Sjogren&#039;s Syndrome https://greenmedinfo.com/taxonomy/term/4386/all en A case report of Non-Hodgkin's lymphoma of the thyroid after many years of immunizations. https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations PMID:  Pol Merkur Lekarski. 2008 Aug ;25(146):155-7. PMID: 18942337 Abstract Title:  [Lymphoma of the thyroid in a patient with autoimmune thyroiditis and Sjögren&#039;s syndrome--case report]. Abstract:  We present the case of a 74 year old patient suffering from primary Non Hodgkin&#039;s lymphoma of the thyroid and Sjogren&#039;s syndrome. A massively enlarging goitre, causing breathlessness in a female patient previously treated for autoimmune inflammation of the thyroid (Hashimoto&#039;s disease) and Sjogren&#039;s syndrome, indicated the need for a fine needle aspiration biopsy (FNA) of the thyroid gland. Non Hodgkin&#039;s lymphoma of the thyroid was diagnosed and chemotherapy was begun. After 10 months of cytostatic treatment clinical tests and imaging indicated complete local regression. However, two months after cessation of chemotherapy the patient suffered a relapse of the disease owing to infiltration of the central nervous system. During the course of palliative radiotherapy the patient died. The main purpose for presenting this case was to describe the problem of primary lymphoma of the thyroid in cases of autoimmune disease. As many years of immunisation may lead to carcinogenesis it is important to raise awareness among medical staff with regard to cases of chronic autoimmune disease. In cases of Hashimoto&#039;s autoimmune disease of the thyroid, monitoring of the anti-thyroid antibodies is indicated, at least annually, as an increase in the concentration of these antibodies over a period of at least seven years would suggest further development of autoimmune disease. If such conditions are accompanied by tumours of the thyroid, surgery should be considered. It is worth keeping in mind that the thyroid can be a site for extra-lymphatic lymphoma. <p><a href="https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations#comments Hashimoto's thyroiditis Lymphoma Sjogren's Syndrome Thyroid Cancer Vaccine-induced Toxicity Vaccination: All Human: Case Report Fri, 13 Dec 2019 21:16:46 +0000 greenmedinfo 204741 at https://greenmedinfo.com A case report of Sjogren's syndrome after hepatitis B vaccination. https://greenmedinfo.com/article/case-report-sjogrens-syndrome-after-hepatitis-b-vaccination PMID:  Arthritis Rheum. 2000 Sep ;43(9):2139-40. PMID: 11014366 Abstract Title:  Sjögren&#039;s syndrome occurring after hepatitis B vaccination. Abstract:  [n/a] <p><a href="https://greenmedinfo.com/article/case-report-sjogrens-syndrome-after-hepatitis-b-vaccination" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-sjogrens-syndrome-after-hepatitis-b-vaccination#comments Sjogren's Syndrome Vaccine-induced Toxicity Vaccination: All Vaccination: Hepatitis B Human: Case Report Tue, 17 Dec 2019 18:00:23 +0000 greenmedinfo 205249 at https://greenmedinfo.com A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis. https://greenmedinfo.com/article/comprehensive-review-influence-epigallocatechin-gallate-sj-grens-syndrome-asso PMID:  Biomed Rep. 2021 Nov ;15(5):95. Epub 2021 Sep 21. PMID: 34631050 Abstract Title:  A comprehensive review of the influence of Epigallocatechin gallate on Sjögren&#039;s syndrome associated molecular regulators of exocytosis (Review). Abstract:  Sjögren&#039;s syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to reduced secretory functions and oral and ocular dryness. The salivary glands are composed of acinar cells that are responsible for the secretion and production of secretory granules, which contain salivarycomponents, such as amylase, mucins and immunoglobulins. This secretion process involves secretory vesicle trafficking, docking, priming and membrane fusion. A failure during any of the steps in exocytosis in the salivary glands results in the altered secretion of saliva. