Oxidative Stress https://greenmedinfo.com/taxonomy/term/5070/all en A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise PMID:  J Complement Integr Med. 2020 May 19. Epub 2020 May 19. PMID: 32427121 Abstract Title:  A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. Abstract:  Natural products are increasing used in preventing and treating various diseases. Mangiferin belongs to the xanthone family, and has potential antiangiogenic, anticancer, immunomodulatory and anti-inflammatory activity along with the antioxidant activity. It is also used in the treatment of cardiac problem, diabetes and neurodegenerative disease. Finding of various researchers proves that mangiferin has a broad spectrum therapeutic application. Motive of this review is to describe the various studies performed on mangiferin for its different pharmacological activities. It also discusses various challenges associated with mangiferin such as stability and bioavailability. Strategies and approaches to improve bioavailability of mangiferin have also been discussed. Both research and review articles were used to write the manuscript. They were collected from various search engines like Pub Med, Science Direct and Google Scholar, using keywords like mangiferin, polyphenol, bioavailability enhancement, solubility enhancement, and antioxidant. Mangiferin being a potent antioxidant is effective in the treatment of various diseases. With novel drug delivery approaches we can overcome poor solubility and bioavailability problem which eventually can result to better utilisation of mangiferin in treating a variety of diseases and make mangiferin a revolutionary drug. <p><a href="https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise" target="_blank">read more</a></p> https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise#comments Inflammation Mangiferin Oxidative Stress Anti-Inflammatory Agents Antioxidants Immunomodulatory Review Mon, 27 Jul 2020 19:17:03 +0000 greenmedinfo 224318 at https://greenmedinfo.com Alpha-mangostin potentially possesses neuroprotective effects in a cellular model of Parkinson's disease. https://greenmedinfo.com/article/alpha-mangostin-potentially-possesses-neuroprotective-effects-cellular-model-p PMID:  J Toxicol. 2015 ;2015:919058. Epub 2015 Aug 18. PMID: 26357513 Abstract Title:  Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells. Abstract:  In vitro studies have shown that extracts from mangosteen (Garcinia mangostana Linn.) act as antioxidants and cytoprotective agents against oxidative damage. The protective effect of alpha-mangostin, the major xanthone found in the pericarp of the mangosteen, in cellular models of Parkinson&#039;s disease (PD), has not been investigated. This study aims to investigate whether alpha-mangostin could protect SH-SY5Y neuroblastoma cells from MPP(+)-induced apoptosis. The effects of alpha-mangostin on MPP(+)-induced cell death were evaluated with a cell viability assay, staining for nuclear DNA morphology, flow cytometry for apoptotic cells and reactive oxygen species (ROS) production, quantitative real-time PCR for the expression of p53, Bax, and Bcl-2, and western blot analysis for cleaved caspase-3. Concomitant treatment with alpha-mangostin attenuated the effect of MPP(+) on cell viability and apoptotic cell death. Alpha-mangostin reduced ROS formation induced by MPP(+). Bax/Bcl-2 expression ratio and expression of p53 were significantly lower in cells cocultured with alpha-mangostin and MPP(+). The cotreated cells showed a significant decrease in activated caspase-3 compared with MPP(+) treatment alone. Our data suggest that cytoprotection of alpha-mangostin against MPP(+)-induced apoptosis may be associated with the reduction of ROS production, modulating the balance of pro- and antiapoptotic genes, and suppression of caspase-3 activation. https://greenmedinfo.com/article/alpha-mangostin-potentially-possesses-neuroprotective-effects-cellular-model-p#comments Mangosteen Oxidative Stress Parkinson's Disease Anti-Apoptotic Antioxidants Neuroprotective Agents Blood Brain Barrier Gene Expression Regulation In Vitro Study Fri, 18 Mar 2016 04:52:26 +0000 greenmedinfo 124957 at https://greenmedinfo.com Astaxanthin alleviates oxidative damage in acute pancreatitis via direct antioxidant mechanisms. https://greenmedinfo.com/article/astaxanthin-alleviates-oxidative-damage-acute-pancreatitis-direct-antioxidant- PMID:  Turk J Gastroenterol. 