Kidney Damage: Antibiotic-Induced https://greenmedinfo.com/taxonomy/term/5864/all en 4 Artificial Sweeteners Linked to 'Nightmare Bacteria' https://greenmedinfo.com/blog/4-artificial-sweeteners-linked-nightmare-bacteria <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter" dir="ltr"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/Screen%20Shot%202023-01-07%20at%201_12_12%20PM.png" style="width: 600px; height: 377px; border-width: 1px; border-style: solid;" /></p> <p dir="ltr"><span style="font-size:18px;"><em><strong>Synthetic sweeteners have been linked to a wide range of health problems, with over 80 documented on the <a href="/toxic-ingredient/artificial-sweeteners" rel="dofollow" target="_blank">GreenMedInfo database</a>, alone. The various mechanisms of their toxicity, however, have not yet been fully elucidated. A new study raises a disturbing possibility that these widely consumed chemicals are driving otherwise 'good bacteria' into developing potentially lethal antibiotic resistance through a gut-mediated process.&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/4-artificial-sweeteners-linked-nightmare-bacteria" target="_blank">read more</a></p> https://greenmedinfo.com/blog/4-artificial-sweeteners-linked-nightmare-bacteria#comments Antibiotic Toxicity Diabetes Mellitus: Type 2 Diarrhea: Antibiotic-Associated Dysbiosis Honey Infection: Antibiotic Resistant Kidney Damage: Antibiotic-Induced Klebsiella Infections Maple Syrup Molasses Obesity Stevia Xylitol Acesulfame potassium Artificial Sweeteners Artificially Sweetened Beverages Aspartame Saccharin Sucralose (aka Splenda) Sat, 07 Jan 2023 17:42:52 +0000 Sayer Ji 269083 at https://greenmedinfo.com Alpha-lipoic acid alleviates colistin nephrotoxicity. https://greenmedinfo.com/article/alpha-lipoic-acid-alleviates-colistin-nephrotoxicity PMID:  Hum Exp Toxicol. 2020 Oct 28:960327120966043. Epub 2020 Oct 28. PMID: 33111558 Abstract Title:  Alpha-lipoic acid alleviates colistin nephrotoxicity in rats. Abstract:  Colistin methanesulfonate (CMS), a clinical form of colistin, is widely used as a last-line treatment for multidrug-resistant (MDR) gram-negative bacterial infections in critically ill patients presenting a considerably high mortality rate. However, nephrotoxicity is considered to be a critical adverse effect that limits CMS&#039;s clinical use. Alpha-lipoic acid (ALA) is a strong antioxidant that is effective in preventing nephrotoxicity in many models. The aim of this study was to investigate ALA&#039;s ability to protect against nephrotoxicity induced by colistin in rats. Male Wistar albino rats were randomly divided into four groups. Group 1 was the control group (Control; n = 6), in which isotonic saline was administered to the rats. Group 2 was the ALA group (ALA; n = 6) in which rats received 100 mg/kg ALA. Groups 3 was the CMS (CMS; n = 7) in which 450.000 IU/kg/day of CMS was administered to the rats. Groups 4 was the CMS + ALA group (n = 6), in which rats were injected with 100 mg/kg of ALA 30 min before administration of CMS. All injections were performed intraperitoneally at 1, 4, 7, and 10 days. Urine was collected by using a metabolic cage for 24 h after each administration. The rats were euthanized under ether anesthesia after 24 h of the last administration. Blood and kidney samples then were collected for histological and biochemical analysis. ALA pretreatment could reverse the effects of colistin-induced nephrotoxicity, partly through its suppressing effect on Nox4 and caspase-3, which in turn results in its antioxidant and antiapoptotic effect. Therefore, ALA may be an effective strategy for the management of colistin nephrotoxicity. <p><a href="https://greenmedinfo.com/article/alpha-lipoic-acid-alleviates-colistin-nephrotoxicity" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-lipoic-acid-alleviates-colistin-nephrotoxicity#comments Alpha-Lipoic Acid Kidney Damage: Antibiotic-Induced Anti-Apoptotic Antibiotics Antioxidants Renoprotective Animal Study Tue, 08 Dec 2020 18:15:41 +0000 greenmedinfo 230858 at https://greenmedinfo.com Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage. https://greenmedinfo.com/article/moringa-oleifera-ethanolic-extract-attenuates-tilmicosin-induced-renal-damage PMID:  Biomed Pharmacother. 