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors, actin, tight junctions and aquaporin 5 all serve an important role in the trafficking regulation of secretory vesicles in the secretion of saliva via exocytosis. Alterations in the expression and distribution of these selected proteins leads to salivary gland dysfunction, including SS. Several studies have demonstrated that green tea polyphenols, most notably Epigallocatechin gallate (EGCG), possess both anti-inflammatory and anti-apoptotic properties in normal human cells. Molecular, cellular and animal studies have indicated that EGCG can provideprotective effects against autoimmune and inflammatory reactions in salivary glands in diseases such as SS. The aim of the present article is to provide a comprehensive and up-to-date review on the possible therapeutic interactions between EGCG and the selected molecular mechanisms associated with SS. <p><a href="https://greenmedinfo.com/article/comprehensive-review-influence-epigallocatechin-gallate-sj-grens-syndrome-asso" target="_blank">read more</a></p> https://greenmedinfo.com/article/comprehensive-review-influence-epigallocatechin-gallate-sj-grens-syndrome-asso#comments EGCG (Epigallocatechin gallate) Sjogren's Syndrome Anti-Apoptotic Anti-Inflammatory Agents Review Fri, 19 Nov 2021 02:42:38 +0000 greenmedinfo 248871 at https://greenmedinfo.com Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity. https://greenmedinfo.com/article/acteoside-promotes-b-cell-derived-il-10-production-and-ameliorates-autoimmunit PMID:  J Leukoc Biol. 2022 Oct ;112(4):875-885. Epub 2022 May 31. PMID: 35638582 Abstract Title:  Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity. Abstract:  IL-10-producing regulatory B (Breg) cells are well recognized for maintaining immune tolerance. The impaired Breg cell function with decreased IL-10-producing capacity has been found in autoimmune diseases, such as rheumatoid arthritis, lupus, and primary Sjogren&#039;s syndrome (pSS). However, seldom therapeutic agents targeting Breg cells are available to treat those autoimmune diseases. Here, we showed that acteoside (AC), a caffeoyl phenylethanoid glycoside from a medicinal herb Radix Rehmanniae, could promote IL-10 production from both human and murine B cells via critically regulating the TLR4/PI3K axis. Moreover, TLR4 was found increased in Breg cells from mice with experimental SS (ESS), a mouse model that recapitulates human pSS. Thus, B cells from the ESS mice were susceptible to AC treatment, showing higher IL-10-producing capacity than those from naïve controls. In addition, AC treatment also promoted the production of IL-10 from TLR4CXCR4plasma cells of ESS mice. Notably, we found that AC was able to enter lymphoid organs upon oral administration. AC treatment effectively increased IL-10B cells in ESS mice and ameliorated disease pathology accompanied by reduced T effector cells, including Th17 and T follicular helper cells in the ESS mice. In conclusion, AC could promote Breg cell function and attenuate ESS pathology in vivo, which may be a promising drug candidate for treating pSS and other autoimmune diseases. <p><a href="https://greenmedinfo.com/article/acteoside-promotes-b-cell-derived-il-10-production-and-ameliorates-autoimmunit" target="_blank">read more</a></p> https://greenmedinfo.com/article/acteoside-promotes-b-cell-derived-il-10-production-and-ameliorates-autoimmunit#comments Autoimmune Diseases Rheumatoid Arthritis Sjogren's Syndrome Verbascoside Interleukin-10 upregulation Interleukin-17 downregulation Animal Study Sun, 09 Oct 2022 01:38:51 +0000 greenmedinfo 264640 at https://greenmedinfo.com Alum induces a Sjögren’s syndrome-like disorder in mice. https://greenmedinfo.com/article/alum-induces-sj-gren-s-syndrome-disorder-mice PMID:  Clin Exp Rheumatol. 