Skin Problems: Compromised Barrier Function https://greenmedinfo.com/taxonomy/term/65883/all en Cholesterol-lowering drugs may contribute to skin disorders. https://greenmedinfo.com/article/cholesterol-lowering-drugs-may-contribute-skin-disorders PMID:  Arch Dermatol. 1987 Nov ;123(11):1535-8. PMID: 3674913 Abstract Title:  Ichthyosis induced by cholesterol-lowering drugs. Implications for epidermal cholesterol homeostasis. Abstract:  Ichthyosis and other disorders of cornification may occur as side effects of treatment with several hypocholesterolemic agents. Recent progress in understanding of the functional role of lipids in stratum corneum provides a new pathophysiologic basis for these earlier clinical observations. In stratum corneum, lipids are segregated within intercellular membranes, where they appear to regulate permeability barrier function and desquamation. Cholesterol is an important constituent of these membranes and may be essential to both of these functions. Perturbation of barrier function induces cholesterologenesis locally within the epidermis. Polar sterol metabolites, such as cholesterol sulfate, may also regulate epidermal sterologenesis under normal or pathologic circumstances. Cholesterol homeostasis may also modulate desquamation. For example, hairless mice fed azacosterol hydrochloride (20,25-diazacholesterol) develop a generalized scaling disorder without loss of barrier function. In these mice, total stratum corneum sterol content is markedly decreased, and topical or systemic repletion with cholesterol can correct the scaling abnormalities. https://greenmedinfo.com/article/cholesterol-lowering-drugs-may-contribute-skin-disorders#comments Ichthyosis Skin Problems: Compromised Barrier Function Statin-Induced Pathologies Anticholesteremic Agents Cholesterol Lowering Drugs Statin Drugs Review Mon, 24 Oct 2011 17:15:21 +0000 greenmedinfo 69189 at https://greenmedinfo.com Statin drugs, when applied topically, adversely affect skin barrier function. https://greenmedinfo.com/article/statin-drugs-when-applied-topically-adversely-affect-skin-barrier-function PMID:  J Clin Invest. 1990 Nov ;86(5):1738-45. PMID: 2243142 Abstract Title:  Cholesterol synthesis is required for cutaneous barrier function in mice. Abstract:  Previous studies have shown that topical acetone treatment results in the removal of stratum corneum lipids and disruption of the permeability barrier. This disruption stimulates epidermal lipid synthesis which is associated with the rapid restoration of stratum corneum lipids and barrier function. The aim of this study was to determine the role of cutaneous cholesterol synthesis in the barrier recovery. Here we show that topical lovastatin, a competitive inhibitor of HMG CoA reductase, inhibits cholesterol synthesis. After acetone disruption of the barrier, the normal rapid return of cholesterol to the stratum corneum and recovery of barrier function is impaired in animals treated topically with lovastatin. When lovastatin animals are simultaneously treated topically with either mevalonate, the immediate product of HMG CoA reductase, or cholesterol, the final end product of the pathway, the recovery of the barrier is normalized. Lovastatin resulted in the delayed secretion and abnormal appearance of lamellar bodies. These results provide the first evidence demonstrating that cholesterol synthesis is required for the maintenance of barrier structure and function and suggests a crucial role for cholesterol synthesis in allowing for terrestrial existence. https://greenmedinfo.com/article/statin-drugs-when-applied-topically-adversely-affect-skin-barrier-function#comments Skin Problems: Compromised Barrier Function Lovastatin Statin Drugs Animal Study Mon, 24 Oct 2011 16:16:25 +0000 greenmedinfo 69180 at https://greenmedinfo.com