Epinepherine-induced Disorders https://greenmedinfo.com/taxonomy/term/6630/all en Lactobacillus probiotics have a cardioprotective effect. https://greenmedinfo.com/article/lactobacillus-probiotics-have-cardioprotective-effect PMID:  J Altern Complement Med. 2001 Aug;7(4):345-54. PMID: 11558777 Abstract Title:  Oral administration of Lactobacillus induces cardioprotection. Abstract:  OBJECTIVES: Our goal was to investigate the potential of oral administration of Lactobacillus to induce cardioprotection against ischemia-reperfusion injury in rat hearts, and to determine whether this protection is associated with myocardial catalase activation and heat shock protein 70 expression. DESIGN: Lactobacillus was administered orally to rats on a daily basis, from 1 to 21 days before global ischemia. Global ischemia was produced by full-stop flow in isolated Langendorff-perfused rat hearts for 20 minutes and was followed by reperfusion. Similarly, saline was administered to control animals. RESULTS: Lactobacillus significantly reduced reperfusion tachyarrhythmia and improved functional recovery of the ischemic rat hearts. These cardioprotective effects were associated with reduction of norepinephrine release at the first minute of reperfusion, activation of myocardial catalase, and overexpression of 70 kd heat stress protein at ischemia and reperfusion (p < 0.05). CONCLUSIONS: Oral administration of Lactobacillus produces marked cardioprotection against ischemia-reperfusion injury. This effect is attributed to activation of the cellular defense system, manifested by activation of the antioxidant pathway, and by expression of protective proteins. Norepinephrine is involved in this process. The results of this study suggest that Lactobacillus, which is generally considered safe, could serve as a basis for the development of a new agent for preventive therapy of various ischemic heart syndromes. https://greenmedinfo.com/article/lactobacillus-probiotics-have-cardioprotective-effect#comments Epinepherine-induced Disorders Lactobacillus probiotics Cardioprotective Animal Study Wed, 16 Sep 2009 03:01:43 +0000 greenmedinfo 47137 at https://greenmedinfo.com Preoperative magnesium supplementation improves the blood catecholamine and magnesium levels following coronary artery bypass surgery. https://greenmedinfo.com/article/preoperative-magnesium-supplementation-improves-blood-catecholamine-and-magnes PMID:  Magnes Res. 2006 Jun;19(2):113-22. PMID: 16955723 Abstract Title:  The effect of preoperative magnesium supplementation on blood catecholamine concentrations in patients undergoing CABG. Abstract:  BACKGROUND: It is well known that magnesium (Mg) plays an important role in many physiological processes such as regulation of blood catecholamine concentrations, particularly epinephrine (E) and norepinephrine (NE). The complex character of extracorporeal circulation (ECC) with intraoperative normovolemic haemodilution (NH) may alter blood Mg levels, which is likely to result in disorders of E and NE. The aim of this study was to analyze the influence of preoperative Mg supplementation on E and NE in patients undergoing CABG. PATIENTS AND METHODS: Forty male patients undergoing CABG under general anaesthesia were included. Patients were randomly divided into two groups: A--the patients receiving pre-operative magnesium supplementation and B--patients without pre-operative magnesium supplementation. The Mg, E and NE blood concentrations were measured in five stages: 1) before anesthesia after the radial artery cannulation, 2) during NH and ECC, 3) immediately after surgery, 4) in the morning of the 1st postoperative day, 5) in the morning of the 2nd postoperative day. The Mg levels were determined by spectrophotometric methods, E and NE were measured by radioimmunoassay methods. RESULTS: The CABG caused a decrease of Mg and an increase of E and NE in both groups, but the changes were significantly higher in group B. CONCLUSIONS: 1) CABG causes a decrease of Mg and an increase of E and NE; 2) Preoperative, oral supplementation of Mg substantially reduces intra- and postoperative disorders. https://greenmedinfo.com/article/preoperative-magnesium-supplementation-improves-blood-catecholamine-and-magnes#comments Coronary Bypass Surgery Epinepherine-induced Disorders Magnesium Human Study Wed, 16 Sep 2009 02:29:37 +0000 greenmedinfo 47131 at https://greenmedinfo.com The Omega-3 fatty acids EPA and DHA lower plasma norepinephrine concentrations in normal volunteers. https://greenmedinfo.com/article/omega-3-fatty-acids-epa-and-dha-lower-plasma-norepinephrine-concentrations-nor PMID:  Nutrition. 