2020 Nov 13 ;133:110997. Epub 2020 Nov 13. PMID: 33197759 Abstract Title:  Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression. Abstract:  Tilmicosin (Til) is a popular macrolide antibiotic, widely used in veterinary practice. The present study was designed to address the efficacy of Moringa oleifera ethanolic extract (MOE) in protecting against Tilmicosin (Til) - induced nephrotoxicity in Sprague Dawley rats. Animals were treated once with Til (75 mg/kg bw, subcutaneously), and/or MOE for 7 days (400 or 800 mg/kg bw, by oral gavage). Til-treatment was associated with significantly increased serum levels of creatinine, urea, sodium, potassium and GGT activity, as well as decreased total protein and albumin concentrations. Renal tissue hydrogen peroxide (HO) and malondialdehyde (MDA) levels were elevated, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes were diminished. The levels of renal tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) and the mRNA expression of intermediate filament protein encoding genes (desmin, nestin and vimentin) in the kidney were up- regulated with histopathological alterations in renal glomeruli, tubules and interstitial tissue. These toxic effects were markedly ameliorated by co-treatment of MOE with Til, in a dose dependent manner. Taken together, these results indicate that MO at 800 mg/kg protects against Til-induced renal injury, likely by its potent antioxidant and anti-inflammatory properties, which make it suitable to be used as a protective supplement with Til therapy. <p><a href="https://greenmedinfo.com/article/moringa-oleifera-ethanolic-extract-attenuates-tilmicosin-induced-renal-damage" target="_blank">read more</a></p> https://greenmedinfo.com/article/moringa-oleifera-ethanolic-extract-attenuates-tilmicosin-induced-renal-damage#comments Kidney Damage: Antibiotic-Induced Moringa oleifera Anti-Inflammatory Agents Antibiotics Antioxidants MicroRNA modulator Renoprotective Animal Study Fri, 27 Nov 2020 18:14:22 +0000 greenmedinfo 230263 at https://greenmedinfo.com Open Sesame! 10 Amazing Health Benefits of This Super-Seed https://greenmedinfo.com/blog/open-sesame-10-amazing-health-benefits-super-seed-1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2022<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Open Sesame! 10 Amazing Health Benefits Of This Super-Seed" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/15465723_m.jpg" style="width: 600px; height: 400px;" /></p> <p><em style="font-size: 18px; letter-spacing: 0px;"><strong><span style="line-height: 24.48px;">Given the growing body of scientific support on its health benefits, sesame would be just as at home in a medicine cabinet as it would be a kitchen cupboard</span></strong></em></p><p><a href="https://greenmedinfo.com/blog/open-sesame-10-amazing-health-benefits-super-seed-1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/open-sesame-10-amazing-health-benefits-super-seed-1#comments Blood Pressure: High Cancers: All Dental Plaque Depression Diabetes Mellitus: Type 2 DNA damage Gingivitis Huntington Disease Kidney Damage: Antibiotic-Induced Melatonin Multiple Sclerosis Sesame oil: topical Sesame Seed Oil Sesame Seeds Sesamol Health Guides: Healing Foods anticancer healing foods natural health Wed, 05 Oct 2022 07:00:00 +0000 Sayer Ji 74920 at https://greenmedinfo.com Rutin attenuates vancomycin-induced renal tubular cell apoptosis. https://greenmedinfo.com/article/rutin-attenuates-vancomycin-induced-renal-tubular-cell-apoptosis PMID:  Phytother Res. 2019 Jun 17. Epub 2019 Jun 17. PMID: 31209949 Abstract