Aging: Immunosenecence https://greenmedinfo.com/taxonomy/term/58722/all en A diet supplemented with thiolic anti-oxidants improves immune function in an animal model of premature aging. https://greenmedinfo.com/article/diet-supplemented-thiolic-anti-oxidants-improves-immune-function-animal-model- PMID:  Clin Exp Pharmacol Physiol. 2002 Nov;29(11):1009-14. PMID: 12366393 Abstract Title:  A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice. Abstract:  1. According to previous studies, Swiss mice of the same age showed striking interindividual differences in behaviour when exposed to a T-maze test, with a slow performance being linked to an impaired immune function, hyperemotional response to stress and a shorter life span compared with mice that quickly explore the maze. These facts led us to propose the slow mice as a model of prematurely ageing mice (PAM). 2. In the present study, we investigated whether this prematurely ageing model could be found in other strains of mice, such as BALB/c mice, by analysing several lymphocytes functions, such as adherence, chemotaxis, proliferative response to the mitogen concanavalin A (Con A), interleukin (IL)-2 release and natural killer (NK) activity. In addition, we tested the probable beneficial effects on these functions of dietary supplementation with thioproline (TP) plus N-acetylcysteine (NAC; 0.1% w/w of each anti-oxidant) in female Swiss and BALB/c mice. 3. Our model of premature ageing, previously reported in Swiss mice, has also been reproduced in the inbred BALB/c mouse strain, in which PAM showing an immunosenescence in several lymphocyte functions, such as lower chemotaxis, proliferative response to Con A, IL-2 release and NK activity, as well as higher adherence, were observed. A short-term (5 week) ingestion of TP + NAC by female Swiss and BALB/c mice improved leucocyte function, increasing chemotaxis, the proliferative response to Con A, IL-2 release and NK activity and decreasing the adherence of lymphocytes. These effects are greatest in cells from PAM of both strains. 4. In conclusion, our model of premature ageing has been reproduced in an inbred strain. In addition, the ingestion of a diet supplemented with two thiolic anti-oxidants, such as NAC and TP, has been shown to be beneficial to the immune response in PAM. https://greenmedinfo.com/article/diet-supplemented-thiolic-anti-oxidants-improves-immune-function-animal-model-#comments Aging: Immunosenecence NAC (N-acetyl-L-cysteine) Thioproline Antioxidants Immunomodulatory Animal Study Wed, 27 Apr 2011 18:01:59 +0000 greenmedinfo 63369 at https://greenmedinfo.com A selenium/arginine mixture prevents chemically-induced immunosuppresion and accelerated aging. https://greenmedinfo.com/article/seleniumarginine-mixture-prevents-chemically-induced-immunosuppresion-and-acce PMID:  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Dec;23(12):1126-9. PMID: 18062883 Abstract Title:  [Effect of seleno-arginine on cellular immunological function in D-gal aging mice]. Abstract:  AIM: To study the effect of seleno-argnine on cellular immunological function in D-gal aging mice.METHODS: The mice were divided into normal group, model group, low seleno-argnine group(L-SeArg) and high seleno-argnine group (H-SeArg). D-galactose induced aging model was set up by s.c. injection for 42 days, i.g. method was used to add Seleno-argnine. Spleen index(SI) and thymus index (TI) were measured. The ability of Spleen cell multiplication and NK cell killing activity were determined by MTT colorimetry. The changes of CD40 and CD40L expression were observed by immunofluorescent assay.RESULTS: Compared with the model mice, seleno-argnine increased spleen index and thynus index, enhanced the ability of spleen cell multiplication, enhanced the expression of CD40 and CD40L, and accelerated the NK cell killing activity. Between the two seleno-argnine groups, the effect of L-SeArg on cellular immunological function was more obvious in D-gal aging mice.The result were statistic ally significantly compared with the model mice(P https://greenmedinfo.com/article/seleniumarginine-mixture-prevents-chemically-induced-immunosuppresion-and-acce#comments Aging Aging: Immunosenecence Arginine Immune Disorders: Low Immune Function Selenium Antiproliferative Immunomodulatory Animal Study Fri, 24 Jun 2011 19:09:01 +0000 