Bladder Degeneration https://greenmedinfo.com/taxonomy/term/6223/all en An aqueous garlic extract alleviates water avoidance stress-induced degeneration of the urinary bladder. https://greenmedinfo.com/article/aqueous-garlic-extract-alleviates-water-avoidance-stress-induced-degeneration- PMID:  BJU Int. 2006 Dec;98(6):1250-4. PMID: 17125482 Abstract Title:  An aqueous garlic extract alleviates water avoidance stress-induced degeneration of the urinary bladder. Abstract:  OBJECTIVE: To investigate the role of aqueous garlic extract (AGE) on the water-avoidance stress (WAS)-induced degeneration of the urinary bladder in a rat model. MATERIALS AND METHODS: Wistar albino rats were exposed to WAS for 2 h/day for 5 days (WAS group), after which, AGE (1 mL/kg) was injected intraperitoneally into the rats (WAS + AGE group). Urinary bladder samples were investigated with both light and scanning electron microscopy, and lipid peroxidation and glutathione levels were also measured in the samples. RESULTS: In the WAS group there was inflammatory cell infiltration, more mast cells and ulcerated areas in the mucosa. In the WAS + AGE group there was relatively normal urothelial alignment, moderate inflammatory cell infiltration and fewer mast cells in the mucosa. The increased lipid peroxidation and decreased glutathione levels in WAS rats were reversed by AGE treatment. CONCLUSIONS: These results show that AGE has a protective effect on WAS-induced degenerative changes in the urinary bladder. https://greenmedinfo.com/article/aqueous-garlic-extract-alleviates-water-avoidance-stress-induced-degeneration-#comments Bladder Degeneration Garlic Animal Study Mon, 20 Apr 2009 06:09:02 +0000 greenmedinfo 41487 at https://greenmedinfo.com Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices. https://greenmedinfo.com/article/flavonoids-hesperidin-have-therapeutic-value-treatment-bleeding-bladder-varice PMID:  Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 14626685 Abstract Title:  [Use of flavonoids (hesperidin) in the treatment of bleeding bladder varices]. Abstract:  OBJECTIVE: To inform of the use of the Flavonoids in the treatment of bladder varicose veins, and their effectiveness. PATIENT: It is informed of 4 cases that went for haematuria, and that in the cystoscopy one observes bladder varicose veins, bleeding in 2 cases, in them you uses Hesperidina 150 mg bid or tid for 30 days. RESULTS: They were good, the 2 cases that bled the haematuria disappeared and in the 4 cases in the control cystoscopy the varicose veins had disappeared. CONCLUSIONS: The treatment antivaricose or antihemorrhoidal can be useful in the treatment of bladder varicose veins. It should be given as minimum by 30 days. https://greenmedinfo.com/article/flavonoids-hesperidin-have-therapeutic-value-treatment-bleeding-bladder-varice#comments Bladder Degeneration Flavonoids Hematuria Hesperidin Vericose Veins: Bladder Human Study Thu, 29 Jul 2010 21:36:29 +0000 greenmedinfo 55803 at https://greenmedinfo.com Sulforaphane protects against chemically-induced damage in bladder cells and tissues. https://greenmedinfo.com/article/sulforaphane-protects-against-chemically-induced-damage-bladder-cells-and-tiss PMID:  Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543 Abstract Title:  Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues. Abstract:  Sulforaphane (SF) is a well known chemopreventive phytochemical and occurs in broccoli and to a lesser extent in other cruciferous vegetables, whereas 4-aminobiphenyl (ABP) is a major human bladder carcinogen and is present at significant levels in tobacco smoke. Here, we show that SF inhibits ABP-induced DNA damage in both human bladder cells in vitro and mouse bladder tissue in vivo, using dG-C8-ABP as a biomarker, which is the predominant ABP-DNA adduct formed in human bladder cells and tissues. SF activates Nrf2, which is a well-recognized chemopreventive target, and activates the Nrf2-regulated cytoprotective signaling pathway. Comparison between wild type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of ABP-induced DNA damage. Moreover, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development. These data, together with our recent observation that SF-enriched broccoli sprout extracts strongly inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer development, suggest that SF is a highly promising agent for bladder cancer prevention and provide a mechanistic insight into the repeated epidemiological observation that consumption of broccoli is inversely associated with bladder cancer risk and mortality. https://greenmedinfo.com/article/sulforaphane-protects-against-chemically-induced-damage-bladder-cells-and-tiss#comments Bladder Cancer Bladder Degeneration DNA damage Sulforaphane Chemopreventive Genoprotective Human Study Sun, 24 Oct 2010 23:29:57 +0000 greenmedinfo 57981 at https://greenmedinfo.com