Bowel Stenosis https://greenmedinfo.com/taxonomy/term/48246/all en Garlic oil is an effective agent in promoting the regression of esophageal stenosis and tissue damage caused by corrosive burns. https://greenmedinfo.com/article/garlic-oil-effective-agent-promoting-regression-esophageal-stenosis-and-tissue PMID:  Ulus Travma Acil Cerrahi Derg. 2017 May ;23(3):181-187. PMID: 28530769 Abstract Title:  Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Abstract:  BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn.METHODS: Twenty-eight rats were randomly divided into 4 equal groups: group 1 (sham), group 2 (control), group 3 (topical treatment), and group 4 (topical and systemic treatment). In groups 2, 3, and 4, corrosive esophageal burns were generated by applying sodium hydroxide to a 1.5-cm segment of the abdominal esophagus. Normal saline was applied to group 2, topical garlic oil to group 3, and topical and systemic garlic oil were used in group 4.RESULTS: The level of hydroxyproline was lower in the topical treatment groups than in the control group (p=0.023). There was difference in tumor necrosis factor alpha level between the systemic treatment groups and the control group (p=0.044). Treatment with garlic oil decreased stenosis index (SI) and histopathological damage score (HDS) in corrosive esophageal burn rats. The SI in the topical treatment group was significantly lower than that of the control group (p=0.016). The HDS was significantly lower in group 4 when compared with the control group (p=0.019).CONCLUSION: Garlic oil is an effective agent in promoting the regression of esophageal stenosis and tissue damage caused by corrosive burns. While the protective effect of garlic oil on tissue damage is more significant when applied topically, the anti-inflammatory effect is more pronounced when applied systemically. Therefore, we believe that the application of garlic oil in patients with corrosive esophageal burns can reduce complication rates. <p><a href="https://greenmedinfo.com/article/garlic-oil-effective-agent-promoting-regression-esophageal-stenosis-and-tissue" target="_blank">read more</a></p> https://greenmedinfo.com/article/garlic-oil-effective-agent-promoting-regression-esophageal-stenosis-and-tissue#comments Bowel Stenosis Burns Garlic Gastroprotective Animal Study Fri, 26 May 2017 16:20:50 +0000 greenmedinfo 148307 at https://greenmedinfo.com Tocotrienols have potenti antifibrogenic effects which may help prevent and/or treat bowel stenosis in Crohn's disease patients. https://greenmedinfo.com/article/tocotrienols-have-potenti-antifibrogenic-effects-which-may-help-prevent-andor- PMID:  Inflamm Bowel Dis. 2010 Aug 3. Epub 2010 Aug 3. PMID: 20684017 Abstract Title:  Tocotrienols have potent antifibrogenic effects in human intestinal fibroblasts. Abstract:  BACKGROUND:: Excessive fibroblast expansion and extracellular matrix (ECM) deposition are key events for the development of bowel stenosis in Crohn&#039;s disease (CD) patients. Tocotrienols are vitamin E compounds with proven in vitro antifibrogenic effects on rat pancreatic fibroblasts. We aimed at investigating the effects of tocotrienols on human intestinal fibroblast (HIF) proliferation, apoptosis, autophagy, and synthesis of ECM. METHODS:: HIF isolated from CD, ulcerative colitis (UC), and normal intestine were treated with tocotrienol-rich fraction (TRF) from palm oil. HIF proliferation was quantified by (3)H-thymidine incorporation, apoptosis was studied by DNA fragmentation, propidium iodide staining, caspase activation, and poly(ADP-ribose) polymerase cleavage, autophagy was analyzed by quantification of LC3 protein and identification of autophagic vesicles by immunofluorescence and production of ECM components was measured by Western blot. RESULTS:: TRF significantly reduced HIF proliferation and prevented basic fibroblast growth factor-induced proliferation in CD and UC, but not control HIF. TRF enhanced HIF death by promoting apoptosis and autophagy. HIF apoptosis, but not autophagy, was prevented by the pan-caspase inhibitor zVAD-fmk, whereas both types of cell death were prevented when the mitochondrial permeability transition pore was blocked by cyclosporin A, demonstrating a key role of the mitochondria in these processes. TRF diminished procollagen type I and lamininγ-1 production by HIF. CONCLUSIONS:: Tocotrienols exert multiple effects on HIF, reducing cell proliferation, enhancing programmed cell death through apoptosis and autophagy, and decreasing ECM production. Considering their in vitro antifibrogenic properties, tocotrienols could be useful to treat or prevent bowel fibrosis in CD patients. (Inflamm Bowel Dis 2010). https://greenmedinfo.com/article/tocotrienols-have-potenti-antifibrogenic-effects-which-may-help-prevent-andor-#comments Bowel Stenosis Crohn's Disease Tocotrienols In Vitro Study Sat, 22 Jan 2011 02:39:07 +0000 greenmedinfo 60387 at https://greenmedinfo.com