Depression: Postmenopausal https://greenmedinfo.com/taxonomy/term/6305/all en (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression. https://greenmedinfo.com/article/gallocatechin-gallate-green-tea-rescues-cognitive-impairment-through-restoring PMID:  Sci Rep. 2021 Jan 13 ;11(1):910. Epub 2021 Jan 13. PMID: 33441611 Abstract Title:  (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression. Abstract:  Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause. To overcome PMD-induced cognitive deficit, Green tea has been suggested as a dietary supplement because of its ameliorating effect on cognitive dysfunction induced by normal aging or neurodegenerative syndromes; however, its clinical use to improve PMD-accompanied cognitive deficit is still limited due to the controversy for the active ingredients and ambiguous mechanism of its action. Here, we developed modified high-temperature-processed green tea extract (HTP-GTE), which showed lower neuronal toxicity than the conventional green tea extract (GTE). We also demonstrated that HTP-GTE administration prevented the development of learned helplessness (LH) in a rat post-menopausal model. Additionally, HTP-GTE improved LH-induced cognitive impairments simultaneously with rescued the long-term synaptic plasticity. This occurred via the restoration of silent synapse formation by increasing the hippocampal BDNF-tyrosine receptor kinase B pathway in the helpless ovariectomized (OVX) rats. Likewise, we also identified that (-)-gallocatechin gallate was the main contributor of the HTP-GTE effect. Our findings suggested that HTP-GTE has a potential as a preventive nutritional supplement to ameliorate cognitive dysfunctions associated with PMD. <p><a href="https://greenmedinfo.com/article/gallocatechin-gallate-green-tea-rescues-cognitive-impairment-through-restoring" target="_blank">read more</a></p> https://greenmedinfo.com/article/gallocatechin-gallate-green-tea-rescues-cognitive-impairment-through-restoring#comments Catechin Depression: Postmenopausal Antidepressive Agents Neuroprotective Agents Animal Study Fri, 28 May 2021 21:42:41 +0000 greenmedinfo 240346 at https://greenmedinfo.com An aqueous extract of pomegranate alone or in combination with citalopram produces antidepressant-like effects. https://greenmedinfo.com/article/aqueous-extract-pomegranate-alone-or-combination-citalopram-produces-antidepre PMID:  Int J Mol Sci. 2017 Dec 19 ;18(12). Epub 2017 Dec 19. PMID: 29257042 Abstract Title:  Aqueous Extract of Pomegranate Alone or in Combination with Citalopram Produces Antidepressant-Like Effects in an Animal Model of Menopause: Participation of Estrogen Receptors. Abstract:  It has been reported that the aqueous extract of pomegranate (AE-PG) has polyphenols with estrogenic-like activities. The present work determines if AE-PG alone or in combination with the selective serotonin reuptake inhibitor, citalopram, has antidepressant-like effects. It was also analyzed the participation of estrogen receptors (ER). AE-PG (0.1, 1.0, 10, or 100 mg/kg) was evaluated in ovariectomized female Wistar rats subjected to the forced swimming test. The effects induced by AE-PG were compared with those of citalopram (2.5, 5.0, 10, and 20.0 mg/kg) and 17β-estradiol (E2; 2.5 5.0, and 10 μg/rat). Likewise, the combination of suboptimal doses of AE-PG (0.1 mg/kg) plus citalopram (2.5 mg/kg) was evaluated. To determine if ER participates in the antidepressant-like action of pomegranate, the estrogen antagonist tamoxifen (15 mg/kg) was administered with AE-PG (1 mg/kg). AE-PG produced antidepressant-like actions with a similar behavioral profile induced by citalopram and E2. Suboptimal doses of citalopram plus AE-PG produced antidepressant-like effects. Tamoxifen was able to block AE-PG&#039;s antidepressant-like actions. These results confirm the participation of ER in AE-PG&#039;s antidepressant-like effects. Furthermore, the additive effects observed with the combined treatment of AE-PG plus citalopram could be advantageous in the treatment of depressive disorders, such as menopause. <p><a href="https://greenmedinfo.com/article/aqueous-extract-pomegranate-alone-or-combination-citalopram-produces-antidepre" target="_blank">read more</a></p> https://greenmedinfo.com/article/aqueous-extract-pomegranate-alone-or-combination-citalopram-produces-antidepre#comments Depression: Postmenopausal Pomegranate Antidepressive Agents Animal Study Sat, 06 Jan 2018 00:09:55 +0000 greenmedinfo 158148 at https://greenmedinfo.com Depression: It's Not Your Serotonin https://greenmedinfo.com/blog/depression-its-not-your-serotonin <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Depression: It's Not Your Serotonin" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/serotonin-deficiency.jpg" style="height: 450px; width: 600px;" /></p> <p><span style="font-size:18px;"><em><strong>Millions believe depression is caused by 'serotonin deficiency,' but where is the science in support of this theory?