Blood Lactate/ Pyruvate Ratio: Elevated https://greenmedinfo.com/taxonomy/term/66449/all en Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction. https://greenmedinfo.com/article/statin-therapy-can-be-associated-high-blood-lactate-pyruvate-ratio-suggestive- PMID:  Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024 Abstract Title:  Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Abstract:  1. Statins inhibit synthesis of mevalonate, a precursor of ubiquinone that is a central compound of the mitochondrial respiratory chain. The main adverse effect of statins is a toxic myopathy possibly related to mitochondrial dysfunction. 2. This study was designed to evaluate the effect of lipid-lowering drugs on ubiquinone (coenzyme Q10) serum level and on mitochondrial function assessed by blood lactate/pyruvate ratio. 3. Eighty hypercholesterolaemic patients (40 treated by statins, 20 treated by fibrates, and 20 untreated patients, all 80 having total cholesterol levels>6.0 mmol l-1) and 20 healthy controls were included. Ubiquinone serum level and blood lactate/pyruvate ratio used as a test for mitochondrial dysfunction were evaluated in all subjects. 4. Lactate/pyruvate ratios were significantly higher in patients treated by statins than in untreated hypercholesterolaemic patients or in healthy controls (P https://greenmedinfo.com/article/statin-therapy-can-be-associated-high-blood-lactate-pyruvate-ratio-suggestive-#comments Blood Lactate/ Pyruvate Ratio: Elevated Coenzyme Q10 Deficiency Mitochondrial Dysfunction Statin-Induced Pathologies Enzyme Inhibitors Myotoxicity Statin Drugs Human Study Wed, 26 Oct 2011 15:17:15 +0000 greenmedinfo 69369 at https://greenmedinfo.com