Mania: Acute https://greenmedinfo.com/taxonomy/term/70364/all en 60 Years of Research Links Gluten Grains to Schizophrenia https://greenmedinfo.com/blog/60-years-research-links-gluten-grains-schizophrenia <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2018<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="60 Years of Research Links Gluten Grains to Schizophrenia" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/greenmedinfo/images/Gluten_Grains_Linked_to_Schizophrenia.png" style="width: 650px; height: 490px;" /></p> <p><span style="font-size:24px;"><em><strong>Does the consumption of gluten-containing grains contribute to psychiatric disorders such as schizophrenia?</strong></em></span></p> <p>Believe it or not, this question has been asked for well over 60 years by researchers who stumbled upon evidence that the removal of gluten from the diet results in improved symptoms, or conversely, that gluten grain consumption leads to higher prevalence of both neurological and psychiatric problems.</p><p><a href="https://greenmedinfo.com/blog/60-years-research-links-gluten-grains-schizophrenia" target="_blank">read more</a></p> https://greenmedinfo.com/blog/60-years-research-links-gluten-grains-schizophrenia#comments Gluten Ataxia Gluten Enteropathy Gluten Sensitivity Mania: Acute Neuropathies Schizophrenia Dark Side of Wheat Gluten Wheat Wheat Germ Agglutinin (WGA) Mon, 27 Aug 2018 20:49:10 +0000 Sayer Ji 89686 at https://greenmedinfo.com Antibiotic treatment can be associated with hypo-mania. https://greenmedinfo.com/article/antibiotic-treatment-can-be-associated-hypo-mania PMID:  J Affect Disord. 2017 Sep ;219:149-156. Epub 2017 May 20. PMID: 28550767 Abstract Title:  Antibiotics and mania: A systematic review. Abstract:  OBJECTIVES: Mania can occur secondary to a medical condition and can be elicited by various pharmacological treatments, both in patients with or without a history of affective disorder. Antibiotic-induced mania or antibiomania is suggested to be a rare phenomenon. We reviewed the literature in order to collect published reports of antibiomania and to summarize new insights about its mechanism and management.METHODS: We performed a MEDLINE-search and used manual cross-referencing for reports of antibiotic-induced mania and included cases in which a (hypo)manic episode was diagnosed in close temporal relationship with the prescription of an antibiotic.RESULTS: 47 cases were published. Patients&#039; ages ranged from 3 to 77 years (mean 40). Two-thirds of the cases were male. Twelve different anti-bacterial agents were implicated, with antitubercular agents, macrolides and quinolones being the most common causative groups.CONCLUSIONS: Antibiotic treatment can be associated with (hypo)mania. The paucity of reported cases precludes statements regarding incidence or antibiotic-specific warnings. In the event of an antibiotic-induced mania, the suspicious drug should be discontinued and manic symptoms can be treated lege artis. The pathophysiological mechanism of antibiomania remains elusive. <p><a href="https://greenmedinfo.com/article/antibiotic-treatment-can-be-associated-hypo-mania" target="_blank">read more</a></p> https://greenmedinfo.com/article/antibiotic-treatment-can-be-associated-hypo-mania#comments Antibiotic Toxicity Mania: Acute Antibiotics Review Tue, 20 Jun 2017 21:56:58 +0000 greenmedinfo 149362 at https://greenmedinfo.com Can Wheat Drive More Than Your Digestive System Crazy? https://greenmedinfo.com/blog/can-wheat-drive-more-your-digestive-system-crazy <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Can Wheat Drive More Than Your Digestive System Crazy" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/greenmedinfo/images/6825830_s.jpg" style="width: 400px; height: 291px;" /></p> <p><span style="font-size:18px;"><em><strong>Wheat could be driving more than your digestive system crazy</strong></em></span></p> <p>While wheat is well known to wreak havoc on the gastrointestinal health of genetically susceptible folks, such as those with celiac disease, and more