2014 Mar-Apr;32(2):251-5. Epub 2014 Apr 9. PMID: 24739520 Abstract Title:  Alum, an aluminum-based adjuvant, induces Sjögren&#039;s syndrome-like disorder in mice. Abstract:  OBJECTIVES: Adjuvant-induced innate immune responses have been suspected to play a role in the initiation of certain autoimmune disorders. This study investigates the role of alum, an aluminum-based adjuvant in the induction of Sjögren&#039;s syndrome-like disorder in mice.METHODS: Inbred, female New Zealand Mixed (NZM) 2758 strain of mice were injected with alum. Control mice were treated similarly with PBS. The mice were monitored for salivary gland dysfunction by measuring pilocarpine-induced salivation. Presence of lymphocytic infiltrates within the submandibular glands was studied by histopathology. Autoantibodies to Ro and La proteins were analysed by ELISA and the presence of anti-nuclear antibodies (ANA) was analysed by indirect immunofluorescence.RESULTS: By eight weeks after treatment, the saliva production in the alum-treated mice was significantly decreased in comparison to the PBS-treated mice. This functional loss persisted till the termination of experiments at 20 wks. The incidence and severity of sialoadenitis was significantly higher in the alum-treated mice. Although there were no differences in the levels of anti-Ro/La autoantibodies in sera of alum and PBS-treated groups, the alum group showed higher ANA reactivity.CONCLUSIONS: In the NZM2758 mice, alum induces a Sjögren&#039;s syndrome-like disorder that is characterised by chronic salivary gland dysfunction and the presence of lymphocytic infiltrates within the salivary glands. Thus, the potential of aluminum-based adjuvants for induction of autoimmunity should be closely monitored in individuals genetically susceptible to developing autoimmune disorders. <p><a href="https://greenmedinfo.com/article/alum-induces-sj-gren-s-syndrome-disorder-mice" target="_blank">read more</a></p> https://greenmedinfo.com/article/alum-induces-sj-gren-s-syndrome-disorder-mice#comments Sjogren's Syndrome Vaccine-induced Toxicity Aluminum Vaccine Adjuvants Animal Study Fri, 16 Jun 2017 22:02:26 +0000 greenmedinfo 149281 at https://greenmedinfo.com An adverse immune reaction to wheat proteins is more commonly apparent (anti-tTG) in Sjögren's syndrome. https://greenmedinfo.com/article/adverse-immune-reaction-wheat-proteins-more-commonly-apparent-anti-ttg-sj-gren PMID:  J Rheumatol. 2003 Dec ;30(12):2613-9. PMID: 14719202 Abstract Title:  Autoantibodies to tissue transglutaminase in Sjögren&#039;s syndrome and related rheumatic diseases. Abstract:  OBJECTIVE: Sjögren&#039;s syndrome (SS) has been reported in up to 15% of patients with biopsy proven celiac disease (CD). The diagnosis of CD in the setting of SS and other systemic rheumatic diseases can be difficult because they are often associated with a number of gastrointestinal symptoms and diseases. Although the diagnosis of CD is often confirmed by a small bowel biopsy, marker autoantibodies directed against the endomysium of transitional epithelium (EMA) and tissue transglutaminase (tTG) are highly correlated with biopsy-proven disease and serve as a valuable screening test. We used an IgA-anti-tissue transglutaminase antibody (anti-tTG) ELISA to assess the prevalence of anti-tTG in an unselected cohort of patients with SS and other systemic rheumatic diseases.METHODS: Sera from 50 patients with SS, 50 with systemic lupus erythematosus (SLE), 50 with rheumatoid arthritis (RA), 30 with systemic sclerosis (SSc), and 50 healthy controls were tested for autoantibodies to tTG. A comparison group of 40 sera from patients with biopsy-confirmed CD was also included. IgA anti-tTG was measured by a commercially available ELISA kit (Inova, San Diego, CA) that employs purified tTG.RESULTS: Six of the 50 (12%) IgA sufficient SS patients had anti-tTG compared to 2 (4%) normal sera, 3 (6%) SLE, 2 (7%) SSc, and 1 (2%) RA. By comparison, in the CD cohort, 33 (83%) had anti-tTG. Five of 6 SS patients with anti-tTG had symptoms, signs, or small bowel biopsy findings consistent with a diagnosis of CD. IgA anti-tTG and EMA were accompanied by other IgA autoantibodies in SS sera.CONCLUSION: Anti-tTG ELISA is a