2020 Oct ;31(10):706-712. PMID: 33169708 Abstract Title:  Astaxanthin alleviates oxidative damage in acute pancreatitis via direct antioxidant mechanisms. Abstract:  BACKGROUND/AIMS: Astaxanthin (ATX) is a naturally occurring carotenoid and a potent antioxidant. Various anti-inflammatory effects of ATX have been examined. We aimed to investigate the protective effect of ATX and its mechanism in a cerulein-induced acute pancreatitis rat model.MATERIALS AND METHODS: The rats were randomized into 2 main groups as control (C) and acute pancreatitis group (AP). AP group was subsequently divided into subgroups as AP+vehicle (AP), AP+ATX, and ATX+peroxisome proliferator-activated receptor-alpha antagonist GW6471 (ATX+GW) groups. To induce AP, the rats were administered cerulein (50µg/kg, intraperitonally [ip]) at 1 hour intervals, whereas the C group received saline. The AP group was treated with vehicle olive oil, ATX 40 mg/kg/orally, or GW6471 and ATX (GW1 mg/kg/ip; ATX; 40 mg/kg/peroral). Treatments were administered after the 1st cerulein injection. At the 7th hour afterthe final injection, the rats were killed and the pancreatic tissue was used for the determination of malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO) activities and luminol-lucigenin chemiluminescence levels. Serum amylase, lipase, and histopathological analyses were performed.RESULTS: Elevated serum lipase and amylase levels in the vehicle-treated AP group (p<p><a href="https://greenmedinfo.com/article/astaxanthin-alleviates-oxidative-damage-acute-pancreatitis-direct-antioxidant-" target="_blank">read more</a></p> https://greenmedinfo.com/article/astaxanthin-alleviates-oxidative-damage-acute-pancreatitis-direct-antioxidant-#comments Astaxanthin Oxidative Stress Pancreatitis Antioxidants Pancreato Protective Agents Animal Study Sun, 22 Nov 2020 16:04:09 +0000 greenmedinfo 230038 at https://greenmedinfo.com Comparative effect of bovine buttermilk, whey, and lactoferrin on the innate immunity receptors and oxidative status of intestinal epithelial cells. https://greenmedinfo.com/article/comparative-effect-bovine-buttermilk-whey-and-lactoferrin-innate-immunity-rece PMID:  Biochem Cell Biol. 2020 Jun 13. Epub 2020 Jun 13. PMID: 32538128 Abstract Title:  Comparative effect of bovine buttermilk, whey, and lactoferrin on the innate immunity receptors and oxidative status of intestinal epithelial cells. Abstract:  Milk contains active molecules with important functional properties as the defensive proteins; among them are the whey protein lactoferrin and proteins of the milk fat globule membrane (MFGM) present in buttermilk. The aim of this study has been to investigate the effect of lactoferrin, whey and buttermilk as modulators of intestinal innate immunity and oxidative stress on intestinal epithelial cells, to evaluate its potential use for the development of functional foods. Innate immune Toll-like receptors (TLR2, TLR4, and TLR9) mRNA expression, lipid peroxidation (MDA+4-HDA) and protein carbonyl levels were analyzed in enterocyte-like Caco-2/TC7 cells treated for 24 hours with different concentrations of lactoferrin, whey or buttermilk. None of the substances analyzed caused oxidative damage; however, whey significantly decreased the levels of lipid peroxidation. Furthermore, both lactoferrin and whey were able to reduce the oxidative stress induced by lipopolysaccharide. Respect to TLR receptors, lactoferrin, whey and buttermilk specifically altered the expression of TLR2, TLR4 and TLR9 receptors, with a strong decrease in TLR4 expression. These results suggest that lactoferrin, whey and buttermilk could be interesting potential ingredients for functional foods as they seem to modulate oxidative stress and inflammatory response induced by TLRs activation. <p><a href="https://greenmedinfo.com/article/comparative-effect-bovine-buttermilk-whey-and-lactoferrin-innate-immunity-rece" target="_blank">read