Title:  Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress. Abstract:  Vancomycin is a glycopeptide antibiotic widely used to treat infections caused by methicillin-resistant Staphylococcus aureus. However, nephrotoxicity is a major adverse side effect, and the development of effective nephroprotective agents remains a priority in antimicrobial chemotherapy. In this study, we investigated the cell protective effects of the flavonol glycoside rutin against vancomycin-induced toxicity. Vancomycin added to porcine renal tubular LLC-PK1 cells caused an increase of production of intracellular reactive oxygen species and subsequent apoptotic cell death. Pretreatment of LLC-PK1 cells with rutin at 5, 10, and 20 μM for 2 hr prior to 2-mM vancomycin exposure for 24 hr significantly decreased intracellular reactive oxygen species and increased superoxide dismutase and catalase activities. Rutin pretreatment also protected cells from vancomycin-induced caspase activation, mitochondrial membrane depolarization, and subsequent apoptosis. This study demonstrates a protective effect of rutin and suggests that rutin coadministration is an alternative therapy for treatment of vancomycin-induced nephrotoxicity. <p><a href="https://greenmedinfo.com/article/rutin-attenuates-vancomycin-induced-renal-tubular-cell-apoptosis" target="_blank">read more</a></p> https://greenmedinfo.com/article/rutin-attenuates-vancomycin-induced-renal-tubular-cell-apoptosis#comments Kidney Damage: Antibiotic-Induced Rutin Anti-Apoptotic Renoprotective Vancomycin In Vitro Study Wed, 10 Jul 2019 20:10:13 +0000 greenmedinfo 190950 at https://greenmedinfo.com Schisandrin B, a compound found within Schisandra, protects gainst Gemtamicin-Induced nephrotoxicity in rats. https://greenmedinfo.com/article/schisandrin-b-compound-found-within-schisandra-protects-gainst-gemtamicin-indu PMID:  Biol Pharm Bull. 2008 Apr;31(4):602-5. PMID: 18379049 Abstract Title:  Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats. Abstract:  Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has been shown to protect against oxidative damage in liver, heart and brain tissues in rodents. In the present study, the effect of long-term Sch B treatment (1-10 mg/kg/d x 15) on gentamicin-induced nephrotoxicity was examined in rats. Sch B treatment protected against gentamicin-induced nephrotoxicity, as evidenced by significant decreases in plasma creatinine and blood urea nitrogen levels. The nephroprotection was associated with the enhancement in renal mitochondrial antioxidant status, as assessed by the level/activity of reduced glutathione, alpha-tocopherol and Mn-superoxide dismutase, as well as the improvement/preservation of mitochondrial functional and structural integrity, as assessed by the extents of ATP generation capacity, malondialdehyde production, Ca2+ loading and cytochrome c release, as well as the sensitivity to Ca2+-induced permeability transition, in control and gentamicin-intoxicated rats. In conclusion, long-term Sch B treatment could enhance renal mitochondrial antioxidant status as well as improve mitochondrial functional and structural integrity, thereby protecting against gentamicin nephrotoxicity. https://greenmedinfo.com/article/schisandrin-b-compound-found-within-schisandra-protects-gainst-gemtamicin-indu#comments Antibiotic Toxicity Kidney Damage: Antibiotic-Induced Nephrotoxicity Schisandra Gentamicin Animal Study Sat, 25 Jul 2009 15:31:17 +0000 greenmedinfo 46009 at https://greenmedinfo.com Sesame Seed Oil attenuates antibiotic-induced kidney damage https://greenmedinfo.com/article/sesame-seed-oil-attenuates-antibiotic-induced-kidney-damage PMID:  Biol Pharm Bull. 2001 Feb;24(2):181-7. PMID: 19487986 Abstract Title:  Protective effect of daily sesame oil supplement on gentamicin-induced renal injury in rats. Abstract:  Gentamicin, an aminoglycoside antibiotic, is widely used in the treatment of Gramnegative