Infertility: Male https://greenmedinfo.com/taxonomy/term/5616/all en A. lappa root may have antiinfertility effects by increasing sperm count and, serum gonadotropin and testosterone levels of nondiabetic mice. https://greenmedinfo.com/article/lappa-root-may-have-antiinfertility-effects-increasing-sperm-count-and-serum-g PMID:  Malays J Med Sci. 2015 Mar-Apr;22(2):25-32. PMID: 26023292 Abstract Title:  Effects of Hydro-alcoholic Extract from Arctium lappa L. (Burdock) Root on Gonadotropins, Testosterone, and Sperm Count and Viability in Male Mice with Nicotinamide/ Streptozotocin-Induced Type 2 Diabetes. Abstract:  BACKGROUND: Reproductive dysfunction is a complication of diabetes. Arctium lappa (burdock) root has hypoglycemic and antioxidative properties, which are traditionally used for treatment of impotence and sterility. Therefore, the aim of this study is to investigate the effects of its hydro alcoholic extract on gonadotropin, testosterone, and sperm parameters in nicotinamide/ streptozotocin-induced diabetic mice.METHODS: In this experimental study, 56 adult male Naval Medical Research Institute (NMRI) mice (30-35 g) were randomly divided into seven groups: control, diabetes, diabetes + glibenclamide (0.25 mg/kg), diabetes + extract (200 or 300 mg/kg), and extract (200 or 300 mg/kg). Diabetes was induced with intraperitoneal injection of nicotinamide (NA) and streptozotocin (STZ). Twenty-four hours after the last extract and drug administration, serum samples, testes, and cauda epididymis were removed immediately for experimental assessment.RESULTS: Body weight, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone levels, and sperm count (P https://greenmedinfo.com/article/lappa-root-may-have-antiinfertility-effects-increasing-sperm-count-and-serum-g#comments Burdock Diabetes Mellitus: Type 2 Infertility: Male Fertility Agents: Male Plant Extracts Animal Study Wed, 06 Jan 2016 00:07:51 +0000 greenmedinfo 122920 at https://greenmedinfo.com Effect of bee venom on reproductive performance and immune response of male rabbits. https://greenmedinfo.com/article/effect-bee-venom-reproductive-performance-and-immune-response-male-rabbits PMID:  Physiol Behav. 2020 Sep 1 ;223:112987. Epub 2020 May 31. PMID: 32492496 Abstract Title:  Effect of bee venom on reproductive performance and immune response of male rabbits. Abstract:  The current study aimed to investigate the effects of injecting bucks with different doses of bee venom (BV) on reproductive performance and immune response during the summer season. Forty-eight male V-line rabbits were randomly distributed among four homogeneous groups (12 bucks each). Three groups were injected BV under the neck skin with 0.1 (G1), 0.2 (G2) and 0.3 (G3) mg/rabbit twice weekly over 20 wks of treatment period. The 4group (G0) was not injected BV and served as a control group. Buck groups that were treated with BV showed significantly (p≤0.05) shorter reaction time (increased libido) compared to the control, and this effect was BV dose-dependent manner. Viable sperm and concentration, total sperm output, live sperm, and fertility percentage were significantly (p≤0.05) higher in BV groups than in the control group. Additionally,testosterone concentration, and some other blood biochemical constituents (total protein, albumin, and glucose) were significantly (p≤0.05) higher in BV groups than those in the control group. The BV doses resulted in a significant (p≤0.05) increase of antioxidant indices (TAC, GST, and GSH) compared to the control group. Furthermore, the Immunoglobulin A (IgA) and immunoglobulin M (IgM) were significantly (p≤0.05) higher in BV groupscompared to the control group. From these results, we concluded that BV had significant positive impacts on some semen quality traits, sexual behavior, blood biochemical parameters, blood antioxidant content, lipid peroxidation biomarkers, and immune response in V-line bucks. <p><a href="https://greenmedinfo.com/article/effect-bee-venom-reproductive-performance-and-immune-response-male-rabbits" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-bee-venom-reproductive-performance-and-immune-response-male-rabbits#comments