Renal Cancer https://greenmedinfo.com/taxonomy/term/5884/all en Aspatame is associated with the creation of numerous cancers in rats. https://greenmedinfo.com/article/aspatame-associated-creation-numerous-cancers-rats PMID:  Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233 Abstract Title:  Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed. Abstract:  Aspartame (APM) is one of the most widely used artificial sweeteners in the world. Its ever-growing use in more than 6000 products, such as soft drinks, chewing gum, candy, desserts, etc., has been accompanied by rising consumer concerns regarding its safety, in particular its potential long-term carcinogenic effects. In light of the inadequacy of the carcinogenicity bioassays performed in the 1970s and 1980s, a long-term mega-experiment on APM was undertaken at the Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation on groups of male and female Sprague-Dawley rats (100-150/sex/group), 8 weeks old at the start of the experiment. APM was administered in feed at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. Treatment lasted until spontaneous death of the animals. The results of the study demonstrate that APM causes: (a) an increased incidence of malignant tumor-bearing animals, with a positive significant trend in both sexes, and in particular in females treated at 50,000 ppm (P https://greenmedinfo.com/article/aspatame-associated-creation-numerous-cancers-rats#comments Bladder Cancer Leukemia Lymphoma Renal Cancer Schwannoma Aspartame Animal Study Fri, 26 Feb 2010 00:56:22 +0000 greenmedinfo 52543 at https://greenmedinfo.com Ethinyl estradiol has a promoting effect on chemically induced kidney cancer proliferation in hamsters. https://greenmedinfo.com/article/ethinyl-estradiol-has-promoting-effect-chemically-induced-kidney-cancer-prolif PMID:  J Cancer Res Clin Oncol. 1994;120(3):131-6. PMID: 8263008 Abstract Title:  Promoting effects of ethinyl estradiol on development of renal proliferative lesions induced by N-nitrosobis (2-oxopropyl)amine in female Syrian golden hamsters. Abstract:  The modulating effects of female sex hormones, ethinylestradiol and levonorgestrel, on the development of renal proliferative lesions after initiation with N-nitrosobis(2-oxopropyl)amine (BOP) were investigated. Three groups of female Syrian golden hamsters, each comprising 30 animals, were given four weekly s.c. injections of BOP (10 mg/kg body weight) and then fed diet containing 1 ppm ethinylestradiol (group 1: BOP/EE), diet containing 10 ppm levonorgestrel (group 2) or basal diet (group 3) for the next 27 weeks. As hormone controls, two groups of 20 female hamsters each received diet containing 1 ppm ethynylestradiol (group 4) and 10 ppm levonorgestrel (group 5) from week 3 for 27 weeks without the prior initiation treatment. The severity of diffuse anisokarya, characterized by varied nuclear size and the incidence of dysplasias of the proximal tubular epithelia induced by BOP, were significantly increased in the BOP/EE group, indicating the promoting effects of the hormone. In the renal dysplastic lesions (small-cluster, cystic, clear-cell and acidophilic cell types), adenomas and nephroblastomas, increases in the numbers of argyrophilic proteins associated with nucleolar organizer regions (NOR) in the nucleus, suggesting a high proliferative activity, were seen in dysplasia of acidophilic cell types and adenomas. In addition, the number of bizarre NOR per nucleus was significantly higher in adenomas than in dysplasias and highest in nephroblastomas. This morphological change in NOR should therefore be a useful parameter for the diagnosis of malignancy of renal tumors. https://greenmedinfo.com/article/ethinyl-estradiol-has-promoting-effect-chemically-induced-kidney-cancer-prolif#comments Kidney Cancer Renal Cancer Carcinogenic Ethinyl Estradiol Animal Study Wed, 03 Nov 2010 15:43:03 +0000 greenmedinfo 58355 at https://greenmedinfo.com Kidney Cancer https://greenmedinfo.com/disease/kidney-cancer <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="238" alt="" src="//cdn.greenmedinfo.com/sites/default/files/KidneyCancer.jpg?1478893088" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_rob3000&#039;&gt;rob3000 / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> https://greenmedinfo.com/disease/kidney-cancer#comments Renal Cancer Wed, 24 Jun 2009 18:58:13 +0000 greenmedinfo 44843 at https://greenmedinfo.com Melatonin sensitizes kidney cancer cells to kahweol-induced programmed cell death. https://greenmedinfo.com/article/melatonin-sensitizes-kidney-cancer-cells-kahweol-induced-programmed-cell-death PMID:  J Pineal Res. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21244481 Abstract Title:  Melatonin sensitizes Caki renal cancer cells to kahweol-induced apoptosis through CHOP-mediated up-regulation of PUMA. Abstract:    Melatonin has recently gained attention as a regulator of biologic processes in addition to its effects on circadian rhythms. The mechanisms whereby melatonin regulates the apoptotic program remain poorly understood. In this study, we investigated the combined effect of melatonin and kahweol onapoptosis of cancer cells, but not in most normal human cell types, thus presenting an attractive novel strategy for cancer treatment. In our experiments, treatment with a combination of melatonin and kahweol induced apoptosis, stimulated DEVDase activity, and DNA fragmentation. Co-treatment with melatonin and kahweol induced up-regulation of p53-upregulated modulator of apoptosis (PUMA) while down-regulation of PUMA expression using small interfering RNAs attenuated melatonin plus kahweol-induced apoptosis. In addition, co-treatment with kahweol and melatonin induced PUMA up-regulation through endoplasmic reticulum stress-mediated C/EBP homologous protein induction and the p53-independent pathway. Our results collectively demonstrate that up-regulation of PUMA contributes to the sensitizing effect of melatonin plus kahweol on apoptosis in cancer cells. https://greenmedinfo.com/article/melatonin-sensitizes-kidney-cancer-cells-kahweol-induced-programmed-cell-death#comments Kahweol Melatonin Renal Cancer Chemosensitizer Tumor Suppressor Protein p53 Upregulation Natural Substance Synergy In Vitro Study Mon, 21 Mar 2011 15:34:58 +0000 greenmedinfo 62724 at https://greenmedinfo.com Review: there is a consistently strong inverse correlations with solar UVB for 15 types of cancers. https://greenmedinfo.com/article/review-there-consistently-strong-inverse-correlations-solar-uvb-15-types-cance PMID:  Anticancer Res. 2012 Jan ;32(1):223-36. PMID: 22213311 Abstract Title:  Ecological Studies of the UVB-Vitamin D-Cancer Hypothesis. Abstract:  UNLABELLED: Background/Aim: This paper reviews ecological studies of the ultraviolet-B (UVB)-vitamin D-cancer hypothesis based on geographical variation of cancer incidence and/or mortality rates.MATERIALS AND METHODS: The review is based largely on three ecological studies of cancer rates from the United States; one each from Australia, China, France, Japan, and Spain; and eight multicountry, multifactorial studies of cancer incidence rates from more than 100 countries.RESULTS: This review consistently found strong inverse correlations with solar UVB for 15 types of cancer: bladder, breast, cervical, colon, endometrial, esophageal, gastric, lung, ovarian, pancreatic, rectal, renal, and vulvar cancer; and Hodgkin&#039;s and non-Hodgkin&#039;s lymphoma. Weaker evidence exists for nine other types of cancer: brain, gallbladder, laryngeal, oral/pharyngeal, prostate, and thyroid cancer; leukemia; melanoma; and multiple myeloma.CONCLUSION: The evidence for the UVB-vitamin D-cancer hypothesis is very strong in general and for many types of cancer in particular. https://greenmedinfo.com/article/review-there-consistently-strong-inverse-correlations-solar-uvb-15-types-cance#comments Bladder Cancer Breast Cancer Cervical Cancer Colon Cancer Colorectal Cancer Endometrial Cancer Esophageal Cancer Hodgkin Lymphoma Lung Cancer Non-Hodgkin Lymphoma Ovarian Cancer Pancreatic Cancer Renal Cancer Vitamin D Vulvar Cancer Chemopreventive Sunlight exposure Meta Analysis Tue, 10 Jan 2012 02:19:58 +0000 greenmedinfo 70692 at https://greenmedinfo.com