</strong></em></span></p> <blockquote> <p><em><strong>"Depression is a serious medical condition that may be due to a chemical imbalance, and Zoloft works to correct this imbalance."</strong></em></p> </blockquote> <p>Herein lies the serotonin myth.</p><p><a href="https://greenmedinfo.com/blog/depression-its-not-your-serotonin" target="_blank">read more</a></p> https://greenmedinfo.com/blog/depression-its-not-your-serotonin#comments Depression Depression: Bipolar Depression: Endogenous Depression: Neurotic Depression: Postmenopausal Depression: Postpartum Serotonin Disorders Antidepressants Fluoxetine (trade name Prozac) Health Guide: Mental Health Selective Serotonin Reuptake Inhibitors (SSRIs) Depression mental health natural alternatives Sun, 04 Jan 2015 12:55:08 +0000 drbrogan 115884 at https://greenmedinfo.com Drum Circles Put Pharmaceutical Antidepressants TO SHAME https://greenmedinfo.com/blog/group-drumming-better-prozac-study-suggests1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2021<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter" dir="ltr"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/drum(1).jpg" style="width: 604px; height: 453px;" /></p> <p class="rtecenter" dir="ltr">Picture: Spontaneous drum circle in Naples, FL</p> <p dir="ltr" id="docs-internal-guid-bd3db383-9fb3-a364-1272-85563a2a5719"><span style="font-size:22px;"><strong><em>A study published in PLoS scientifically validates what so many drum circle participants have already experienced first hand: group drumming produces significant changes in well-being, including improvements in depression, anxiety and social resilience.</em></strong></span></p><p><a href="https://greenmedinfo.com/blog/group-drumming-better-prozac-study-suggests1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/group-drumming-better-prozac-study-suggests1#comments Anxiety Disorders Depression Depression: Postmenopausal Psychological Well-Being Antidepressive Agents Anxiolytic Drumming Tue, 22 Mar 2016 19:11:36 +0000 Sayer Ji 125088 at https://greenmedinfo.com It appears that fennel is effective in menopausal women with depression and anxiety disorders. https://greenmedinfo.com/article/it-appears-fennel-effective-menopausal-women-depression-and-anxiety-disorders PMID:  J Obstet Gynaecol. 2017 Sep 11:1-6. Epub 2017 Sep 11. PMID: 28891367 Abstract Title:  Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women: a double-blind randomised controlled trial. Abstract:  The aim of this study was to evaluate the effect of Foeniculum vulgare (fennel) on anxiety and depression symptoms in postmenopausal women. This study was a double-blind, randomised, placebo-controlled trial, in which 60 eligible postmenopausal women were selected and then randomly assigned to fennel and placebo groups. Then, symptoms of anxiety and depression were measured using Hospital Anxiety and Depression Scale (HADS) and Zung&#039;s Self Rating Depression Scale (SDS). Following the intervention, the score of HADS (depression and anxiety subgroups) and SDS did not show any significant decrease in the sample under study. However, the analysis of patients with depression or anxiety disorder showed a borderline or significant improvement. Further studies with a larger sample size are required to confirm the findings. Impact statement Current knowledge on the subject: Based on the results of in vivo and in vitro animal studies, fennel may have anti-depressant and anti-anxiety properties. The contribution made by this study: It appears that fennel is effective in menopausal women with depression and anxiety disorders. The implications of findings for clinical practice and future research: Further studies with a larger sample size are required to confirm the actual effect of fennel in clinical setting. <p><a href="https://greenmedinfo.com/article/it-appears-fennel-effective-menopausal-women-depression-and-anxiety-disorders" target="_blank">read more</a></p> https://greenmedinfo.com/article/it-appears-fennel-effective-menopausal-women-depression-and-anxiety-disorders#comments Depression: Postmenopausal Fennel Postmenopausal Disorders: Anxiety Anti-Anxiety Agents Antidepressive Agents Human Study Fri, 17 Nov 2017 02:10:24 +0000 greenmedinfo 155932 at https://greenmedinfo.com Kefir has positive effects on sleep disturbances, depression, and quality of life in postmenopausal women. https://greenmedinfo.com/article/kefir-has-positive-effects-sleep-disturbances-depression-and-quality-life-post PMID:  Holist Nurs Pract. 