Premature Puberty https://greenmedinfo.com/taxonomy/term/64371/all en Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats. https://greenmedinfo.com/article/bisphenol-exposure-advances-puberty-onset-changing-kiss1-expression-firstly-ar PMID:  Reprod Toxicol. 2022 Apr 14 ;110:141-149. Epub 2022 Apr 14. PMID: 35429613 Abstract Title:  Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats. Abstract:  Bisphenol A (BPA) is ubiquitous in the environment and its adverse effects on precocious puberty have been reported. But its mechanism is not clear. In the present study, the potential effects of BPA on endocrine functions of hypothalamus, especially in the arcuate (ARC) nucleus and anteroventral periventricular (AVPe) nucleus, were studied from postnatal day 15 (PND15) to PND35 in female Sprague-Dawley (SD) rats. Neonatal rats were exposed to 0.5 mg·kg·dayBPA or corn oil vehicle from PND1 to PND14 via intramuscular injection. From PND20 to PND 25, BPA caused enrichment of H3K4me2 and H3K4me3 at Kiss1 promoter, concurrent with elevated gene expressions of Kiss1 and GnRH1 in ARC and strikingly increased serum E2 levels in BPA group on PND25. Until PND30, BPA induced obviously overexpression of Kiss1 and GnRH1 in AVPe nucleus. Subsequently, the vagina opening and first ovulation had occurred earlier in rats with BPA exposure in respect to vehicle by PND35. In this study, it is suggested that the effects of BPA on precocious puberty may be due to its action to activate Kiss1 gene in ARC during the juvenile period (from PND20 to PND25) firstly, subsequently to evoke the AVPe neurons, resulting in precocious puberty in the end. <p><a href="https://greenmedinfo.com/article/bisphenol-exposure-advances-puberty-onset-changing-kiss1-expression-firstly-ar" target="_blank">read more</a></p> https://greenmedinfo.com/article/bisphenol-exposure-advances-puberty-onset-changing-kiss1-expression-firstly-ar#comments Bisphenol Toxicity Premature Puberty Bisphenol A Animal Study Wed, 18 May 2022 21:01:29 +0000 greenmedinfo 257816 at https://greenmedinfo.com Consumption of caffeinated and artificially sweetened soft drinks was positively associated with risk of early menarche in a US cohort of African American and Caucasian girls. https://greenmedinfo.com/article/consumption-caffeinated-and-artificially-sweetened-soft-drinks-was-positively- PMID:  Am J Clin Nutr. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26178725 Abstract Title:  Consumption of caffeinated and artificially sweetened soft drinks is associated with risk of early menarche. Abstract:  BACKGROUND: Early menarche has been linked to risk of several chronic diseases. Prospective research on whether the intake of soft drinks containing caffeine, a modulator of the female reproductive axis, is associated with risk of early menarche is sparse.OBJECTIVE: We examined the hypothesis that consumption of caffeinated soft drinks in childhood is associated with higher risk of early menarche.DESIGN: The National Heart, Lung, and Blood Institute Growth and Health Study recruited and enrolled 2379 (1213 African American, 1166 Caucasian) girls aged 9-10 y (from Richmond, CA; Cincinnati, OH; and Washington, DC) and followed them for 10 y. After exclusions were made, there were 1988 girls in whom we examined prospective associations between consumption of caffeinated and noncaffeinated sugar- and artificially sweetened soft drinks and early menarche (defined as menarche age https://greenmedinfo.com/article/consumption-caffeinated-and-artificially-sweetened-soft-drinks-was-positively-#comments Menarche: Early Onset Premature Puberty Artificially Sweetened Beverages Caffeine Increased Risk Human Study Fri, 28 Aug 2015 04:47:12 +0000 greenmedinfo 120079 at https://greenmedinfo.com Mycotoxins: The Hidden Hormone Danger In Our Food Supply https://greenmedinfo.com/blog/mycotoxins-hidden-hormone-danger-our-food-supply1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/Mycotoxins_greenmedinfo.jpg" style="width: 600px; height: 400px;" /></p> <p><span style="font-size:24px;"><em><strong>Over 30 years ago, scientists observed mycotoxin contaminated animal feed (grains) interfering with normal sexual development in young female pigs, resulting in estrogenic syndromes and precocious puberty. More recent human research in the U.S. is confirms that the contamination of our food supply with fungal toxins is adversely affecting the sexual development of young girls. </strong></em></span></p><p><a href="https://greenmedinfo.com/blog/mycotoxins-hidden-hormone-danger-our-food-supply1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/mycotoxins-hidden-hormone-danger-our-food-supply1#comments Aflatoxicosis Female Fungal Infection Liver Damage: Aflatoxin-Induced Mold Toxicity Mycotoxicity Premature Puberty Puberty: Precocious Sexual Development: Premature Aflatoxin Glyphosate Mycotoxin Ochratoxin A Wheat Zearalenone (ZEA) Fri, 31 Jul 2020 13:10:16 +0000 Sayer Ji 85691 at https://greenmedinfo.com Phthalates adversely affect reproductive outcomes and children's health. https://greenmedinfo.com/article/phthalates-adversely-affect-reproductive-outcomes-and-childrens-health PMID:  Int J Occup Med Environ Health. 