Asbestos Toxicity https://greenmedinfo.com/taxonomy/term/50316/all en Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos. https://greenmedinfo.com/article/artichoke-phytocomplex-modulates-serum-micrornas-patients-exposed-asbestos PMID:  J Exp Clin Cancer Res. 2022 Aug 20 ;41(1):255. Epub 2022 Aug 20. PMID: 35987988 Abstract Title:  Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial. Abstract:  BACKGROUND: Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis. Mesothelioma has the potential to represent an appropriate disease to prevent because of its strong association with asbestos exposure and the long latency from exposure to the disease on-set.METHODS: In the present study, we tested biological activity and toxicity of an artichoke freeze-dried extract (AWPC) as potential complementary preventive/early stage treatment agent for mesothelioma. This phase II clinical study then was conducted in 18 male-patients with evidence of radiographic characteristics related to asbestos exposure such as asbestosis or benign pleural disease as surrogate disease for mesothelioma clinical model.RESULTS: We investigate AWPC biological activity assessing its effect on mesothelin serum level, a glycoprotein with low expression in normal mesothelial cells and high expression in mesothelioma and asbestos related diseases. We also assess the AWPC effect on circulating miRNAs, as novel biomarkers of both cancer risk and response to therapeutic targets. While we found a small and not significant effect of AWPC on mesothelin serum levels, we observed that AWPC intake modulated 11 serum miRNAs related to gene-pathways connected to mesothelioma etiology and development. In terms of toxicity, we also did not observe any severe adverse effects associated to AWPC treatment, only gastro-intestinal symptoms were reported by five study participants.CONCLUSIONS: We observed an interesting AWPC effect on miRNAs which targets modulate mesothelioma development. New and much larger clinical studies based on follow-up of workers exposed to asbestos are needed to corroborate the role of AWPC in prevention and early treatment of mesothelioma.TRIAL REGISTRATION: ClinicalTrials.gov, NCT02076672 . Registered 03/03/2014. <p><a href="https://greenmedinfo.com/article/artichoke-phytocomplex-modulates-serum-micrornas-patients-exposed-asbestos" target="_blank">read more</a></p> https://greenmedinfo.com/article/artichoke-phytocomplex-modulates-serum-micrornas-patients-exposed-asbestos#comments Artichoke Asbestos Toxicity Mesothelioma MicroRNA modulator Human Study Sun, 29 Jan 2023 17:48:38 +0000 greenmedinfo 270230 at https://greenmedinfo.com Green tea has a protective effect against carcinogenesis induced by asbestos plus benzo(a)pyrene in rat. https://greenmedinfo.com/article/green-tea-has-protective-effect-against-carcinogenesis-induced-asbestos-plus-b PMID:  Biomed Environ Sci. 1995 Mar;8(1):54-8. PMID: 7605600 Abstract Title:  Inhibitory effect of green tea extract on the carcinogenesis induced by asbestos plus benzo(a)pyrene in rat. Abstract:  In this experiment lung carcinoma was induced by crocidolite plus benzo(a)pyrene in rat. From the cancer models, we observed that the incidence (16.0%) of lung carcinomas was lower, and the survival time (376 days) of the first case of carcinoma and the mean survival time (758 days) of the rats with carcinoma were higher in the group of rats drinking 2% green tea extract for life than in the positive group (without drinking green tea extract). The mortality ratio (0.5047) was smaller in the experimental group than in the positive control group, and the survival curve of the experimental group significantly raised up, in comparison with the positive group. https://greenmedinfo.com/article/green-tea-has-protective-effect-against-carcinogenesis-induced-asbestos-plus-b#comments Asbestos Toxicity Benzo[a]pyrene-induced Toxicity Green Tea Lung Cancer Animal Study Wed, 09 Feb 2011 19:16:30 +0000 greenmedinfo 60948 at https://greenmedinfo.com Green tea protects against asbestos-induced cell injury. https://greenmedinfo.com/article/green-tea-protects-against-asbestos-induced-cell-injury PMID:  Planta Med. 2000 Dec;66(8):762-4. PMID: 11199139 Abstract Title:  Protective effects of green tea catechins against asbestos-induced cell injury. Abstract:  Green tea extract was found to provide a strong protective effect against asbestos-induced injury of peritoneal macrophages and red blood cells in vitro. The main polyphenolic constituents of green tea