Bee Venom Infertility: Male Immunomodulatory Animal Study Tue, 15 Sep 2020 17:33:11 +0000 greenmedinfo 226932 at https://greenmedinfo.com Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival. https://greenmedinfo.com/article/effects-roundup-and-its-main-component-glyphosate-upon-mammalian-sperm-functio PMID:  Sci Rep. 2020 Jul 3 ;10(1):11026. Epub 2020 Jul 3. PMID: 32620848 Abstract Title:  Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival. Abstract:  The wide use of glyphosate-based herbicides (GBHs) has become a matter of concern due to its potential harmful effects on human health, including men fertility. This study sought to investigate, using the pig as a model, the impact of pure glyphosate and its most known commercial formulation, Roundup, on sperm function and survival. With this purpose, fresh commercial semen doses were incubated with different concentrations (0-360 µg/mL) of glyphosate (GLY; exp. 1) or Roundup, at the equivalent GLY concentration (exp. 2), at 38 °C for 3 h. Glyphosate at 360 µg/mL significantly (P <p><a href="https://greenmedinfo.com/article/effects-roundup-and-its-main-component-glyphosate-upon-mammalian-sperm-functio" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-roundup-and-its-main-component-glyphosate-upon-mammalian-sperm-functio#comments Glyphosate Toxicity Infertility: Male Glyphosate Risk Factors Animal Study Fri, 14 Aug 2020 15:41:25 +0000 greenmedinfo 225235 at https://greenmedinfo.com "Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss." https://greenmedinfo.com/article/decreased-vitro-fertility-male-rats-exposed-fluoride-induced-oxidative-stress- PMID:  Toxicol Appl Pharmacol. 2008 Aug 1 ;230(3):352-7. Epub 2008 Mar 28. PMID: 18455746 Abstract Title:  Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss. Abstract:  Fluorosis, caused by drinking water contamination with inorganic fluoride, is a public health problem in many areas around the world. The aim of the study was to evaluate the effect of environmentally relevant doses of fluoride on in vitro fertilization (IVF) capacity of spermatozoa, and its relationship to spermatozoa mitochondrial transmembrane potential (DeltaPsi(m)). Male Wistar rats were administered at 5 mg fluoride/kg body mass/24 h, or deionized water orally for 8 weeks. We evaluated several spermatozoa parameters in treated and untreated rats: i) standard quality analysis, ii) superoxide dismutase (SOD) activity, iii) the generation of superoxide anion (O(2)(-)), iv) lipid peroxidation concentration, v) ultrastructural analyses of spermatozoa using transmission electron microscopy, vi) DeltaPsi(m), vii) acrosome reaction, and viii) IVF capability. Spermatozoa from fluoride-treated rats exhibited a significant decrease in SOD activity (~33%), accompanied with a significant increase in the generation of O(2)() (~40%), a significant decrease in DeltaPsi(m) (~33%), and a significant increase in lipid peroxidation concentration (~50%), relative to spermatozoa from the control group. Consistent with this finding, spermatozoa from fluoride-treated rats exhibited altered plasmatic membrane. In addition, the percentage of fluoride-treated spermatozoa capable of undergoing the acrosome reaction was decreased relative to control spermatozoa (34 vs. 55%), while the percentage fluoride-treated spermatozoa capable of oocyte fertilization was also significantly lower than the control group (13 vs. 71%). These observations suggest that subchronic exposure to fluoride causes oxidative stress damage and loss of mitochondrial transmembrane potential, resulting in reduced fertility. https://greenmedinfo.com/article/decreased-vitro-fertility-male-rats-exposed-fluoride-induced-oxidative-stress-#comments Infertility: Male Oxidative Stress Sperm Quality: Low Anti-Fertility Oxidant Sodium Fluoride Animal Study Sun, 10 Mar 2013 10:42:48 +0000 greenmedinfo 92931 at https://greenmedinfo.com 100% of male subjects tested had measurable urinary concentrations of parabens, and concentrations correlate with DNA damage in sperm. https://greenmedinfo.com/article/100-male-subjects-tested-had-measurable-urinary-concentrations-parabens-and-co PMID:  Environ Health Perspect. 