Cystitis: Hemorrhagic https://greenmedinfo.com/taxonomy/term/67465/all en 8 and 10-Gingerol reduces urothelial damage in ifosfamide-induced hemorrhagic cystitis. https://greenmedinfo.com/article/8-and-10-gingerol-reduces-urothelial-damage-ifosfamide-induced-hemorrhagic-cys PMID:  Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb 27. Epub 2023 Feb 27. PMID: 36843129 Abstract Title:  [8] and [10]-Gingerol reduces urothelial damage in ifosfamide-induced hemorrhagic cystitis via JAK/STAT/FOXO signaling pathway via IL-10. Abstract:  Acrolein is the main toxic metabolite of ifosfamide (IFO) that causes urothelial damage by oxidative stress and inflammation. Here, we investigate the molecular mechanism of action of gingerols, Zingiber officinale bioactive molecules, as an alternative treatment for ifosfamide-induced hemorrhagic cystitis. Female Swiss mice were randomly divided into 5 groups: control; IFO; IFO + Mesna; and IFO + [8]- or [10]-gingerol. Mesna (80 mg/kg, i.p.) was given 5 min before, 4 and 8 h after IFO (400mg/kg, i.p.). Gingerols (25 mg/kg, p.o.) were given 1 h before and 4 and 8 h after IFO. Animals were euthanized 12 h after IFO injection. Bladders were submitted to macroscopic and histological evaluation. Oxidative stress and inflammation were assessed by malondialdehyde (MDA) or myeloperoxidase assays, respectively. mRNA gene expression was performed to evaluate mesna and gingerols mechanisms of action. Mesna was able to protect bladder tissue by activating NF-κB and NrF2 pathways. However, we demonstrated that gingerols acted as an antioxidant and anti-inflammatory agent stimulating the expression of IL-10, which intracellularly activates JAK/STAT/FOXO signaling pathway. <p><a href="https://greenmedinfo.com/article/8-and-10-gingerol-reduces-urothelial-damage-ifosfamide-induced-hemorrhagic-cys" target="_blank">read more</a></p> https://greenmedinfo.com/article/8-and-10-gingerol-reduces-urothelial-damage-ifosfamide-induced-hemorrhagic-cys#comments Cystitis: Hemorrhagic Gingerol Anti-Inflammatory Agents Interleukin-10 upregulation Animal Study Tue, 06 Jun 2023 22:37:08 +0000 greenmedinfo 273962 at https://greenmedinfo.com Alleviation of cyclophosphamide-induced hemorrhagic cystitis by dietary pomegranate. https://greenmedinfo.com/article/alleviation-cyclophosphamide-induced-hemorrhagic-cystitis-dietary-pomegranate PMID:  J Pediatr Hematol Oncol. 2018 May 4. Epub 2018 May 4. PMID: 29734214 Abstract Title:  Alleviation of Cyclophosphamide-induced Hemorrhagic Cystitis by Dietary Pomegranate: A Comparative Experimental Study With Mesna. Abstract:  In this study, we investigated the effects of pomegranate on alleviating cyclophosphamide-induced hemorrhagic cystitis (HC). Initially, 16 Sprague-Dawley rats were allocated into 4 groups: group 1 (control), group 2 (CP) in which HC was induced by cyclophosphamide; group 3 (CP+M), HC-induced rats that received Mesna regimen, and group 4 (CP+P), which compromised rats that had been on a 14-day diet of pomegranate juice before HC induction. Cystometry was performed a few hours before euthanasia; after euthanasia, aortic blood samples and bladder tissue samples were obtained to perform TUNEL assay, and histopathologic and biochemical assessments. Urodynamic findings revealed that mean detrusor pressure in CP+P was significantly lower compared with that in CP and CP+M (P<p><a href="https://greenmedinfo.com/article/alleviation-cyclophosphamide-induced-hemorrhagic-cystitis-dietary-pomegranate" target="_blank">read more</a></p> https://greenmedinfo.com/article/alleviation-cyclophosphamide-induced-hemorrhagic-cystitis-dietary-pomegranate#comments Chemotherapy-Induced Toxicity: Cyclophosphamide Cystitis: Hemorrhagic Pomegranate Chemoprotective Agents Animal Study Wed, 09 May 2018 21:37:03 +0000 greenmedinfo 163968 at https://greenmedinfo.com Atorvastatin-induced hemorrhagic cystitis has been reported. https://greenmedinfo.com/article/atorvastatin-induced-hemorrhagic-cystitis-has-been-reported PMID:  Urology. 