reliable method to indicate a coexisting diagnosis of CD in patients with SS. Interestingly, the frequency of false positive tTG tests in any of the systemic rheumatic diseases is not significantly greater than in controls. Further, our study shows that anti-tTG is more prevalent in SS than in other systemic rheumatic diseases. The tTG ELISA may be used as a screening test to identify patients with SS who are at risk and require further evaluation for the presence of CD. https://greenmedinfo.com/article/adverse-immune-reaction-wheat-proteins-more-commonly-apparent-anti-ttg-sj-gren#comments Sjogren's Syndrome Gluten Immunoreactive Wheat Anti-tissue Transglutaminase Antibodies Human Study Fri, 30 Mar 2012 22:17:10 +0000 greenmedinfo 73763 at https://greenmedinfo.com Blueberry stem extract prevents lacrimal hyposecretion. https://greenmedinfo.com/article/blueberry-stem-extract-prevents-lacrimal-hyposecretion PMID:  In Vivo. 2023 ;37(3):1003-1015. PMID: 37103112 Abstract Title:  Blueberry Stem Extract Prevents Lacrimal Hyposecretion in Non-obese Diabetic MiceActivation of AMPK. Abstract:  BACKGROUND/AIM: Tears secreted from the lacrimal gland are essential for preserving the ocular surface. Thus, dysfunction of the lacrimal gland in Sjögren&#039;s syndrome (SS) can lead to dry eye, resulting in a reduced quality of life. We previously reported that blueberry &#039;leaf&#039; water extract prevents lacrimal hyposecretion in male non-obese diabetic (NOD) mice in a SS-like model. In this study, we investigated the effect of blueberry &#039;stem&#039; water extract (BStEx) on lacrimal hyposecretion in NOD mice.MATERIALS AND METHODS: Male NOD mice were fed 1% BStEx or control (AIN-93G) for 2, 4, or 6 weeks from 4 weeks of age. Pilocarpine-induced tear secretion was measured using a phenol red-impregnated thread. The lacrimal glands were histologically evaluated by HE staining. Inflammatory cytokine levels in the lacrimal glands were measured using ELISA. Immunostaining was performed to examine aquaporin 5 (AQP5) localization. The expression levels of autophagy-related proteins, AQP5, and phosphorylated AMPK were measured using western blotting.RESULTS: After feeding BStEx to mice for 4 or 6 weeks, tear volume was observed to have increased in the BStEx group compared with that in the control group. There were no significant differences in inflammatory cell infiltration, autophagy-related protein expression, or the localization and expression of AQP5 in the lacrimal glands between the two groups. In contrast, AMPK phosphorylation increased in the BStEx group.CONCLUSION: BStEx prevented lacrimal hyposecretion in the SS-like model of male NOD mice, probably by opening tight junctions via the activation of AMPK in lacrimal acinar cells. <p><a href="https://greenmedinfo.com/article/blueberry-stem-extract-prevents-lacrimal-hyposecretion" target="_blank">read more</a></p> https://greenmedinfo.com/article/blueberry-stem-extract-prevents-lacrimal-hyposecretion#comments Blueberry Dry Eye Syndromes Sjogren's Syndrome Plant Extracts Animal Study Tue, 04 Jul 2023 17:32:29 +0000 greenmedinfo 275966 at https://greenmedinfo.com Bovine Colostrum has beneficial effects in Sjogren's syndrome and oral lichen planus. https://greenmedinfo.com/article/bovine-colostrum-has-beneficial-effects-sjogrens-syndrome-and-oral-lichen-plan PMID:  Clin Oral Investig. 2002 Mar;6(1):11-20. PMID: 11996158 Abstract Title:  Oral findings in patients with primary Sjögren&#039;s syndrome and oral lichen planus--a preliminary study on the effects of bovine colostrum-containing oral hygiene products. Abstract:  Bovine colostrum is rich in antimicrobial substances and growth factors. The purpose of this open study was to examine and compare the interventory effects of daily use of bovine colostrum-containing oral hygiene products (CHP) on oral symptoms and findings in 20 patients with primary Sjogren&#039;s syndrome (pSS) and 20 age-matched patients with oral lichen planus (OLP). Objective oral measures and