Graying Hair https://greenmedinfo.com/taxonomy/term/5875/all en A low serum copper concentration may play a role in premature graying of hairs. https://greenmedinfo.com/article/low-serum-copper-concentration-may-play-role-premature-graying-hairs PMID:  Biol Trace Elem Res. 2012 Apr ;146(1):30-4. Epub 2011 Oct 7. PMID: 21979243 Abstract Title:  Serum iron, zinc, and copper concentration in premature graying of hair. Abstract:  Premature graying of hair with unclear etiology, which is known as premature canities, is a common cause of referrals to the dermatologists. We assessed the relationship between serum iron, copper, and zinc concentrations with premature canities. This study was conducted on patients under 20 years old suffering from premature canities, having a minimum of ten gray hair fibers, and referring to university hospitals of Isfahan (Iran). The results were compared with age-sex-matched controls. Demographic data and disease characteristics were recorded for two groups. We studied serum iron,copper, and zinc concentrations of 66 patients and 66 controls using atomic absorption and Ferrozine methods. The mean age of studied cases was 17.8 ± 2.0 years, and the mean age of the onset of canities was 15.5 ± 3.2 years with no significant difference between males and females (P &gt; 0.05). Serum copper concentration was significantly lower in patients compared with controls (90.7 ± 37.4 vs. 105.3 ± 50.2 μg/dL, P = 0.048), but serum iron concentration was significantly lower in controls compared to patients (88.8 ± 39.5 vs. 108.3 ± 48.4 μg/dL, P = 0.008). Also, there was no significant difference between patients and controls in serum zinc concentration (114.8 ± 67.8 vs. 108.2 ± 49.9 μg/dL, P = 0.285). According to these results, among copper, zinc, and iron, a low serum copper concentration may play a role in premature graying of hairs in our society. Further studies are needed to find the underlying mechanism of this relationship. <p><a href="https://greenmedinfo.com/article/low-serum-copper-concentration-may-play-role-premature-graying-hairs" target="_blank">read more</a></p> https://greenmedinfo.com/article/low-serum-copper-concentration-may-play-role-premature-graying-hairs#comments Copper Copper Deficiency Graying Hair Hair: Graying Zinc Risk Factors Human Study Fri, 04 Feb 2022 15:34:49 +0000 greenmedinfo 252732 at https://greenmedinfo.com Grey Hair Can Regain Its Color - if You Relieve Stress https://greenmedinfo.com/blog/grey-hair-can-regain-its-color-if-you-relieve-stress <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2022<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Grey_Hair_Can_Regain_Its_Color-If_You_Relieve_Stress-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><em><strong>There's now definitive proof that hair greying is reversible, albeit rare, in humans. What's more, stressful life events play a primary role in triggering your hair to turn grey, while relaxation -- like a two-week vacation -- may help give your roots back their original color</strong></em></span></p> <p>Grey hair is one of the earliest and most obvious signs of <strong><a href="/disease/aging" rel="dofollow" target="_blank">aging</a></strong>. By the time most people reach their 30s, hair begins to go grey, becoming progressively greyer with time. It's generally assumed that once a hair goes grey, there's no going back, but a team from Columbia University in New York and colleagues suggests this may not be the case.</p><p><a href="https://greenmedinfo.com/blog/grey-hair-can-regain-its-color-if-you-relieve-stress" target="_blank">read more</a></p> https://greenmedinfo.com/blog/grey-hair-can-regain-its-color-if-you-relieve-stress#comments Aging Graying Hair Stress and Anxiety Health Guide: Aging anti aging natural health oxidative stress Mon, 01 Aug 2022 22:55:16 +0000 GMI Research Group 261371 at https://greenmedinfo.com L-methionine may help prevent hair graying by preventing met oxidation. https://greenmedinfo.com/article/l-methionine-may-help-prevent-hair-graying-preventing-met-oxidation PMID:  FASEB J. 2009 Jul ;23(7):2065-75. Epub 2009 Feb 23. PMID: 19237503 Abstract Title:  Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. Abstract:  Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT-Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H(2)O(2)) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and Western blot in association with a functional loss of methionine sulfoxide (Met-S=O) repair in the entire gray hair follicle. Accordingly, Met-S=O formation of Met residues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzyme functionality, as evidenced by FT-Raman spectroscopy, computer