greenmedinfo 64892 at https://greenmedinfo.com Acupuncture is effective to attenuate stress and stimulate lymphocyte proliferation in the elderly. https://greenmedinfo.com/article/acupuncture-effective-attenuate-stress-and-stimulate-lymphocyte-proliferation- PMID:  Neurosci Lett. 2010 Oct 22;484(1):47-50. Epub 2010 Aug 13. PMID: 20709154 Abstract Title:  Acupuncture is effective to attenuate stress and stimulate lymphocyte proliferation in the elderly. Abstract:  Acupuncture has increasingly been used to treat many conditions, including psychiatric disorders and immunological-related disorders. However, the effects of acupuncture as stress management and immune functions in the elderly are largely unclear. Here we investigated the effects of acupuncture on stress-related psychological symptoms and cellular immunity in young adults and elderly subjects. The acupuncture treatment consisted of six sessions and the procedures included the insertion of needles at bilateral acupoints LI4, SP6 and ST36. Psychological variables (depression, anxiety and stress) were investigated by means of self-assessment inventories. Peripheral blood mononuclear cells were isolated and cultured in vitro to measure mitogen-induced T-cell proliferation as well as cellular sensitivity to dexamethasone. All data were assessed before and after the intervention. Acupuncture was able to significantly reduce depression (p https://greenmedinfo.com/article/acupuncture-effective-attenuate-stress-and-stimulate-lymphocyte-proliferation-#comments Aging: Immunosenecence Anxiety Disorders Depression Elderly: Age Specific Diseases Acupuncture Immunostimulatory Human Study Wed, 27 Apr 2011 18:14:30 +0000 greenmedinfo 63374 at https://greenmedinfo.com Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea. https://greenmedinfo.com/article/decreasing-pro-inflammatory-cytokine-and-reversing-immunosenescence-extracts-p PMID:  Food Chem. 2012 Dec 15 ;135(4):2222-8. Epub 2012 Jul 15. PMID: 22980794 Abstract Title:  Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM). Abstract:  Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for infections, cancer and autoimmune conditions in the elderly. Senescence-accelerated mouse (SAM) was used to study the protective effects of Pu-erh tea in the elderly. The senile-prone sub-strain, SAM-P8 mice were administered individually with ripened or crude Pu-erh tea at 125, 250 or 500mg/kg. The results showed that Pu-erh tea significantly increased the fractions of naïve T lymphocytes, CD8(+)CD28(+) T lymphocytes and NK cells in the peripheral blood, but decreased the levels of IL-6 in aged mice. These data suggested that the Pu-erh tea reversed the immunosenescence by restoring the immune deficiency and decreasing pro-inflammatory cytokine. Thus, long term drinking of Pu-erh tea may be beneficial for the aged population in terms of increasing the body&#039;s resistance to infection and cancer. <p><a href="https://greenmedinfo.com/article/decreasing-pro-inflammatory-cytokine-and-reversing-immunosenescence-extracts-p" target="_blank">read more</a></p> https://greenmedinfo.com/article/decreasing-pro-inflammatory-cytokine-and-reversing-immunosenescence-extracts-p#comments Aging: Immunosenecence Black Tea Cancers: All Polyphenols Immunomodulatory Immunostimulatory Plant Extracts Animal Study Wed, 15 Apr 2020 00:14:47 +0000 greenmedinfo 218585 at https://greenmedinfo.com Epimedium flavonoids slow immunosenescence via NF-kappaB down-regulation. https://greenmedinfo.com/article/epimedium-flavonoids-slow-immunosenescence-nf-kappab-down-regulation PMID:  Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jul;26(7):620-4. PMID: 16983917 Abstract Title:  [Mechanism of epimedium flavonoids in regulating immuno-senescence via nuclear factor-kappa B related signal transduction pathway]. Abstract:  OBJECTIVE: To explore the mechanism of epimedium flavonoids (EF) in regulating immunosenescence via nuclear factor-kappa B (NF-kappaB) related signal transduction pathway.METHODS: (1) The apoptosis index (AI) of splenic lymphocyte in aged rats was monitored by flow cytometry, that of young rats was taken as control. (2) The differential expression profile of NF-kappaB related signals in aged rats allocated in the control group (aged rats, group A), the EF treated group (group B), the PDTC (a NF-kappaB inhibitor) treated