Liver Damage https://greenmedinfo.com/taxonomy/term/52610/all en A review on the role of phytoconstituents chrysin on the protective effect on liver and kidney. https://greenmedinfo.com/article/review-role-phytoconstituents-chrysin-protective-effect-liver-and-kidney PMID:  Curr Drug Discov Technol. 2023 Oct 25. Epub 2023 Oct 25. PMID: 37921185 Abstract Title:  A Review on the Role of Phytoconstituents Chrysin on the Protective Effect on Liver and Kidney. Abstract:  BACKGROUND: The chance of contracting significant diseases increases due to an unhealthy and contemporary lifestyle. Chrysin is a flavonoid of the flavone class in numerous plants, including Passiflora and Pelargonium. Chrysin has long been used to treat a variety of illnesses. Chrysin, an essential flavonoid, has many pharmacological actions, including anticancer, antiviral, anti-inflammatory, anti-arthritic, depressive, hypolipidemic, hepatoprotective, and nephroprotective activity.PURPOSE: This explorative review was commenced to provide a holistic review of flavonoids confirming that Chrysin has a therapeutic potential on the liver and kidney and reduces the hepatotoxicity and nephrotoxicity induced by diverse toxicants, which can be helpful for the toxicologists, pharmacologists, and chemists to develop new safer pharmaceutical products with chrysin and other toxicants.STUDY DESIGN: The most relevant studies that were well-explained and fit the chosen topic best were picked. The achieved information was analyzed to determine the outcome by screening sources by title, abstract, and whole work. Between themselves, the writers decided on the studies to be considered. The necessary details were systematically organized into titles and subtitles and compressively discussed.METHOD: The information presented in this review is obtained using targeted searches on several online platforms, including Google Scholar, Scifinder, PubMed, Science Direct, ACS publications, and Wiley Online Library. The works were chosen based on the inclusion criteria agreed upon by all authors.RESULTS: Chrysin is a promising bioactive flavonoid with significant health benefits, and its synthetic replacements are being utilized as pharmaceuticals to treat various diseases. Findings revealed that Chrysin exhibits hepatoprotective actions against several hepatotoxicants like 2,3,7,8 tetrachlorodibenzo- p-dioxin, carbon tetrachloride (CCl4), cisplatin, and others by lowering the levels of liver toxicity biomarkers and enhancing antioxidant levels. Additionally, chrysin has potential nephroprotective properties against various nephrotoxicants, like Cisplatin, Doxorubicin, Paracetamol, Gentamicin, Streptazosin, and others by dropping kidney toxicity marker levels, reducing oxidative stress, and improving the antioxidant level.CONCLUSION: According to this revised study, chrysin is a promising phytoconstituent that can be utilized as an alternate treatment for various medications that cause hepatotoxicity and nephrotoxicity. With active chrysin, several dosage forms targeting the liver and kidneys can be formulated. <p><a href="https://greenmedinfo.com/article/review-role-phytoconstituents-chrysin-protective-effect-liver-and-kidney" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-role-phytoconstituents-chrysin-protective-effect-liver-and-kidney#comments Chrysin Kidney Damage Liver Damage Antioxidants Hepatoprotective Renoprotective Review Mon, 27 Nov 2023 01:00:59 +0000 greenmedinfo 283907 at https://greenmedinfo.com Ameliorative effect of kefir against γ-irradiation induced liver injury in male rats: impact on oxidative stress and inflammation. https://greenmedinfo.com/article/ameliorative-effect-kefir-against-irradiation-induced-liver-injury-male-rats-i PMID:  Environ Sci Pollut Res Int. 2020 Jun 25. Epub 2020 Jun 25. PMID: 32588307 Abstract Title:  Ameliorative effect of kefir againstγ-irradiation induced liver injury in male rats: impact on oxidative stress and inflammation. Abstract:  Ionizing radiation is a double-edged sword because of its benefits and risks to human health. Therefore, protecting human organs from harmful effects of radiation is an important concern