neohesperidin https://greenmedinfo.com/category/substance/neohesperidin en Antioxidant and pancreatic lipase inhibitory effects of flavonoids from different citrus peel extracts. https://greenmedinfo.com/article/antioxidant-and-pancreatic-lipase-inhibitory-effects-flavonoids-different-citr PMID:  Food Chem. 2020 Apr 11 ;326:126785. Epub 2020 Apr 11. PMID: 32438224 Abstract Title:  Antioxidant and pancreatic lipase inhibitory effects of flavonoids from different citrus peel extracts: An in vitro study. Abstract:  Obesity and oxidative damage are two important risk factors associated closely with metabolic syndrome. Utilization of functional food ingredients is considered as a feasible way to tackle these challenges. In the present study, eight representative species of citrus peel extracts (CPEs) were evaluated and compared for their flavonoid profiles, antioxidant activities, and pancreatic lipase (PL) inhibitory capacities and mechanisms. Results indicated that hesperidin, naringin, neohesperidin, narirutin and eriocitrin were the five major flavonoids in CPEs, among which hesperidin was the main active PL inhibitor. Moreover, hesperidin could interact with PL by hydrogen bonds and van der Waals forces, and the interaction would not obviously change the secondary structure of PL. Overall, ponkan peel extract, having the strongest overall antioxidant activity, the highest content of hesperidin and total phenolic compounds among all tested CPEs, is a promising natural ingredient to scavenge free radicals and manage obesity. <p><a href="https://greenmedinfo.com/article/antioxidant-and-pancreatic-lipase-inhibitory-effects-flavonoids-different-citr" target="_blank">read more</a></p> https://greenmedinfo.com/article/antioxidant-and-pancreatic-lipase-inhibitory-effects-flavonoids-different-citr#comments Citrus naringin Citrus Peel Hesperidin Metabolic Syndrome X neohesperidin Obesity Oxidative Stress Antioxidants Enzyme Inhibitors: Pancreatic Lipase In Vitro Study Wed, 03 Jun 2020 04:49:13 +0000 greenmedinfo 221360 at https://greenmedinfo.com Citrus flavonoids as promising phytochemicals targeting diabetes and related complications. https://greenmedinfo.com/article/citrus-flavonoids-promising-phytochemicals-targeting-diabetes-and-related-comp PMID:  Nutrients. 2020 Sep 23 ;12(10). Epub 2020 Sep 23. PMID: 32977511 Abstract Title:  Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Abstract:  The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies. <p><a href="https://greenmedinfo.com/article/citrus-flavonoids-promising-phytochemicals-targeting-diabetes-and-related-comp" target="_blank">read more</a></p> https://greenmedinfo.com/article/citrus-flavonoids-promising-phytochemicals-targeting-diabetes-and-related-comp#comments Citrus naringin Diabetic Complications Diosgenin Flavonoids Fruit: All Hesperidin Naringenin neohesperidin Nobiletin Quercetin Rutin Tangeretin Xanthohumol Antioxidants Hepatoprotective Hypoglycemic Agents Hypolipidemic Renoprotective Review Sun, 27 Sep 2020 09:31:15 +0000 greenmedinfo 227273 at https://greenmedinfo.com Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells. https://greenmedinfo.com/article/hesperidin-promotes-programmed-cell-death-downregulation-nongenomic-estrogen-r PMID:  Biomed Pharmacother. 2018 Apr 14 ;103:336-345. Epub 2018 Apr 14. PMID: 29665555 Abstract Title:  Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells. Abstract:  Endometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified. We found that Hsd significantly suppressed the proliferation of EC cells in dose and time dependent manner. Mechanistic studies showed that Hsd could contribute apoptosis by inducing externalization of phosphatidyl serine (PS), caspase-3 activity and loss of mitochondrial membrane (MMP). Furthermore, we examined that Hsd could also significantly upregulate the expression of proapoptotic Bax subgroup genes (Bax and Bik) while downregulating the anti-apoptotic protein Bcl-2 in EC cell lines. According to GO enrichment and KEGG pathway