more</a></p> https://greenmedinfo.com/article/comparative-effect-bovine-buttermilk-whey-and-lactoferrin-innate-immunity-rece#comments Fermented Foods and Beverages Lactoferrin Oxidative Stress Whey Anti-Inflammatory Agents Antioxidants Immunomodulatory In Vitro Study Wed, 16 Sep 2020 17:58:28 +0000 greenmedinfo 227012 at https://greenmedinfo.com Effect of grape juice, red wine and resveratrol solution on antioxidant, anti-inflammatory, hepactic function and lipid profile in rats feds with high-fat diet. https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma PMID:  Nat Prod Res. 2020 May 13:1-6. Epub 2020 May 13. PMID: 32400183 Abstract Title:  Effect of grape juice, red wine and resveratrol solution on antioxidant, anti-inflammatory, hepactic function and lipid profile in rats feds with high-fat diet. Abstract:  The objective was to investigate the role of consumption of grape juice (GJ), red wine (RW) or resveratrol solution (RS) on rats treated with a high-fat diet (HFD). Among the drinks offered, GJ had lower content of polyphenols and trans-resveratrol. Nevertheless, GJ showed similar content of anthocyanin and antioxidant activity to RW, although higher than RS. In rats treated with HFD, consumption of GJ presented best antioxidant and anti-inflammatory activity, reducing glutathione peroxidase and interleukin-6 serum levels. In addition, GJ promoted better levels of cholesterol and liver markers. On the other hand, RW aggravated the oxidizing effect of HFD, increasing catalase activity and interleukin-6 level. Already, RS showed no benefit in animals. Thus, GJ minimized the effects of HFD on oxidative stress and inflammation beyond promoted better levels of lipid profile and liver biomarkers. However, consumption of RS showed no benefit and RW revealed a pro-oxidant effect, as did HFD. <p><a href="https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma#comments Grape Inflammation Oxidative Stress Red Wine Resveratrol Anti-Inflammatory Agents Antioxidants Hypolipidemic Animal Study Sat, 05 Sep 2020 15:05:33 +0000 greenmedinfo 226356 at https://greenmedinfo.com Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia PMID:  Life Sci. 2020 Aug 15 ;255:117833. Epub 2020 May 22. PMID: 32450167 Abstract Title:  Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Abstract:  AIMS: This study aimed to evaluate the effect of oleuropein (OLE), the main phenolic compound present in olive leaves, on kidney ischemia-reperfusion injury (IRI) and to explore the underlying protective mechanism.MAIN METHODS: Rat kidneys were subjected to 60 min of bilateral warm ischemia followed by 120 min of reperfusion. OLE was administered orally 48 h, 24 h and 30 min prior to ischemia at doses of 10, 50 and 100 mg/kg body weight. The creatinine, urea, uric acid concentrations and lactate dehydrogenase (LDH) activity in plasma were evaluated. Oxidative stress and inflammation parameters were also assessed. Renal expression of AMP-activated protein kinase (p-AMPK), endothelial nitric oxide synthase (eNOS), mitogen-activated protein kinases (MAPK), inflammatory proteins and apoptotic proteins were evaluated using Western blot.KEY FINDINGS: Our results showed that OLE at 50 mg/kg reduced kidney IRI as revealed by a significant decrease of plasmatic creatinine, urea, uric acid concentrations and LDH activity. In parallel, OLE up-regulated antioxidant capacities. Moreover, OLE diminished the level of CRP and the expression of cyclooxygenase 2 (COX-2). Finally, OLE enhanced AMPK phosphorylation as well as eNOS expression whereas MAPK, and cleaved caspase-3 implicated in cellular apoptosis were attenuated in the ischemic kidneys.SIGNIFICANCE: In conclusion, this study shows that OLE could be used as therapeutic agent to reduce IRI through its anti-oxidative, anti-inflammatory and anti-apoptotic properties. <p><a href="https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia#comments Inflammation Ischemia Kidney Damage Oleuropein Oxidative Stress Anti-Apoptotic Anti-Inflammatory Agents Antioxidants Cyclooxygenase 2 Inhibitors Animal Study Wed, 05 Aug 2020 23:11:16 +0000 greenmedinfo 224772 at