of researchers. Kefir, as a good source of probiotics, received growing interest in protective medicine owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. Thus, this study was planned to investigate the protective role of kefir againstγ-radiation-induced hepatotoxicity. Thirty-two male rats were distributed in four groups: (I) control, (II) received Kefir orally (5 ml/kg body weight) for 28 days, (III) exposed to whole body γ-irradiation (6.5 Gy) to induce hepatotoxicity, and (IV) was pretreated with kefir for 21 days thenexposed to γ-irradiation followed by 7 days of kefir treatment. At the end of the experiment, complete blood picture (CBC), liver function, and lipid profile were estimated. Furthermore, levels of lipid peroxidation, nitric oxide content, and endogenous antioxidants, in addition to concentrationsof copper, iron, and calcium were measured in liver tissue. Furthermore, monocyte chemoattractant protein-1 (MCP-1) and relative gene expression of nuclear factor kappa (NF-κB) were assessed. The results revealed that oral administration of kefir significantly reduced the radiation-induced hepatichistological alterations, hepatic function impairment, and dyslipidemia. Moreover, kefir notably ameliorated the state of oxidative stress and appeared to inhibit the induced inflammation. This study provides a possible counteracting role of kefir against hepatotoxicity induced γ-radiation. This can focus the benefit of kefir application as a prophylactic treatment to limit hepatic inflammation during radiotherapy. <p><a href="https://greenmedinfo.com/article/ameliorative-effect-kefir-against-irradiation-induced-liver-injury-male-rats-i" target="_blank">read more</a></p> https://greenmedinfo.com/article/ameliorative-effect-kefir-against-irradiation-induced-liver-injury-male-rats-i#comments Kefir Liver Damage Radiation Anti-Inflammatory Agents Antioxidants Radioprotective Animal Study Sat, 01 Aug 2020 17:34:03 +0000 greenmedinfo 224589 at https://greenmedinfo.com Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet. https://greenmedinfo.com/article/effects-grape-juice-red-wine-and-resveratrol-liver-parameters-rat-submitted-hi PMID:  An Acad Bras Cienc. 2020 ;92(2):e20191230. Epub 2020 Aug 10. PMID: 32785427 Abstract Title:  Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet. Abstract:  This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver. <p><a href="https://greenmedinfo.com/article/effects-grape-juice-red-wine-and-resveratrol-liver-parameters-rat-submitted-hi" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-grape-juice-red-wine-and-resveratrol-liver-parameters-rat-submitted-hi#comments Grape High Fat Diet Liver Damage Red Wine Resveratrol Hepatoprotective Animal Study Sat, 05 Sep 2020 00:10:11 +0000 greenmedinfo 226334 at https://greenmedinfo.com Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect. https://greenmedinfo.com/article/melittin-ameliorates-inflammation-mouse-acute-liver-failure-inhibition-pkm2-me PMID:  Acta Pharmacol Sin. 2020 Sep 16. Epub 2020 Sep 16. PMID: 32939034 Abstract Title:  Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect. Abstract:  Acute liver failure (ALF) is a fatal clinical syndrome with no special drug. Recent evidence shows that modulation of macrophage to inhibit inflammation may be a promising strategy for ALF treatment. In this study we investigated the potential therapeutic effects of melittin, a major peptide component of bee venom both in mice model of ALF and in LPS-stimulated macrophages in vitro, and elucidated the underlying mechanisms. ALF was induced in mice by intraperitoneal injection of D-galactosamine/LPS. Then the mice were treated with melittin (2, 4, and 8 mg/kg, ip). We showed that melittin treatment markedly improved mortality, attenuated severe symptoms and signs, and alleviated hepatic inflammation in D-galactosamine/LPS-induced ALF mice with the optimal dose being 4 mg/kg. In addition, melittin within the effective doses did not cause significant in vivo toxicity. In LPS-stimulated RAW264.7 macrophages, melittin (0.7 μM) exerted anti-oxidation and anti-inflammation effects. We showed that LPS stimulation promoted