simulation, and enzyme kinetics, which leads to gradual loss of hair color. Notably, under in vitro conditions, Met oxidation can be prevented by L-methionine. In summary, our data feed the long-voiced, but insufficiently proven, concept of H(2)O(2)-induced oxidative damage in the entire human hair follicle, inclusive of the hair shaft, as a key element in senile hair graying, which does not exclusively affect follicle melanocytes. This new insight could open new strategies for intervention and reversal of the hair graying process. https://greenmedinfo.com/article/l-methionine-may-help-prevent-hair-graying-preventing-met-oxidation#comments Aging Graying Hair Methionine Oxidative Stress Antioxidants Human In Vitro Thu, 14 May 2015 20:12:16 +0000 greenmedinfo 117405 at https://greenmedinfo.com Superoxide dismutase prevents free radical and UV-A light induced hair graying in a mouse model. https://greenmedinfo.com/article/superoxide-dismutase-prevents-free-radical-and-uv-light-induced-hair-graying-m PMID:  Photochem Photobiol. 2004 Nov-Dec;80(3):579-82. PMID: 15623346 Abstract Title:  Protective effect of superoxide dismutase against hair graying in a mouse model. Abstract:  Oxygen free radicals play a role in the aging process, and the protective effect of various antioxidants has been intensively studied, in particular for cutaneous aging. Besides hereditary factors, free radical-mediated damage to melanocytes of the hair follicle has been considered as a mechanism for aging of the hair. It was the aim of this study to evaluate the role of photosensitization reactions for hair graying and to demonstrate potential protective effects of superoxide dismutase (SOD). Mice with black hair were depilated with the fingertips on a surface of 6 x 2.5 cm on both sides of the dorsum. The right side received five applications of a SOD-containing gel before exposure to psoralen (concentration 0.5 mg/mL) plus UV-A (365 nm, 4 J/cm2). The left side was pretreated in the same way with a gel free of SOD. When the hair started growing again, the SOD-protected side was covered with black hair, whereas the hair on the vehicle-treated side was gray or white in 27 of the 30 animals studied. The 0.01% SOD concentration was as protective as the 0.1% concentration. Heat-inactivated SOD, applied in another five animals, was not protective. Using fluorescent labeling of the SOD with fluorescein isothiocyanate, epifluorescence microscopy and digital imaging processing, we show that SOD applied to the skin surface penetrates through the follicular appendages, as well as through the unbroken stratum corneum. Our findings suggest that superoxide radicals, generated by interaction of UV-A light with the sensitizer, initiated the formation of secondary products with well-known DNA-damaging effects, such as lipid peroxidation products and tumor necrosis factor alpha. SOD prevented the damage to melanocyte DNA by dismutating superoxide. Photosensitization may be another mechanism for hair graying, which can be influenced by antioxidants. Given the large number of exogenous and endogenous sensitizers, this mechanism deserves further study for human hair graying. https://greenmedinfo.com/article/superoxide-dismutase-prevents-free-radical-and-uv-light-induced-hair-graying-m#comments Aging Graying Hair Hair: Graying Superoxide dismutase Animal Study Thu, 18 Jun 2009 00:03:14 +0000 greenmedinfo 44801 at https://greenmedinfo.com This study suggests that there is a significant association between tobacco use and aging on graying of hair. https://greenmedinfo.com/article/study-suggests-there-significant-association-between-tobacco-use-and-aging-gra PMID:  Niger J Surg. 2014 Jul ;20(2):83-6. PMID: 25191099 Abstract Title:  Association between use of tobacco and age on graying of hair. Abstract:  AIMS AND OBJECTIVES: To determine the association between smoking, chewing tobacco (gutka), and age of individual on graying of hair.MATERIALS AND METHODS: The present study was conducted on 120 patients attending the Outpatient Department of the DJ College of Dental Sciences and Research, Modinagar, UP. The individuals were classified into four groups (group I, II, III, IV) on the basis of the form of tobacco use (smoking or chewing). The Pearson correlation coefficient was utilized to find the correlation between the mean percentage of individuals with gray hair, risk multiplication factor (RMF), and age of the individual.RESULTS: Mean percentage of individual with gray hair and RMF (r = 0.6487) are found to be positively associated. A significant and positive correlation was observed between the age of the individual and the frequency of individuals with gray