analysis of differentially expressed genes in Hsd treated EC cells, we identified that Hsd could promote cell death via downregulation of estrogen receptor I (ESRI) that was directly related to ERK/MAPK pathway. Taken together, our study first showed that Hsd could be an antiestrogenic compound that could modulate nongenomic estrogen receptor signaling through inhibition of EC cell growth. Our findings may provide us a novel growth inhibitory agent for EC treatment after verifying its molecular mechanism with in vivo studies. <p><a href="https://greenmedinfo.com/article/hesperidin-promotes-programmed-cell-death-downregulation-nongenomic-estrogen-r" target="_blank">read more</a></p> https://greenmedinfo.com/article/hesperidin-promotes-programmed-cell-death-downregulation-nongenomic-estrogen-r#comments Endometrial Cancer neohesperidin Apoptotic In Vitro Study Fri, 20 Apr 2018 00:20:48 +0000 greenmedinfo 163030 at https://greenmedinfo.com Neohesperidin exerts lipid-regulating effects in vitro and in vivo. https://greenmedinfo.com/article/neohesperidin-exerts-lipid-regulating-effects-vitro-and-vivo PMID:  Pharmacology. 2017 ;100(3-4):115-126. Epub 2017 May 30. PMID: 28554169 Abstract Title:  Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis. Abstract:  The purpose of this study is to prove the lipid-regulating effects of neohesperidin (NHP) and explore the potential mechanisms related to fibroblast growth factor 21 (FGF21) and AMP-activated protein kinase (AMPK). Free fatty acids (FFAs)-induced lipid-accumulated HepG2 cells, acutely egg yolk-induced dyslipidemia and chronically diet-induced obese (DIO) model mice were treated with NHP. Biochemical analyses were carried out to determine the lipid profiles. Western blotting and real-time PCR were employed to analyze FGF21, AMPK and the related proteins or mRNA expressions. Body weight and food intake were measured in DIO mice. siRNA or inhibitors of FGF21 or AMPK were utilized in further study. NHP showed potent hypolipidemic effect in HepG2 cells loaded with FFAs and reversed the pathological changes of lipid in the acute or chronic dyslipidemia mouse model. It obviously improved the lipid profiles in plasma, liver and gastrocnemius muscles in DIO mice, and led to a significant body weight loss. Simultaneously, FGF21 protein expression or secretion, and AMPK/sirtuin type 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) axis or related molecules, was improved by NHP in HepG2 cells and/or DIO mice. Furthermore, the siRNA or inhibitor targeting FGF21 or AMPK rejected the triglyceride-lowering effect of NHP. In conclusion, NHP regulates lipid metabolism in vivo and in vitro via FGF21 and AMPK/SIRT1/PGC-1αsignaling axis. <p><a href="https://greenmedinfo.com/article/neohesperidin-exerts-lipid-regulating-effects-vitro-and-vivo" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-exerts-lipid-regulating-effects-vitro-and-vivo#comments Dyslipidemias neohesperidin Hypolipidemic Animal Study In Vitro Study Fri, 20 Apr 2018 00:09:21 +0000 greenmedinfo 163027 at https://greenmedinfo.com Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro. https://greenmedinfo.com/article/neohesperidin-inhibits-cardiac-remodeling-induced-ang-ii-vivo-and-vitro PMID:  Biomed Pharmacother. 2020 Jun 9 ;129:110364. Epub 2020 Jun 9. PMID: 32531678 Abstract Title:  Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro. Abstract:  Cardiac hypertrophy and remodeling are among the major health challenges facing countries around the world today. Neohesperidin plays an important role in influencing cell apoptosis, cell growth, tumorigenesis and tumor microenvironment, but the mechanism and role of Neohesperidin in cardiac hypertrophy and remodeling caused by Angiotensin II has not been fully elucidated. This study used Angiotensin II to induce cardiac hypertrophy and cardiac remodeling in mice. Echocardiography was used to evaluate cardiac function, H&amp;E and Masson trichrome staining were used to detect myocardial histological changes. Cardiac cell