recently, <strong><a href="/article/diarrhea-predominant-irritable-bowel-syndrome-associated-celiac-disease-associated-serum-igg" rel="dofollow" target="_blank">irritable bowel syndrome</a></strong>, new research published in the journal <em>Psychiatry Research</em> indicates that sensitivity to one of the components in wheat known as <strong><a href="/toxic-ingredient/gliadin" rel="dofollow" target="_blank">gliadin</a></strong> could be driving some into states of acute mania:</p><p><a href="https://greenmedinfo.com/blog/can-wheat-drive-more-your-digestive-system-crazy" target="_blank">read more</a></p> https://greenmedinfo.com/blog/can-wheat-drive-more-your-digestive-system-crazy#comments Celiac Disease Depression: Bipolar Gluten Sensitivity Mania: Acute Dark Side of Wheat Gliadin Gluten Gluten exorphins Health Guide: Food-Brain Connection Health Guide: Mental Health Wheat Tue, 13 Mar 2012 16:28:46 +0000 Sayer Ji 73383 at https://greenmedinfo.com Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania. https://greenmedinfo.com/article/efficacy-and-safety-palmitoylethanolamide-adjunctive-treatment-acute-mania PMID:  Psychiatry Clin Neurosci. 2022 Oct ;76(10):505-511. Epub 2022 Jul 19. PMID: 35737597 Abstract Title:  Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: A randomized, double-blind, placebo-controlled trial. Abstract:  AIM: Palmitoylethanolamide is an endogenous fatty acid amide with neuroprotective and anti-inflammatory actions. We performed a randomized, double-blind, placebo-controlled clinical trial to investigate the efficacy and safety of palmitoylethanolamide combination therapy in acute mania.METHODS: Patients in the acute phase of mania were assigned into two parallel groups given either lithium (blood level of 0.8-1.1 mEq/L) and risperidone 3 mg plus palmitoylethanolamide 600 mg or placebo twice per day for 6 weeks. All participants were assessed with the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), and Extrapyramidal Symptom Rating Scale (ESRS) at baseline and at weeks 1, 2, 4, and 6.RESULTS: A total of 63 patients (32 in palmitoylethanolamide and 31 in placebo groups) completed the trial. We found a significant effect for time×treatment interaction on the YMRS score (F = 5.22, d.f. = 2.34, P= 0.004) from baseline to study end point. Results from independent t test showed a significantly greater decrease in YMRS scores in the palmitoylethanolamide group, compared with the placebo group, from baseline to weeks 4 and 6 (P= 0.018 and P= 0.002, respectively). There was no significant difference between palmitoylethanolamide and placebo groups based on ESRS scores or ESRS changes in scores (P&gt;0.05).CONCLUSIONS: Our findings provide preliminary evidence that palmitoylethanolamide is an effective adjunctive medication that improves manic symptoms and overall clinical status in acute episodes of mania. However, larger sample sizes and more extended follow-up therapy are needed in future studies to confirm our findings. <p><a href="https://greenmedinfo.com/article/efficacy-and-safety-palmitoylethanolamide-adjunctive-treatment-acute-mania" target="_blank">read more</a></p> https://greenmedinfo.com/article/efficacy-and-safety-palmitoylethanolamide-adjunctive-treatment-acute-mania#comments Mania: Acute Palmitoylethanolamide Anti-Inflammatory Agents Human Study Mon, 29 May 2023 16:46:07 +0000 greenmedinfo 272973 at https://greenmedinfo.com Here's Why You Should NEVER Eat Wheat https://greenmedinfo.com/blog/heres-why-you-should-never-eat-wheat <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2016<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><div title="Page 1"> <p class="rtecenter"><a href="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/files/wheat(1).jpg"><img alt="Never Eat Wheat: Here's Why! " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/wheat.jpg" style="width: 535px; height: 267px;" /></a></p> <p>[Note: The following information is not intended to take the place of medical advice and/or treatment from your personal physicians.