self-assessment of oral symptoms and general health were conducted before and after 90 days&#039; use of CHP. The pSS patients had more systemic diseases, medication intake, oral dryness, poorer general health and lower salivary secretion than the OLP patients, who had the highest plaque index (PI) and the most mucosal soreness. Oral dryness and soreness were correlated to general health. In both patient groups. unstimulated whole saliva flow rate (UWS) had increased, PI and periodontal pocket depth (PPD) were reduced, and general health and oral dryness and soreness had improved after using CHP. A decrease in hyphae was found in candida smears from both groups and in blastospores in OLP smears. A reduction in the extension of the mucosal lesions was observed in 15 OLP patients. Results suggested beneficial effects of intervention with CHP on oral symptoms, general health, UWS, PI, PPD and candidal load in two patient groups--pSS and OLP--representing different oral symptomatology.     https://greenmedinfo.com/article/bovine-colostrum-has-beneficial-effects-sjogrens-syndrome-and-oral-lichen-plan#comments Colostrum Oral Lichen Planus Sjogren's Syndrome Human Study Mon, 20 Apr 2009 06:19:41 +0000 greenmedinfo 43893 at https://greenmedinfo.com BPA accelerated the progression and further deterioration of primary Sjögren's syndrome. https://greenmedinfo.com/article/bpa-accelerated-progression-and-further-deterioration-primary-sj-grens-syndrom PMID:  Immunopharmacol Immunotoxicol. 2019 Dec 26:1-9. Epub 2019 Dec 26. PMID: 31876196 Abstract Title:  impact of bisphenol A on maturation and function of monocyte-derived dendritic cells in patients with primary Sjögren&#039;s syndrome. Abstract:  Epidemiological studies have shown that environmental factors accelerate the progress of primary Sjögren&#039;s syndrome (pSS). Bisphenol A (BPA), a classic endocrine disrupting chemical, affects the immune system. However, the impact of BPA on pSS has not yet been reported. The present study aimed to evaluate the potential relationship between BPA, estrogen receptor (ER), and pSS.We studied the impact of BPA on monocyte-derived dendritic cells (moDCs) from pSS patients and age-matched healthy controls (HCs). Morphological effects were observed under inverted microscope. Surface markers were analyzed by flow cytometry. ER and cytokine profiles were assessed using real-time polymerase chain reaction. The ability of moDCs to stimulate CD4T cells activation was assessed by mixed lymphocyte reaction (MLR).moDCs from both pSS patients and HCs expressed ERα as well as ERβ. After BPA-exposure, expression of ERα increased significantly in pSS patients, while that of ERβ remained unchanged. moDCs from BPA-exposed pSS patients showed irregular morphology and reduction in cell aggregation. BPA increased HLA-DR on moDCs of pSS patients via ERα, and promoted the secretion of IL6 and IL12. When co-cultured with BPA-treated moDCs, cytokines (IFN-γ, IL4, IL17, IL10) and transcription factors (T-bet, Gata3, RoR-γt, Foxp3) of CD4T cells showed imbalance of Th1/Th2/Th17/Treg polarization, with Th1 and Th17 dominating.BPA altered the function of moDCs through ERα, including antigen capture, secretion of inflammatory factors, and ability to stimulate T cells, as well as accelerated the progression and further deterioration of pSS. <p><a href="https://greenmedinfo.com/article/bpa-accelerated-progression-and-further-deterioration-primary-sj-grens-syndrom" target="_blank">read more</a></p> https://greenmedinfo.com/article/bpa-accelerated-progression-and-further-deterioration-primary-sj-grens-syndrom#comments Bisphenol Toxicity Sjogren's Syndrome Bisphenol A Increased Risk In Vitro Study Fri, 27 Dec 2019 23:33:45 +0000 greenmedinfo 206274 at https://greenmedinfo.com Cardamonin is a potential candidate for controlling inflammation during primary Sjögren's syndrome. https://greenmedinfo.com/article/cardamonin-potential-candidate-controlling-inflammation-during-primary-sj-gren PMID:  Immunopharmacol Immunotoxicol. 