100% O(2) exposure for six hours. Western blotting and real-time PCR using iNOS, eNOS, nNOS antibodies and primers were performed in the rat model of ROP and the dispersed retinal cell culture. RESULTS: In both in vivo and in vitro OIR, the expression of iNOS antibody and mRNA was increased and of eNOS and nNOS were reduced in the resveratrol-treated group. CONCLUSIONS: In conclusion, resveratrol appeared to exert retinal protective effects via modulation of NO-mediated mechanism in in vivo and in vitro OIR models. https://greenmedinfo.com/article/resveratrol-may-have-therapeutic-role-retinopathy-prematurity#comments Resveratrol Retinal Detachment Retinopathy of Prematurity Nitric Oxide Inhibitor Stilbenes Animal Study Fri, 11 Mar 2011 20:53:04 +0000 greenmedinfo 62644 at https://greenmedinfo.com Retinal Pigment Epithelial Detachment https://greenmedinfo.com/disease/retinal-pigment-epithelial-detachment <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="302" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Retina_3.jpg?1486070497" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_lightscribe&#039;&gt;lightscribe / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Retinal Detachment Tue, 14 Apr 2009 07:25:35 +0000 greenmedinfo 21842 at https://greenmedinfo.com The pharmacological effects of lutein and zeaxanthin on visual disorders and cognition diseases. https://greenmedinfo.com/article/pharmacological-effects-lutein-and-zeaxanthin-visual-disorders-and-cognition-d PMID:  Molecules. 2017 Apr 20 ;22(4). Epub 2017 Apr 20. PMID: 28425969 Abstract Title:  The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases. Abstract:  Lutein (L) and zeaxanthin (Z) are dietary carotenoids derived from dark green leafy vegetables, orange and yellow fruits that form the macular pigment of the human eyes. It was hypothesized that they protect against visual disorders and cognition diseases, such as age-related macular degeneration (AMD), age-related cataract (ARC), cognition diseases, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, uveitis and diabetic retinopathy. The mechanism by which they are involved in the prevention of eye diseases may be due their physical blue light filtration properties and local antioxidant activity. In addition to their protective roles against light-induced oxidative damage, there are increasing evidences that L and Z may also improve normal ocular function by enhancing contrast sensitivity and by reducing glare disability. Surveys about L and Z supplementation have indicated that moderate intakes of L and Z are associated with decreased AMD risk and less visual impairment. Furthermore, this review discusses the appropriate consumption quantities, the consumption safety of L, side effects and future research directions. <p><a href="https://greenmedinfo.com/article/pharmacological-effects-lutein-and-zeaxanthin-visual-disorders-and-cognition-d" target="_blank">read more</a></p> https://greenmedinfo.com/article/pharmacological-effects-lutein-and-zeaxanthin-visual-disorders-and-cognition-d#comments Blue Light Toxicity Cataract Diabetic Retinopathy Eye Damage Lutein Macular Degeneration Retinal Degeneration: Light-Induced Retinal Detachment Retinitis Pigmentosa Uveitis Zeaxanthin Antioxidants Review Mon, 03 Dec 2018 21:06:39 +0000 greenmedinfo 174978 at https://greenmedinfo.com