https://greenmedinfo.com Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide. https://greenmedinfo.com/article/effects-oridonin-growth-performance-and-oxidative-stress-broilers-challenged-l PMID:  Poult Sci. 2016 Oct 1 ;95(10):2281-9. Epub 2016 May 3. PMID: 27143760 Abstract Title:  Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide. Abstract:  This study was conducted to investigate the effects of oridonin (ORI) on growth performance and antioxidant capacity in broiler chickens that were repeatedly challenged with lipopolysaccharide (LPS). A total of 384 one-day-old male Arbor Acre broiler chickens were randomly assigned to 8 treatments with 6 replicate cages per treatment and 8 birds per replicate. There were 4 dietary treatments: the control group (birds fed the basal diet), the ORI 50 group, the ORI 80 group, and the ORI 100 group (the basal diet supplemented with 50, 80, and 100 mg/kg oridonin, respectively). Broilers were intraperitoneally injected with either 250μg/kg BW LPS or an equivalent amount of sterile saline at 16, 18, and 20 d of age. LPS decreased the average daily weight gain (ADG), the average daily feed intake (ADFI), and the feed conversion ratio (FCR) of broiler chickens (P0.05). LPS stimulation increased the relative weight of the spleen and bursa (P<p><a href="https://greenmedinfo.com/article/effects-oridonin-growth-performance-and-oxidative-stress-broilers-challenged-l" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-oridonin-growth-performance-and-oxidative-stress-broilers-challenged-l#comments Lipopolysaccharide-Induced Toxicity Oridonin Oxidative Stress Antioxidants Catalase Up-Regulation Nrf2 activation Animal Study Mon, 07 Sep 2020 18:46:42 +0000 greenmedinfo 226474 at https://greenmedinfo.com Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn. https://greenmedinfo.com/article/effects-three-drying-methods-polyphenol-composition-and-antioxidant-activities PMID:  Food Sci Biotechnol. 2020 Mar ;29(3):351-358. Epub 2019 Oct 5. PMID: 32257518 Abstract Title:  Effects of three drying methods on polyphenol composition and antioxidant activities ofSonn. Abstract:  The aim of this study was to investigate the effects of three different drying methods, freeze drying (FD), vacuum drying (VD) and oven drying (OD) on phenolic contents and antioxidant activities of litchi fruits. 20 polyphenols were exactly identified in the litchi fruits by UPLC-QqQ/MS. Significant losses were observed in the contents of total polyphenols and antioxidant activities in the dried litchi when compared with the fresh litchi. Principle component analysis indicated that there was significant difference of phenolic component between the use of thermal drying (VD and OD) and FD. Our results suggest that FD is the optimum drying method for litchi fruits considering the content of total polyphenols and antioxidant activities. <p><a href="https://greenmedinfo.com/article/effects-three-drying-methods-polyphenol-composition-and-antioxidant-activities" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-three-drying-methods-polyphenol-composition-and-antioxidant-activities#comments Lychee Oxidative Stress Polyphenols Antioxidants In Vitro Study Sat, 15 Aug 2020 19:01:01 +0000 greenmedinfo 225306 at https://greenmedinfo.com F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats. https://greenmedinfo.com/article/f-religisoa-protects-against-isoniazid-rifampicin-and-paracetamol-induced-oxid PMID:  Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821 Abstract Title:  Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity. Abstract:  BACKGROUND: The present study was designed to investigate the hepato protective effect of methanolic extract of Ficus religisoa L., Moraceae, on isoniazid-rifampicin and paracetamol induced hepatotoxicity in rats.MATERIALS AND METHODS: Male Wistar albino rats were divided into six groups; group 1 served as a control received vehicle (Distilled water), group 2 served as a toxic control, received isoniazid-rifampicin (100 mg/ kg, i.p.) or paracetamol 200mg/kg, p.o in sterile water, groups 3, 4 and 5 received 100, 200 and 300mg/kg bw, p.o. methanolic extract of F. religisoa along with INH+RIF or paracetamol and group 6 received Liv 52 as reference standard. All the treatment protocols