Klesiella Pneumonia Infection https://greenmedinfo.com/taxonomy/term/6218/all en Antimicrobial activity of polyphenolic compounds from spirulina against food-borne bacterial pathogens. https://greenmedinfo.com/article/antimicrobial-activity-polyphenolic-compounds-spirulina-against-food-borne-bac PMID:  Saudi J Biol Sci. 2021 Jan ;28(1):459-464. Epub 2020 Oct 27. PMID: 33424328 Abstract Title:  Antimicrobial activity of polyphenolic compounds fromagainst food-borne bacterial pathogens. Abstract:  Food-borne drug-resistant bacteria have adverse impacts on both food manufacturers and consumers. Disillusionment with the efficacy of current preservatives and antibiotics for controlling food-borne pathogens, especially drug-resistant bacteria, has led to a search for safer alternatives from natural sources.have been recognized as a food supplement, natural colorant, and enriched source of bioactive secondary metabolites. The main objectives of this study were to isolate polyphenolic compounds fromand analyze their antibacterial potential against drug-resistant food-borne bacterial pathogens. We found that fraction B of methanol extract contained a high quantity of polyphenols exhibiting broad spectrum antimicrobial effects against drug-resistant food-borne bacterial pathogens. Potential secondary metabolites, such as benzophenone, dihydro-methyl-phenylacridine, carbanilic acid, dinitrobenzoate, propanediamine, isoquinoline, piperidin, oxazolidin, and pyrrolidine, were identified by gas chromatography and mass spectrophotometry (GCMS). These metabolites are active against both gram-positive and gram-negative pathogens. Our work suggests that phenolic compounds fromprovide a natural and sustainable source of food preservatives for future use. <p><a href="https://greenmedinfo.com/article/antimicrobial-activity-polyphenolic-compounds-spirulina-against-food-borne-bac" target="_blank">read more</a></p> https://greenmedinfo.com/article/antimicrobial-activity-polyphenolic-compounds-spirulina-against-food-borne-bac#comments Escherichia coli Infections Klesiella Pneumonia Infection Pseudomonas aeruginosa Spirulina Staphylococcus aureus infection Anti-Bacterial Agents In Vitro Study Sat, 30 Jan 2021 02:51:15 +0000 greenmedinfo 233725 at https://greenmedinfo.com Curcumin alone or in combination with clarithromycin showed a much more significant reduction in neutrophil influx along with reduced levels of various inflammatory parameters. https://greenmedinfo.com/article/curcumin-alone-or-combination-clarithromycin-showed-much-more-significant-redu PMID:  J Infect Dev Ctries. 2014 Jul ;8(7):838-44. Epub 2014 Jul 14. PMID: 25022293 Abstract Title:  Phytochemical-induced reduction of pulmonary inflammation during Klebsiella pneumoniae lung infection in mice. Abstract:  INTRODUCTION: Curcumin, a polyphenol derived from the herb Curcuma longa, has number of antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities. Its anti-inflammatory property was here studied alone and in combination with clarithromycin in a mouse model of acute inflammation.METHODOLOGY: A total of 80 mice divided into four groups were used. Mice receiving curcumin and/or clarithromycin were fed orally with curcumin (150 mg/kg/day) for 15 days prior to infection, whereas clarithromycin was administered orally (30 mg/kg/day) 12 hours post infection. Simultaneously, the control group receiving only infection but no treatment was also set up. Bacterial load estimation, histopathological examination and analysis of inflammatory parameters was performed on various days for all groups.RESULTS: Intranasal inoculation of bacteria resulted in significant increase in neutrophil infiltration along with increased production of various inflammatory mediators (malondialdehyde, myeloperoxidase, nitric oxide, TNFα) in lung tissue. Clarithromycin treatment significantly decreased the bacterial load and other inflammatory components in infected mice, but animals receiving curcumin alone or in combination with clarithromycin showed a much more significant (p https://greenmedinfo.com/article/curcumin-alone-or-combination-clarithromycin-showed-much-more-significant-redu#comments Curcumin Klebsiella Infections Klesiella Pneumonia Infection Anti-Inflammatory Agents Immunomodulatory Animal Study Thu, 30 Jul 2015 19:54:11 +0000 greenmedinfo 119467 at https://greenmedinfo.com Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection. https://greenmedinfo.com/article/synergistic-effect-chlorogenic-acid-and-levofloxacin-against-klebsiella-pneumo PMID:  Sci Rep. 2020 11 17 ;10(1):20013. Epub 2020 Nov 17. PMID: 33203903 Abstract Title:  Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo. Abstract:  The study aimed to investigate the antibacterial effect and potential mechanisms of chlorogenic acid (CA) in Klebsiella pneumonia (KPN) induced infection in vitro and in vivo. 62 KPN strains were collected from the First People&#039;s Hospital of Yunnan Province. CA and CA combined Levofloxacin (LFX) were detected for KPN biofilm (BF) formation in vitro. The lung infection mice model were established by KPN. The effect of CA (500 mg/kg), LFX (50 mg/kg) and CA combined LFX (250 mg/kg + 25 mg/kg) were evaluated through the survival of mice, the changes of inflammation factors of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in serum, the histopathological analysis of lung and the protein expression of NLRP3 signaling pathway in vivo. A total of 62 KPNs were isolated and identified, of which 13 (21%) strains were BF positive. 