Ataxia https://greenmedinfo.com/taxonomy/term/67440/all en "Whereas the development of anti-transglutaminase 2 IgA is linked with gastrointestinal disease, an anti-transglutaminase 6 IgG and IgA response is prevalent in gluten ataxia." https://greenmedinfo.com/article/whereas-development-anti-transglutaminase-2-iga-linked-gastrointestinal-diseas PMID:  Ann Neurol. 2008 Sep ;64(3):332-43. PMID: 18825674 Abstract Title:  Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Abstract:  OBJECTIVE: Gluten sensitivity typically presents as celiac disease, a chronic, autoimmune-mediated, small-intestinal disorder. Neurological disorders occur with a frequency of up to 10% in these patients. However, neurological dysfunction can also be the sole presenting feature of gluten sensitivity. Development of autoimmunity directed toward different members of the transglutaminase gene family could offer an explanation for the diversity in manifestations of gluten sensitivity. We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction.METHODS: Using recombinant human transglutaminases, we developed enzyme-linked immunosorbent assays and inhibition assays to analyze serum samples of patients with gluten-sensitive gastrointestinal and neurological disorders, and various control groups including unrelated inherited or immune conditions for the presence and specificity of autoantibodies.RESULTS: Whereas the development of anti-transglutaminase 2 IgA is linked with gastrointestinal disease, an anti-transglutaminase 6 IgG and IgA response is prevalent in gluten ataxia, independent of intestinal involvement. Such antibodies are absent in ataxia of defined genetic origin or in healthy individuals. Inhibition studies showed that in those patients with ataxia and enteropathy, separate antibody populations react with the two different transglutaminase isozymes. Furthermore, postmortem analysis of brain tissue showed cerebellar IgA deposits that contained transglutaminase 6.INTERPRETATION: Antibodies against transglutaminase 6 can serve as a marker in addition to human leukocyte antigen type and detection of anti-gliadin and anti-transglutaminase 2 antibodies to identify a subgroup of patients with gluten sensitivity who may be at risk for development of neurological disease. https://greenmedinfo.com/article/whereas-development-anti-transglutaminase-2-iga-linked-gastrointestinal-diseas#comments Ataxia Gluten Ataxia Gliadin Immunoreactive Human Study Fri, 30 Mar 2012 21:12:02 +0000 greenmedinfo 73748 at https://greenmedinfo.com Celiac disease should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia. https://greenmedinfo.com/article/celiac-disease-should-be-ruled-out-differential-diagnosis-neurological-dysfunc PMID:  Arq Neuropsiquiatr. 2004 Dec ;62(4):969-72. Epub 2004 Dec 15. PMID: 15608953 Abstract Title:  Neurological manifestations of celiac disease. Abstract:  Celiac disease (CD/ Nontropicalsprue, gluten-sensitive enteropathy) is a malabsortive condition in which an allergic reaction to the cereal grain-protein gluten (present in wheat, rye and barley) causes small intestine mucosal injury. The onset is in the first four decades of life, with a female to male ratio of 2:1. It may be associated with a wide spectrum of neurological manifestations including cerebellar ataxia, epileptic seizures, dementia, neuropathy, myopathy and multifocal leucoencephalopathy. We report three patients with neurological manifestations related with CD: one with cerebellar ataxia, one with epilepsy and one with cognitive impairment. The diagnosis of CD was confirmed by serologic tests (antiendomysial and antigliadin antibodies) and biopsy of the small intestine. In two patients the neurological symptoms preceded the gastrointestinal abnormalities and in all of them gluten restriction failed to improve the neurological disability. CONCLUSION: CD should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia. A gluten free diet, the mainstay of treatment, failed to improve the neurological disability. https://greenmedinfo.com/article/celiac-disease-should-be-ruled-out-differential-diagnosis-neurological-dysfunc#comments Ataxia Celiac Disease Dementia Epilepsy Gluten Neurotoxic Review Fri, 13 Apr 2012 17:38:20 +0000 greenmedinfo 74209 at https://greenmedinfo.com Neurotoxic shellfish poisoning may result from Red tide contaminated seafood. https://greenmedinfo.com/article/neurotoxic-shellfish-poisoning-may-result-red-tide-contaminated-seafood PMID:  Mar Drugs. 2008 ;6(3):431-55. Epub 2008 Jul 12. PMID: 19005578 Abstract Title:  Neurotoxic shellfish poisoning. Abstract:  Neurotoxic shellfish poisoning (NSP) is caused by consumption of molluscan shellfish contaminated with brevetoxins primarily produced by the dinoflagellate, Karenia brevis. Blooms of K. brevis, called Florida red tide, occur frequently along the Gulf of Mexico. Many shellfish beds in the US (and other nations) are routinely monitored for presence of K. brevis and other brevetoxin-producing organisms. As a result, few NSP cases are reported annually from the US. However, infrequent larger outbreaks do occur. Cases are usually associated with recreationally-harvested shellfish collected during or post red tide blooms. Brevetoxins are neurotoxins which activate voltage-sensitive sodium channels causing sodium influx and nerve membrane depolarization. No fatalities have been reported, but hospitalizations occur. NSP involves a cluster of gastrointestinal and neurological symptoms: nausea and vomiting, paresthesias