2009 Mar ;73(3):681.e5-6. Epub 2008 May 12. PMID: 18468659 Abstract Title:  Atorvastatin-induced hemorrhagic cystitis: a case report. Abstract:  The first case of hemorrhagic cystitis due to atorvastatin for treatment of hyperlipidemia is reported. Hematuria resolved spontaneously with discontinuation of the drug. https://greenmedinfo.com/article/atorvastatin-induced-hemorrhagic-cystitis-has-been-reported#comments Cystitis: Hemorrhagic Statin-Induced Pathologies Atorvastatin Statin Drugs Human: Case Report Sun, 13 Nov 2011 04:46:54 +0000 greenmedinfo 69844 at https://greenmedinfo.com Hyperbaric oxygen therapy completely resolves post-radiation haematuria in 52.1% of cases. https://greenmedinfo.com/article/hyperbaric-oxygen-therapy-completely-resolves-post-radiation-haematuria-521-ca PMID:  Urology. 2016 Apr 25. Epub 2016 Apr 25. PMID: 27125879 Abstract Title:  Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Radiation-Induced Haemorrhagic Cystitis. Abstract:  OBJECTIVE: To evaluate the efficacy of hyperbaric oxygen therapy (HBO) in the treatment of post-radiation haematuria (PRH) and to identify the predictive factors for a successful outcome.MATERIALS AND METHODS: We conducted a retrospective study and included all patients treated with HBO for PRH in a university hospital centre between January 2003 and December 2013. We studied the patients&#039; clinical characteristics, radiotherapy indication, treatments preceding HBO, the grade of haematuria diagnosed based on the CTCAE classification v 4.03 and the efficacy of HBO. The success of HBO was defined as the total or partial resolution of haematuria.RESULTS: We included 71 patients with a median age of 72 (39-87) years. PRHs were severe (grade≥3) in 50 (70.4%) of the cases. Radiotherapy was indicated in the treatment of prostate cancer in 61 (85.9%) patients. The median length of time between haematuria and HBO was 8 (1-154) months. Prior to HBO, 46 (64.8%) patients underwent electrocoagulation of the bladder. HBO sessions were compounded by 9 cases of barotraumatic otitis, 5 cases of transient visual disturbance, and one case of finger paresthesia. On average, 29 (3-50) sessions were carried out. Treatment was effective in 46 (64.8%) patients, 37 (52.1%) of whom were completely cured. A haematuria grade of less than 3 was a predictive factor in successful treatment (p=0.027). Median follow-up was 15 (1-132) months.CONCLUSION: Hyperbaric oxygen therapy completely resolves post-radiation haematuria in 52.1% of cases. Prolonged patient follow-up is required in order to confirm the efficacy of this treatment. https://greenmedinfo.com/article/hyperbaric-oxygen-therapy-completely-resolves-post-radiation-haematuria-521-ca#comments Chemotherapy and Radiation Toxicity Cystitis: Hemorrhagic Hyperbaric Treatment Human Study Fri, 06 May 2016 18:54:57 +0000 greenmedinfo 127031 at https://greenmedinfo.com Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis. https://greenmedinfo.com/article/pramipexole-and-lactoferrin-ameliorate-cyclophosphamide-induced-haemorrhagic-c PMID:  Int Immunopharmacol. 2022 Nov ;112:109282. Epub 2022 Oct 3. PMID: 36194984 Abstract Title:  Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis via targeting Sphk1/S1P/MAPK, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1βsignalling pathways and modulating the Nrf2/HO-1 pathway. Abstract:  BACKGROUND: The use of cyclophosphamide (CP) as a chemotherapeutic agent is limited by its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient treatments for such problems is extensively ongoing.OBJECTIVE: This research aims to assess the uroprotective effect of pramipexole (PPX) and/or lactoferrin (LF) against CP-induced HC, in addition to shedding light on their possible molecular targets.METHODS: Adult male Sprague-Dawley rats were orally administered PPX (3 mg/kg) and/or LF (300 mg/kg) for seven consecutive days, followed by a single intraperitoneal injection of CP (150 mg/kg).RESULTS: Pretreatment of