extract, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG), were also efficient in preventing injury of cells following exposure to asbestos fibers. The protective efficacies of EGCG and ECG expressed as IC50 values were, respectively, 10 microM and 12 microM if peritoneal macrophages were injured by chrysotile and 4 microM and 5 microM in the case of crocidolite-induced cell injury. Antiradical and chelating properties of ECG and EGCG were evaluated and it was concluded that the protective effect of catechins against asbestos-induced injury may be related to both scavenger properties towards to superoxide anion and the ability to chelate iron ions. https://greenmedinfo.com/article/green-tea-protects-against-asbestos-induced-cell-injury#comments Asbestos Toxicity Catechin EGCG (Epigallocatechin gallate) Green Tea In Vitro Study Wed, 09 Feb 2011 19:11:08 +0000 greenmedinfo 60946 at https://greenmedinfo.com Quercetin and rutin protect against asbestos-induced disease. https://greenmedinfo.com/article/quercetin-and-rutin-protect-against-asbestos-induced-disease PMID:  Free Radic Biol Med. 1996;21(4):487-93. PMID: 8886799 Abstract Title:  Protective effect of natural flavonoids on rat peritoneal macrophages injury caused by asbestos fibers. Abstract:  Exposure of macrophages to asbestos fibers resulted in enhancement of the production of oxygen radicals, determined by a lucigenin enhanced chemiluminescence (LEC) assay, a formation of thiobarbituric acid reactive substances (TBARS), a LDH release into the incubation mixture, and a rapid lysis of the cells. Rutin (Rut) and quercetin (Qr) were effective in inhibiting LEC, TBARS formation, and reducing peritoneal macrophages injury caused by asbestos. The concentrations pre-treatment of antioxidants that were required to prevent the injury of peritoneal macrophages caused by asbestos by 50% (IC50) were 90 microM and 290 microM for Qr and Rut, respectively. Both flavonoids were found to be oxidized during exposure of peritoneal macrophages to asbestos and the oxidation was SOD sensitive. The efficacy of flavonoids as antioxidant agents as well as superoxide ion scavengers was also evaluated using appropriate model systems, and both quercetin and rutin were found to be effective in scavenging O2.-. These findings indicate that flavonoids are able to prevent the respiratory burst in rat peritoneal macrophages exposed to asbestos at the stage of activated oxygen species generation, mainly as superoxide scavengers. On the basis of this study it was concluded that natural flavonoids quercetin and rutin would be promising drug candidates for a prophylactic asbestos-induced disease. https://greenmedinfo.com/article/quercetin-and-rutin-protect-against-asbestos-induced-disease#comments Asbestos Toxicity Oxidative Stress Quercetin Rutin In Vitro Study Wed, 09 Feb 2011 19:13:34 +0000 greenmedinfo 60947 at https://greenmedinfo.com The use of polyphenols might represent a promising strategy to contrast the development or to prevent malignant mesothelioma. https://greenmedinfo.com/article/use-polyphenols-might-represent-promising-strategy-contrast-development-or-pre PMID:  Nutrients. 2016 ;8(5). Epub 2016 May 9. PMID: 27171110 Abstract Title:  The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium. Abstract:  Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching an effective dose has prompted investigations to evaluate the effects of polyphenols for the therapy and prevention of MM. Dietary polyphenols are able to inhibit cancer cell growth by targeting multiple signaling pathways, reducing inflammation, and modulating immune response. The ability of polyphenols to modulate the production of pro-inflammatory molecules by targeting signaling pathways or ROS might represent a key mechanism to prevent and/or to contrast the development of MM. In this review, we will report the current knowledge on the ability of polyphenols to modulate the immune system and production of mediators of inflammation, thus revealing an important tool in preventing and/or counteracting the growth of MM. https://greenmedinfo.com/article/use-polyphenols-might-represent-promising-strategy-contrast-development-or-pre#comments Asbestos Toxicity Curcumin EGCG (Epigallocatechin gallate) Mesothelioma Polyphenols Quercetin Resveratrol Rutin Anti-Inflammatory Agents Anticarcinogenic Agents Antiproliferative Apoptotic Prophylactic Agents Dose Response Review Mon, 04 Jul 2016 22:26:08 +0000 greenmedinfo 129621 at https://greenmedinfo.com