Preterm birth: Uterus Contractions https://greenmedinfo.com/taxonomy/term/5981/all en A semi-synthetic analog of diosmin has been used to stop uterine contractions and preterm delivery. https://greenmedinfo.com/article/semi-synthetic-analog-diosmin-has-been-used-stop-uterine-contractions-and-pret PMID:  Akush Ginekol (Sofiia). 2008;47(5):7-9. PMID: 19227769 Abstract Title:  [Using phlebodia in pregnant women during preterm delivery]. Abstract:  Phlebodia possess complex mechanism of action; except the venotonic one, it blocks the production of mediators of inflammation-prostaglandins and leukotriens; thus stops the uterine contractions and the preterm delivery. We use the tablet at pregnant women for preterm delivery. It was given one tablet a day /600 mg/ along with the tocolytic therapy. https://greenmedinfo.com/article/semi-synthetic-analog-diosmin-has-been-used-stop-uterine-contractions-and-pret#comments Diosmin Preterm birth: Uterus Contractions Tocolytic Agents Human Study Wed, 09 Sep 2009 22:53:54 +0000 greenmedinfo 46976 at https://greenmedinfo.com Chinese skullcap may suppress premature labor. https://greenmedinfo.com/article/chinese-skullcap-may-suppress-premature-labor PMID:  J Biomed Sci. 2009 Mar 4;16:27. PMID: 19272127 Abstract Title:  In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. Abstract:  Scutellariae Radix is one of the well-known tocolytic Chinese herbs. Oroxylin A is isolated from the root of Scutellaria baicalensis. The main syndrome of preterm birth is caused by uterus contractions from excitatory factors. Administration of tocolytic agents is a strategy to prevent the occurrence of preterm births. The aim of this study was to investigate the effects of oroxylin A on contractions of uterine strips isolated from non-pregnant female Wistar rats (250-350 g). Contractions of the uterus were induced with acetylcholine (Ach) (1 microM), PGF2alpha (0.1 microM), oxytocin (10-3 U/ml), KCl (56.3 mM), tetraethylammonium (TEA; 1 and 10 mM), 4-aminopyridine (4-AP; 5 mM), glipizide (30 microM), a nitric oxide synthase (NOS) inhibitor (LNNA; 10-3M), a beta-receptor blocker (propranolol; 10 microM), and a cyclooxygenase inhibitor (indomethacin; 60 microM). The inhibitory effects of the amplitude and frequency of spontaneous contractions by oroxylin A were antagonized with Ach (IC50 22.85 microM), PGF2alpha (IC5027.28 microM), oxytocin (IC50 12.34 microM), TEA; 1 and 10 mM (IC50 52.73 and 76.43 microM), 4-AP (IC50 67.16 microM), and glipizide (IC5027.53 microM), but oroxylin A was not influenced by Ca2+-free medium, LNNA, propranolol, or indomethacin. Otherwise, oroxylin A-mediated relaxation of the rat uterus might occur through opening of uterine calcium-dependent potassium channels or adenosine triphosphate potassium channel activation. This suggests that oroxylin A is the tocolytic principle constituent of Scutellariae Radix, and oroxylin A may provide a lead compound for new tocolytic drug development in the future. https://greenmedinfo.com/article/chinese-skullcap-may-suppress-premature-labor#comments Chinese Skullcap Preterm birth: Uterus Contractions Tocolytic Agents In Vitro Study Wed, 08 Jul 2009 12:34:31 +0000 greenmedinfo 45182 at https://greenmedinfo.com