2011 Feb ;119(2):252-7. Epub 2010 Sep 28. PMID: 20876036 Abstract Title:  Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. Abstract:  BACKGROUND: Parabens are commonly used as antimicrobial preservatives in cosmetics, pharmaceuticals, and food and beverage processing. Widespread human exposure to parabens has been recently documented, and some parabens have demonstrated adverse effects on male reproduction in animal studies. However, human epidemiologic studies are lacking.OBJECTIVE: We investigated relationships between urinary concentrations of parabens and markers of male reproductive health in an ongoing reproductive epidemiology study.METHODS: Urine samples collected from male partners attending an infertility clinic were analyzed for methyl paraben (MP), propyl paraben (PP), butyl paraben (BP), and bisphenol A (BPA). Associations with serum hormone levels (n = 167), semen quality parameters (n = 190), and sperm DNA damage measures (n = 132) were assessed using multivariable linear regression.RESULTS: Detection rates in urine were 100% for MP, 92% for PP, and 32% for BP. We observed no statistically significant associations between MP or PP and the outcome measures. Categories of urinary BP concentration were not associated with hormone levels or conventional semen quality parameters, but they were positively associated with sperm DNA damage (p for trend = 0.03). When urinary BPA quartiles were added to the model, BP and BPA were both positively associated with sperm DNA damage (p for trend = 0.03). Assessment of paraben concentrations measured on repeated urine samples from a subset of the men (n = 78) revealed substantial temporal variability.CONCLUSIONS: We found no evidence for a relationship between urinary parabens and hormone levels or semen quality, although intraindividual variability in exposure and a modest sample size could have limited our ability to detect subtle relationships. Our observation of a relationship between BP and sperm DNA damage warrants further investigation. https://greenmedinfo.com/article/100-male-subjects-tested-had-measurable-urinary-concentrations-parabens-and-co#comments DNA damage Infertility: Male Genotoxic Parabens Human Study Sat, 28 Apr 2012 18:23:38 +0000 greenmedinfo 75028 at https://greenmedinfo.com 1800 MHz increases oxidative stress and apoptosis in mouse-derived sperm cells, but N-acetyl cysteine and autophagy prevented EMF-associated cell death. https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n- PMID:  Toxicol Lett. 2014 Aug 4 ;228(3):216-24. Epub 2014 May 9. PMID: 24813634 Abstract Title:  The protective effect of autophagy on mouse spermatocyte derived cells exposure to 1800MHz radiofrequency electromagnetic radiation. Abstract:  The increasing exposure to radiofrequency (RF) radiation emitted from mobile phone use has raised public concern regarding the biological effects of RF exposure on the male reproductive system. Autophagy contributes to maintaining intracellular homeostasis under environmental stress. To clarify whether RF exposure could induce autophagy in the spermatocyte, mouse spermatocyte-derived cells (GC-2) were exposed to 1800MHz Global System for Mobile Communication (GSM) signals in GSM-Talk mode at specific absorption rate (SAR) values of 1w/kg, 2w/kg or 4w/kg for 24h, respectively. The results indicated that the expression of LC3-II increased in a dose- and time-dependent manner with RF exposure, and showed a significant change at the SAR value of 4w/kg. The autophagosome formation and the occurrence of autophagy were further confirmed by GFP-LC3 transient transfection assay and transmission electron microscopy (TEM) analysis. Furthermore, the conversion of LC3-I to LC3-II was enhanced by co-treatment with Chloroquine (CQ), indicating autophagic flux could be enhanced by RF exposure. Intracellular ROS levels significantly increased in a dose- and time-dependent manner after cells were exposed to RF. Pretreatment with anti-oxidative