aerobic glycolysis of macrophages through increasing glycolytic rate, upregulated the levels of Warburg effect-related enzymes and metabolites including lactate, LDHA, LDH, and GLUT-1, and activated Akt/mTOR/PKM2/HIF-1α signaling. Melittin treatment suppressed M2 isoform of pyruvate kinase (PKM2), thus disrupted the Warburg effect to alleviate inflammation. Molecular docking analysis confirmed that melittin targetedPKM2. In LPS-stimulated RAW264.7 macrophages, knockdown of PKM2 caused similar anti-inflammation effects as melittin did. In D-galactosamine/LPS-induced ALF mice, melittin treatment markedly decreased the expression levels of PKM2 and HIF-1α in liver. This work demonstrates that melittin inhibits macrophage activation-mediated inflammation via inhibition of aerobic glycolysis by targeting PKM2, which highlights a novel strategy of using melittin for ALF treatment. <p><a href="https://greenmedinfo.com/article/melittin-ameliorates-inflammation-mouse-acute-liver-failure-inhibition-pkm2-me" target="_blank">read more</a></p> https://greenmedinfo.com/article/melittin-ameliorates-inflammation-mouse-acute-liver-failure-inhibition-pkm2-me#comments Bee Venom Liver Damage Liver Failure: Acute Anti-Inflammatory Agents Hepatoprotective Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor Animal Study Wed, 14 Oct 2020 20:12:28 +0000 greenmedinfo 228117 at https://greenmedinfo.com Proteomic analysis of liver mitochondria of db/db mice treated with grape seed procyanidin B2. https://greenmedinfo.com/article/proteomic-analysis-liver-mitochondria-dbdb-mice-treated-grape-seed-procyanidin PMID:  J Food Biochem. 2020 Aug 19:e13443. Epub 2020 Aug 19. PMID: 32815169 Abstract Title:  Proteomic analysis of liver mitochondria of db/db mice treated with grape seed procyanidin B2. Abstract:  Hepatic damage has been recognized as one of the major complications in diabetes mellitus. Our previous studies have verified that grape seed procyanidin B2 (GSPB2) played a protective effect on hepatic damage of diabetes. We used isobaric tag for relative and absolute quantitation proteomics here to identify the alterant mitochondrial protein profile in diabetic liver and to seek the protective targets of GSPB2. Proteomics found that 171 proteins were upregulated or downregulated in the liver mitochondria of diabetic group compared to the control group. Of these proteins, 61 were normalized after GSPB2 treatment. These back-regulated proteins are involved in the process of fatty acid oxidation, tricarboxylic acid cycle, oxidative phosphorylation, oxidative stress, and apoptosis. Some differentially expressed proteins were confirmed by western blotting. Our study might help to better understand the mechanism of mitochondrial dysfunction in diabetic liver damage, and provide novel targets for estimating the protective effects of GSPB2. PRACTICAL APPLICATIONS: Grape seed procyanidin B2 (GSPB2), a polyphenolic component found in red wine and grapes, has beneficial effects such as antioxidative stress, antiapoptosis, and cardiovascular protection. We used proteomics here to identify the differentially expressed mitochondrial proteins in diabetic liver after GSPB2 treatment and to seek the protective targets of GSPB2. We found that the differentially expressed proteins were involved in carbon metabolism, oxidative phosphorylation, fatty acid metabolism, citrate cycle, oxidative stress, and apoptosis. These proteins may play a key role in diabetic hepatic damage as functional proteins. Targeting these proteins including apply of GSPB2 could potentially lead to an effective treatment in the diabetic hepatic disease. <p><a href="https://greenmedinfo.com/article/proteomic-analysis-liver-mitochondria-dbdb-mice-treated-grape-seed-procyanidin" target="_blank">read more</a></p> https://greenmedinfo.com/article/proteomic-analysis-liver-mitochondria-dbdb-mice-treated-grape-seed-procyanidin#comments Liver Damage Procyanidin B2 Anti-Apoptotic Antioxidants Hepatoprotective In Vitro Study Sat, 29 Aug 2020 15:50:48 +0000 greenmedinfo 225941 at https://greenmedinfo.com The effect of emodin on liver disease - comprehensive advances in molecular mechanisms. https://greenmedinfo.com/article/effect-emodin-liver-disease-comprehensive-advances-molecular-mechanisms PMID:  Eur J Pharmacol. 