group (group C) and the PDTC plus EF treated group (group D), was determined and the main significant molecules in them were analyzed with gene microarray of 96 genes related to NF-kappaB signal pathway.RESULTS: Excessive apoptosis of T lymphocyte cell was seen in aged rats, and it was significantly suppressed in group B and D. In group B, 73 genes were up-regulated to different extent, including 10 of the NF-kappaB/Rel/IB gene family, transduction signal molecule member of NIK/IKK/I B/Rel/NF-kappaB, NF-kappaB regulatory target genes, trans-membrane receptors, transcription factors, and receptor protein, etc. But the up-regulation on NF-kappaB gene family could not be seen in group C and that on others were also alleviated, while in the group D, the NF-kappaB gene family and its related transduction pathway were still activated to some extent. The NF-kappaB gene family showed a markedly common feature after EF intervention, either used alone or in combination with PDTC, i.e. the significant upregulated NF-kappaB1, NF-kappaB2, Rel B and I Bepsilon, and activated NIK/IKK/I B/Rel/NF-kappaB pathway.CONCLUSION: EF can suppress the excessive apoptosis of splenic lymphocyte in aged rats and activate Rel/NF-kappaB/ I B/IKK and their signal transduction pathway to up-regulate NF-kappaB through adjusting I Bepsilon and I Balpha, which may be the essential mechanism of EF in rebuilding the immune homeostasis of T lymphocyte apoptosis and retarding immunosenescence. https://greenmedinfo.com/article/epimedium-flavonoids-slow-immunosenescence-nf-kappab-down-regulation#comments Aging: Immunosenecence Epimedium Flavonoids NF-kappaB Inhibitor Animal Study Wed, 27 Apr 2011 18:33:46 +0000 greenmedinfo 63379 at https://greenmedinfo.com Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets. https://greenmedinfo.com/article/grape-polyphenols-corrects-ageing-related-detriments-neutrophil-functionality- PMID:  Inflammopharmacology. 2018 Oct ;26(5):1349-1358. Epub 2018 Jun 27. PMID: 29951779 Abstract Title:  Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets. Abstract:  Oxidative stress and inflammation are intricately interlinked as aetiological factors in the context of ageing and chronic disease-related accelerated ageing. Previous research by our group has highlighted the anti-oxidant and anti-inflammatory potential of grape-derived polyphenols in the context of acute inflammation and oxidative stress. The aim here was to add to this by assessing efficacy of the treatment (acutely) to address ageing-associated cumulative pro-oxidant and pro-inflammatory changes in an in vitro model. Blood from young and aged humans was analysed for baseline oxidative stress and inflammatory status. Isolated neutrophils were acutely exposed to the polyphenol treatment in vitro. The chemokinetic capacity of treated and control neutrophils in response to fMLP was subsequently determined in a Dunn chamber, using live cell imaging. Neutrophils were also analysed for the expression of selected molecular markers associated with functional capacity and oxidative stress. Results indicate that the aged population had significantly worse oxidative stress and inflammatory profiles (higher plasma conjugated dienes and MPO) than young controls. Neutrophils isolated from both young and aged individuals had improved chemokinetic accuracy and capacity after in vitro polyphenol treatment. Additionally, increased shedding of CD16 and expression of CD66b suggested sites via which the polyphenol achieved improved neutrophil motility. We conclude that grape seed-derived polyphenols facilitated improved neutrophil functionality by acting on the molecular targets elucidated here. <p><a href="https://greenmedinfo.com/article/grape-polyphenols-corrects-ageing-related-detriments-neutrophil-functionality-" target="_blank">read more</a></p> https://greenmedinfo.com/article/grape-polyphenols-corrects-ageing-related-detriments-neutrophil-functionality-#comments Aging: Immunosenecence Grape Polyphenols Anti-Inflammatory Agents Antioxidants Immunomodulatory In Vitro Study Tue, 14 Apr 2020 23:21:58 +0000 greenmedinfo 218581 at https://greenmedinfo.com High phobic anxiety is related to lower leukocyte telomere length in women. https://greenmedinfo.com/article/high-phobic-anxiety-related-lower-leukocyte-telomere-length-women PMID:  PLoS One. 2012 ;7(7):e40516. Epub 2012 Jul 11. PMID: 22808180 Abstract Title:  High phobic anxiety is related to lower leukocyte telomere length in women. Abstract:  BACKGROUND: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety--phobic anxiety--is related to telomere length.METHODOLOGY/PRINCIPAL FINDINGS: Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42-69 years) who: were participants in the Nurses&#039; Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (z-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend = 0.09); this association was similar after adjustment for confounders--paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend = 0.15). Notably, a threshold was identified. Among women with Crown-Crisp https://greenmedinfo.com/article/high-phobic-anxiety-related-lower-leukocyte-telomere-length-women#comments Aging: Immunosenecence Anxiety Disorders Immune System Diseases Mind-Body Medicine Telomere Length Human In Vitro Mon, 15 Oct 2012 16:04:46 +0000 greenmedinfo 82807 at https://greenmedinfo.com Immunostimulating activity of Lycium chinense Miller root extract through enhancing cytokine and chemokine production and phagocytic capacity of macrophages. https://greenmedinfo.com/article/immunostimulating-activity-lycium-chinense-miller-root-extract-through-enhanci PMID:  J Food Biochem. 2020 Mar 26:e13215. Epub 2020 Mar 26. PMID: 32215941 Abstract Title:  Immunostimulating activity of Lycium chinense Miller root extract through enhancing cytokine and chemokine production and phagocytic capacity of macrophages. Abstract:  Whereas the fruits and a small portion of root bark of Lycium trees are commonly marketed in Korea as traditional medicine or functional foods, majority of their whole roots have been largely discarded. To develop the whole root of these plants as more value-added materials, this study aimed to evaluate the potential immunostimulating activity of a water extract (GTR-101) from L. chinense Miller roots using macrophages. The GTR-101 (0-500 μg/ml) significantly, dose-dependently increased the secretion of pro-inflammatory cytokines (TNF-α and IL-6), chemokines (RANTES and MIP-1α), nitric oxide, and the expression of inducible nitric oxide synthase, and activated the Akt, NF-κB, and MAPKs (ERK and p38) signaling proteins. GTR-101also significantly enhanced the phagocytic activity of RAW 264.7 cells and bone marrow-derived macrophages. These results suggest that GTR-101 stimulates the early innate immunity via inducing the pro-inflammatory cytokine and chemokine secretion and enhancing the phagocytic activity of macrophages.PRACTICAL APPLICATIONS: The GTR-101 prepared from L. chinense Miller roots may be useful for enhancing body&#039;s defense systems especially in the elderly and cancer patients with an impaired or reduced immune response and may thus be effectively used as a natural immunostimulating ingredient in health foods or complementary medicine. <p><a href="https://greenmedinfo.com/article/immunostimulating-activity-lycium-chinense-miller-root-extract-through-enhanci" target="_blank">read more</a></p> https://greenmedinfo.com/article/immunostimulating-activity-lycium-chinense-miller-root-extract-through-enhanci#comments Aging: Immunosenecence Cancers: All Goji Immunostimulatory In Vitro Study Sat, 09 May 2020 12:19:26 +0000 greenmedinfo 220033 at https://greenmedinfo.com L. brevis KCCM 12203P could be used as a probiotic or applied to functional food processing and pharmaceutical fields for immunocompromised people. https://greenmedinfo.com/article/l-brevis-kccm-12203p-could-be-used-probiotic-or-applied-functional-food-proces PMID:  J Microbiol Biotechnol. 2019 Sep 30. Epub 2019 Sep 30. PMID: 31581386 Abstract Title:  Probiotic and antioxidant properties of nobleKCCM 12203P isolated from kimchi and evaluation of immune-stimulating activities of its heat-killed cells in RAW 264.7 cells. Abstract:  The purpose of this study was to determine the probiotic properties ofKCCM 12203P isolated from the Korean traditional food kimchi and to evaluate the antioxidative activity and immune-stimulating potential of its heat-killed cells to improve their bio-functional activities.GG, which is a representative commercial probiotic, was used as a comparative sample. Regarding probiotic properties,KCCM 12203P was resistant to 0.3% pepsin with a pH of 2.5 for 3 h and 0.3% oxgall