followed 21 days for INH+RIF model and seven days for paracetamol model, after treatment rats were sacrificed and blood was used for biochemical and liver was used for histological studies.RESULTS: Administration of INH+RIF and paracetamol caused a significant elevation in the levels of liver marker enzymes (P https://greenmedinfo.com/article/f-religisoa-protects-against-isoniazid-rifampicin-and-paracetamol-induced-oxid#comments Fig Liver Damage: Drug-Induced Oxidative Stress Hepatoprotective Isoniazid Paracetamol Plant Extracts Animal Study Tue, 10 Nov 2015 21:25:00 +0000 greenmedinfo 121517 at https://greenmedinfo.com Free radical concentration increase within the cell caused by radiofrequency/microwave radiation seems to be a biologically relevant hypothesis to give clear insight into the RF/MW action at non-thermal level of radiation. https://greenmedinfo.com/article/free-radical-concentration-increase-within-cell-caused-radiofrequencymicrowave PMID:  Arh Hig Rada Toksikol. 2012 Sep ;63(3):407-16. PMID: 23152390 Abstract Title:  Biological indicators in response to radiofrequency/microwave exposure. Abstract:  Over the years, due to rapid technological progress, radiation from man-made sources exceeded that of natural origin. There is a general concern regarding a growing number of appliances that use radiofrequency/ microwave (RF/MW) radiation with particular emphasis on mobile communication systems. Since nonthermal biological effects and mechanisms of RF/MW radiation are still uncertain, laboratory studies on animal models, tissues, cells, and cell free system are of extraordinary importance in bioelectromagnetic research. We believe that such investigations play a supporting role in public risk assessment. Cellular systems with the potential for a clear response to RF/MW exposures should be used in those studies. It is known that organism is a complex electrochemical system where processes of oxidation and reduction regularly occur. One of the plausible mechanisms is connected with generation of reactive oxygen species (ROS). Depending on concentration, ROS can have both beneficial and deleterious effects. Positive effects are connected with cell signalling, defence against infectious agents, and proliferative cell ability. On the other hand, excessive production, which overloads antioxidant defence mechanism, leads to cellular damage with serious potential for disease development. ROS concentration increase within the cell caused by RF/MW radiation seems to be a biologically relevant hypothesis to give clear insight into the RF/MW action at non-thermal level of radiation. In order to better understand the exact mechanism of action and its consequences, further research is needed in the field. We would like to present current knowledge on possible biological mechanisms of RF/MW actions. <p><a href="https://greenmedinfo.com/article/free-radical-concentration-increase-within-cell-caused-radiofrequencymicrowave" target="_blank">read more</a></p> https://greenmedinfo.com/article/free-radical-concentration-increase-within-cell-caused-radiofrequencymicrowave#comments Oxidative Stress Radiation Induced Illness Cytotoxic Electromagnetic Field Harms Electromagnetic Radiation Oxidant Review Thu, 03 Oct 2019 23:20:27 +0000 greenmedinfo 198004 at https://greenmedinfo.com In vitro antioxidant activity of Ficus carica L. latex from 18 different cultivars. https://greenmedinfo.com/article/vitro-antioxidant-activity-ficus-carica-l-latex-18-different-cultivars PMID:  Sci Rep. 2020 Jul 2 ;10(1):10852. Epub 2020 Jul 2. PMID: 32616768 Abstract Title:  In vitro antioxidant activity of Ficus carica L. latex from 18 different cultivars. Abstract:  As synthetic antioxidants that are widely used in foods are known to cause detrimental health effects, studies on natural additives as potential antioxidants are becoming increasingly important. In this work, the total phenolic content (TPC) and antioxidant activity of Ficus carica Linn latex from 18 cultivars were investigated. The TPC of latex was calculated using the Folin-Ciocalteu assay. 