2020 Sep 5 ;882:173269. Epub 2020 Jun 14. PMID: 32553811 Abstract Title:  The effect of emodin on liver disease -- comprehensive advances in molecular mechanisms. Abstract:  Liver injury could be caused by a variety of causes, including alcohol, drug poisoning, autoimmune overreaction, etc. In the period of liver injury, hepatic stellate cells (HSCs) will be activated and produce excessive extracellular matrix (ECM). If injury cannot be suppressed, liver injury will develop into fibrosis, even cirrhosis and liver cancer. It is reported that some monomer components extracted from traditional Chinese medicine have better effects on protecting liver. Emodin, an anthraquinone compound extracted from the traditional Chinese medicine RHEI RADIX ET RHIZOMA, has anti-inflammatory, antioxidant, liver protection and anti-cancer effects, and can prevent liver injury induced by a variety of factors. By searching literatures related to the liver protection of emodin in PUBMED, SINOMED, EBM and CNKI databases, it was found that emodin could inhibit the production and promote the secretion of bile acids, and have a protective effect on intrahepatic cholestasis. Also, emodin reduce collagen synthesis and anti-hepatic fibrosis by inhibiting oxidative stress, TGF-β/Smad pathway and HSCs proliferation, and promoting apoptosis of HSCs. Emodin can also regulate lipid metabolism and regulate the synthesis and oxidation of lipids and cholesterol to protect the nonalcoholic fatty liver. Besides, emodin can induce the apoptosis of hepatocellular carcinoma cells byacting on the death receptor pathway and mitochondrial apoptosis pathway, thus inhibiting the development of hepatocellular carcinoma. Moreover, emodin can modulate immunity and improve immune rejection in liver transplantation animals. In conclusion, emodin has a good effect on liver protection, but further experimental data are needed to verify it. <p><a href="https://greenmedinfo.com/article/effect-emodin-liver-disease-comprehensive-advances-molecular-mechanisms" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-emodin-liver-disease-comprehensive-advances-molecular-mechanisms#comments Emodin Liver Cancer Liver Damage Liver Disease Liver Fibrosis Organ Transplantation: Liver Anti-Fibrotic Antioxidants Apoptotic Hepatoprotective Hypolipidemic Immunomodulatory Transforming growth factor beta (TGF-β) inhibitor Review Sun, 09 Aug 2020 17:37:44 +0000 greenmedinfo 225011 at https://greenmedinfo.com 21 Reasons to Add Oyster Mushrooms to Your Meals https://greenmedinfo.com/blog/21-reasons-add-oyster-mushrooms-your-meals <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/21_Reasons_to_Add_Oyster_Mushrooms_to_Your_Meals-GreenMedInfo.jpg" /></p> <p><em style="font-size: 18px; letter-spacing: 0px;"><strong>Oyster mushrooms stand out among fungi for their mild seafood-like flavor and carnivorous tendencies. Plus, oyster mushrooms support human health by protecting your bones and liver, warding off diabetes, providing antioxidants and much more</strong></em></p><p><a href="https://greenmedinfo.com/blog/21-reasons-add-oyster-mushrooms-your-meals" target="_blank">read more</a></p> https://greenmedinfo.com/blog/21-reasons-add-oyster-mushrooms-your-meals#comments Bacterial Infections Cancers: All Diabetes Mellitus: Type 2 Liver Damage Mushrooms: All Oxidative Stress Oyster Mushroom Vitamin C Cancer Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods healing foods natural remedies proper nutrition Thu, 21 Oct 2021 23:25:40 +0000 GMI Research Group 247586 at https://greenmedinfo.com 6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway. https://greenmedinfo.com/article/6-gingerol-ameliorates-sepsis-induced-liver-injury-through-nrf2-pathway PMID:  Int Immunopharmacol. 2020 Jan 21 ;80:106196. Epub 2020 Jan 21. PMID: 31978803 Abstract Title:  6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway. Abstract:  Sepsis-induced liver injury is very common in intensive care units. Here, we investigated the effects of 6-gingerol on sepsis-induced liver injury and the role of the Nrf2 pathway in this process. 