solution for 24 h, having approximately a 99% survival rate. It also showed strong adhesion activity (6.84%) onto HT-29 cells and did not produceβ-glucuronidase but produced high quantities of leucine arylamidase, valine arylamidase, β-galactosidase, and-acetyl-β-glucosaminidase. For antioxidant activity, it appeared that viable cells had higher radical scavenging activity in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, while in the 2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assay, heat-killed cells had higher antioxidant activity. Additionally,KCCM 12203P showed higher lipid oxidation inhibition ability thanGG; however, there was no significant difference (<p><a href="https://greenmedinfo.com/article/l-brevis-kccm-12203p-could-be-used-probiotic-or-applied-functional-food-proces" target="_blank">read more</a></p> https://greenmedinfo.com/article/l-brevis-kccm-12203p-could-be-used-probiotic-or-applied-functional-food-proces#comments Aging: Immunosenecence Lactobacillus Brevis Immunostimulatory In Vitro Study Sat, 12 Oct 2019 19:37:57 +0000 greenmedinfo 198792 at https://greenmedinfo.com Melatonin and the immune system in aging. https://greenmedinfo.com/article/melatonin-and-immune-system-aging PMID:  Neuroimmunomodulation. 2008 ;15(4-6):272-8. Epub 2008 Nov 26. PMID: 19047804 Abstract Title:  Melatonin and the immune system in aging. Abstract:  Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals. <p><a href="https://greenmedinfo.com/article/melatonin-and-immune-system-aging" target="_blank">read more</a></p> https://greenmedinfo.com/article/melatonin-and-immune-system-aging#comments Aging: Immunosenecence Melatonin Immunomodulatory Immunostimulatory Review Wed, 15 Apr 2020 00:27:58 +0000 greenmedinfo 218589 at https://greenmedinfo.com Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation. https://greenmedinfo.com/article/melatonin-and-tumeric-ameliorate-aging-induced-changes-implication-immunoglobu PMID:  Int J Physiol Pathophysiol Pharmacol. 2018 ;10(2):70-82. Epub 2018 Apr 20. PMID: 29755640 Abstract Title:  Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation. Abstract:  Aging is associated with several biological, physiological, cellular and histological changes. In the present study, we investigated the effect of aging on different signaling pathways, including antioxidant system, apoptosis and immune status. Several natural products were used to ameliorate and block aging-related changes. Melatonin and turmeric have been known to ameliorate and decrease aging-related changes. However, the exact mechanism(s) of their action is not fully understood. In the present study, we tried to uncover the regulatory mechanism(s) by which melatonin and turmeric work against aging. We found that aging differentially regulated blood serum immunoglobulins; increased IgA and decreased IgE. Furthermore, all the serum cytokines investigated (TNF-α, IFN-γ, IL-6 and IL-8) were highly increased by aging. In addition, the antioxidant upstream regulators; DJ-1 and NRF2 were markedly repressed with aging in thymus tissues. We also found that aging induced apoptosis promoting genes p53 and Bax mRNA in thymus tissues. Finally, we found clear histological changes in thymus and spleen tissues. Administration of either melatonin or tumeric clearly ameliorated and blocked to some extinct the effect of aging. Altogether, aging was associated with downregulation of antioxidant regulators; DJ-1 and NRF2, promoted apoptosis and induced changes in the immune status. Furthermore, melatonin and tumeric markedly reversed the action of aging through activating DJ-1/NRF2 signaling pathway and inhibiting p53/Bax apoptotic pathway. <p><a href="https://greenmedinfo.com/article/melatonin-and-tumeric-ameliorate-aging-induced-changes-implication-immunoglobu" target="_blank">read more</a></p> https://greenmedinfo.com/article/melatonin-and-tumeric-ameliorate-aging-induced-changes-implication-immunoglobu#comments Aging: Immunosenecence Melatonin Turmeric Antioxidants Immunomodulatory Animal Study Wed, 29 Apr 2020 15:06:15 +0000 greenmedinfo 219542 at https://greenmedinfo.com Melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices. https://greenmedinfo.com/article/melatonin-supplementation-may-enhance-immunity-aged-individuals-upregulating-i PMID:  J Biomed Res. 2016 Jul ;30(4):314-21. Epub 2016 