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2&#039;-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric ion reducing antioxidant power (FRAP) were used for antioxidant activity assessment. The bioactive compounds from F. carica latex were extracted via maceration and ultrasound-assisted extraction (UAE) with 75% ethanol as solvent. Under the same extraction conditions, the latex of cultivar &#039;White Genoa&#039; showed the highest antioxidant activity of 65.91% ± 1.73% and 61.07% ± 1.65% in DPPH, 98.96% ± 1.06% and 83.04% ± 2.16% in ABTS, and 27.08 ± 0.34 and 24.94 ± 0.84 mg TE/g latex in FRAP assay via maceration and UAE, respectively. The TPC of &#039;White Genoa&#039; was 315.26 ± 6.14 and 298.52 ± 9.20 µg GAE/mL via the two extraction methods, respectively. The overall results of this work showed that F. carica latex is a potential natural source of antioxidants. This finding is useful for further advancements in the fields of food supplements, food additives and drug synthesis in the future. <p><a href="https://greenmedinfo.com/article/vitro-antioxidant-activity-ficus-carica-l-latex-18-different-cultivars" target="_blank">read more</a></p> https://greenmedinfo.com/article/vitro-antioxidant-activity-ficus-carica-l-latex-18-different-cultivars#comments Fig Oxidative Stress Antioxidants In Vitro Study Thu, 23 Jul 2020 19:21:39 +0000 greenmedinfo 224062 at https://greenmedinfo.com It is concluded that the cardioprotective effect of resveratrol is due to the antioxidant effect and other antiaging effects. https://greenmedinfo.com/article/it-concluded-cardioprotective-effect-resveratrol-due-antioxidant-effect-and-ot PMID:  Oxid Med Cell Longev. 2018 ;2018:1390483. Epub 2018 May 2. PMID: 29854072 Abstract Title:  Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol. Abstract:  The substantial increase in the number of elderly people in our societies represents a challenge for biology and medicine. The societies of the industrialized countries are subject to a progressive aging process that translates into an increase in the cardiovascular risk of the population. In the present work, the activity of catalase and superoxide dismutase was evaluated, as well as markers of oxidative stress (concentration of nitric oxide and total lipoperoxidation in its main components: malondialdehyde and 4-hydroxyalkene) in cardiomyocytes during the aging process in rats treated with resveratrol. Rats were divided into 4 groups according to the following categories: control (without treatment), negative control group (administered with physiological solution with 10% ethanol), positive control group (administered with vitamin E, 2 mg/kg/day), and group administered with resveratrol (10 mg/kg/day); these groups in turn were divided into 2, 4, 6, and 8 months of treatment. The analysis of nitric oxide showed a decreased level in the cardiac tissue in the groups treated with resveratrol; the same occurs when total lipoperoxidation is analyzed. The enzymatic activity studied (catalase and superoxide dismutase) did not present significant changes with respect to the controls. It is concluded that the cardioprotective effect of resveratrol is due to the antioxidant effect and other antiaging effects and not to the activation of the enzymes catalase and superoxide dismutase. <p><a href="https://greenmedinfo.com/article/it-concluded-cardioprotective-effect-resveratrol-due-antioxidant-effect-and-ot" target="_blank">read more</a></p> https://greenmedinfo.com/article/it-concluded-cardioprotective-effect-resveratrol-due-antioxidant-effect-and-ot#comments Aging: Heart Oxidative Stress Resveratrol Cardioprotective Animal Study Fri, 15 Jun 2018 20:42:24 +0000 greenmedinfo 165878 at https://greenmedinfo.com low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. https://greenmedinfo.com/article/low-dose-alpha-cypermethrin-exposure-induced-several-metabolic-and-redox-alter PMID:  Pestic Biochem Physiol. 