2019 Jul/Aug;33(4):207-213. PMID: 30768439 Abstract Title:  Effects of Kefir on Quality of Life and Sleep Disturbances in Postmenopausal Women. Abstract:  The aim of this study is to identify the effects of kefir, an alternative treatment method, on quality of life and sleep disturbances in postmenopausal women. In this study, it is seen that kefir has positive effects on sleep disturbances, depression, and quality of life in postmenopausal women. <p><a href="https://greenmedinfo.com/article/kefir-has-positive-effects-sleep-disturbances-depression-and-quality-life-post" target="_blank">read more</a></p> https://greenmedinfo.com/article/kefir-has-positive-effects-sleep-disturbances-depression-and-quality-life-post#comments Depression: Postmenopausal Kefir Postmenopausal Disorders Postmenopausal Disorders: Insomnia Human Study Tue, 27 Aug 2019 00:55:53 +0000 greenmedinfo 195022 at https://greenmedinfo.com Maca has a beneficial effect on psychological symptoms and sexual dysfunction in postmenopausal women. https://greenmedinfo.com/article/maca-has-beneficial-effect-psychological-symptoms-and-sexual-dysfunction-postm PMID:  Menopause. 2008 Nov-Dec;15(6):1157-62. PMID: 18784609 Abstract Title:  Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Abstract:  OBJECTIVE: To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women. DESIGN: Fourteen postmenopausal women completed a randomized, double-blind, placebo-controlled, crossover trial. They received 3.5 g/day of powered Maca for 6 weeks and matching placebo for 6 weeks, in either order, over a total of 12 weeks. At baseline and weeks 6 and 12 blood samples were collected for the measurement of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin, and the women completed the Greene Climacteric Scale to assess the severity of menopausal symptoms. In addition, aqueous and methanolic Maca extracts were tested for androgenic and estrogenic activity using a yeast-based hormone-dependent reporter assay. RESULTS: No differences were seen in serum concentrations of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin between baseline, Maca treatment, and placebo (P &gt; 0.05). The Greene Climacteric Scale revealed a significant reduction in scores in the areas of psychological symptoms, including the subscales for anxiety and depression and sexual dysfunction after Maca consumption compared with both baseline and placebo (P &lt; 0.05). These findings did not correlate with androgenic or alpha-estrogenic activity present in the Maca as no physiologically significant activity was observed in yeast-based assays employing up to 4 mg/mL Maca extract (equivalent to 200 mg/mL Maca). CONCLUSIONS: Preliminary findings show that Lepidium meyenii (Maca) (3.5 g/d) reduces psychological symptoms, including anxiety and depression, and lowers measures of sexual dysfunction in postmenopausal women independent of estrogenic and androgenic activity. https://greenmedinfo.com/article/maca-has-beneficial-effect-psychological-symptoms-and-sexual-dysfunction-postm#comments Depression: Postmenopausal Maca Postmenopausal Disorders Human Study Sat, 25 Jul 2009 17:21:01 +0000 greenmedinfo 46048 at https://greenmedinfo.com Maca improves learning and attenuates depression in ovariectomized mice. https://greenmedinfo.com/article/maca-improves-learning-and-attenuates-depression-ovariectomized-mice PMID:  BMC Complement Altern Med. 2006 Jun 23;6:23. PMID: 16796734 Abstract Title:  Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice. Abstract:  BACKGROUND: Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4000 and 4500 m altitude in the central Peruvian Andes, particularly in Junin plateau and is used traditionally to enhance fertility. Maca is a cultivated plant and different cultivars are described according to the color of the hypocotyls. METHODS: The study aimed to elucidate the effect of Yellow, Red and Black Maca on cognitive function and depression in ovariectomized (OVX) mice. In all experiments OVX mice were treated during 21 days and divided in four groups: control group, Yellow Maca, Red Maca and Black Maca. Latent learning was assessed using the water finding task and the antidepressant activity of the three varieties of Maca was evaluated using the forced swimming test. Animals were sacrificed at the end of each treatment and the uterus were excised and weighed. RESULTS: Black Maca was the variety that showed the best response