May 20. PMID: 27533940 Abstract Title:  Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes. Abstract:  Melatonin plays a critical role in regulating photoperiodic signals and has recently been shown to decrease immunosenescence with age. In this study, we examined whether melatonin activates T lymphocytes as major adaptive immune cells in in vitro and in vivo models. Splenocytes, CD4(+), and naïve CD4 T lymphocytes were isolated from the spleen of BALB/c mice and the cell population patterns and mRNA profiles associated with T cell activation (CD28 and p21) and the melatonin receptor (MT1A and MT1B) were assessed. The T cell activation-related proteins Ki67 and Bcl2 were also evaluated to confirm the relationship between gene and protein levels. Our data clearly revealed that CD28, p21, MT1A, and MT1B mRNA were highly expressed in the presence of melatonin. Co-culture of CD4(+) T lymphocyte and peritoneal macrophage 7 days after melatonin administration to young and aged mice significantly increased APRIL mRNA, suggesting induction or maintenance of T lymphocyte responses. We also found that the intracellular amount of Ki67 and Bcl2 proteins were significantly upregulated in aged CD4(+) T lymphocytes, suggesting enhancing T cell proliferation and ling-term maintenance of memory T cells. Taken together, we conclude that melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices in association with T lymphocytes and may be an attractive pharmacological candidate for aged and immunocompromised individuals. <p><a href="https://greenmedinfo.com/article/melatonin-supplementation-may-enhance-immunity-aged-individuals-upregulating-i" target="_blank">read more</a></p> https://greenmedinfo.com/article/melatonin-supplementation-may-enhance-immunity-aged-individuals-upregulating-i#comments Aging: Immunosenecence Melatonin Immunomodulatory Immunostimulatory In Vitro Study Tue, 14 Apr 2020 22:36:12 +0000 greenmedinfo 218580 at https://greenmedinfo.com NAC and thioproline retard immune function in an animal model of aging. https://greenmedinfo.com/article/nac-and-thioproline-retard-immune-function-animal-model-aging PMID:  Proc Nutr Soc. 2010 Nov;69(4):651-9. Epub 2010 Sep 28. PMID: 20875196 Abstract Title:  Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants. Abstract:  Several immune functions are markers of health, biological age and predictors of longevity. A chronic oxidative and inflammatory state is the main cause of ageing and the immune system is involved in the rate of ageing. Thus, several murine models of premature ageing have been proposed owing to their early immunosenescence and oxidative stress, such as ovariectomised rats and mice, obese rats and anxious mice. In the last model, the most extensively studied by us, mice showing anxiety have an aged immune function and redox status as well as a shorter longevity in comparison with animals without anxiety of the same chronological age, being denominated prematurely ageing mice. A confirmation of the above is that the administration of diets supplemented with antioxidants improves the redox status and immune functions and increases the longevity of prematurely ageing mice. Antioxidant precursors of glutathione such as thioproline or N-acetylcysteine, which have a relevant role in ageing, have been the most widely investigated in adult prematurely ageing mice in our laboratory. In the present work, we have studied the effects of the ingestion for 5 weeks of a diet supplemented with 0·1% (w/w) thioproline+N-acetylcysteine on several functions of leucocytes from chronological old (69-73 weeks of age) prematurely ageing mice of two strains (Swiss and BALB/c). The results show an improvement of the immune functions, with their values becoming closer to those in adult animals (24±2 weeks). Thus, an adequate nutrition with antioxidants, even in aged subjects, could be a good strategy to retard ageing. https://greenmedinfo.com/article/nac-and-thioproline-retard-immune-function-animal-model-aging#comments Aging Aging: Immunosenecence NAC (N-acetyl-L-cysteine) Thioproline Antioxidants Animal Study Wed, 27 Apr 2011 17:52:53 +0000 greenmedinfo 63367 at https://greenmedinfo.com Noni fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. https://greenmedinfo.com/article/noni-fruit-juice-delays-immunosenescence-lymphocytes-lymph-nodes-old-f344-rats