of the mouth, lips and tongue as well as distal paresthesias, ataxia, slurred speech and dizziness. Neurological symptoms can progress to partial paralysis; respiratory distress has been recorded. Recent research has implicated new species of harmful algal bloom organisms which produce brevetoxins, identified additional marine species which accumulate brevetoxins, and has provided additional information on the toxicity and analysis of brevetoxins. A review of the known epidemiology and recommendations for improved NSP prevention are presented. https://greenmedinfo.com/article/neurotoxic-shellfish-poisoning-may-result-red-tide-contaminated-seafood#comments Ataxia Dizziness Gastrointestinal Complaints Neurologic Disorders Neurotoxic Shellfish Poisoning Red Tide Associated Toxicity Brevetoxin Neurotoxic Red tide Review Thu, 08 Dec 2011 20:24:31 +0000 greenmedinfo 70172 at https://greenmedinfo.com Progressive ataxia with palatal tremor due to gluten sensitivity has been reported. https://greenmedinfo.com/article/progressive-ataxia-palatal-tremor-due-gluten-sensitivity-has-been-reported PMID:  Mov Disord. 2012 Jan ;27(1):62-3. PMID: 22252893 Abstract Title:  Progressive ataxia with palatal tremor due to gluten sensitivity. Abstract:  No abstract available. https://greenmedinfo.com/article/progressive-ataxia-palatal-tremor-due-gluten-sensitivity-has-been-reported#comments Ataxia Tremor Gluten Neurotoxic Human: Case Report Mon, 26 Mar 2012 17:03:02 +0000 greenmedinfo 73656 at https://greenmedinfo.com Statins have been reported to cause ataxia in bipolar disorder. https://greenmedinfo.com/article/statins-have-been-reported-cause-ataxia-bipolar-disorder PMID:  J Clin Psychiatry. 2010 Mar ;71(3):359. PMID: 20331937 Abstract Title:  Statins can produce ataxia in bipolar disorder: two case reports. Abstract:  No abstract is available. https://greenmedinfo.com/article/statins-have-been-reported-cause-ataxia-bipolar-disorder#comments Ataxia Bipolar Disorder Simvastatin Statin Drugs Human: Case Report Sun, 13 Nov 2011 04:02:58 +0000 greenmedinfo 69830 at https://greenmedinfo.com Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome. https://greenmedinfo.com/article/sulforaphane-improves-mitochondrial-metabolism-fibroblasts-patients-fragile-x- PMID:  Neurobiol Dis. 2021 Sep ;157:105427. Epub 2021 Jun 19. PMID: 34153466 Abstract Title:  Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome. Abstract:  CGG expansions between 55 and 200 in the 5&#039;-untranslated region of the fragile-X mental retardation gene (FMR1) increase the risk of developing the late-onset debilitating neuromuscular disease Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). While the science behind this mutation, as a paradigm for RNA-mediated nucleotide triplet repeat expansion diseases, has progressed rapidly, no treatment has proven effective at delaying the onset or decreasing morbidity, especially at later stages of the disease. Here, we demonstrated the beneficial effect of the phytochemical sulforaphane (SFN), exerted through NRF2-dependent and independent manner, on pathways relevant to brain function, bioenergetics, unfolded protein response, proteosome, antioxidant defenses, and iron metabolism in fibroblasts from FXTAS-affected subjects at all disease stages. This study paves the way for future clinical studies with SFN in the treatment of FXTAS, substantiated by the established use of this agent in clinical trials of diseases with NRF2 dysregulation and in which age is the leading risk factor. <p><a href="https://greenmedinfo.com/article/sulforaphane-improves-mitochondrial-metabolism-fibroblasts-patients-fragile-x-" target="_blank">read more</a></p> https://greenmedinfo.com/article/sulforaphane-improves-mitochondrial-metabolism-fibroblasts-patients-fragile-x-#comments Ataxia Fragile X Syndrome Oxidative Stress Sulforaphane Antioxidants Human In Vitro Wed, 31 May 2023 17:38:26 +0000 greenmedinfo 273232 at https://greenmedinfo.com The Overlooked Vitamin That Improves Autoimmune Disease and Autonomic Dysfunction https://greenmedinfo.com/blog/overlooked-vitamin-improves-autoimmune-disease-and-autonomic-dysfunction <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2021<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/TheOverlookedVitaminThatImprovesAutoimmuneDiseaseandAutonomicDysfunction.jpg" style="width: 600px; height: 315px;" /></span></span></p> <p dir="ltr"><span style="font-size:18px;"><em><strong><span style="font-family:verdana,geneva,sans-serif;">Thiamin may be the missing link to treating autoimmune disease and autonomic dysfunction. Although deficiencies in this vitamin have long been considered eradicated, case studies show supplementation with this nutrient improves fatigue in autoimmune patients in a matter of hours to days</span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/overlooked-vitamin-improves-autoimmune-disease-and-autonomic-dysfunction" target="_blank">read more</a></p> https://greenmedinfo.com/blog/overlooked-vitamin-improves-autoimmune-disease-and-autonomic-dysfunction#comments Antioxidant formulas Ataxia Autoimmune Diseases Cancers: All Culinary Herbs and Spices Hashimoto's thyroiditis Headache Herbs: General Hypotension Inflammatory Bowel Diseases Magnesium Tachycardia Vegetables: All Health Guide: Food-Brain Connection Health Guide: Herbs and Traditional Knowledge Health Guides: Healing Foods autoimmune disease chronic disease healing foods Mon, 01 Feb 2021 12:48:43 +0000 AliLeVere 167879 at https://greenmedinfo.com