2018 Apr ;40(2):126-133. Epub 2018 Jan 5. PMID: 29303022 Abstract Title:  Cardamonin inhibits pro-inflammatory cytokine production and suppresses NO pathway in PBMCs from patients with primary Sjögren&#039;s syndrome. Abstract:  Primary Sjögren&#039;s syndrome (pSS) is a systemic autoimmune disorder with a complex pathophysiology primarily affecting exocrine glands, leading to compromised secretory function. Recent studies imply that many inflammatory mediators, such as pro-inflammatory cytokines and nitric oxide, are critical in the development and perpetuation of pSS systemic manifestations. In the current study, we aimed to investigate the ex vivo immunomodulatory effect of cardamonin (CHO), on pro-inflammatory cytokines, TNF-α, IL-6 and inducible nitric oxide synthase (iNOS) expression during pSS. For this purpose, peripheral blood mononuclear cells isolated from pSS patients and healthy controls were cultured with different concentrations of cardamonin. Cytokine levels were measured by ELISA and NO production was assessed using the Griess method. Inducible nitric oxide synthase expression and NF-κB activity were analyzed by immunofluorescence staining. Our results suggest that cardamonin inhibits TNF-α, IL-6 and NO production and downregulates iNOS expression and NF-κB activation. Collectively, our results highlight the ex vivo immunomodulatory effects of cardamonin on pro-inflammatory cytokine production and NO pathway in pSS patients. Therefore, cardamonin is a potential candidate for controlling inflammation during pSS. <p><a href="https://greenmedinfo.com/article/cardamonin-potential-candidate-controlling-inflammation-during-primary-sj-gren" target="_blank">read more</a></p> https://greenmedinfo.com/article/cardamonin-potential-candidate-controlling-inflammation-during-primary-sj-gren#comments Cardamonin Inflammation Sjogren's Syndrome Anti-Inflammatory Agents Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Human Study Wed, 14 Aug 2019 23:31:26 +0000 greenmedinfo 193788 at https://greenmedinfo.com Celiac disease prevalance is significantly higher in those diagnosed with Sjogren's syndrome. https://greenmedinfo.com/article/celiac-disease-prevalance-significantly-higher-those-diagnosed-sjogrens-syndro PMID:  Rheumatol Int. 2004 Sep;24(5):278-82. Epub 2003 Sep 17. PMID: 13680146 Abstract Title:  Coeliac disease in Sjögren&#039;s syndrome--a study of 111 Hungarian patients. Abstract:  Recent studies report that in patients with Sjögren&#039;s syndrome (SS), concomitant coeliac disease (CD) is more frequent than in the average healthy population, with dominance of the latent/silent form. We further investigated this to characterise the clinical and immunolaboratory features of SS patients with CD. One hundred and eleven patientswith SS were involved in the study. After detailed history, blood samples were taken for antibodies to gliadin, endomysium, and tissue transglutaminase. Of them, six had positive serology for CD and underwent jejunoscopy and small bowel biopsy to confirm the diagnosis of CD. In five patients, the diagnosis was established histologically. The frequency of CD in the SS population was significantly higher than in the non-SS European population (4.5:100 vs 4.5-5.5:1,000). Laboratory findings in these patients showed significantly higher erythrocyte sedimentation rates and IgG, IgA, and IgM levels.On the basis of these findings, we recommend screening, follow-up, and regular gastrointestinal care of SS patients to identify CD cases and help them to avoid severe malnutrition and intestinal malignancies. https://greenmedinfo.com/article/celiac-disease-prevalance-significantly-higher-those-diagnosed-sjogrens-syndro#comments Celiac Disease Sjogren's Syndrome Gliadin Wheat Diseases that are Linked Human Study Tue, 29 Jun 2010 20:37:54 +0000 greenmedinfo 55586 at https://greenmedinfo.com Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome. https://greenmedinfo.com/article/combined-use-total-glucosides-paeony-and-hydroxychloroquine-primary-sj-grens-s