</p> <h1 class="rtecenter"> <strong>Digestion Sessions Interview with Sean Croxton</strong></h1> <p><strong>Sean Croxton</strong>: Sayer Ji, welcome to the Sessions!</p> <p><strong>Sayer Ji</strong>: Thank you! It's a great honor to be here.</p><p><a href="https://greenmedinfo.com/blog/heres-why-you-should-never-eat-wheat" target="_blank">read more</a></p> https://greenmedinfo.com/blog/heres-why-you-should-never-eat-wheat#comments Attention Deficit Disorder with Hyperactivity Carnitine Celiac Disease Flaxseed Gluten Ataxia Gluten Sensitivity Mania: Acute Schizophrenia Dark Side of Wheat Gliadin Gluten Wheat Wheat Germ Agglutinin (WGA) Wed, 29 Oct 2014 00:37:32 +0000 Sayer Ji 115146 at https://greenmedinfo.com Impending Doom: Could Omega-3s be Virtually Wiped Out by 2100? https://greenmedinfo.com/blog/impending-doom-could-omega-3s-be-virtually-wiped-out-2100 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Impending_Doom_Could_Omega-3s_be_Virtually_Wiped_Out_by_2100-GreenMedInfo.jpg" /></p> <p><em><span style="font-size:18px;"><strong>The year 2100 might still be a few decades from now, but along with it comes the likely disappearance of a naturally occurring essential omega-3 fatty acid if climate change continues unabated</strong></span></em></p><p><a href="https://greenmedinfo.com/blog/impending-doom-could-omega-3s-be-virtually-wiped-out-2100" target="_blank">read more</a></p> https://greenmedinfo.com/blog/impending-doom-could-omega-3s-be-virtually-wiped-out-2100#comments Arthritis: Rheumatoid Depression DHA (Docosahexaenoic Acid) Fish Inflammation Mania: Acute Omega-3 Fatty Acids Health Guide: Food-Brain Connection Health Guides: Healing Foods healing food natural health omega-3 fatty acids Tue, 08 Oct 2019 18:31:46 +0000 GMI reporter 198417 at https://greenmedinfo.com Individuals with mania have significantly increased levels of IgG antibodies to gliadin. https://greenmedinfo.com/article/individuals-mania-have-significantly-increased-levels-igg-antibodies-gliadin PMID:  Psychiatry Res. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22386570 Abstract Title:  Markers of gluten sensitivity in acute mania: A longitudinal study. Abstract:  Increased levels of antibodies to gliadin, which is derived from the wheat protein, gluten, have been reported in schizophrenia and bipolar disorder in cross-sectional studies. We examined longitudinally the levels of antibody reactivity to gliadin in acute mania. The sample included 60 individuals assessed during a hospital stay for acute mania, 39 at a six month follow-up, and a sample of 143 non-psychiatric controls. Antibodies to gliadin were measured by enzyme immunoassay. The relationship of the antibodies to the clinical course of mania was analyzed by the use of regression models. Individuals with mania had significantly increased levels of IgG antibodies to gliadin, but not other markers of celiac disease, at baseline compared with controls in multivariate analyses. However, these levels were not significantly different from those of controls at the six month follow-up. Among the individuals with mania, elevated levels at follow-up were significantly associated with re-hospitalization in the six month follow-up period. The monitoring and control of gluten sensitivity may have significant effects on the management of individuals hospitalized with acute mania. https://greenmedinfo.com/article/individuals-mania-have-significantly-increased-levels-igg-antibodies-gliadin#comments Gluten Sensitivity Mania: Acute Gluten Anti-Gliadin Antibodies Human Study Tue, 13 Mar 2012 03:29:49 +0000 greenmedinfo 73379 at https://greenmedinfo.com Low EPA + DHA levels coincide with the initial onset of mania, and increasing risk for developing bipolar disorder https://greenmedinfo.com/article/low-epa-dha-levels-coincide-initial-onset-mania-and-increasing-risk-developing PMID:  Early Interv Psychiatry. 