Angelman Syndrome https://greenmedinfo.com/taxonomy/term/696/all en Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. https://greenmedinfo.com/article/cannabidiol-attenuates-seizures-and-eeg-abnormalities-angelman-syndrome-model- PMID:  J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31503547 Abstract Title:  Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. Abstract:  Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in AS individuals are common, debilitating, and often drug-resistant. Therefore, there is an unmet need for better treatment options. Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, has antiseizure activity and behavioral benefits in preclinical and clinical studies for some disorders associated with epilepsy, suggesting that the same could be true for AS. Here we show that acute CBD (100 mg/kg) attenuated hyperthermia- and acoustically-induced seizures in a mouse model of AS. However, neither acute CBD nor a two-weeklong course of CBD administered immediately after a kindling protocol could halt the pro-epileptogenic plasticity observed in AS model mice. CBD had a dose-dependent sedative effect, but did not have an impact on motor performance. CBD abrogated the enhanced intracortical local field potential power, including delta and theta rhythms observed in AS model mice, indicating that CBD administration could also help normalize the EEG deficits observed in individuals with AS. Our results provide critical preclinical evidence supporting CBD treatment of seizures and alleviation of EEG abnormalities in AS, and will thus help guide the rational development of CBD as an AS treatment. <p><a href="https://greenmedinfo.com/article/cannabidiol-attenuates-seizures-and-eeg-abnormalities-angelman-syndrome-model-" target="_blank">read more</a></p> https://greenmedinfo.com/article/cannabidiol-attenuates-seizures-and-eeg-abnormalities-angelman-syndrome-model-#comments Angelman Syndrome Cannabidiol Epilepsy Anticonvulsants Animal Study Sat, 14 Sep 2019 20:03:21 +0000 greenmedinfo 196455 at https://greenmedinfo.com Happy Puppet Syndrome https://greenmedinfo.com/disease/happy-puppet-syndrome <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="384" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Brain_86.jpg?1476568926" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_alila&#039;&gt;alila / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Angelman Syndrome Tue, 14 Apr 2009 07:18:52 +0000 greenmedinfo 20239 at https://greenmedinfo.com Puppet Children https://greenmedinfo.com/disease/puppet-children <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/NervousSystem_198.jpg?1485889456" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_pixologic&#039;&gt;pixologic / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Angelman Syndrome Tue, 14 Apr 2009 07:25:16 +0000 greenmedinfo 21761 at https://greenmedinfo.com