PMID:  Immun Inflamm Dis. 2023 Oct ;11(10):e1044. PMID: 37904705 Abstract Title:  Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren&#039;s syndrome: A systematic review. Abstract:  OBJECTIVE: To assess the effectiveness and safety of the total glucosides of paeony (TGP) combined with hydroxychloroquine (HCQ) on the treatment of primary Sjögren&#039;s syndrome (pSS) by conducting a meta-analysis.METHODS: Eight databases were searched for randomized controlled trials (RCTs) reporting the use of TGP combined with HCQ for pSS, which are before May 10, 2022. Meta-analyses were performed on disappeared clinical symptoms (dry mouth and dry eyes), Schirmer&#039;s test, saliva flow test, erythrocyte sedimentation rate (ESR), index of immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), and adverse events (AEs). The Revman 5.4 software was used for this meta-analysis.RESULTS: Seven RCTs which included 632 participants were identified. The pooled results showed significant differences in clinical symptoms disappear (dry mouth and dry eyes) (p = .0004), IgM (p <p><a href="https://greenmedinfo.com/article/combined-use-total-glucosides-paeony-and-hydroxychloroquine-primary-sj-grens-s" target="_blank">read more</a></p> https://greenmedinfo.com/article/combined-use-total-glucosides-paeony-and-hydroxychloroquine-primary-sj-grens-s#comments Sjogren's Syndrome Natural Substance/Drug Synergy Review Thu, 07 Dec 2023 19:37:52 +0000 greenmedinfo 284415 at https://greenmedinfo.com Data support pro- and anti-inflammatory roles within EFA metabolism https://greenmedinfo.com/article/data-support-pro-and-anti-inflammatory-roles-within-efa-metabolism PMID:  Prostaglandins Leukot Essent Fatty Acids. 1998 Oct ;59(4):239-45. PMID: 9849649 Abstract Title:  Essential fatty acid status in cell membranes and plasma of patients with primary Sjogren&#039;s syndrome. Correlations to clinical and immunologic variables using a new model for classification and assessment of disease manifestations. Abstract:  In 41 primary Sjögren&#039;s syndrome patients we compared fatty acid levels within erythrocyte phospholipids, plasma phospholipids, plasma triglycerides and plasma cholesterol esters, with the immunopathological and clinical disease status. Docosahexaenoic acid was the essential fatty acid (EFA), the levels of which correlated (inversely) most closely with the clinical disease status (r=-0.33 to -0.50). Levels of dihomogammalinolenic acid and eicosapentaenoic acid correlated inversely to levels of IgM rheumatoid factors (r=-0.33) and anti-SSA/Ro antibodies (r=-0.40) respectively. Moreover, levels of anti-SSA/Roantibodies (r=-0.34-0.40) correlated with levels of the proinflammatory arachidonic acid. Sigma n-3 EFA/sigma n-6 EFA ratios correlated significantly to the quantitative estimates of immunopathological and clinical disease status. Our data are in agreement with current understanding of pro- and anti-immunoinflammatory roles within EFA metabolism, and support the rationale for intervention studies. https://greenmedinfo.com/article/data-support-pro-and-anti-inflammatory-roles-within-efa-metabolism#comments DHA (Docosahexaenoic Acid) Essential Fatty Acids Sjogren's Syndrome Anti-Inflammatory Agents Cell Membranes Essential Fatty Acids Sjogrens Syndrome Human Study Sun, 08 Apr 2012 23:31:53 +0000 greenmedinfo 74036 at https://greenmedinfo.com DHEA restores concentrations of sex steroids in primary Sjogren's syndrome. https://greenmedinfo.com/article/dhea-restores-concentrations-sex-steroids-primary-sjogrens-syndrome PMID:  J Clin Endocrinol Metab. 