8 (13%) strains were extended spectrum β-lactamase strains (ESBLs), and 20 (32%) strains are ESBLs biofilm positive. In vitro study, CA and LFX showed a synergistic effect on KPN biofilm formation. In vivo mice experiment, CA, especially CA + LFX treated group significantly decreased the serum levels of TNF-α, IL-1β and IL-6, improved the survival ratio and lung pathology changes, and also reduced the protein expression of ASC, caspase 1 p20, IL-1β and phosphor NF-κB p65. CA could effectively alleviate lung infection of KPN infected mice, and the antibacterial effection is strengthened by combined with LFX. The study provide a theroy basis for making rational and scientific antibacterial therapy strategy in clinic. <p><a href="https://greenmedinfo.com/article/synergistic-effect-chlorogenic-acid-and-levofloxacin-against-klebsiella-pneumo" target="_blank">read more</a></p> https://greenmedinfo.com/article/synergistic-effect-chlorogenic-acid-and-levofloxacin-against-klebsiella-pneumo#comments Chlorogenic Acid Klebsiella Infections Klesiella Pneumonia Infection Anti-Bacterial Agents Anti-Inflammatory Agents Interleukin-1 beta downregulation Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Natural Substance/Drug Synergy Animal Study In Vitro Study Fri, 27 Nov 2020 22:35:39 +0000 greenmedinfo 230301 at https://greenmedinfo.com The present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action. https://greenmedinfo.com/article/present-review-investigates-potential-use-these-triterpenes-against-human-path PMID:  Evid Based Complement Alternat Med. 2015 ;2015:620472. Epub 2015 Feb 22. PMID: 25793002 Abstract Title:  Antimicrobial activity of oleanolic and ursolic acids: an update. Abstract:  Triterpenoids are the most representative group of phytochemicals, as they comprise more than 20,000 recognized molecules. These compounds are biosynthesized in plants via squalene cyclization, a C30 hydrocarbon that is considered to be the precursor of all steroids. Due to their low hydrophilicity, triterpenes were considered to be inactive for a long period of time; however, evidence regarding their wide range of pharmacological activities is emerging, and elegant studies have highlighted these activities. Several triterpenic skeletons have been described, including some that have presented with pentacyclic features, such as oleanolic and ursolic acids. These compounds have displayed incontestable biological activity, such as antibacterial, antiviral, and antiprotozoal effects, which were not included in a single review until now. Thus, the present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action, via in vivo studies, and the future perspectives about the use of compounds for human or even animal health are also discussed. https://greenmedinfo.com/article/present-review-investigates-potential-use-these-triterpenes-against-human-path#comments Bacillus Cereus infection Enterococcus Infections Hepatitis B Hepatitis C Herpes Simplex Virus Type 1 Herpes Simplex Virus Type 2 Klesiella Pneumonia Infection Mycobacterium Tuberculosis Oleanolic acid Staphylococcus aureus infection Staphylococcus aureus: Methicillin-resistant (MRSA) Streptococcus Infections Ursolic Acid Anti-Bacterial Agents Antimicrobial Antiviral Agents Review Fri, 07 Aug 2015 16:51:31 +0000 greenmedinfo 119661 at https://greenmedinfo.com Thymus vulgaris extracts can be applied as antimicrobial agents against the pathogenic bacteria particularly in biofilm forms. https://greenmedinfo.com/article/thymus-vulgaris-extracts-can-be-applied-antimicrobial-agents-against-pathogeni PMID:  Avicenna J Phytomed. 2015 Jul-Aug;5(4):309-18. PMID: 26442753 Abstract Title:  The inhibitory effect of Thymus vulgaris extracts on the planktonic form and biofilm structures of six human pathogenic bacteria. Abstract:  OBJECTIVE: Microorganisms are responsible for many problems in industry and medicine because of biofilm formation. Therefore, this study was aimed to examine the effect of Thymus vulgaris (T. vulgaris) extracts on the planktonic form and biofilm structures of six pathogenic bacteria.MATERIALS AND METHODS: Antimicrobial activities of the plant extracts against the planktonic form of the bacteria were determined using the disc diffusion method. MIC and MBC values were evaluated using macrobroth dilution technique. Anti-biofilm effects were assessed by microtiter plate method.RESULTS: According to disc diffusion test (MIC and MBC), the ability of Thymus vulgaris (T. vulgaris ) extracts for inhibition of bacteria in planktonic form was confirmed. In dealing with biofilm structures, the inhibitory effect of the extracts was directly correlated to their concentration. Except for the inhibition of biofilm formation, efficacy of each extract was independent from type of solvent.CONCLUSION: According to the potential of Thymus vulgaris (T. vulgaris) extracts to inhibit the test bacteria in planktonic and biofilm form, it can be suggested that Thymus vulgaris (T. vulgaris) extracts can be applied as antimicrobial agents against the pathogenic bacteria particularly in biofilm forms. https://greenmedinfo.com/article/thymus-vulgaris-extracts-can-be-applied-antimicrobial-agents-against-pathogeni#comments Klesiella Pneumonia Infection Pseudomonas aeruginosa Staphylococcus aureus infection Streptococcus pneumoniae infection Thyme Antimicrobial Plant Extracts In Vitro Study Thu, 11 Feb 2016 03:18:34 +0000 greenmedinfo 123903 at https://greenmedinfo.com