Ovarian Cancer: Estrogen Induced https://greenmedinfo.com/taxonomy/term/71722/all en "Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression." https://greenmedinfo.com/article/genistein-soy-phytoestrogen-prevents-growth-bg-1-ovarian-cancer-cells-induced- PMID:  Int J Oncol. 2012 Nov 29. Epub 2012 Nov 29. PMID: 23229410 Abstract Title:  Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression. Abstract:  An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in vitro cell viability assay, E2 or BPA significantly increased the growth of BG-1 cells. This increased proliferative activity was reversed by treatment with ICI 182,780, a well-known ER antagonist, while cell proliferation was further promoted in the presence of propyl pyrazole triol (PPT), an ERα agonist. These results imply that cell proliferation increased by E2 or BPA was mediated by ERs, particularly ERα. BPA clearly acted as a xenoestrogen in BG-1 ovarian cancer cells by mimicking E2 action. In contrast, GEN effectively suppressed BG-1 cell proliferation promoted by E2 or BPA by inhibiting cell cycle progression. E2 and BPA increased the expression of cyclin D1, a factor responsible for the G1/S cell cycle transition. They also decreased the expression of p21, a potent cyclin-dependent kinase (CDK) inhibitor that arrests the cell cycle in G1 phase, and promoted the proliferation of BG-1 cells. As shown by its repressive effect on cell growth, GEN decreased the expression of cyclin D1 augmented by E2 or BPA. On the other hand, GEN increased the p21 expression downregulated by E2 or BPA. Collectively, our findings suggest that GEN, a dietary phytoestrogen, has an inhibitory effect on the growth of estrogen-dependent cancers promoted by E2 or BPA. https://greenmedinfo.com/article/genistein-soy-phytoestrogen-prevents-growth-bg-1-ovarian-cancer-cells-induced-#comments Bisphenol-A Toxicity Breast Cancer: Estrogen Genistein Ovarian Cancer Ovarian Cancer: Estrogen Induced 17beta-estradiol Bisphenol A Cell cycle arrest In Vitro Study Wed, 19 Dec 2012 12:44:27 +0000 greenmedinfo 87105 at https://greenmedinfo.com Flaxseed May Be a Potent Ovarian Cancer KILLER https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Flaxseed: Ovarian Cancer KILLER? " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/ovarian.png" style="width: 600px; height: 400px;" title="Flaxseed May Be A Potent Ovarian Cancer KILLER" /></p> <p><span style="font-size:18px;"><em><strong>Effective and safe treatments for ovarian cancer simply do not exist today within conventional medical practice. However, promising research indicates that flaxseed and at least 30 other natural substances do have potent anti-ovarian cancer properties</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer" target="_blank">read more</a></p> https://greenmedinfo.com/blog/flaxseed-may-be-potent-ovarian-cancer-killer#comments Curcumin Flaxseed Genistein Ovarian Cancer Ovarian Cancer Stem Cell Ovarian Cancer: Estrogen Induced Resveratrol Turmeric Bisphenol A Cancer Cow Milk anti-tumor cure Ovarian cancer flaxseed kill cancer kill Ovarian cancer ovarian cancer Overdiagnosis RESVERATROL Thu, 11 Sep 2014 16:14:48 +0000 Sayer Ji 114733 at https://greenmedinfo.com Induced growth of ovarian cancer cells by 17β-estradiol or various endocrine disrupting chemicals was reversed b https://greenmedinfo.com/article/induced-growth-ovarian-cancer-cells-17-estradiol-or-various-endocrine-disrupti PMID:  Mol Med Report. 2012 Apr 23. Epub 2012 Apr 23. PMID: 22552626 Abstract Title:  Induced growth of BG-1 ovarian cancer cells by 17β-estradiol or various endocrine disrupting chemicals was reversed by resveratrol via downregulation of cell cycle progression. Abstract:  Resveratrol (trans-3,4&#039;,5-trihydroxystilbene; RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of estrogen-dependent cancers. In this study, we evaluated the inhibitory effect of RES on the cell proliferation induced by various EDCs in BG-1 ovarian cancer cells. Various EDCs, such as bisphenol A (BPA), nonylphenol (NP), octylphenol (OP), methoxychlor (MXC) and hexabromocyclododecane (HBCD), were employed in this study. In the in vitro experiments, treatment of BG-1 cells with E2, BPA, NP, OP, MXC or HBCD resulted in an increase of cell growth. By contrast, increased cell viability induced by these EDCs was reversed when co-cultured with RES. In addition, we examined the regulation of cell cycle-related genes by RT-PCR and western blot analysis. Treatment with each EDC was found to decrease only the gene expression of p21 and increase the expression of cell cycle-dependent kinase 2 (CDK2). However, co-treatment with RES and each EDC resulted in an increased gene expression of p21 and a decreased expression of CDK2. Cyclin D1 was increased by downregulating p21 only when treated with each EDC in the absence of RES, while co-treatment with RES and each EDC decreased the geneexpression of cyclin D1 by upregulating p21. Taken together, RES appears to be an inhibitor of cyclin D1 and CDK2 and is responsible for the cell cycle arrest at the G1 phase. In addition, when co-treated with each EDC, RES increased the expression of p21 and resulted in the growth inhibition ofBG-1 ovarian cancer cells. Taken together, these results indicate the antiproliferative effect of RES, a dietary phytoestrogen, on estrogen-dependent ovarian cancer cells activated by EDCs. https://greenmedinfo.com/article/induced-growth-ovarian-cancer-cells-17-estradiol-or-various-endocrine-disrupti#comments Ovarian Cancer: Estrogen Induced Resveratrol 17beta-estradiol Bisphenol A Carcinogenic Hexabromocyclododecane Methoxychlor Nonylphenol Octylphenol In Vitro Study Mon, 07 May 2012 18:12:55 +0000 greenmedinfo 75393 at https://greenmedinfo.com Ovarian Cancer: What We Think We Know May Harm Us https://greenmedinfo.com/blog/ovarian-cancer-what-we-think-we-know-may-harm-us <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2015<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Ovarian Cancer: What We Think We Know May Harm Us" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/ovarian_cancer_harms_diagnosis.jpg" style="height: 365px; width: 550px;" /></p> <p><em><strong>What do we really know about ovarian cancer risk and the 'gene mutations' considered largely responsible for increasing it? The answer is quite surprising and opens up the possibility for a radical change in how we diagnosis and treat the most lethal gynecological cancer in existence.&nbsp; </strong></em></p> <p>Ovarian cancer strikes fear into the hearts of women, their families, and their doctors, alike. &nbsp;Risks of false positive diagnosis leading to a treatment that has been demonstrated to result in the worst outcomes of any gynecologic cancer have led&nbsp; the <em>U.S. Preventive Services Task Force (USPSTF) </em>to recommend against routine screening.<a href="#_ftn1" name="_ftnref1" title="">[1]</a></p><p><a href="https://greenmedinfo.com/blog/ovarian-cancer-what-we-think-we-know-may-harm-us" target="_blank">read more</a></p> https://greenmedinfo.com/blog/ovarian-cancer-what-we-think-we-know-may-harm-us#comments Breast Cancer: BRCA1 Cancer Stem Cells Chemotherapy Curcumin Green Tea Ovarian Cancer Ovarian Cancer Stem Cell Ovarian Cancer: Estrogen Induced Ovarian Cancer: Overdiagnosis Ovarian Cysts Resveratrol Cancer BRCA MYTH Mon, 23 Jun 2014 12:40:08 +0000 Sayer Ji 112995 at https://greenmedinfo.com