2011 Jun ;24(2):115-41. Epub 2011 May 19. PMID: 21594692 Abstract Title:  Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Abstract:  Phthalates are a family of industrial chemicals that have been used for a variety of purposes. As the potential consequences of human exposure to phthalates have raised concerns in the general population, they have been studied in susceptible subjects such as pregnant women, infants and children. This article aims at evaluating the impact of exposure to phthalates on reproductive outcomes and children health by reviewing most recent published literature. Epidemiological studies focusing on exposure to phthalates and pregnancy outcome, genital development, semen quality, precocious puberty, thyroid function, respiratory symptoms and neurodevelopment in children for the last ten years were identified by a search of the PubMed, Medline, Ebsco, Agricola and Toxnet literature bases. The results from the presented studies suggest that there are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children&#039;s neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder. Results of few studies demonstrate negative associations between phthalate levels commonly experienced by the public and impaired sperm quality (concentration, morphology, motility). Phthalates negatively impact also on gestational age and head circumference; however, the results of the studies were not consistent. In all the reviewed studies, exposure to phthalates adversely affected the level of reproductive hormones (luteinizing hormone, free testosterone, sex hormone-binding globulin), anogenital distance and thyroid function. The urinary levels of phthalates were significantly higher in the pubertal gynecomastia group, in serum in girls with premature thelarche and in girls with precocious puberty. Epidemiological studies, in spite of their limitations, suggest that phthalates may affect reproductive outcome and children health. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented. https://greenmedinfo.com/article/phthalates-adversely-affect-reproductive-outcomes-and-childrens-health#comments Gynecomastia Premature Puberty Premature Thelarche Endocrine Disruptor Phthalates Review Sat, 13 Aug 2011 19:58:24 +0000 greenmedinfo 68094 at https://greenmedinfo.com Pyrethroid insecticide cypermethrin accelerates pubertal onset in male mice. https://greenmedinfo.com/article/pyrethroid-insecticide-cypermethrin-accelerates-pubertal-onset-male-mice PMID:  Environ Sci Technol. 2017 Aug 8. Epub 2017 Aug 8. PMID: 28731686 Abstract Title:  Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axis. Abstract:  Pyrethroids, a class of insecticides that are widely used worldwide, have been identified as endocrine-disrupting chemicals (EDCs). Our recent epidemiological study reported on an association of increased pyrethroids exposure with elevated gonadotropins levels and earlier pubertal development in Chinese boys. In this study, we further investigated the effects of cypermethrin (CP), one of the most ubiquitous pyrethroid insecticides, on hypothalamic-pituitary-gonadal (HPG) axis and pubertal onset in male animal models. Early postnatal exposure to CP at environmentally relevant doses (0.5, 5, and 50μg/kg CP) significantly accelerated the age of puberty onset in male mice. Administration of CP induced a dose-dependent increase in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone in male mice. CP did not affect gonadotropin-releasing hormone (GnRH) gene expression in the hypothalamus, but CP at higher concentrations stimulated GnRH pulse frequency. CP could induce the secretion of LH and FSH, as well as the expression of gonadotropin subunit genes [chorionic gonadotropin α (CGα), LHβ, and FSHβ] in pituitary gonadotropes. CP stimulated testosterone production and the expression of steroidogenesis-related genes [steroidogenic acute regulatory (StAR) and Cytochrome p 450, family 11, subfamily A, polypeptide 1 (CYP11A1)] in testicular Leydig cells. The interference with hypothalamic sodium channels as well as calcium channels in pituitarygonadotropes and testicular Leydig cells was responsible for CP-induced HPG axis maturation. Our findings established in animal models provide further evidence for the biological plausibility of pyrethroid exposure as a potentially environmental contributor to earlier puberty in males. <p><a href="https://greenmedinfo.com/article/pyrethroid-insecticide-cypermethrin-accelerates-pubertal-onset-male-mice" target="_blank">read more</a></p> https://greenmedinfo.com/article/pyrethroid-insecticide-cypermethrin-accelerates-pubertal-onset-male-mice#comments Premature Puberty Pyrethroid insecticide Animal Study Fri, 18 Aug 2017 20:07:55 +0000 greenmedinfo 151883 at https://greenmedinfo.com