2015 Oct 20. Epub 2015 Oct 20. PMID: 26486098 Abstract Title:  Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Abstract:  AIM: Mood disorders are associated with low levels of the long-chain omega-3 (LCn-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This study investigated LCn-3 fatty acid biostatus in youth with or at varying risk for developing mania to assess its utility as a prodromal risk biomarker.METHOD: Erythrocyte fatty acid composition was determined in healthy adolescents (n = 28, HC), asymptomatic adolescents with a biological parent with bipolar I disorder (n = 30; &#039;high risk&#039;, HR), adolescents with a biological parent with bipolar I disorder and major depressive disorder, or depressive disorder not otherwise specified (n = 36; &#039;ultra-high risk&#039;, UHR), and first-episode adolescent bipolar manic patients (n = 35, BP).RESULTS: Group differences were observed for DHA (P ≤ 0.0001) and EPA (P = 0.03). Compared with HC, erythrocyte EPA + DHA (&#039;omega-3 index&#039;) was significantly lower in BP (-24%, P ≤ 0.0001) and UHR (-19%, P = 0.0006) groups, and there was a trend in the HR group (-11%, P = 0.06). Compared with HC (61%), a greater percentage of HR (77%, P = 0.02), UHR (80%, P = 0.005) and BP (97%, P = 0.001) subjects exhibited EPA + DHA levels of ≤4.0%. Among all subjects (n = 130), EPA + DHA was inversely correlated with manic (r = -0.29, P = 0.0008) and depressive (r = -0.28, P = 0.003) symptom severity. The AA/EPA + DHA ratio was significantly greater in BP (+22%, P = 0.0002) and UHR (+16%, P = 0.001) groups.CONCLUSIONS: Low EPA + DHA levels coincide with the initial onset of mania, and increasing risk for developing bipolar disorder is associated with graded erythrocyte EPA + DHA deficits. Low erythrocyte EPA + DHA biostatus may represent a promising prodromal risk biomarker warranting additional evaluation infuture prospective studies. https://greenmedinfo.com/article/low-epa-dha-levels-coincide-initial-onset-mania-and-increasing-risk-developing#comments Bipolar Disorder DHA (Docosahexaenoic Acid) EPA (Eicosapentaenoic Acid) Mania: Acute Omega-3 Fatty Acid Deficiency Risk Factors Human Study Thu, 26 Nov 2015 16:36:12 +0000 greenmedinfo 121802 at https://greenmedinfo.com There is a significant negative association between the rate of hospital admissions due to depressive disorders and solar activity. https://greenmedinfo.com/article/there-significant-negative-association-between-rate-hospital-admissions-due-de PMID:  Rev Med Chil. 2010 Jun ;138(6):694-700. PMID: 20919478 Abstract Title:  [Association between hospital admissions due to affective disorders and solar activity. Analysis of 16 years]. Abstract:  BACKGROUND: Exposure to solar activity may be associated with incidence of depressive and manic disorders.AIM: To assess the link between solar activity and appearance of affective disorders.MATERIAL AND METHODS: We examined 1862 clinical records of a psychiatric clinic located in Santiago, Chile. Patients with major depression and manic disorders were included in the study, only when they were admitted at the clinic for the first time. Solar activity was calculated using the Wolf number, which is given by the formula R = K(10g+f), where&quot;g&quot;stands for the groups of sunspots and&quot;f&quot;is the total number of sunspots. We examined the correlation between annual incidence of hospital admissions and average Wolf numbers for the period 1990-2005, which corresponds to approximately one and half solar cycles of 16 years.RESULTS: A total of 450 medical records corresponding to 299 patients (199 women) with depressive symptoms and 151 patients (73 women) with mania, were analyzed. There was a higher number of admissions for depression during the years with lower solar activity. Admissions due to mania tended to increase in the years with high solar activity. There was a negative correlation between the number of hospital admissions due to depression and solar activity (Spearman r = -0.812, p https://greenmedinfo.com/article/there-significant-negative-association-between-rate-hospital-admissions-due-de#comments Bipolar Disorder Depression: Bipolar Mania: Acute Solar Cycle Human Study Fri, 22 Jun 2012 19:04:39 +0000 greenmedinfo 77618 at https://greenmedinfo.com