NAC obviously decreased the conversion of LC3-I to LC3-II and attenuated the degradation of p62 induced by RF exposure. Meanwhile, phosphorylated extracellular-signal-regulated kinase (ERK) significantly increased after RF exposure at the SAR value of 2w/kg and 4w/kg. Moreover, we observed that RF exposure did not increase the percentage of apoptotic cells, but inhibition of autophagy could increase the percentage of apoptotic cells. These findings suggested that autophagy flux could be enhanced by 1800MHz GSM exposure (4w/kg), which is mediated by ROS generation. Autophagy may play an important role in preventing cells from apoptotic cell death under RF exposure stress. <p><a href="https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n-" target="_blank">read more</a></p> https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n-#comments Infertility Infertility: Male NAC (N-acetyl-L-cysteine) Oxidative Stress Radiation Induced Illness Sperm Count: Low Sperm Quality: Low Antioxidant Apoptotic Cell Phone Exposure Electromagnetic Field Harms Electromagnetic Radiation Electromagnetic Radiation: 1.8 GHz Microwave Radiation Mobile Phone Radiation Oxidant Autophagy Autophagy Up-regulation Cell Phones electromagnetic fields electromagnetic frequencies electromagnetic radiation EMF infertility male infertility Male Infertility and Cellular Phones Radio Frequency Electromagnetic Radiation Exposure In Vitro Study Fri, 02 Aug 2019 20:17:48 +0000 greenmedinfo 192634 at https://greenmedinfo.com 44 Reasons Cell Phones Can Cause Cancer https://greenmedinfo.com/blog/44-reasons-cell-phones-can-cause-cancer1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2022<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><br /> <img alt="44 Reasons To Believe Cell Phones Can Cause Cancer" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/cell_phone_talking.jpg" style="width: 450px; height: 225px;" /><br /> <span style="font-size:12px;"><strong><span style="letter-spacing: 0px;">Originally Published On </span><strong style="letter-spacing: 0px;"><a href="https://www.electricsense.com/8822/cell-phones-cause-cancer-fact/" rel="dofollow" target="_blank">ElectricSense.com</a></strong></strong></span></p> <p><span style="font-size:22px;"><em><strong>Is there a connection between cell phones and cancer? Here are 44 reasons to believe that cell phones can cause cancer</strong></em></span></p> <p>Cell phones emit microwave radio-frequency radiation.&nbsp;Fact.</p> <p>This radiation has the ability to penetrate our bodies.&nbsp;Fact.</p> <p>Our governments do virtually nothing to protect us from these dangers.&nbsp;Fact.</p><p><a href="https://greenmedinfo.com/blog/44-reasons-cell-phones-can-cause-cancer1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/44-reasons-cell-phones-can-cause-cancer1#comments Acoustic Neuromas ADHD Arthritis Autism Cancer Depression Gliomas Headaches Heart Attacks Infertility: Male Leukemia Melanoma Meningioma Mobile Phone-Induced Oxidative Stress Oral Cancer Thyroid Cancer Tinnitus Cell Phone Exposure Electromagnetic Field Harms Microwave Radiation Acoustic Neuromas ADHD arthritis Autism Cancer Cell Phones Depression Gliomas Headaches Heart Attacks Infertility: Male leukemia melanoma Meningioma Oral Cancer radiation Thyroid Cancer tinnitus Mon, 26 Aug 2019 15:55:46 +0000 lloydelectricsense 115458 at https://greenmedinfo.com 900 MHz EMF induces morphological and biological that are possibly attributed to hormonal changes. https://greenmedinfo.com/article/900-mhz-emf-induces-morphological-and-biological-are-possibly-attributed-hormo PMID:  Saudi Med J. 2005 Mar ;26(3):405-10. PMID: 15806208 Abstract Title:  Biological and morphological effects on the reproductive organ of rats after exposure to electromagnetic field. Abstract:  OBJECTIVE: The biological effect of electromagnetic field (EMF) emitted from mobile phones is a current debate and still a controversial issue. Therefore, little is known on the possible adverse effects on reproduction as mobile phone bio-effects are only a very recent concern. The aim of this experimental study was to