hair.CONCLUSION: This study suggests that there is a significant association between tobacco use and aging on graying of hair. <p><a href="https://greenmedinfo.com/article/study-suggests-there-significant-association-between-tobacco-use-and-aging-gra" target="_blank">read more</a></p> https://greenmedinfo.com/article/study-suggests-there-significant-association-between-tobacco-use-and-aging-gra#comments Graying Hair Hair: Graying Smoking Risk Factors Human Study Fri, 04 Feb 2022 15:37:53 +0000 greenmedinfo 252733 at https://greenmedinfo.com Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin. https://greenmedinfo.com/article/topical-bixin-confers-nrf2-dependent-protection-against-photodamage-and-hair-g PMID:  Front Pharmacol. 2018 ;9:287. Epub 2018 Mar 27. PMID: 29636694 Abstract Title:  Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Abstract:  Environmental exposure to solar ultraviolet (UV) radiation causes acute photodamage, premature aging, and skin cancer, attributable to UV-induced genotoxic, oxidative, and inflammatory stress. The transcription factor NRF2 [nuclear factor erythroid 2 (E2)-related factor 2] is the master regulator of the cellular antioxidant response protecting skin against various environmental stressors including UV radiation and electrophilic pollutants. NRF2 in epidermal keratinocytes can be activated using natural chemopreventive compounds such as the apocarotenoid bixin, an FDA-approved food additive and cosmetic ingredient from the seeds of the achiote tree (). Here, we tested the feasibility of topical use of bixin for NRF2-dependent skin photoprotection in two genetically modified mouse models [SKH1 and C57BL/6J (versus)]. First, we observed that a bixin formulation optimized for topical NRF2 activation suppresses acute UV-induced photodamage inbut notSKH1 mice, a photoprotective effect indicated by reduced epidermal hyperproliferation and oxidative DNA damage. Secondly, it was demonstrated that topical bixin suppresses PUVA (psoralen + UVA)-induced hair graying inbut notC57BL/6J mice. Collectively, this research provides the firstevidence that topical application of bixin can protect against UV-induced photodamage and PUVA-induced loss of hair pigmentation through NRF2 activation. Topical NRF2 activation using bixin may represent a novel strategy for human skin photoprotection, potentially complementing conventional sunscreen-based approaches. <p><a href="https://greenmedinfo.com/article/topical-bixin-confers-nrf2-dependent-protection-against-photodamage-and-hair-g" target="_blank">read more</a></p> https://greenmedinfo.com/article/topical-bixin-confers-nrf2-dependent-protection-against-photodamage-and-hair-g#comments Bixin Graying Hair Ultraviolet Radiation Induced Damage Antioxidants Nrf2 activation Photoprotective Animal Study Mon, 10 May 2021 22:07:54 +0000 greenmedinfo 239434 at https://greenmedinfo.com Tribulus stimulates the growth and melanine synthesis in hair follicle melanocytes indicating that it may contribute to slowing the progression of graying hair. https://greenmedinfo.com/article/tribulus-stimulates-growth-and-melanine-synthesis-hair-follicle-melanocytes-in PMID:  Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1777-9. PMID: 17259119 Abstract Title:  [Effect of Tribulus terrestris extract on melanocyte-stimulating hormone expression in mouse hair follicles]. Abstract:  OBJECTIVE: To observe the effect of Tribulus terrestris extract on melanocyte stimulating hormone (MSH) expression in C57BL/6J mouse hair follicles, and investigate the role of Tribulus terrestris extract in activation, proliferation, epidermal migration of dormant hair follicle melanocytes. METHODS: The aqueous extract of Tribulus terrestris was administered orally in specific pathogen-free C57BL/6J mouse at the daily dose equivalent to 1 g/1 kg in adult human, and the expression and distribution of MSH in the mouse hair follicles was observed with immunohistochemistry. RESULTS: The positivity rate of MSH expression in the hair follicle melanocytes was 75% in mice treated with the extract, significantly higher than the rate of only 18.75% in the control group (P&lt;0.01). CONCLUSION: The aqueous extract of Tribulus terrestris can significantly increase MSH expression in the hair follicle melanocytes by activating tyrosinase activity and promoting melanocyte proliferation, melanine synthesis, and epidermal migration of dormant melanocytes. https://greenmedinfo.com/article/tribulus-stimulates-growth-and-melanine-synthesis-hair-follicle-melanocytes-in#comments Graying Hair Hair: Graying Tribulus Animal Study Sat, 19 Sep 2009 14:35:19 +0000 greenmedinfo 47188 at https://greenmedinfo.com