2005 Jun;21(6):705-10. PMID: 15925295 Abstract Title:  Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial. Abstract:  OBJECTIVE: We previously reported that administration of fish oil rich in docosahexaenoic acid (DHA) increased the plasma ratio of epinephrine to norepinephrine (NE) at rest in young adults who were under chronic stress and that this effect was achieved mainly through depression of NE. However, not many reports have documented the effects of eicosapentaenoic acid (EPA) and DHA on blood catecholamine levels in healthy humans. Therefore, we performed another intervention study to test their effect on catecholamines with healthy subjects under no chronic stress. METHODS: Twenty-one healthy young adults (15 men and 6 women) were randomly assigned to an omega-3 group (n = 9) or a control group (n = 12) in a double-blind manner. Twenty capsules of shellfish-derived lipids containing 762 mg of EPA plus DHA per day were administered to the omega-3 group for 2 mo. The controls took the same amount of placebo capsules. Fasting blood samples after a 30-min rest with a catheter in a forearm vein were obtained at the start and the end of the study for catecholamine measurements. RESULTS: EPA but not DHA concentrations in red blood cells significantly increased in the omega-3 group compared with the control group (P https://greenmedinfo.com/article/omega-3-fatty-acids-epa-and-dha-lower-plasma-norepinephrine-concentrations-nor#comments Catecholamines: Elevated DHA (Docosahexaenoic Acid) EPA (Eicosapentaenoic Acid) Epinepherine-induced Disorders Fish Oil Animal Study Sat, 23 Jan 2010 21:34:45 +0000 greenmedinfo 49943 at https://greenmedinfo.com Wild honey protects against epinephrine-induced cardiac disorders and vasomotor dysfunction. https://greenmedinfo.com/article/wild-honey-protects-against-epinephrine-induced-cardiac-disorders-and-vasomoto PMID:  J Med Food. 2008 Mar;11(1):91-8. PMID: 18361743 Abstract Title:  Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. Abstract:  Induction of hyperadrenergic activity was experimentally achieved in urethane-anesthetized rats using epinephrine (adrenaline). Acute administration of epinephrine (100 microg/kg) for 2 hours induced several cardiac disorders and vasomotor dysfunction. Pretreatment with natural wild honey (5 g/kg) for 1 hour prior to the injection with epinephrine (100 mug/kg) protected the anesthetized normal rats from the incidence of epinephrine-induced cardiac disorders and vasomotor dysfunction. Moreover, posttreatment with natural wild honey (5 g/kg) following the injection with epinephrine (100 microg/kg) for 1 hour showed several ameliorative outcomes to the electrocardiographic parameters and vasomotor dysfunction of anesthetized stressed rats. Furthermore, natural wild honey preserved the positive inotropic effect of epinephrine in both cases. Also, the total antioxidant capacity (AOC) of natural wild honey was found to be very pronounced. Levels of both reduced glutathione and ascorbic acid (vitamin C) were considered relatively high in natural wild honey. Activity of superoxide dismutase (SOD) was also high, whereas catalase activity was relatively low, especially when compared to the value of SOD activity. It would appear from the results of the present study that natural wild honey may exert its cardioprotective and therapeutic effects against epinephrine-induced cardiac disorders and vasomotor dysfunction directly, via its very pronounced total AOC and its great wealth of both enzymatic and nonenzymatic antioxidants involved in cardiovascular defense mechanisms, besides its substantial quantities of mineral elements such as magnesium, sodium, and chlorine, and/or indirectly, via the enhancement of the endothelium-derived relaxing factor nitric oxide release through the influence of ascorbic acid (vitamin C). https://greenmedinfo.com/article/wild-honey-protects-against-epinephrine-induced-cardiac-disorders-and-vasomoto#comments Epinepherine-induced Disorders Honey Animal Study Wed, 16 Sep 2009 02:26:18 +0000 greenmedinfo 47130 at https://greenmedinfo.com