in the water finding task, particularly in the trained mice. The three varieties were effective to reduce finding latency in non trained and trained mice (P &lt; 0.05). In the force swimming test, all varieties assessed reduced the time of immobility and increased uterine weight in OVX mice. CONCLUSION: Black Maca appeared to have more beneficial effects on latent learning in OVX mice; meanwhile, all varieties of Maca showed antidepressant activity. https://greenmedinfo.com/article/maca-improves-learning-and-attenuates-depression-ovariectomized-mice#comments Depression: Postmenopausal Maca Animal Study Sat, 25 Jul 2009 17:34:24 +0000 greenmedinfo 46056 at https://greenmedinfo.com Pilates-based exercises and acupressure can effectively improve women's sleep quality. https://greenmedinfo.com/article/pilates-based-exercises-and-acupressure-can-effectively-improve-womens-sleep-q n/a PMID:  Iran J Nurs Midwifery Res. 2017 Mar-Apr;22(2):140-146. PMID: 28584553 Abstract Title:  Comparison of the Effect of Acupressure and Pilates-Based Exercises on Sleep Quality of Postmenopausal Women: A Randomized Controlled Trial. Abstract:  BACKGROUND: Postmenopausal women experience a variety of symptoms, among which sleep disorder is one of the most common problems. Acupressure and Pilates exercise programs are effective nonpharmaceutical treatments which can improve sleep quality. In the present study, we aimed to compare the effects of acupressure and Pilates-based exercises on the sleep quality of postmenopausal women referred to medical clinics. MATERIALS AND METHODS: In this single-blinded randomized controlled clinical trial, we recruited 108 women aged 40-60 years who were randomly assigned into one control and two intervention groups using balanced block randomization method (three groups of 36 each). The patients in the Pilates exercise group participated in an exercise training program of three 1-hour sessions per week for 6 consecutive weeks. The participants of acupressure group received acupressure intervention three times a week for 6 weeks. The sleep quality of all participants was assessed and recorded using the Pittsburgh Sleep Quality Index (PSQI) once before and once after the intervention. RESULTS: The results showed no statistically significant difference among the three groups on the total scores of sleep quality after the intervention. The intragroup comparison revealed that the changes in the mean total scores were significant in both the intervention groups (P&lt;0.001) but not in the control group (P = 0.76). CONCLUSIONS: Pilates-based exercises and acupressure can effectively improve women&#039;s sleep quality. Both techniques can be applied as effective alternative and complementary methods for improving sleep quality during the postmenopausal period. https://greenmedinfo.com/article/pilates-based-exercises-and-acupressure-can-effectively-improve-womens-sleep-q#comments Depression: Postmenopausal Acupressure Pilates Acupressure Depression: Postmenopausal Pilates Human Study Fri, 09 Jun 2017 19:05:27 +0000 greenmedinfo 148938 at https://greenmedinfo.com Pomegranate improves depressive symptoms and bone properties in a menopausal syndrome model due to its estrogen content (estradiol, estrone and estriol). https://greenmedinfo.com/article/pomegranate-improves-depressive-symptoms-and-bone-properties-menopausal-syndro PMID:  J Ethnopharmacol. 2004 May;92(1):93-101. PMID: 15099854 Abstract Title:  Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. Abstract:  Pomegranate is known to contain estrogens (estradiol, estrone, and estriol) and show estrogenic activities in mice. In this study, we investigated whether pomegranate extract is effective on experimental menopausal syndrome in ovariectomized mice. Prolongation of the immobility time in forced swimming test, an index of depression, was measured 14 days after ovariectomy. The bone mineral density (BMD) of the tibia was measured by X-ray absorptiometry and the structure and metabolism of bone were also analyzed by bone histomorphometry. Administration of pomegranate extract (juice and seed extract) for 2 weeks to ovariectomized mice prevented the loss of uterus weight and shortened the immobility time compared with 5% glucose-dosed mice (control). In addition, ovariectomy-induced decrease of BMD was normalized by administration of the pomegranate extract. The bone volume and the trabecular number were significantly increased and the trabecular separation was decreased in the pomegranate-dosed group compared with the control group. Some histological bone formation/resorption parameters were significantly increased by