2009 Jun;94(6):2044-51. Epub 2009 Mar 24. PMID: 19318446 Abstract Title:  Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren&#039;s syndrome; supplementation with dehydroepiandrosterone restores the concentrations. Abstract:  CONTEXT: Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren&#039;s syndrome. OBJECTIVE: Our aim was to investigate: 1) effects of 50 mg oral DHEA/day on changes in serum levels of DHEA and 12 of its metabolites; 2) relationships between steroid levels and disease characteristics; and 3) whether these parameters were influenced by DHEA. DESIGN: Twenty-three postmenopausal women with primary Sjogren&#039;s syndrome and subnormal levels of DHEA-S were included in a randomized, 9-month, controlled, double blind crossover study. Liquid chromatography/mass spectrometry (MS)/MS and gas chromatography/MS were used to measure the sex steroids. Anti-SS-A/Ro and/or anti-SS-B/La, salivary gland focus score, salivary flow rates, dry mouth and eye symptoms, and routine laboratory tests were assessed. RESULTS: Baseline erythrocyte sedimentation rate was inversely correlated with testosterone (Testo), dihydrotestosterone, and DHEA-S (rs = -0.42, -0.45, and -0.58, respectively). Dry mouth symptoms correlated with low Testo and androstenedione, whereas dry eyes correlated with low estrogens, most strongly estrone (rs = -0.63). Presence of anti-SS-A and/or anti-SS-B was independently associated with low estradiol (area under the receiver operating characteristic curve, 0.82). All metabolites increased during DHEA but not during placebo. The relative increases were less for estrogens and Testo compared to dihydrotestosterone and glucuronidated androgen metabolites. Dry mouth symptoms decreased during DHEA therapy. CONCLUSIONS: Disease manifestations in primary Sjogren&#039;s syndrome were associated with low sex hormone levels, dry mouth symptoms with low androgens, and dry eyes with low estrogens. Exogenous DHEA was preferentially transformed into androgens rather than into estrogens. https://greenmedinfo.com/article/dhea-restores-concentrations-sex-steroids-primary-sjogrens-syndrome#comments DHEA (Dehydroepiandrosterone) Sjogren's Syndrome Human Study Tue, 07 Jul 2009 16:51:19 +0000 greenmedinfo 45109 at https://greenmedinfo.com EGCG inhibits autoantigen expression in a way relevant to the treatment of Sjogen's syndrome. https://greenmedinfo.com/article/egcg-inhibits-autoantigen-expression-way-relevant-treatment-sjogens-syndrome PMID:  J Pharmacol Exp Ther. 2005 Nov;315(2):805-11. Epub 2005 Jul 26. PMID:16046615 Abstract Title:  Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells. Abstract:  Autoimmune disorders, characterized by inflammation and apoptosis of target cells leading to tissue destruction, are mediated in part by autoantibodies against normal cellular components (autoantigens) that may be overexpressed. For example, antibodies against the autoantigens SS-A/Ro and SS-B/La are primary markers for systemic lupus erythematosus and Sjögren&#039;s syndrome. Recently, studies in animals demonstrated that green tea consumption may reduce the severity of some autoimmune disorders, but the mechanism is unclear. Herein, we sought to determine whether the most abundant green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), affects autoantigen expression in human cells. Cultures of pooled normal human primary epidermal keratinocytes and of an immortalized human salivary acinar cell line were incubated with 100 microM EGCG (a physiologically achievable level for topical application or oral administration) for various time periods and then analyzed by cDNA microarray analysis, reverse transcription-polymerase chain reaction, and Western blotting for expression of several major autoantigen candidates. EGCG inhibited the transcription and translation of major autoantigens, including SS-B/La, SS-A/Ro, coilin, DNA topoisomerase I, and alpha-fodrin. These findings, taken together with green tea&#039;s anti-inflammatory and antiapoptotic effects, suggest that green tea polyphenols could serve as an important component in novel approaches to combat autoimmune disorders in humans.   https://greenmedinfo.com/article/egcg-inhibits-autoantigen-expression-way-relevant-treatment-sjogens-syndrome#comments EGCG (Epigallocatechin gallate) Sjogren's Syndrome Mon, 20 Apr 2009 06:19:42 +0000 greenmedinfo 43894 at https://greenmedinfo.com