Metabolic Acidosis https://greenmedinfo.com/taxonomy/term/70756/all en Chronic metabolic acidosis may be the cause of cachexia. https://greenmedinfo.com/article/chronic-metabolic-acidosis-may-be-cause-cachexia PMID:  Med Hypotheses. 2008 ;70(6):1167-73. Epub 2008 Jan 3. PMID: 18180110 Abstract Title:  Chronic metabolic acidosis may be the cause of cachexia: body fluid pH correction may be an effective therapy. Abstract:  Cachexia is a pathological state characterized by weight loss and protein mobilization during various diseases. Nutritional supplementation or appetite stimulants are unable to restore the loss of lean body mass. Agents interfering with TNF-alpha have not been very successful to date. Only eicosapentaenoic acid was able to interfere with the action of proteolysis-inducing factors. An acceleration of proteolysis and branched-chain amino acid oxidation was correlated with chronic metabolic acidosis. Therefore, we suggest here that the main cause of cachexia is the increased acidity of the body fluids, which results in a higher and non-specific proteolysis of muscle proteins. Moderate hypoxia might be close related to lactic acid production within the whole body, not only in the cancer cells. Anorexia seems to be a consequence, but a cause of cachexia: the cachectic patients are in fact well fed, unfortunately they use fatty acids from their fat and glucose via muscle proteins, amino acids, alanine, and lactic acid. Our hypothesis is consistent with the most findings reported in literature and opens new ways for cachexia prevention and therapy, such as pH correction or higher oxygenation. https://greenmedinfo.com/article/chronic-metabolic-acidosis-may-be-cause-cachexia#comments Cachexia Metabolic Acidosis PH Correction Commentary Fri, 12 Sep 2014 17:37:21 +0000 greenmedinfo 114740 at https://greenmedinfo.com Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported. https://greenmedinfo.com/article/metabolic-acidosis-mimicking-diabetic-ketoacidosis-after-use-calorie-free-mine PMID:  Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081 Abstract Title:  Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water. Abstract:  A previously healthy boy was admitted with fever, tachycardia, dyspnea, and was vomiting. A blood test showed a severe metabolic acidosis with pH 7.08 and an anion gap of 36 mmol/L. His urine had an odor of acetone. The serum glucose was 5.6 mmol/L, and no glucosuria was found. Diabetic ketoacidosis could therefore be eliminated. Lactate level was normal. Tests for the most common metabolic diseases were negative. Because of herpes stomatitis, the boy had lost appetite and only been drinking Diet Coke and water the last days. Diet Coke or Coca-Cola Light is sweetened with a blend containing cyclamates, aspartame, and acesulfame potassium, all free of calories. The etiology of the metabolic acidosis appeared to be a catabolic situation exaggerated by fasting with no intake of calories. The elevated anion gap was due to a severe starvation ketoacidosis, mimicking a diabetic ketoacidosis. Pediatricians should recommend carbohydrate/calorie-containing fluids for rehydration of children with acute fever, diarrhea, or illness. https://greenmedinfo.com/article/metabolic-acidosis-mimicking-diabetic-ketoacidosis-after-use-calorie-free-mine#comments Acidosis Metabolic Acidosis Acesulfame potassium Artificial Sweeteners Artificially Sweetened Beverages Aspartame Sodium Cyclamate False Diabetic Ketoacidosis Human: Case Report Fri, 30 Mar 2012 11:36:15 +0000 greenmedinfo 73723 at https://greenmedinfo.com