size was determined by WGA staining. The protein content of the signaling pathway was detected by Western blot, and the mRNA expression of fibrosis and hypertrophy markers was detected by qPCR. DHE staining was used to detect oxidative stress. We also observed the effect of Neohesperidin on Ang II-induced NRCMs. The results showed that neohesperidin can significantly inhibit Ang II-induced myocardial contractile dysfunction, cardiac hypertrophy, myocardial fibrosis, myocardial oxidative stress and inflammation. These results suggest that Neohesperidin can alleviate cardiac hypertrophy and remodeling caused by Ang II, and its mechanism may be related to the inhibition of multiple signaling pathways. <p><a href="https://greenmedinfo.com/article/neohesperidin-inhibits-cardiac-remodeling-induced-ang-ii-vivo-and-vitro" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-inhibits-cardiac-remodeling-induced-ang-ii-vivo-and-vitro#comments Cardiac Hypertrophy neohesperidin Anti-Inflammatory Agents Antioxidants Cardioprotective Animal Study In Vitro Study Thu, 30 Jul 2020 22:38:23 +0000 greenmedinfo 224496 at https://greenmedinfo.com Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice. https://greenmedinfo.com/article/neohesperidin-inhibits-tgf-1smad3-signaling-and-alleviates-bleomycin-induced-p PMID:  Eur J Pharmacol. 2019 Dec 1 ;864:172712. Epub 2019 Oct 2. PMID: 31586469 Abstract Title:  Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice. Abstract:  Idiopathic pulmonary fibrosis (IPF) is a fatal growing problem, with limited therapeutic options. Transforming growth factor beta 1 (TGF-β1) plays a critical role in many pathological processes that characterize pulmonary fibrosis. Effective and well-tolerated antifibrotic agents that interfere with TGF-β1 signaling would be an ideal treatment but no such treatments are available. In this study, we identified that the natural compound, neohesperidin, antagonizes TGF-β1/Smad3 signaling. We found that neohesperidin not only inhibited the TGF-β1-induced injury to alveolar epithelial cells but also decreased the TGF-β1-induced myofibroblast differentiation, extracellular matrix production, and fibroblast migration. Furthermore, we obtained in vivo evidence that neohesperidin treatment inhibited bleomycin-induced lung injuries and even attenuated established pulmonary fibrosis in mice. Our data suggest that neohesperidin can target the critical signaling pathway and profibrogenic responses in progressive pulmonary fibrosis and may have a potential use in treatment. <p><a href="https://greenmedinfo.com/article/neohesperidin-inhibits-tgf-1smad3-signaling-and-alleviates-bleomycin-induced-p" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-inhibits-tgf-1smad3-signaling-and-alleviates-bleomycin-induced-p#comments neohesperidin Pulmonary Fibrosis: Bleomycin-Induced Anti-Fibrotic Chemoprotective Agents Transforming growth factor beta (TGF-β) inhibitor Animal Study Fri, 24 Jan 2020 20:16:43 +0000 greenmedinfo 209229 at https://greenmedinfo.com Neohesperidin prevents Aβ25-35-induced apoptosis in primary cultured hippocampal neurons. https://greenmedinfo.com/article/neohesperidin-prevents-25-35-induced-apoptosis-primary-cultured-hippocampal-ne PMID:  Neurochem Res. 2018 Jun 30. Epub 2018 Jun 30. PMID: 29961232 Abstract Title:  Neohesperidin Prevents Aβ-Induced Apoptosis in Primary Cultured Hippocampal Neurons by Blocking the S-Nitrosylation of Protein-Disulphide Isomerase. Abstract:  A growing body of literature has established a link between the cerebral ischaemic injury and pathological state of Alzheimer&#039;s disease (AD), and this correlation indicated that the preventive agent for ischaemia might improve the pathology of AD. Our previous studies have demonstrated that Neohesperidin (NH) exhibited neuroprotective effects against cerebral ischemia via the down-regulation of Bcl-2, Akt/PI3K and Nrf2 pathways. In the present study, we first confirmed the protective effects of NH on Aβ-induced neurotoxicity on primary cultured