These findings suggest that blackberry consumption could help prevent or reduce manic episodes. https://greenmedinfo.com/article/these-findings-suggest-blackberry-consumption-could-help-prevent-or-reduce-man PMID:  Neurosci Lett. 2020 Jan 1 ;714:134566. Epub 2019 Nov 4. PMID: 31698027 Abstract Title:  Blackberry extract improves behavioral and neurochemical dysfunctions in a ketamine-induced rat model of mania. Abstract:  Bipolar disorder is a chronic mood disorder characterized by episodes of mania and depression. The aim of this study was to investigate the effects of blackberry extract on behavioral parameters, oxidative stress and inflammatory markers in a ketamine-induced model of mania. Animals were pretreated with extract (200 mg/kg, once a day for 14 days), lithium chloride (45 mg/kg, twice a day for 14 days), or vehicle. Between the 8th and 14th days, the animals received an injection of ketamine (25 mg/kg) or vehicle. On the 15th day, thirty minutes after ketamine administration, the animals&#039; locomotion was assessed using open-field apparatus. After the experiments, the animals were euthanized and cerebral structures were removed for neurochemical analyses. The results showed that ketamine treatment induced hyperlocomotion and oxidative damage in the cerebral cortex, hippocampus and striatum. In contrast,pretreatment with the extract or lithium was able to prevent hyperlocomotion and oxidative damage in the cerebral cortex, hippocampus, and striatum. In addition, IL-6 and IL-10 levels were increased by ketamine, while the extract prevented these effects in the cerebral cortex. Pretreatment with theextract was also effective in decreasing IL-6 and increasing the level of IL-10 in the striatum. In summary, our findings suggest that blackberry consumption could help prevent or reduce manic episodes, since this extract have demonstrated neuroprotective properties as well as antioxidant and anti-inflammatory effects in the ketamine-induced mania model. <p><a href="https://greenmedinfo.com/article/these-findings-suggest-blackberry-consumption-could-help-prevent-or-reduce-man" target="_blank">read more</a></p> https://greenmedinfo.com/article/these-findings-suggest-blackberry-consumption-could-help-prevent-or-reduce-man#comments Blackberry Mania: Acute Anti-Inflammatory Agents Interleukin-10 upregulation Interleukin-6 Downregulation Neuroprotective Agents Animal Study Thu, 05 Dec 2019 23:06:10 +0000 greenmedinfo 203792 at https://greenmedinfo.com Why Every Woman Needs To Have a Gluten Antibody Test BEFORE Pregnancy https://greenmedinfo.com/blog/why-every-woman-needs-have-gluten-antibody-test-pregnancy <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Why Every Woman Needs To Have a Gluten Antibody Test BEFORE Pregnancy" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/wheat_link_disease.jpg" /></p> <p>It is becoming more well known that poor digestion, leaky gut and dysbiosis can lead to health problems outside of the GI tract. In several previous articles I have discussed the effects of <a href="http://realfoodforager.com/gluten-may-compromise-the-blood-brain-barrier/" target="_blank">gluten on the brain</a> as well as the effects of <a href="http://realfoodforager.com/the-connection-between-gluten-and-heart-disease/" target="_blank">gluten on the cardiovascular system</a>. In addition to these hazards, current research indicates a clear relationship between a mother's sensitivity to gluten and the mental health of her child.</p><p><a href="https://greenmedinfo.com/blog/why-every-woman-needs-have-gluten-antibody-test-pregnancy" target="_blank">read more</a></p> https://greenmedinfo.com/blog/why-every-woman-needs-have-gluten-antibody-test-pregnancy#comments Celiac Disease Food Allergies: Wheat Infertility Infertility: Female Mania: Acute Non-Celiac Gluten Sensitivity (NCGS) Psychoses Schizophrenia Dark Side of Wheat Dietary Modification: Wheat/Gluten Free Gliadin Gluten Wheat Wheat Germ Agglutinin (WGA) Wed, 15 Jan 2014 15:53:07 +0000 jill@realfoodforager.com 111033 at https://greenmedinfo.com