determine the biological and morphological effects of 900 MHz radiofrequency (RF) EMF on rat testes.METHODS: The study was performed in the Physiology and Histology Research Laboratories of Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey in May 2004. Twenty adult male Sprague-Dawley rats weighing 270-320 gm were randomized into 2 groups of 10 animals: Group I (control group) was not exposed to EMF and Group II (EMF group) was exposed to 30 minutes per day, 5 days a week for 4 weeks to 900 MHz EMF. Testes tissues were submitted for histologic and morphologic examination. Testicular biopsy score count and the percentage of interstitial tissue to the entire testicular tissue were registered. Serum testosterone, plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were assayed biochemically.RESULTS: The weight of testes, testicular biopsy score count and the percentage of interstitial tissue to the entire testicular tissue were not significantly different in EMF group compared to the control group. However, the diameter of the seminiferous tubules and the mean height of the germinal epithelium were significantly decreased in EMF group (p<p><a href="https://greenmedinfo.com/article/900-mhz-emf-induces-morphological-and-biological-are-possibly-attributed-hormo" target="_blank">read more</a></p> https://greenmedinfo.com/article/900-mhz-emf-induces-morphological-and-biological-are-possibly-attributed-hormo#comments Infertility: Male Testosterone Electromagnetic Field Harms Electromagnetic Radiation Endocrine Disruptor Animal Study Tue, 08 Oct 2019 21:18:32 +0000 greenmedinfo 198452 at https://greenmedinfo.com A Combination of γ-tocopherol-rich mixture of tocopherols and ascorbic acid restores fertility in cases of tyrosine nitration-associated male infertility. https://greenmedinfo.com/article/combination-tocopherol-rich-mixture-tocopherols-and-ascorbic-acid-restores-fer PMID:  Antioxidants (Basel). 2020 Jul 13 ;9(7). Epub 2020 Jul 13. PMID: 32668798 Abstract Title:  A Novel Combination ofγ-Tocopherol-Rich Mixture of Tocopherols and Ascorbic Acid Restores Fertility in Cases of Tyrosine Nitration-Associated Male Infertility in Mice. Abstract:  Infertility is an important health problem that affects up to 16% of couples worldwide. Male infertility is responsible for 50% of the cases. Currently, a physical examination, hormone profiling and the evaluation of two consecutive semen samples (to determine the sperm concentration, motility, morphology and, in very few cases, sperm DNA integrity) are the sole tools that physicians have to evaluate infertility in men. Antioxidant therapy is often used to improve sperm quality and function in infertile men. However, there are controversial results regarding the efficacy of these treatments.male mice are subfertile, displaying significant oxidative damage in the lipids, proteins and DNA of their spermatozoa. Here, we usedmale mice to test whether a novel combination of tocopherols that contained 60%γ-tocopherol and ascorbic acid could restore their fertility. These mice were fed with the supplemented (Vit. Mix) or control diets. To assess sperm quality, we determined the motility, levels of lipid peroxidation, DNA oxidation and tyrosine nitration in the spermatozoa. The number of pups sired by themice fed with the Vit. Mix diet was higher than that sired by the males fed with the control diet, and the pups&#039; mortality was lower. The sperm quality was improved in the males fed with the supplemented diet. We concluded that treatment with a supplement composed of tocopherols and rich inγ-tocopherol and ascorbic acid is effective in restoring fertility in cases where oxidative stress and high levels of tyrosine nitration are associated with male infertility. <p><a href="https://greenmedinfo.com/article/combination-tocopherol-rich-mixture-tocopherols-and-ascorbic-acid-restores-fer" target="_blank">read more</a></p> https://greenmedinfo.com/article/combination-tocopherol-rich-mixture-tocopherols-and-ascorbic-acid-restores-fer#comments Infertility: Male Vitamin C Vitamin E: Gamma-Tocopherol Fertility Agents: Male