2016 Nov ;134:49-54. Epub 2016 Apr 19. PMID: 27914539 Abstract Title:  The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns. Abstract:  Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy. <p><a href="https://greenmedinfo.com/article/low-dose-alpha-cypermethrin-exposure-induced-several-metabolic-and-redox-alter" target="_blank">read more</a></p> https://greenmedinfo.com/article/low-dose-alpha-cypermethrin-exposure-induced-several-metabolic-and-redox-alter#comments Fetal Origin of Adult Disease Oxidative Stress Pesticide Toxicity Prenatal Chemical Exposures Cypermethrin Risk Reduction Animal Study Tue, 26 Sep 2017 23:32:11 +0000 greenmedinfo 153421 at https://greenmedinfo.com Myricetin inhibits angiotensin converting enzyme and induces nitric oxide production in HUVEC cell line. https://greenmedinfo.com/article/myricetin-inhibits-angiotensin-converting-enzyme-and-induces-nitric-oxide-prod PMID:  Gen Physiol Biophys. 2020 May ;39(3):249-258. PMID: 32525818 Abstract Title:  Myricetin inhibits angiotensin converting enzyme and induces nitric oxide production in HUVEC cell line. Abstract:  Nitric oxide is known as relaxing factor because it acts as a vasodilator, increases blood flow, and inhibits platelet aggregation and adhesion, on the other hand nitric oxide can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. As the complete mechanism of myricetin and its cardiovascular benefits is not completely understood, the aim of this study was to investigate the antihypertensive activity of myricetin in human umbilical vein endothelial cell (HUVEC). Angiotensin converting enzyme (ACE) activity, nitric oxide production, reactive oxygen species (ROS) scavenger activity, cellular calcium concentration, and endothelial nitric oxide synthase (eNOS) activity and protein expression was investigated in HUVEC treated with different concentration of myricetin (1-60µM). Myricetin increased nitric oxide production in HUVEC through decreased ROS levels and increased nitric oxide production and eNOS activation. Activation of eNOS enzyme was achieved by an increase of cellular calcium concentration. At the same examined concentration of myricetin, the activity ofACE was significantly inhibited. These findings indicate that myricetin may be helpful for lowering blood pressure; this could be achieved through dietary intervention or by the production of new antihypertensive treatments from a natural product. <p><a href="https://greenmedinfo.com/article/myricetin-inhibits-angiotensin-converting-enzyme-and-induces-nitric-oxide-prod" target="_blank">read more</a></p> https://greenmedinfo.com/article/myricetin-inhibits-angiotensin-converting-enzyme-and-induces-nitric-oxide-prod#comments Myricetin Oxidative Stress Angiotensin-Converting Enzyme Inhibitors Nitric Oxide Enhancer In Vitro Study Thu, 16 Jul 2020 18:45:05 +0000 greenmedinfo 223655 at https://greenmedinfo.com Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia. https://greenmedinfo.com/article/naringenin-downregulates-inflammation-mediated-nitric-oxide-overproduction-and PMID:  J Food Biochem. 2020 Aug 7:e13422. Epub 2020 Aug 7. PMID: 32770581 Abstract Title:  Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia. Abstract:  Nitric oxide is a key regulating factor for physiological functions, when elevated during inflammatory conditions, NO, can lower endogenous antioxidants level. Naringenin, a bioflavonoid has shown to possess anti-inflammatory action. However, its role in NO-mediated responses has not been elucidated till date. This study was designed to investigate antioxidant potential of naringenin against inflammation-mediated nitric oxide overproduction and antioxidant status with an improved glycemic profile in diabetic rats. From total rats, Group 1 received normal saline, while remaining received single intraperitoneal injection of alloxan and were then equally divided into group 2, 3, and 4, which latter received no-treatment, metformin (50 mg kg day) and naringenin (50 mg kg day), respectively, for 1 month. Results showed that naringenin significantly downregulated levels of glucose (p <p><a href="https://greenmedinfo.com/article/naringenin-downregulates-inflammation-mediated-nitric-oxide-overproduction-and" target="_blank">read more</a></p> https://greenmedinfo.com/article/naringenin-downregulates-inflammation-mediated-nitric-oxide-overproduction-and#comments Hyperglycemia Inflammation Naringenin Oxidative Stress Anti-Inflammatory Agents Antioxidants In Vitro Study Wed, 12 Aug 2020 18:15:42 +0000 greenmedinfo 225116 at https://greenmedinfo.com