hippocampal neurons. We further demonstrated NH attenuated Aβ-induced apoptosis by preventing neurotoxicity associated with lethal UPR and ER stress via blocking S-nitrosylation of protein-disulphide isomerase (PDI). These results suggested that S-nitrosylation of PDI and ER dysfunction might be the synergistic and synchronous pathological process between cerebral ischaemia and AD. <p><a href="https://greenmedinfo.com/article/neohesperidin-prevents-25-35-induced-apoptosis-primary-cultured-hippocampal-ne" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-prevents-25-35-induced-apoptosis-primary-cultured-hippocampal-ne#comments Alzheimer's Disease neohesperidin Neuroprotective Agents In Vitro Study Tue, 10 Jul 2018 21:18:49 +0000 greenmedinfo 167156 at https://greenmedinfo.com Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota. https://greenmedinfo.com/article/neohesperidin-prevents-colorectal-tumorigenesis-altering-gut-microbiota PMID:  Pharmacol Res. 2019 10 ;148:104460. Epub 2019 Sep 24. PMID: 31560944 Abstract Title:  Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota. Abstract:  Neohesperidin (NHP), derived from citrus fruits, has attracted considerable interest due to its preventative and therapeutic effects on numerous diseases. However, little progress has been made in determining the exact function of NHP on tumorigenesis. In the current study, we found that NHP inhibited colorectal tumorigenesis in the APCtransgenic mouse model, as well as induced apoptosis and blocked angiogenesis in vivo. Our in-cell study suggested that this tumorigenic preventative effect of NHP is not due to the direct impact on tumor cells. Intriguingly, by utilizing 16 s rRNA gene-based microbiota sequencing, the relative abundance of Bacteroidetes was decreased, while Firmicutes and Proteobacteria were increased in the presence of NHP. Additionally, the fecal microbiota transplantation experiment further revealed that feeding with fecal of NHP-treated mice induced considerable inhibition of tumorigenesis, which indicates that the alteration of gut microbiota is responsible for NHP-mediated prevention of colorectal tumorigenesis. Thus, our study not only suggests the efficacy of NHP as a potent natural product for preventing colorectal cancer but also proposes a compelling model to connect the gut microbiota to the preventative effect of NHP on tumorigenesis. <p><a href="https://greenmedinfo.com/article/neohesperidin-prevents-colorectal-tumorigenesis-altering-gut-microbiota" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-prevents-colorectal-tumorigenesis-altering-gut-microbiota#comments Colorectal Cancer neohesperidin Chemopreventive Gastrointestinal Agents Transgenic Animal Study Fri, 24 Jan 2020 20:19:04 +0000 greenmedinfo 209230 at https://greenmedinfo.com Neohesperidin suppresses IgE-mediated anaphylactic reactions. https://greenmedinfo.com/article/neohesperidin-suppresses-ige-mediated-anaphylactic-reactions PMID:  Phytother Res. 2019 Aug ;33(8):2034-2043. Epub 2019 Jun 14. PMID: 31197891 Abstract Title:  Neohesperidin suppresses IgE-mediated anaphylactic reactions and mast cell activation via Lyn-PLC-Capathway. Abstract:  Mast cells play an essential role in IgE-FcεR1-mediated allergic diseases. Citrus aurantium is a prolific source of flavonoids with various biological activities, including anti-inflammatory, antioxidant, and anti-tumor efficacies. Neohesperidin is a novel flavonoid isolated from the leaves of C. aurantium. In this study, the anti-allergicand anti-inflammatory potentials of neohesperidin were investigated along with its molecular mechanism. The anti-anaphylactic activity of neohesperidin was evaluated through hind paw extravasation study in mice. Calcium imaging was used to assess intracellular Camobilization. The levels of cytokines and chemokines were measured using enzyme immunoassay kits. Western blotting was used to explore the related molecular signaling pathways. Neohesperidin suppressed IgE-induced mast cell activations, including degranulation