infections; however, dose-limiting nephrotoxicity restricts its optimal use. We investigated the effect of a daily sesame oil supplement on oxidative-stress-associated renal injury induced by a single daily dose of gentamicin in rats. Renal injury was induced by a single subcutaneous daily dose of gentamicin (100 mg/kg/day for 7 days), and then the effects of oral sesame oil (0.25, 0.5, and 1 mL/kg/day for 7 days) on renal injury, oxidative stress, hydroxyl radical, superoxide anion, and nitric oxide were assessed after treatment. Sesame oil inhibited gentamicin-induced renal injury, lipid peroxidation, hydroxyl radical, and superoxide anion, as well as nitric oxide production. In addition, sesame oil inhibited xanthine oxidase activity and inducible nitric oxide synthase expression in gentamicin-challenged rats. We hypothesize that a daily sesame oil supplement attenuates oxidativestress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats. https://greenmedinfo.com/article/sesame-seed-oil-attenuates-antibiotic-induced-kidney-damage#comments Antibiotic Toxicity Kidney Damage: Antibiotic-Induced Sesame Seed Oil Animal Study Fri, 12 Jun 2009 00:38:59 +0000 greenmedinfo 44751 at https://greenmedinfo.com Spirulina platensis alone or in combination with vitamin c minimized the nephrotoxic effects of amikacin. https://greenmedinfo.com/article/spirulina-platensis-alone-or-combination-vitamin-c-minimized-nephrotoxic-effec PMID:  Environ Sci Pollut Res Int. 2019 Jan 26. Epub 2019 Jan 26. PMID: 30685861 Abstract Title:  Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits. Abstract:  The current study was performed to investigate the nephroprotective efficacy of Spirulina platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in protecting against amikacin (AMK)-induced nephrotoxicity in rabbits. Forty-two male New Zealand rabbits were allocated to seven equal groups, receiving (I) normal saline as negative controls, (II) oral SP (500 mg/kg body weight), (III) oral AA (20 mg/kg bw), (IV) intramuscular AMK injection (100 mg/kg bw), (V) AMK plus SP, (VI) AMK plus AA, or (VII) AMK plus SP and AA at the aforementioned doses. The treatments were given once/day for 7 days. Data analysis showed that in comparison to the control group, AMK-intoxicated rabbits showed significant increases (p ≤ 0.05) in serum concentrations of creatinine, uric acid, and urea, as well as renal tissue concentrations of tumor necrosis factor-α [TNF-α], malondialdehyde [MDA], and nitric oxide [NO]. Moreover, significant (p ≤ 0.05) reductions in renal glutathione concentration, antioxidant enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase), and total antioxidant capacity were noted following AMK intoxication. Treatment by SP ameliorated most of the aforementioned AMK-induced alterations. Although treatment with AA significantly reduced the renal tissue MDA, NO, and TNF-α concentrations, it was not associated with significant ameliorations of AMK-induced changes in the serum concentrations of renal function markers or renal tissue antioxidant parameters. The nephroprotective effects of SP-AA combination were more potent than SP alone in several parameters. In conclusion, SP alone or in combination with AA minimized the nephrotoxic effects of AMK through their antioxidant and anti-inflammatory activities. <p><a href="https://greenmedinfo.com/article/spirulina-platensis-alone-or-combination-vitamin-c-minimized-nephrotoxic-effec" target="_blank">read more</a></p> https://greenmedinfo.com/article/spirulina-platensis-alone-or-combination-vitamin-c-minimized-nephrotoxic-effec#comments Antibiotic Toxicity Kidney Damage: Antibiotic-Induced Spirulina Vitamin C Anti-Inflammatory Agents Antibiotics Antioxidants Malondialdehyde Down-regulation Nitric Oxide Inhibitor Renoprotective Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Tue, 12 Feb 2019 02:30:35 +0000 greenmedinfo 179537 at https://greenmedinfo.com