ovariectomy but were normalized by administration of the pomegranate extract. These changes suggest that the pomegranate extract inhibits ovariectomy-stimulated bone turnover. It is thus conceivable that pomegranate is clinically effective on a depressive state and bone loss in menopausal syndrome in women. https://greenmedinfo.com/article/pomegranate-improves-depressive-symptoms-and-bone-properties-menopausal-syndro#comments Depression: Postmenopausal Estrogen Deficiency Menopausal Syndrome Osteoporosis Pomegranate Antidepressive Agents Ovariectomy-Induced Changes Plant Extracts Animal Study Wed, 17 Mar 2010 13:04:37 +0000 greenmedinfo 53457 at https://greenmedinfo.com The administration of soybean could enhance the response to SSRI anti depressants in menopausal women. https://greenmedinfo.com/article/administration-soybean-could-enhance-response-ssri-anti-depressants-menopaus-0 PMID:  Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653 Abstract Title:  Effects of antidepressants and soybean association in depressive menopausal women. Abstract:  Depression in menopausal women has been widely described for many years ago and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p https://greenmedinfo.com/article/administration-soybean-could-enhance-response-ssri-anti-depressants-menopaus-0#comments Depression Depression: Postmenopausal Soy Antidepressive Agents Fluoxetine (trade name Prozac) Sertraline Natural Substance/Drug Synergy Human Study Fri, 03 Apr 2015 21:22:20 +0000 greenmedinfo 116614 at https://greenmedinfo.com The administration of soybean could enhance the response to SSRI anti depressants in menopausal women. https://greenmedinfo.com/article/administration-soybean-could-enhance-response-ssri-anti-depressants-menopausal PMID:  Acta Pol Pharm. 2014 Mar-Apr;71(2):323-7. PMID: 25272653 Abstract Title:  Effects of antidepressants and soybean association in depressive menopausal women. Abstract:  Depression in menopausal women has been widely described for many years ago and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p https://greenmedinfo.com/article/administration-soybean-could-enhance-response-ssri-anti-depressants-menopausal#comments Depression Depression: Postmenopausal Soy Antidepressive Agents Fluoxetine (trade name Prozac) Sertraline Natural Substance/Drug Synergy Human Study Fri, 03 Apr 2015 21:21:43 +0000 greenmedinfo 116613 at https://greenmedinfo.com The tradiational Chinese herbal Bu-Wang-San improves cognitive ability in an animal model of menopause-induced impairment of learning and memory. https://greenmedinfo.com/article/tradiational-chinese-herbal-bu-wang-san-improves-cognitive-ability-animal-mode PMID:  J Pharm Pharmacol. 2009 Jan;61(1):95-101. PMID: 19126302 Abstract Title:  Effect of traditional Chinese herbal Bu-Wang-San on synaptic plasticity in ovariectomised rats. Abstract:  OBJECTIVES: The neuroprotective effects of Bu-Wang-San (BWS) and its effects on spine synapse plasticity were investigated in ovariectomised rats.METHODS: Thirty-six ovariectomised rats were divided into three groups: untreated controls, treatment with 17beta-estradiol or with BWS. After 3 months, spatial acquisition and spatial retention were measured using the Morris water maze. Swim time, swim distance, swim speed, quadrant time and platform crossing were recorded. Spine synapse density in the hippocampus was examined by transmission electron microscopy. The expression of synaptophysin P38 (P38) mRNA was examined by real-time PCR and the protein expression of P38 was examined by Western blot.KEY FINDINGS: In spatial acquisition and spatial retention, the BWS group functioned significantly better than the control group. Ultrastructural observation of the hippocampus showed that BWS significantly increased spine synapse density compared with the ovariectomised group. In addition, BWS significantly increased P38 mRNA and protein expression in the hippocampus. Thus, the positive effect of BWS on learning and memory in rats was associated with increased spinal synapse density and increased P38 mRNA and protein expression in the hippocampus following menopause-induced injury.CONCLUSIONS: These results suggest that BWS could improve cognitive ability following menopause-induced impairment of learning and memory. https://greenmedinfo.com/article/tradiational-chinese-herbal-bu-wang-san-improves-cognitive-ability-animal-mode#comments Depression: Postmenopausal Memory Impairment: Hormone Deficiency Induced Traditional Chinese Medicine: Bu-Wang-San Ovariectomy-Induced Changes Animal Study Tue, 24 May 2011 22:16:39 +0000 greenmedinfo 64205 at https://greenmedinfo.com