PMID:  J Integr Med. 2018 05 ;16(3):199-207. Epub 2018 Apr 12. PMID: 29691190 Abstract Title:  Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. Abstract:  OBJECTIVE: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni (M. citrifolia) fruit juice (NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.METHODS: Lymphocytes isolated from axillary and inguinal lymph nodes of young (3-4 months) and old (18-21 months) rats were treated in vitro with different concentrations (0.0001%, 0.01%, and 1%) of NFJ for a period of 24 h. In the in vivo study, old (16-17 months) male F344 rats were treated with 5 mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60 d. Concanavalin A (Con A)-induced lymphocyte proliferation, interleukin-2 (IL-2) and interferon-γ (IFN-γ) production and expression of intracellular markers, such as phospho-extracellular signal-regulated kinase (p-ERK1/2), phospho-cAMP response element-binding protein, phospho-protein kinase B (p-Akt), phospho-tyrosine hydroxylase (p-TH), phospho-nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α (p-IκB-α) and phospho-nuclear factor-κB (p-NF-κB p65 and p50) were examined in the lymphocytes of lymph nodes.RESULTS: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-γ production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-κB p65 and p50.CONCLUSION: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. <p><a href="https://greenmedinfo.com/article/noni-fruit-juice-delays-immunosenescence-lymphocytes-lymph-nodes-old-f344-rats" target="_blank">read more</a></p> https://greenmedinfo.com/article/noni-fruit-juice-delays-immunosenescence-lymphocytes-lymph-nodes-old-f344-rats#comments Aging: Immunosenecence Noni Immunostimulatory Animal Study Sat, 11 Aug 2018 02:33:58 +0000 greenmedinfo 168855 at https://greenmedinfo.com Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells. https://greenmedinfo.com/article/phytochemicals-inhibit-immunosuppressive-functions-myeloid-derived-suppressor- PMID:  Int Immunopharmacol. 2018 Aug ;61:231-240. Epub 2018 Jun 9. PMID: 29894862 Abstract Title:  Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders. Abstract:  Traditional herbal medicine has provided natural remedies against cancers and many age-related inflammatory diseases for thousands of years. Modern drug discovery techniques have revealed several active ingredients and their medicinal targets have been characterized. Concurrently, there has been great progress in understanding the pathological mechanisms underpinning cancers and inflammatory diseases. These studies have demonstrated that immature myeloid-derived suppressor cells (MDSCs) have a crucial role in the immune escape of cancer cells thus promoting tumor growth. Inflammatory factors stimulate the recruitment, expansion, and activation of MDSCs in tumors and inflamed tissues. The immunosuppression generated by MDSCs has an important role in the resolution of acute inflammation but in chronic inflammatory disorders, the activation of MDSCs suppresses the innate and adaptive immune responses thus aggravating the disease processes in association with tumors, chronic infections, and many degenerative diseases. Currently, MDSCs are important drug discovery targets in cancers and chronic inflammatory diseases. Interestingly, there are promising reports that certain phytochemicals can function as potent inhibitors of the immunosuppressive MDSCs that could partially explain the therapeutic benefits of herbal medicine. We will briefly describe the immune suppressive functions of MDSCs in cancers and age-related inflammatory diseases and then review in detail the chemically characterized phytochemicals of different herbal categories, e.g. flavonoids, terpenoids, retinoids, curcumins, andβ-glucans, which possess the MDSC-dependent antitumor and anti-inflammatory properties. <p><a href="https://greenmedinfo.com/article/phytochemicals-inhibit-immunosuppressive-functions-myeloid-derived-suppressor-" target="_blank">read more</a></p> https://greenmedinfo.com/article/phytochemicals-inhibit-immunosuppressive-functions-myeloid-derived-suppressor-#comments Aging: Immunosenecence Alzheimer's Disease Beta-glucan Cancers: All Curcumin Flavonoids Inflammation Anti-Inflammatory Agents Immunomodulatory Review Tue, 14 Apr 2020 23:25:04 +0000 greenmedinfo 218583 at https://greenmedinfo.com