Animal Study Sun, 19 Jul 2020 22:52:16 +0000 greenmedinfo 223884 at https://greenmedinfo.com A correlation exists between mobile phone radiation exposure, DNA-fragmentation level and decreased sperm motility. https://greenmedinfo.com/article/correlation-exists-between-mobile-phone-radiation-exposure-dna-fragmentation-l PMID:  Cent European J Urol. 2014 ;67(1):65-71. Epub 2014 Apr 17. PMID: 24982785 Abstract Title:  The influence of direct mobile phone radiation on sperm quality. Abstract:  INTRODUCTION: It is impossible to imagine a modern socially-active man who does not use mobile devices and/or computers with Wi-Fi function. The effect of mobile phone radiation on male fertility is the subject of recent interest and investigations. The aim of this study was to investigate the direct in vitro influence of mobile phone radiation on sperm DNA fragmentation and motility parameters in healthy subjects with normozoospermia.MATERIAL AND METHODS: 32 healthy men with normal semen parameters were selected for the study. Each sperm sample was divided into two equal portions (A and B). Portions A of all involved men were placed for 5 hours in a thermostat, and portions B were placed into a second thermostat for the same period of time, where a mobile phone in standby/talk mode was placed. After 5 hours of incubation the sperm samples from both thermostats were re-evaluated regarding basic motility parameters. The presence of DNA fragmentation in both A and B portions of each sample was determined each hour using a standard sperm chromatin dispersion test.RESULTS: The number of spermatozoa with progressive movement in the group, influenced by electromagnetic radiation, is statistically lower than the number of spermatozoa with progressive movement in the group under no effect of the mobile phone. The number of non-progressive movement spermatozoa was significantly higher in the group, which was influenced by cell phone radiation. The DNA fragmentation was also significantly higher in this group.CONCLUSIONS: A correlation exists between mobile phone radiation exposure, DNA-fragmentation level and decreased sperm motility. <p><a href="https://greenmedinfo.com/article/correlation-exists-between-mobile-phone-radiation-exposure-dna-fragmentation-l" target="_blank">read more</a></p> https://greenmedinfo.com/article/correlation-exists-between-mobile-phone-radiation-exposure-dna-fragmentation-l#comments DNA damage Infertility: Male Mobile Phone Radiation Wi-Fi Radiation Risk Factors Human Study Tue, 14 Feb 2017 00:00:44 +0000 greenmedinfo 143467 at https://greenmedinfo.com A higher intake of soy foods and soy isoflavones is associated with lower sperm concentration. https://greenmedinfo.com/article/higher-intake-soy-foods-and-soy-isoflavones-associated-lower-sperm-concentrati PMID:  Hum Reprod. 2008 Nov;23(11):2584-90. Epub 2008 Jul 23. PMID: 18650557 Abstract Title:  Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Abstract:  BACKGROUND: High isoflavone intake has been related to decreased fertility in animal studies, but data in humans are scarce. Thus, we examined the association of soy foods and isoflavones intake with semen quality parameters. METHODS: The intake of 15 soy-based foods in the previous 3 months was assessed for 99 male partners of subfertile couples who presented for semen analyses to the Massachusetts General Hospital Fertility Center. Linear and quantile regression were used to determine the association of soy foods and isoflavones intake with semen quality parameters while adjusting for personal characteristics. RESULTS: There was an inverse association between soy food intake and sperm concentration that remained significant after accounting for age, abstinence time, body mass index, caffeine and alcohol intake and smoking. In the multivariate-adjusted analyses, men in the highest category of soy food intake had 41 million sperm/ml less than men who did not consume soy foods (95% confidence interval = -74, -8; P, trend = 0.02). Results for individual soy isoflavones were similar to the results for soy foods and were strongest for glycitein, but