6-Gingerol is the principal ingredient of ginger that exerts anti-inflammatory and antioxidant effects. Using cecal ligation and puncture (CLP) to induce polymicrobial sepsis and related liver injury, we found that mice pre-treated with 6-Gingerol showed less incidences of severe liver inflammation and death than untreated CLP groups. 6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1β, and caspase-1. Consistent with these findings, 6-gingerol reduced the effects of pyroptosis induced by lipopolysaccharide (LPS) and adenosine 5&#039;-triphosphate (ATP) in RAW 264.7 cells, as evidenced by IL-1β and caspase-1 protein levels in the supernatant and propidium iodide (PI) staining. 6-Gingerol was shown to activate the Nrf2 pathway in vivo and in vitro. Notably, Nrf2 siRNA transfection nullified the inhibitory effects of 6-gingerol on pyroptosis in vitro. In summary, these findings suggested that 6-gingerol alleviated sepsis-induced liver injury by inhibiting pyroptosis through theNrf2 pathway. <p><a href="https://greenmedinfo.com/article/6-gingerol-ameliorates-sepsis-induced-liver-injury-through-nrf2-pathway" target="_blank">read more</a></p> https://greenmedinfo.com/article/6-gingerol-ameliorates-sepsis-induced-liver-injury-through-nrf2-pathway#comments Gingerol Liver Damage Sepsis Antioxidants Hepatoprotective Nrf2 activation In Vitro Study Tue, 28 Jan 2020 21:28:13 +0000 greenmedinfo 209715 at https://greenmedinfo.com A comparative study of the hepatoprotective effect of Centella asiatica extract on lipopolysaccharide/d-galactosamine-induced acute liver injury. https://greenmedinfo.com/article/comparative-study-hepatoprotective-effect-centella-asiatica-extract-lipopolysa PMID:  Nutrients. 2021 Nov 15 ;13(11). Epub 2021 Nov 15. PMID: 34836346 Abstract Title:  A Comparative Study of the Hepatoprotective Effect ofExtract (CA-HE50) on Lipopolysaccharide/d-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice. Abstract:  Acute liver failure (ALF) refers to the sudden loss of liver function and is accompanied by several complications. In a previous study, we revealed the protective effect of50% ethanol extract (CA-HE50) on acetaminophen-induced liver injury. In the present study, we investigate the hepatoprotective effect of CA-HE50 in a lipopolysaccharide/galactosamine (LPS-D-Gal)-induced ALF animal model and compare it to existing therapeutic silymarin,mycelia (LEM) extracts, ursodeoxycholic acid (UDCA) and dimethyl diphenyl bicarboxylate (DDB). Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group. In particular, AST and ALT levels of the 200 mg/kg CA-HE50 group were significantly decreased compared to positive control groups. Lactate dehydrogenase (LDH) levels were significantly decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group and LDH levels of the 200 mg/kg CA-HE50 group were similar to those of the positive control groups. Superoxide dismutase (SOD) activity was significantly increased in the 100 mg/kg CA-HE50, LEM and UDCA groups compared to the vehicle control group and, in particular, the 100 mg/kg CA-HE50 group increased significantly compared to positive control groups. In addition, the histopathological lesion score was significantly decreased in the CA-HE50 and positive control groups compared with the vehicle control group and the histopathological lesion score of the 200 mg/kg CA-HE50 group was similar to that of the positive control groups. These results show that CA-HE50 has antioxidant and hepatoprotective effects at a level similar to that of silymarin, LEM, UDCA and DDB, which are known to have hepatoprotective effects; further, CA-HE50 has potential as a prophylactic and therapeutic agent in ALF. <p><a href="https://greenmedinfo.com/article/comparative-study-hepatoprotective-effect-centella-asiatica-extract-lipopolysa" target="_blank">read more</a></p> https://greenmedinfo.com/article/comparative-study-hepatoprotective-effect-centella-asiatica-extract-lipopolysa#comments Gotu Kola Lipopolysaccharide-Induced Toxicity Liver Damage Hepatoprotective Animal Study Sun, 05 Dec 2021 19:43:18 +0000 greenmedinfo 249721 at https://greenmedinfo.com A comprehensive review on Sesamum indicum. https://greenmedinfo.com/article/comprehensive-review-sesamum-indicum PMID:  J Ethnopharmacol. 