Bile Duct Injury https://greenmedinfo.com/taxonomy/term/67164/all en A case of atorvastatin-induced prolonged cholestasis with bile duct damage has been reported. https://greenmedinfo.com/article/case-atorvastatin-induced-prolonged-cholestasis-bile-duct-damage-has-been-repo PMID:  Clin Drug Investig. 2010 ;30(3):205-9. PMID: 20155993 Abstract Title:  Atorvastatin-induced prolonged cholestasis with bile duct damage. Abstract:  We report a case of acute-onset, long-lasting cholestasis induced by atorvastatin. This antihyperlipidaemic drug was taken for 40 days by a 72-year-old male as a treatment for his mixed dyslipidaemia. At that point, the patient presented with asthenia, nausea, painless icterus, acholic stools and hyperchromic urine with biochemical analyses showing a dramatic increase in bilirubin (total bilirubin 22 mg/dL; direct bilirubin 21 mg/dL) and alkaline phosphatase (up to 4-fold over the normal level) with less marked increases in transaminases. Liver histology showed a pattern of cholestasis with evident signs of cholangiolitis and damage of the interlobular bile ducts. Serum transaminase and bilirubin levels returned to normal within 5 months after atorvastatin withdrawal while alkaline phosphatase normalized after only 8 months. Scores on both the Maria and Victorino clinical scale for the diagnosis of drug-induced hepatitis and the Naranjo Adverse Drug Reaction Probability Scale indicated that atorvastatin was the probable cause of prolonged cholestasis in this patient. This is a rare case of cholestasis probably caused by atorvastatin and unusually characterized by bile duct damage. https://greenmedinfo.com/article/case-atorvastatin-induced-prolonged-cholestasis-bile-duct-damage-has-been-repo#comments Alkaline Phosphatase: Elevated Bile Duct Injury Bilirubin: Elevated Cholangiolitis Cholestasis Hepatitis: Cholestatic Statin-Induced Pathologies Anticholesteremic Agents Atorvastatin Human: Case Report Fri, 11 Nov 2011 00:23:40 +0000 greenmedinfo 69741 at https://greenmedinfo.com Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury. https://greenmedinfo.com/article/atorvastatin-has-been-reported-have-caused-severe-acute-hepatitis-symptomatic- PMID:  Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578 Abstract Title:  Severe acute cholestatic hepatitis with prolonged cholestasis and bile-duct injury following atorvastatin therapy: a case report. Abstract:  We report the case of a patient who exhibited severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury following the prescription of atorvastatin. After withdrawal the drug, the patient&#039;s wellbeing slowly improves and biological features normalize in 4 months. Therapy aimed at treating severe liver steatosis and hypercholesterolemia. Atorvastatin is a highly effective 3-hydroxy-3 methylglutamyl- coenzyme A reductase (statin) used to lower low-density lipoprotein. Reported frequent adverse events of the medication include nausea, depression, myalgia, abdominal pain and abnormal liver function tests. Although abnormal liver function tests is not an uncommon side effect of the medication, more serious liver injury is rare. In a recent literature review, about ten cases of serious hepatotoxicity have been documented. In the typical presentation, the duration of exposure prior to hepatic toxicity is variable. Liver injury is generally of the mixed type. A prolonged cholestasis for more than 3 months has been seldom reported. Morphological changes includes canalicular cholestasis, feathery degeneration but no cholangiolitis nor cholangitis under the form of cytological and inflammatory changes at the level of interlobular bile ducts. This case report provides further evidence that among statins, atorvastatin may be implicated in drug-induced liver injury and indicates for the first time that such liver injury may be followed by prolonged cholestasis and interlobular bile duct injury. Atorvastatin has thus to be added to the list of medication potentially responsible for bile duct injury. https://greenmedinfo.com/article/atorvastatin-has-been-reported-have-caused-severe-acute-hepatitis-symptomatic-#comments Bile Duct Injury Chemically-Induced Liver Damage Cholestasis Statin-Induced Pathologies Anticholesteremic Agents Atorvastatin Hepatotoxic Statin Drugs Human: Case Report Fri, 11 Nov 2011 00:19:00 +0000 greenmedinfo 69737 at https://greenmedinfo.com Cleanse and Restore with Herbs https://greenmedinfo.com/blog/cleanse-and-restore-herbs <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><br /> <img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Cleanse%20and%20Restore%20With%20Herbs.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><strong><em>Though they have been used for centuries as medicine, medical science is finally beginning to look at the evidence proving that food and herbs are the most effective, powerful healers</em></strong></span></p> <p>Holistic healing systems share a core concept that is critical to success in almost all natural therapies. Practitioners are very concerned about making sure that the body eliminates all its metabolic wastes, and that new harmful substances do not enter the body and wreak havoc.</p><p><a href="https://greenmedinfo.com/blog/cleanse-and-restore-herbs" target="_blank">read more</a></p> https://greenmedinfo.com/blog/cleanse-and-restore-herbs#comments All-Cause Mortality Bile Duct Injury Blood Diseases Burdock Cancer Patients Daikon radish Dandelion Inflammation Inulin Jaundice Kidney Damage Lignan Liver Damage Liver Disease Radish Anti-Bacterial Agents Antiproliferative Detoxifier Health Guide: Herbs and Traditional Knowledge Health Guides: Healing Foods Stress Chinese Herbs healing food healing herbs kidney damage leukemia Liver Liver Detox natural cancer treatments Natural Healing natural health Mon, 16 May 2016 23:55:21 +0000 kartapurkhkhalsa 127504 at https://greenmedinfo.com Melatonin rescued the apoptotic changes via the intrinsic pathway. https://greenmedinfo.com/article/melatonin-rescued-apoptotic-changes-intrinsic-pathway PMID:  Int J Mol Sci. 2016;17(8). Epub 2016 Aug 20. PMID: 27556445 Abstract Title:  Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. Abstract:  Bile duct ligation (BDL)-treated rats display cholestasis and liver damages. The potential protective activity of melatonin in young BDL rats in terms of apoptosis, mitochondrial function, and endoplasmic reticulum (ER) homeostasis has not yet been evaluated. Three groups of young male Sprague-Dawley rats were used: one group received laparotomy (Sham), a second group received BDL for two weeks (BDL), and a third group received BDL and intraperitoneal melatonin (100 mg/day) for two weeks (BDL + M). BDL group rats showed liver apoptosis, increased pro-inflamamtory mediators, caspases alterations, anti-apoptotic factors changes, and dysfunction of ER homeostasis. Melatonin effectively reversed apoptosis, mainly through intrinsic pathway and reversed ER stress. In addition, in vitro study showed melatonin exerted its effect mainly through the melatonin 2 receptor (MT2) in HepG2 cells. In conclusion, BDL in young rats caused liver apoptosis. Melatonin rescued the apoptotic changes via the intrinsic pathway, and possibly through the MT2 receptor. Melatonin also reversed ER stress induced by BDL. https://greenmedinfo.com/article/melatonin-rescued-apoptotic-changes-intrinsic-pathway#comments Bile Duct Injury Melatonin Anti-Apoptotic Hepatoprotective Animal Study Thu, 25 Aug 2016 15:52:43 +0000 greenmedinfo 134044 at https://greenmedinfo.com