CP-intoxicated rats with either PPX or LF mitigated oxidative urinary bladder damage via upregulation of the Nrf2/HO-1 signalling pathway, resulting in a significant reduction in bladder MDA and 8-OHdG levels with concomitant elevations in SOD activity and GSH content. Simultaneously, both drugs markedly halted inflammation in bladder tissue through inhibition of the TLR4/NF-κB signalling pathway, followed by a significant decrease in inflammatory cytokine levels (TNF-αand IL-6). Interestingly, the PPX/LF protocol downregulated p-p38, p-ERK1/2, Sphk1, and S1P protein expression and inhibited the NLRP3/caspase1/IL-1βaxis. PPX/LF also significantly reduced BAX and caspase-3, in addition to increasing Bcl-2 levels in bladder tissue of CP-treated animals. These biochemical findings were supported by the improvement in the histological alterations induced by CP in the urinary bladder.CONCLUSIONS: The current study verified the protective effect of PPX and LF against CP-induced HC by halting oxidative stress, inflammation, and apoptosis. The molecular mechanism underlying this protective effect may involve targeting the crosstalk among Sphk1/S1P/MAPK/NF-κB, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1βsignalling pathways and modulating the Nrf2/HO-1 signalling pathway. <p><a href="https://greenmedinfo.com/article/pramipexole-and-lactoferrin-ameliorate-cyclophosphamide-induced-haemorrhagic-c" target="_blank">read more</a></p> https://greenmedinfo.com/article/pramipexole-and-lactoferrin-ameliorate-cyclophosphamide-induced-haemorrhagic-c#comments Chemotherapy-Induced Toxicity: Cyclophosphamide Cystitis: Hemorrhagic Inflammation Lactoferrin Anti-Inflammatory Agents Antioxidants Heme oxygenase-1 up-regulation Interleukin-6 Downregulation NF-kappaB Inhibitor Nrf2 activation Superoxide Dismutase Up-regulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Fri, 02 Dec 2022 14:59:50 +0000 greenmedinfo 267295 at https://greenmedinfo.com Refractory radiation-induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. https://greenmedinfo.com/article/refractory-radiation-induced-hemorrhagic-cystitis-can-be-successfully-and-safe PMID:  Int J Urol. 2015 Oct ;22(10):962-6. Epub 2015 Jul 5. PMID: 26146963 Abstract Title:  Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis. Abstract:  OBJECTIVES: To analyze the efficacy of hyperbaric oxygen for the treatment of radiation-induced hemorrhagic cystitis and to identify factors associated with successful treatment.METHODS: Clinical records from 176 patients with refractory radiation-induced hemorrhagic cystitis treated at the Portuguese Navy Center for Underwater and Hyperbaric Medicine, during a 15-year period, were retrospectively analyzed. Evolution of macroscopic hematuria was used to analyze treatment efficacy and correlated with other external variables.RESULTS: From a total of 176 treated patients, 23.9% evidenced other radiation-induced soft tissue lesions. After an average on 37 sessions, 89.8% of patients showed resolution of hematuria, with only 1.7% of adverse events. In our sample, hematuria resolution after treatment with hyperbaric oxygen was statistically associated to the need for transfusion therapy (P = 0.026) and the number of sessions of hyperbaric oxygen (P = 0.042). No relationship was found with the remaining variables.CONCLUSIONS: Refractory radiation-induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. Treatment effectiveness seems to be correlated with the need for transfusion therapy and the number of sessions performed. <p><a href="https://greenmedinfo.com/article/refractory-radiation-induced-hemorrhagic-cystitis-can-be-successfully-and-safe" target="_blank">read more</a></p> https://greenmedinfo.com/article/refractory-radiation-induced-hemorrhagic-cystitis-can-be-successfully-and-safe#comments Chemotherapy and Radiation Toxicity Cystitis: Hemorrhagic Hyperbaric Treatment Radioprotective Human Study Fri, 10 Feb 2017 20:06:55 +0000 greenmedinfo 143348 at https://greenmedinfo.com