2021 Aug 5:114503. Epub 2021 Aug 5. PMID: 34364969 Abstract Title:  A comprehensive review on Sesamum indicum L.: Botanical, ethnopharmacological, phytochemical, and pharmacological aspects. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Sesamum indicum L. (Pedaliaceae) is an annual plant, which has been domesticated for well over 5000 years. It is widely cultivated for its seeds and is one of the oldest known oilseed crops. Traditionally, its seeds, seed oil, and different organs of the plant have been used to treat various diseases or conditions like ulcers, asthma, wound healing, amenorrhea, hemorrhoids, inflammations, etc. AIM OF THE REVIEW: The main aim of this review is to provide an outline and to assess the reported ethnopharmacological, phytochemical, pharmacological and toxicological studies of Sesamum indicum L.MATERIALS AND METHODS: An extensive literature survey was done on various search engines like PubMed, Web of Science, Scopus, SciFinder, Google Scholar, Science direct, etc. Other literature sources like Wikipedia, Ethnobotanical books, Chapters were also studied to get maximum information possible on the Sesamum indicum L.RESULTS: Over 160 different phytochemical compounds have been characterized and isolated from seeds, seed oil, and various plant organs, including lignans, polyphenols, phytosterols, phenols, anthraquinones, naphthoquinones, triterpenes, cerebroside, fatty acids, vitamins, proteins, essential amino acids, and sugars using suitable analytical techniques (e.g., LC-MS, GC-MS, HPTLC, HPLC). All the reported pharmacological activities like antioxidant, anticancer, antipyretic, antihypertensive, hepatoprotective, and anti-inflammatory are due to the virtue of these phytochemical compounds.CONCLUSION: This review mainly highlights the botanical aspect of Sesamum indicum and its phytochemical constituents, ethnomedicinal uses, different pharmacological activities followed by ongoing clinical trials and future prospects. Sesamum indicum has great importance in traditional Indian medicine, which is further supported by modern pharmacological studies, especially in hepatoprotection, inflammation, and cancer. Several researchers have suggested that Sesamum indicum extracts and isolated compounds could have a wide therapeutic potency range. More research is needed to uncover key features of Sesamum indicum in medical practice, such as structure-activity relationships, toxicity, and therapeutic potential. In order to fully explore the plant&#039;s potential, safety assessments and implementation of an integrated cultivation method are also areas that need to investigate. <p><a href="https://greenmedinfo.com/article/comprehensive-review-sesamum-indicum" target="_blank">read more</a></p> https://greenmedinfo.com/article/comprehensive-review-sesamum-indicum#comments Cancers: All Hypertension Inflammation Liver Damage Oxidative Stress Sesame Seeds Anti-Inflammatory Agents Antihypertensive Agents Antioxidants Hepatoprotective Review Wed, 11 Aug 2021 22:27:14 +0000 greenmedinfo 244183 at https://greenmedinfo.com A maple syrup extract alleviates liver injury in type 2 diabetic model mice. https://greenmedinfo.com/article/maple-syrup-extract-alleviates-liver-injury-type-2-diabetic-model-mice PMID:  Nutr Res. 2019 Oct 24 ;73:97-101. Epub 2019 Oct 24. PMID: 31945627 Abstract Title:  A maple syrup extract alleviates liver injury in type 2 diabetic model mice. Abstract:  A recent study showed that 54% of type 2 diabetes (T2D) patients have nonalcoholic fatty liver disease, which is a risk factor for aggravation diabetic symptoms. Previous studies suggested components in maple syrup alleviated liver injury and found polyphenols as food components to improve the symptoms and complications of diabetes. Therefore, we hypothesized that a polyphenol fraction in maple syrup improves the symptoms and complications of diabetes. To address the hypothesis, we investigated the effects of a polyphenol-rich maple syrup extract (MSE) on