did not reach statistical significance. The inverse relation between soy food intake and sperm concentration was more pronounced in the high end of the distribution (90th and 75th percentile) and among overweight or obese men. Soy food and soy isoflavone intake were unrelated to sperm motility, sperm morphology or ejaculate volume. CONCLUSIONS: These data suggest that higher intake of soy foods and soy isoflavones is associated with lower sperm concentration. https://greenmedinfo.com/article/higher-intake-soy-foods-and-soy-isoflavones-associated-lower-sperm-concentrati#comments Infertility: Male Isoflavones Soy Human Study Sat, 30 Jan 2010 14:47:34 +0000 greenmedinfo 50561 at https://greenmedinfo.com A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals. https://greenmedinfo.com/article/meta-analysis-based-adverse-outcome-pathway-male-reproductive-toxicity-induced PMID:  J Hazard Mater. 2024 Mar 5 ;465:133375. Epub 2023 Dec 28. PMID: 38160553 Abstract Title:  A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals. Abstract:  The male reproductive toxicity of microplastics (MPs) and nanoplastics (NPs) has attracted great attention, but the latent mechanisms remain fragmented. This review performed the adverse outcome pathway (AOP) analysis and meta-analysis in 39 relevant studies, with the AOP analysis to reveal the cause-and-effect relationships of MPs/NPs-induced male reproductive toxicity and the meta-analysis to quantify the toxic effects. In the AOP framework, increased reactive oxygen species (ROS) is the molecular initiating event (MIE), which triggered several key events (KEs) at different levels. At the cellular level, the KEs included oxidative stress, mitochondrial dysfunction, sperm DNA damage, endoplasmic reticulum stress, apoptosis and autophagy of testicular cells, repressed expression of steroidogenic enzymes and steroidogenic acute regulatory protein, disrupted hypothalamic-pituitary-testicular (HPT) axis, and gut microbiota alteration. These KEs further induced the reduction of testosterone, impaired blood-testis barrier (BTB), testicular inflammation, and impaired spermatogenesis at tissue/organ levels. Ultimately, decreased sperm quality or quantity was noted and proved by meta-analysis, which demonstrated that MPs/NPs led to a decrease of 5.99 million/mL in sperm concentration, 14.62% in sperm motility, and 23.56% in sperm viability, while causing an increase of 10.65% in sperm abnormality rate. Overall, this is the first AOP for MPs/NPs-mediated male reproductive toxicity in mammals. The innovative integration of meta-analysis into the AOP analysis increases the rigorism of the results. <p><a href="https://greenmedinfo.com/article/meta-analysis-based-adverse-outcome-pathway-male-reproductive-toxicity-induced" target="_blank">read more</a></p> https://greenmedinfo.com/article/meta-analysis-based-adverse-outcome-pathway-male-reproductive-toxicity-induced#comments Infertility: Male Microplastic Toxicity Sperm Quality: Low Meta Analysis Review Sat, 02 Mar 2024 20:00:38 +0000 greenmedinfo 289093 at https://greenmedinfo.com A review of monosodium glutamate (MSG)-induced male reproductive dysfunction. https://greenmedinfo.com/article/review-monosodium-glutamate-msg-induced-male-reproductive-dysfunction PMID:  Toxics. 2020 Jan 22 ;8(1). Epub 2020 Jan 22. PMID: 31979139 Abstract Title:  Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review. Abstract:  Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged biological difficulty in reproducing their offspring after having unrestricted sexual intercourse for at least twelve months. Several factors have been implicated in the cause and progression of reproductive dysfunction, including poor nutrition, drug side effects, disease states, and toxicant ingestion. A well-known food additive that has been found to be potent at initiating reproductive anomalies in males is monosodium glutamate (MSG). This regular flavor enhancer is widely used as a taste enhancer in several diets. The different mechanisms by which it may induce reproductive dysfunctions include spermatogenic alteration