Insulin: Low https://greenmedinfo.com/taxonomy/term/48020/all en Curcumin has an insulin releasing effect in rat-isolated pancreatic islets. https://greenmedinfo.com/article/curcumin-has-insulin-releasing-effect-rat-isolated-pancreatic-islets PMID:  Angiology. 2010 Aug;61(6):557-66. Epub 2010 Apr 14. PMID: 20395228 Abstract Title:  The effect of curcumin on insulin release in rat-isolated pancreatic islets. Abstract:  Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-1. Islets were isolated from rats and divided into control islets, islets incubated in different curcumin concentrations, islets incubated in hemin, islets incubated in curcumin and HO inhibitor, stannous mesoporphyrin (SnMP), islets incubated in hemin and SnMP, islets incubated in SnMP only, and islets incubated in 16.7 mmol/L glucose. Heme-oxygenase activity, HO-1 expression, and insulin estimation was assessed. Insulin secretion, HO-1 gene expression and HO activity were significantly increased in islets incubated in curcumin, hemin, and glucose compared with controls. This increase in insulin secretion was significantly decreased by incubation of islets in SnMP. The action of curcumin on insulin secretion from the isolated islets may be, in part, mediated through increased HO-1 gene expression. https://greenmedinfo.com/article/curcumin-has-insulin-releasing-effect-rat-isolated-pancreatic-islets#comments Curcumin Diabetes Mellitus: Type 1 Insulin: Low Insulin-releasing Animal Study Thu, 10 Feb 2011 22:12:49 +0000 greenmedinfo 61153 at https://greenmedinfo.com Curcumin may increase insulin production in healthy subjects. https://greenmedinfo.com/article/curcumin-may-increase-insulin-production-healthy-subjects PMID:  Nutr J. 2010;9:43. Epub 2010 Oct 12. PMID: 20937162 Abstract Title:  Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Abstract:  BACKGROUND: Previous animal studies have shown that Curcuma (C.) longa lowers plasma glucose. C. longa may thus be a promising ingredient in functional foods aimed at preventing type 2 diabetes. The purpose of the study is to study the effect of C. longa on postprandial plasma glucose, insulin levels and glycemic index (GI) in healthy subjects.METHODS: Fourteen healthy subjects were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with capsules containing a placebo or C. longa. Finger-prick capillary and venous blood samples were collected before, and 15, 30, 45, 60, 90, and 120 min after the start of the OGTT to measure the glucose and insulin levels, respectively.RESULTS: The ingestion of 6 g C. longa had no significant effect on the glucose response. The change in insulin was significantly higher 30 min (P = 0.03) and 60 min (P = 0.041) after the OGTT including C. longa. The insulin AUCs were also significantly higher after the ingestion of C. longa, 15 (P = 0.048), 30 (P = 0.035), 90 (P = 0.03), and 120 (P = 0.02) minutes after the OGTT.CONCLUSIONS: The ingestion of 6 g C. longa increased postprandial serum insulin levels, but did not seem to affect plasma glucose levels or GI, in healthy subjects. The results indicate that C. longa may have an effect on insulin secretion. https://greenmedinfo.com/article/curcumin-may-increase-insulin-production-healthy-subjects#comments Curcumin Insulin Disorders Insulin: Low Plant Extracts Human Study Fri, 21 Jan 2011 18:48:49 +0000 greenmedinfo 60320 at https://greenmedinfo.com Enrichment of gut microbiota with lactobacillus reuteri increases insulin secretion https://greenmedinfo.com/article/enrichment-gut-microbiota-lactobacillus-reuteri-increases-insulin-secretion PMID:  Diabetes Care. 2015 Jun 17. Epub 2015 Jun 17. PMID: 26084343 Abstract Title:  Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept. Abstract:  OBJECTIVE: Ingestion of probiotics can modify gut microbiota and alter insulin resistance and diabetes development in rodents. We hypothesized that daily intake of Lactobacillus reuteri increases insulin sensitivity by changing cytokine release and insulin secretion via modulation of the release of glucagon-like peptides (GLP)-1 and -2.RESEARCH DESIGN AND METHODS: A prospective, double-blind, randomized trial was performed in 21 glucose tolerant humans (11 lean: age 49± 7 years, BMI 23.6 ± 1.7 kg/m(2); 10 obese: age 51 ± 7 years, BMI 35.5 ± 4.9 kg/m(2)). Participants ingested 10(10) b.i.d. L. reuteri or placebo over 4 weeks. Oral glucose tolerance and isoglycemic glucose infusion tests were used to assess incretin effect and GLP-1 and GLP-2 secretion, and euglycemic-hyperinsulinemic clamps with [6,6-(2)H2]glucose were used to measure peripheral insulin sensitivity and endogenous glucose production. Muscle and hepatic lipid contents were assessed by (1)H-magnetic resonance spectroscopy, and immune status, cytokines, and endotoxin were measured with specific assays.RESULTS: In glucose tolerant volunteers, daily administration of L. reuteri increased glucose-stimulated GLP-1 and GLP-2 release by 76% (P https://greenmedinfo.com/article/enrichment-gut-microbiota-lactobacillus-reuteri-increases-insulin-secretion#comments Insulin: Low Lactobacillus reuteri Probiotics Insulin-releasing Microbiota Human Study Wed, 24 Jun 2015 00:07:53 +0000 greenmedinfo 118407 at https://greenmedinfo.com Trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up-regulating antioxidant enzyme activity and decreasing lipid peroxidation. https://greenmedinfo.com/article/trigonelline-has-beneficial-effect-diabetes-through-decreasing-blood-glucose-a PMID:  Fundam Clin Pharmacol. 2011 Dec 16. Epub 2011 Dec 16. PMID: 22172053 Abstract Title:  Experimental diabetes treated with trigonelline: effect onβ cell and pancreatic oxidative parameters. Abstract:  Oxidative stress in diabetes coexists with a reduction in the antioxidant status, which can further increase the deleterious effects of free radicals. Trigonelline is the major component of Mirabilis jalapa L., which has been used to treat diabetes in China. The present study was designed to evaluate the beneficial effects of trigonelline against hyperglycemia, hyperlipidemia,β cell damage and antioxidant of pancreas in diabetic rats. Diabetic rats were induced by intraperitoneal injection 35 mg/kg streptozotocin and a high-carbohydrate/high-fat diet. Rats were divided into four groups: normal control, diabetic control, trigonelline-treated diabetic, and glibenclamide-treated diabetic. After 4-week treatment, blood glucose, serum insulin, total cholesterol (TC), and triglyceride (TG) levels, insulin content in pancreas, and oxidative stress parameters in pancreatic homogenate were assayed. Pancreas was examined by hematoxylin/eosin staining. Trigonelline significantly decreased blood glucose, TC, and TG levels of diabetic rats. Pancreas-to-body weight ratio, insulin level, insulin sensitivity index, insulin content in pancreas, malonaldehyde and nitric oxide contents, and superoxide dismutase, catalase, glutathione and inducible nitric oxide synthase activities were altered in diabetic rats, and were near control levels treated with trigonelline. These findings suggest that trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up-regulating antioxidant enzyme activity and decreasing lipid peroxidation. https://greenmedinfo.com/article/trigonelline-has-beneficial-effect-diabetes-through-decreasing-blood-glucose-a#comments Diabetes Mellitus: Type 1 Hyperglycemia Insulin Resistance Insulin: Low Trigonelline Hypoglycemic Agents Insulin Sensitizers Animal Study Fri, 24 Feb 2012 12:54:22 +0000 greenmedinfo 73020 at https://greenmedinfo.com