a T2D model mice. KK-Amice were fed a normal or 0.1% MSE-supplemented diet for 43 days. The results showed that the levels of serum alanine aminotransferase and aspartate aminotransferase were significantly reduced in mice that ingested MSE. Hepatic genes related to lipogenesis and lipolysis were down- and upregulated, respectively, in mice that ingested MSE. These results suggest that MSE intake alleviates liver injury and suppresses lipid accumulation in the livers of T2D mice. <p><a href="https://greenmedinfo.com/article/maple-syrup-extract-alleviates-liver-injury-type-2-diabetic-model-mice" target="_blank">read more</a></p> https://greenmedinfo.com/article/maple-syrup-extract-alleviates-liver-injury-type-2-diabetic-model-mice#comments Diabetes Mellitus: Type 2 Diabetic Complications Liver Damage Maple Syrup Hepatoprotective Animal Study Wed, 29 Jan 2020 20:30:44 +0000 greenmedinfo 209854 at https://greenmedinfo.com A new possible mechanism by which punicalagin protects against liver injury induced by type 2 diabetes mellitus. https://greenmedinfo.com/article/new-possible-mechanism-which-punicalagin-protects-against-liver-injury-induced PMID:  J Agric Food Chem. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31698901 Abstract Title:  A New Possible Mechanism by which Punicalagin Protects Against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. Abstract:  The aim of this study was to investigate the protective effect of punicalagin (PU), a main component of pomegranate polyphenols, against liver injury induced by type 2 diabetes mellitus (T2DM) and to explore the molecular mechanism based on autophagy in vivo and in vitro. In T2DM mice, we found that PU significantly improved liver histology, reversed serum biochemical abnormalities, and increased the autophagosome number in the liver. In HepG2 cells cultured in a high-glucose environment, PU upregulated the glucose uptake level. Both in vivo and in vitro, PU upregulated the expression of autophagy-related proteins, such as LC3b and p62, and reduced the phosphorylated Akt/total Akt and phosphorylated FoxO3a/total FoxO3a protein ratios, and these effects were enhanced by LY294002 (a PI3K/Akt inhibitor). In summary, our current findings suggest that PU protects against liver injury induced by T2DM by restoring autophagy through the Akt/FoxO3a signaling pathway. <p><a href="https://greenmedinfo.com/article/new-possible-mechanism-which-punicalagin-protects-against-liver-injury-induced" target="_blank">read more</a></p> https://greenmedinfo.com/article/new-possible-mechanism-which-punicalagin-protects-against-liver-injury-induced#comments Diabetes Mellitus: Type 2 Liver Damage Punicalagin Hepatoprotective Animal Study In Vitro Study Fri, 15 Nov 2019 05:22:16 +0000 greenmedinfo 201861 at https://greenmedinfo.com A review of Schisandra chinensis and its phytotherapeutical applications. https://greenmedinfo.com/article/review-schisandra-chinensis-and-its-phytotherapeutical-applications PMID:  Ceska Slov Farm. 2019 ;68(3):95-118. PMID: 31431019 Abstract Title:  Schisandra chinensis and its phytotherapeutical applications. Abstract:  Schisandra (Schisandra chinensis) has been used for centuries as a plant of traditional Chinese medicine. Its biological activity and pharmacological use are associated with dibenzocyclooctadiene lignans, while specific polysaccharides may also be involved. The lignans of schisandra are genus-specific. Their activity has been investigated in hundreds of studies that have confirmed adaptogenic effects, central nervous system stimulation, hepatoprotective effects and potential anticancer potential. This summary review of the literature synthesizes the current state-of-the-art in research on bioactivities of schisandra constituents, description of folk use ofextracts, overview of clinical studies and additional information on in vitro tests bringing insight into mechanisms of action. <p><a href="https://greenmedinfo.com/article/review-schisandra-chinensis-and-its-phytotherapeutical-applications" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-schisandra-chinensis-and-its-phytotherapeutical-applications#comments Cancers: All Central Nervous System Diseases Liver Damage Schisandra Chemotherapeutic Hepatoprotective Neuroprotective Agents Phytotherapy Plant Extracts Review Thu, 02 Apr 2020 17:03:32 +0000 greenmedinfo 217782 at https://greenmedinfo.com A review of the chemical constituents and bioactivities of Psoralea corylifolia. https://greenmedinfo.com/article/review-chemical-constituents-and-bioactivities-psoralea-corylifolia PMID:  Am J Chin Med. 2016 ;44(1):35-60. PMID: 26916913 Abstract Title:  The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review. Abstract:  Psoralea corylifolia Linn. (P. corylifolia) is an important medicinal plant with thousands of years of clinical application. It has been widely used in many traditional Chinese medicine formulas for the treatment of various diseases such as leucoderma and other skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer. Phytochemical studies indicated that coumarins, flavonoids, and meroterpenes are the main components of P. corylifolia, and most of these components are present in the seeds or fruits. The extracts and active components of P. corylifolia demonstrated multiple biological activities, including estrogenic, antitumor, anti-oxidant, antimicrobial, antidepressant, anti-inflammatory, osteoblastic, and hepatoprotective activities. This paper systematically summarized literatures on the chemical constituents and biological activities of P. corylifolia, which provided useful information for the further research and development toward this potent medicinal plant. <p><a href="https://greenmedinfo.com/article/review-chemical-constituents-and-bioactivities-psoralea-corylifolia" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-chemical-constituents-and-bioactivities-psoralea-corylifolia#comments Babchi Depression Flavonoids Inflammation Liver Damage Oxidative Stress Anti-Inflammatory Agents Antidepressive Agents Antimicrobial Antineoplastic Agents Antioxidants Hepatoprotective Phytotherapy Plant Extracts Review Thu, 27 Feb 2020 21:05:41 +0000 greenmedinfo 214214 at https://greenmedinfo.com A review of the hepataprotective effects of ginsenoside Rg1. https://greenmedinfo.com/article/review-hepataprotective-effects-ginsenoside-rg1 n/a PMID:  J Ethnopharmacol. 2017 Apr 17. Epub 2017 Apr 17. PMID: 28427912 Abstract Title:  Hepataprotective effects of ginsenoside Rg1 - a review. Abstract:  BACKGROUND AND ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng has been used as efficient tonic and for the treatment of various diseases including hepatic disorders. Ginseng saponins, also known as ginsenosides, are principal constituents and have been treated to be responsible for disparate ginseng health benefits. The current review mainly focuses on ginsenoside Rg1, a compound isolated from traditional Chinese herbal medicine Panax ginseng Meyer. AIMS: To summary the hepataprotective effects and related mechanisms of ginsenoside Rg1, we conclude this review by combining the literature and our own researches. METHODS: As evidenced, we organized the pharmacological function of ginsenoside Rg1 by searching the pubmed. It has been deeply studied and summarized in the field of neurobiology, however, in this paper we described the pharmacological function of Rg1 in liver related to antioxidative stress and anti-inflammation. R&amp;D: Individual ginsenoside could be used since it shows a wide array of beneficial functions in the regulation and disorders of acute and chronic hepatotoxicity, hepatitis, hepatic fibrosis and cirrhosis in various pathways and different mechanisms. Of note, the antioxidant hepatic protection of ginsenoside Rg1 is mainly through the induction of Keap1-Nrf2-ARE signaling pathway. CONCLUSION: The multi-target actions of Rg1 substantiates it as a promising drug candidate for the treatment of hepatic impairment in different factors induced liver diseases. https://greenmedinfo.com/article/review-hepataprotective-effects-ginsenoside-rg1#comments Ginsenosides Liver Damage Liver Disease Hepatoprotective Ginsenosides Hepatoprotective liver damage Liver Disease Review Fri, 12 May 2017 20:47:52 +0000 greenmedinfo 147678 at https://greenmedinfo.com