resulting in a low sperm count, high sperm abnormality, reduced live sperm and decreased sperm pH, oxidative damage (increased lipid peroxidation and reduced antioxidant enzyme activities), histological alteration (blood hemorrhage, distorted germ and Sertoli cells), as well as gonadotropin imbalance (reduced testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations). Therefore, this review discusses various established mechanisms through which MSG may induce reproductive dysfunction and the treatment strategies to ameliorate its toxic effects. <p><a href="https://greenmedinfo.com/article/review-monosodium-glutamate-msg-induced-male-reproductive-dysfunction" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-monosodium-glutamate-msg-induced-male-reproductive-dysfunction#comments Infertility: Male Monosodium Glutamate (MSG) Risk Factors Review Sat, 15 Feb 2020 19:47:22 +0000 greenmedinfo 212063 at https://greenmedinfo.com A review of natural products in regulation of male fertility. https://greenmedinfo.com/article/review-natural-products-regulation-male-fertility PMID:  Indian J Med Res. 2018 12 ;148(Suppl):S107-S114. PMID: 30964087 Abstract Title:  Natural products in regulation of male fertility. Abstract:  Medicinal plants may prove useful in developing plant-based strategies for regulation of male fertility. The present review describes the antifertility potential of certain medicinal plants, viz. Azadirachta indica, Curcuma longa, Allamanda cathartica and Bacopa monnieri in Parkes (P) male mice. The results suggested that treatment with the aqueous extracts of these plants caused reversible suppression of spermatogenesis and fertility in P mice and that there were no signs of detectable toxicity in treated mice. Further research needs to be done to develop plant-based strategies for control of male fertility. <p><a href="https://greenmedinfo.com/article/review-natural-products-regulation-male-fertility" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-natural-products-regulation-male-fertility#comments Bacopa Curcuma Longa Infertility: Male Fertility Agents: Male Review Fri, 12 Jul 2019 17:26:57 +0000 greenmedinfo 191090 at https://greenmedinfo.com A review of Withania somnifera in male infertility. https://greenmedinfo.com/article/review-withania-somnifera-male-infertility PMID:  Phytomedicine. 2018 Nov 15 ;50:247-256. Epub 2017 Nov 29. PMID: 30466985 Abstract Title:  Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. Abstract:  BACKGROUND: Withania somnifera Dunal, commonly known as Indian ginseng, has been in use since ancient times as anti-stress agent, aphrodisiac, for impotence and infertility treatment.PURPOSE: To evaluate the efficacy and safety of W. somnifera treatment in infertile men.STUDY DESIGN: An evidence-based systematic review and meta-analysis using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.METHODS: Published literature was searched in PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/).RESULTS: Four clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) were included in the study. As only one RCT included, meta-analysis of RCT was not performed; however, systematically reviewed data demonstrated statistical (p ≤ .002 versus baseline) increase in sperm concentration (167%), semen volume (59%), and sperm motility (57%) in oligospermic males after 90 days of W. somnifera treatment, as well, serum testosterone (17%) and luteinizing hormone (34%) levels. Meta-analysis of observational (versus pre-treatment) studies showed that W. somnifera treatment significantly improved semen parameters (semen volume: mean difference [MD], 0.28  ml; 95% confidence interval [CI], 0.12 to 0.43; p = .0004; sperm concentration: MD, 13.57 million/ml; 95% CI, 11.12 to 16.01; p <p><a href="https://greenmedinfo.com/article/review-withania-somnifera-male-infertility" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-withania-somnifera-male-infertility#comments Ashwagandha Infertility: Male Sperm Quality: Low Meta Analysis Phytotherapy Review Fri, 15 Feb 2019 03:47:56 +0000 greenmedinfo 179751 at https://greenmedinfo.com