and secretion of cytokines and eicosanoids through inhibiting phosphorylation of Lyn kinase. Neohesperidin inhibited the release of histamine and other proinflammatory cytokines through a mast cell-dependent passive cutaneous anaphylaxis animal model. Histological studies demonstrated that neohesperidin substantially inhibited IgE-induced cellular infiltration and attenuated mast cell activation in skin tissue. In conclusion, our study revealed that neohesperidin could inhibit allergic responses in vivo and in vitro, and the molecule may be regarded as a novel agent for preventing mast cell-immediate and delayed allergic diseases. <p><a href="https://greenmedinfo.com/article/neohesperidin-suppresses-ige-mediated-anaphylactic-reactions" target="_blank">read more</a></p> https://greenmedinfo.com/article/neohesperidin-suppresses-ige-mediated-anaphylactic-reactions#comments Allergies Anaphylactic Reaction IgE-Mediated Hypersensitivity neohesperidin Immunomodulatory Animal Study In Vitro Study Fri, 24 Jan 2020 20:13:28 +0000 greenmedinfo 209226 at https://greenmedinfo.com The anti-aging potential of neohesperidin and its synergistic effects with other citrus flavonoids. https://greenmedinfo.com/article/anti-aging-potential-neohesperidin-and-its-synergistic-effects-other-citrus-fl PMID:  Molecules. 2019 Nov 13 ;24(22). Epub 2019 Nov 13. PMID: 31766122 Abstract Title:  The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan ofBY4742. Abstract:  The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have been explored in the current literature. However, the studies on the synergistic effects between the different flavonoid compounds were quite limited in previous reports. In this study, by using a high throughput assay, we tested the synergistic effects between different citrus flavonoids throughout the yeast&#039;s chronological lifespan (CLS). We studied the effect of four flavonoid compounds including naringin, hesperedin, hesperitin, neohesperidin, as well as their different combinations on the CLS of the yeast strain BY4742. Their ROS scavenging ability, in vitro antioxidant activity and the influence on the extracellular pH were also tested. The results showed that neohesperidin extended the yeast&#039;s CLS in a concentration-dependent manner. Especially, we found that neohesperidin showed great potential in extending CLS of budding yeast individually or synergistically with hesperetin. The neohesperidin exhibited the strongest function in decreasing the reactive oxygen species (ROS) accumulation in yeast. These findings clearly indicated that neohesperidin is potentially an anti-aging citrus flavonoid, and its synergistic effect with other flavonoids on yeast&#039;s CLS will be an interesting subject for future research of the anti-aging function of citrus fruits. <p><a href="https://greenmedinfo.com/article/anti-aging-potential-neohesperidin-and-its-synergistic-effects-other-citrus-fl" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-aging-potential-neohesperidin-and-its-synergistic-effects-other-citrus-fl#comments Aging Flavonoids neohesperidin Oxidative Stress Antioxidants Natural Substance Synergy In Vitro Study Fri, 24 Jan 2020 20:28:18 +0000 greenmedinfo 209233 at https://greenmedinfo.com The results suggest neohesperidin possesses therapeutic potential as a natural anti-catabolic treatment in osteoporosis. https://greenmedinfo.com/article/results-suggest-neohesperidin-possesses-therapeutic-potential-natural-anti-cat PMID:  Mol Cell Endocrinol. 