Infant Acute Monocytic Leukemia https://greenmedinfo.com/taxonomy/term/69154/all en Antiviral, cytotoxic, and antioxidant activities of three edible agaricomycetes mushrooms: Pleurotus columbinus, Pleurotus sajor-caju, and Agaricus bisporus. https://greenmedinfo.com/article/antiviral-cytotoxic-and-antioxidant-activities-three-edible-agaricomycetes-mus PMID:  J Fungi (Basel). 2021 Aug 8 ;7(8). Epub 2021 Aug 8. PMID: 34436184 Abstract Title:  Antiviral, Cytotoxic, and Antioxidant Activities of Three Edible Agaricomycetes Mushrooms:,, and. Abstract:  In this study, we investigated aqueous extracts of three edible mushrooms:(white button mushroom),(oyster mushroom), and(grey oyster mushroom). The extracts were biochemically characterized for total carbohydrate, phenolic, flavonoid, vitamin, and protein contents besides amino acid analysis. Triple TOF proteome analysis showed 30.1% similarity between proteomes of the twospp. All three extracts showed promising antiviral activities. Whileextract showed potent activity against adenovirus (Ad7, selectivity index (SI) = 4.2),showed strong activity against herpes simplex II (HSV-2; SI = 3.7). The extracts showed low cytotoxicity against normal human peripheral blood mononuclear cells (PBMCs) and moderate cytotoxicity against prostate (PC3, DU-145); colorectal (Colo-205); cecum carcinoma (LS-513); liver carcinoma (HepG2); cervical cancer (HeLa); breast adenocarcinoma (MDA-MB-231 and MCF-7) as well as leukemia (CCRF-CEM); acute monocytic leukemia (THP1); acute promyelocytic leukemia (NB4); and lymphoma (U937) cell lines. Antioxidant activity was evaluated using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging, 2,2&#039;-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid) ABTS radical cation scavenging, and oxygen radical absorbance capacity (ORAC) assays. The three extracts showed potential antioxidant activities with the maximum activity recorded for(ICµg/mL) = 35.13 ± 3.27 for DPPH, 13.97 ± 4.91 for ABTS, and 29.42 ± 3.21 for ORAC assays. <p><a href="https://greenmedinfo.com/article/antiviral-cytotoxic-and-antioxidant-activities-three-edible-agaricomycetes-mus" target="_blank">read more</a></p> https://greenmedinfo.com/article/antiviral-cytotoxic-and-antioxidant-activities-three-edible-agaricomycetes-mus#comments Breast Cancer Cervical Cancer Colorectal Cancer Herpes Simplex Virus Type 2 Infant Acute Monocytic Leukemia Lymphoma Medicinal Mushrooms Promyelocytic leukemia Prostate Cancer White Button Mushroom Antioxidants Antiviral Agents Cytotoxic In Vitro Study Sun, 21 Nov 2021 01:36:37 +0000 greenmedinfo 249128 at https://greenmedinfo.com Curcumin slows proliferation in the infant acute monocytic leukemia cell line. https://greenmedinfo.com/article/curcumin-slows-proliferation-infant-acute-monocytic-leukemia-cell-line PMID:  Cell Physiol Biochem. 2011 ;28(6):1169-80. Epub 2011 Dec 16. PMID: 22179005 Abstract Title:  Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1. Abstract:  Acute Myeloid Leukemia (AML) accounts for approximately one fifth of all childhood leukemia yet is responsible for a significant proportion of morbidity and mortality in this population. For this reason, research to identify novel targets for the development of effective AML therapeutics has intensified in the recent past. The THP-1 cell line, which was originally established from an infant diagnosed with AML, provides an experimental model for functional, pre-clinical therapeutics and target identification studies of AML. Here we show the expression of the voltage gated potassium channel Kv11.1 in THP-1 cells as opposed to normal hematopoietic stem cells. In addition, curcumin, a natural polyphenol derived from the plant Curcuma longa, effectively blocked Kv11.1 activity and also inhibited the proliferation of these cells. Curcumin was rapidly internalized by THP-1 cells and possibly exerts potential growth inhibitory activity by interacting with intracellular epitopes of the ion channel. Inhibition of ionic currents carried by Kv11.1 resulted in depolarization of cell membrane potential. We propose that the inhibition of Kv11.1 activity by curcumin may lead to interference with leukemic cell physiology and consequently the suppression of survival and proliferation of AML cells. https://greenmedinfo.com/article/curcumin-slows-proliferation-infant-acute-monocytic-leukemia-cell-line#comments Curcumin Infant Acute Monocytic Leukemia Antiproliferative In Vitro Study Wed, 01 Feb 2012 20:09:25 +0000 greenmedinfo 71022 at https://greenmedinfo.com Lion's mane induces programmed cell death in monocytic leukemia cells. https://greenmedinfo.com/article/lions-mane-induces-programmed-cell-death-monocytic-leukemia-cells PMID:  Food Funct. 2011 Jun ;2(6):348-56. Epub 2011 Jun 8. PMID: 21779573 Abstract Title:  Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Abstract:  Phytochemicals in some foods are a potential source of bioactive safe compounds for cancer chemoprevention and suppression of tumor initiation, promotion, and metastasis. In the present study, we evaluated hot water (HWE), microwaved 50% ethanol (MWE), acidic (ACE), and alkaline (AKE) extracts of the fruitbody (sporocarp) of Hericium erinaceus (Yamabushitake, Lion&#039;s Mane) mushrooms for their ability to induce apoptosis (programmed cell death) in U937 human monocytic leukemia cells. Cell culture, cell viability, cytotoxicity, flow cytometry, chromosomal DNA integrity, mitochondrial membrane potential, expression of pro- and anti-apoptotic proteins, and activation and inhibition of caspase assays were carried out to help define the mechanism of observed apoptosis. The aqueous and aqueous/ethanolic extracts were active in all assays, whereas the acidic and alkaline extracts with the similar proximate compositions were both inactive. The results of the bioassays with the active extracts are consistent with an apoptosis mechanism governing suppression of the cell proliferation pathway that involves activation of mitochondria-mediated caspase-3 and caspase-9 but not caspase-8. Proximate analysis of the freeze-dried mushroom powder showed that it contains high amounts of proteins, carbohydrates, and minerals. The results indicate that H. erinaceus mushrooms may have therapeutic potential against human leukemia. https://greenmedinfo.com/article/lions-mane-induces-programmed-cell-death-monocytic-leukemia-cells#comments Infant Acute Monocytic Leukemia Leukemia: Monocytic Lion's Mane (Hericium Erinaceus) Antiproliferative Apoptotic Caspase-3 Activation Caspase-9 Activation In Vitro Study Thu, 23 Feb 2012 17:26:09 +0000 greenmedinfo 72984 at https://greenmedinfo.com