2017 Jan 5 ;439:369-378. Epub 2016 Sep 21. PMID: 27664516 Abstract Title:  Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice. Abstract:  Excessive bone resorption by osteoclasts plays an important role in osteoporosis. Bone loss occurs in ovariectomised (OVX) mice in a similar manner to that in humans, so this model is suitable for evaluating potential new therapies for osteoporosis. Neohesperidin (NE) is a flavonoid compound isolated from citrus fruits. Its role in bone metabolism is unknown. In this study we found that neohesperidin inhibits osteoclast differentiation, bone resorption and the expression of osteoclast marker genes, tartrate-resistant acid phosphatase and cathepsin K. In addition, neohesperidin inhibited receptor activator of NF-κB ligand (RANKL)-induced activation of NF-κB, and the degradation of inhibitor of kappa B-alpha (IκBα). Furthermore, neohesperidin inhibited RANKL induction of nuclear factor of activated T-cells (NFAT) and calcium oscillations. In vivo treatment of ovariectomised mice with neohesperidin protected against bone loss in mice. The results suggest neohesperidin has anti-osteoclastic effects in vitro and in vivo and possesses therapeutic potential as a natural anti-catabolic treatment in osteoporosis. <p><a href="https://greenmedinfo.com/article/results-suggest-neohesperidin-possesses-therapeutic-potential-natural-anti-cat" target="_blank">read more</a></p> https://greenmedinfo.com/article/results-suggest-neohesperidin-possesses-therapeutic-potential-natural-anti-cat#comments neohesperidin Osteoporosis Anti-Apoptotic NF-kappaB Inhibitor Ovariectomy-Induced Changes Animal Study In Vitro Study Fri, 20 Apr 2018 00:13:19 +0000 greenmedinfo 163029 at https://greenmedinfo.com Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes. https://greenmedinfo.com/article/therapeutic-effect-neohesperidin-tnf-stimulated-human-rheumatoid-arthritis-fib PMID:  Chin J Nat Med. 2021 Oct ;19(10):741-749. PMID: 34688464 Abstract Title:  Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes. Abstract:  During the pathogensis of rheumatoid arthritis (RA), activated RA fibroblast-like synoviocytes (RA-FLSs) combines similar proliferative features as tumor and inflammatory features as osteoarthritis, which eventually leads to joint erosion. Therefore, it is imperative to research and develop new compounds, which can effectively inhibit abnormal activation of RA-FLSs and retard RA progression. Neohesperidin (Neo) is a major active component of flavonoid compounds with anti-inflammation and anti-oxidant properties. In this study, the anti-inflammation, anti-migration, anti-invasion, anti-oxidant and apoptosis-induced effects of Neo on RA-FLSs were explored to investigate the underlying mechanism. The results suggested that Neo decreased the levels of interleukin IL-1β, IL-6, IL-8, TNF-α, MMP-3, MMP-9 and MMP-13 in FLSs. Moreover, Neo blocked the activation of the MAPK signaling pathway. Furthermore, treatment with Neo induced the apoptosis of FLSs, and inhibited the migration of FLSs. It was also found that Neo reduced the accumulation of reactive oxygen species (ROS) induced by TNF-α. Taken together, our results highlighted that Neo may act as a potential and promising therapeutic drug for the management of RA. <p><a href="https://greenmedinfo.com/article/therapeutic-effect-neohesperidin-tnf-stimulated-human-rheumatoid-arthritis-fib" target="_blank">read more</a></p> https://greenmedinfo.com/article/therapeutic-effect-neohesperidin-tnf-stimulated-human-rheumatoid-arthritis-fib#comments neohesperidin Rheumatoid Arthritis Anti-Inflammatory Agents Tumor Necrosis Factor (TNF) Alpha Inhibitor In Vitro Study Sun, 28 Nov 2021 19:22:36 +0000 greenmedinfo 249399 at https://greenmedinfo.com Therapeutic effects of citrus flavonoids neohesperidin, hesperidin and its aglycone, hesperetin on bone health. https://greenmedinfo.com/article/therapeutic-effects-citrus-flavonoids-neohesperidin-hesperidin-and-its-aglycon PMID:  Biomolecules. 2022 04 23 ;12(5). Epub 2022 Apr 23. PMID: 35625554 Abstract Title:  Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health. Abstract:  Flavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These phytochemicals can be found in seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, in citrus fruits. Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential. Neohesperidin, in the form of neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. In general, these flavanones have been investigated as a strategy to control bone diseases, such as osteoporosis and osteoarthritis. In this literature review, we compiled studies that investigated the effects of neohesperidin, hesperidin and its aglycone, hesperetin, on bone health. In vitro studies showed that these flavanones exerted an antiosteoclastic and anti- inflammatory effects, inhibiting the expression of osteoclastic markers and reducing the levels of reactive oxygen species, proinflammatory cytokines and matrix metalloproteinase levels. Similarly, such studies favored the osteogenic potential of preosteoblastic cells and induced the overexpression of osteogenic markers. In vivo, these flavanones favored the regeneration of bone defects and minimized inflammation in arthritis- and periodontitis-induced models. Additionally, they exerted a significant anticatabolic effect in ovariectomy models, reducing trabecular bone loss and increasing bone mineral density. Although research should advance to the clinical field, these flavanones may have therapeutic potential for controlling the progression of metabolic, autoimmune or inflammatory bone diseases. <p><a href="https://greenmedinfo.com/article/therapeutic-effects-citrus-flavonoids-neohesperidin-hesperidin-and-its-aglycon" target="_blank">read more</a></p> https://greenmedinfo.com/article/therapeutic-effects-citrus-flavonoids-neohesperidin-hesperidin-and-its-aglycon#comments Flavonoids Hesperidin neohesperidin Osteoarthritis Osteoporosis Periodontitis Anti-Inflammatory Agents Review Sun, 03 Jul 2022 16:30:20 +0000 greenmedinfo 260009 at https://greenmedinfo.com This study identified three lead compounds hesperidin, narirutin, and neohesperidin suitable for multitarget SARS-CoV-2 inhibition. https://greenmedinfo.com/article/study-identified-three-lead-compounds-hesperidin-narirutin-and-neohesperidin-s PMID:  Molecules. 2022 Oct 28 ;27(21). Epub 2022 Oct 28. PMID: 36364158 Abstract Title:  Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants. Abstract:  The rapid spread of SARS-CoV-2 required immediate actions to control the transmission of the virus and minimize its impact on humanity. An extensive mutation rate of this viral genome contributes to the virus&#039; ability to quickly adapt to environmental changes, impacts transmissibility and antigenicity, and may facilitate immune escape. Therefore, it is of great interest for researchers working in vaccine development and drug design to consider the impact of mutations on virus-drug interactions. Here, we propose a multitarget drug discovery pipeline for identifying potential drug candidates which can efficiently inhibit the Receptor Binding Domain (RBD) of spike glycoproteins from different variants of SARS-CoV-2. Eight homology models of RBDs for selected variants were created and validated using reference crystal structures. We then investigated interactions between host receptor ACE2 and RBDs from nine variants of SARS-CoV-2. It led us to conclude that efficient multi-variant targeting drugs should be capable of blocking residues Q(R)493 and N487 in RBDs. Using methods of molecular docking, molecular mechanics, and molecular dynamics, we identified three lead compounds (hesperidin, narirutin, and neohesperidin) suitable for multitarget SARS-CoV-2 inhibition. These compounds are flavanone glycosides found in citrus fruits - an active ingredient of Traditional Chinese Medicines. The developed pipeline can be further used to (1) model mutants for which crystal structures are not yet available and (2) scan a more extensive library of compounds against other mutated viral proteins. <p><a href="https://greenmedinfo.com/article/study-identified-three-lead-compounds-hesperidin-narirutin-and-neohesperidin-s" target="_blank">read more</a></p> https://greenmedinfo.com/article/study-identified-three-lead-compounds-hesperidin-narirutin-and-neohesperidin-s#comments Coronavirus Infection Flavonoids Hesperidin neohesperidin Antiviral Agents SARS-CoV-2 Spike Protein In Vitro Study Tue, 30 May 2023 19:42:49 +0000 greenmedinfo 273092 at https://greenmedinfo.com