hyperlipidemia https://greenmedinfo.com/category/keywords/hyperlipidemia en 8 Healing Properties of Strawberries https://greenmedinfo.com/blog/8-healing-properties-strawberries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Juicy Reasons to Eat More Strawberries" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Strawberries1.jpg" style="width: 500px; height: 333px;" /></p> <p><strong><span style="font-size:18px;"><em>Who doesn't love <a href="/substance/strawberry" rel="dofollow" target="_blank">strawberries</a>? And you don't need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there's lots more to strawberries than the flavor.</em></span><a href="#_edn1" name="_ednref1" title="">[i]</a></strong></p> <p>Their study was <strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/24345049" rel="nofollow" target="_blank">published in the journal <em>Critical Reviews in Food Science and Nutrition</em></a></strong> with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry's status as a "functional food."</p><p><a href="https://greenmedinfo.com/blog/8-healing-properties-strawberries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-healing-properties-strawberries#comments Alzheimer's Disease Anthocyanins Blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases Carotenoids Catechin Ellagic Acid Flavonoids Hyperglycemia Hyperlipidemia Hypertension Kaempferol Naringenin Parkinson's Disease Phytosterols Polyphenols Potassium Quercetin Strawberry Vitamin C Vitamin E Antioxidants Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Anthocyanins Antioxidants blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases CAROTENOIDS Catechin Ellagic Acid Flavonoids hyperglycemia hyperlipidemia hypertension Kaempferol Naringenin Parkinson's disease phytosterols POLYPHENOLS potassium QUERCETIN Strawberry Vitamin C VITAMIN E Sat, 18 Feb 2023 17:30:10 +0000 GMI Research Group 114933 at https://greenmedinfo.com An overview of the preclinical pharmacological properties of Nigella sativa. https://greenmedinfo.com/article/overview-preclinical-pharmacological-properties-nigella-sativa n/a PMID:  J Physiol Pharmacol. 2016 Dec ;67(6):801-817. PMID: 28195061 Abstract Title:  Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance. Abstract:  Nigella sativa (N. sativa, black seeds; or sometimes known by many other names such as the blessed seed by the Arabs, black cumin in the Holy Bible, black caraway and Kalonji in South Asia) has been traditionally used for many years not only as a food but also as complementary drug. It is the objective of this communication to review the evidence-based pre-clinical pharmacological actions of N. sativa as a basis of its existing and potential new human clinical uses. Primary PubMed literature searches and secondary Medline searches were conducted to define N. sativa pre-clinical pharmacological and toxicological actions using a retrospective narrative review of the published studies. The ground seeds, its oil and its various extracts exhibit very broad pharmacological actions in laboratory studies, which are predictive of human clinical efficacy. In laboratory studies, N. sativa possesses anti-inflammatory, analgesic, anti-diabetic, anti-hyperlipidemic, anti-convulsant, anti-microbial, anti-ulcer, anti-hypertensive, anti-asthmatic and anti-cancer activities. Its mode of action is mediated via several mechanisms, which include anti-oxidant, immunomodulating, cytoprotective and an inhibitory effect on some mediators of inflammation. Although the seeds contain many chemical components, thymoquinone and alpha-hederin are proven to be pharmacologically active. Despite N. sativa broad and worldwide pharmacological characterization, only limited non-clinical safety studies were reported. N. sativa has many potentially important therapeutic applications. The black seeds clearly warrant formal preclinical drug development consideration to investigate the pharmacology of its components, to standardize the contents of the dosage forms, to define the methods of the pharmaceutical preparation, to determine its pharmacokinetics characteristics and its safety profile. It is our opinion that N. sativa should be considered for clinical development initially for unmet therapeutic uses, especially in the fields of oncology, neurology, rheumatology, pulmonary medicine, infectious diseases and endocrinology. https://greenmedinfo.com/article/overview-preclinical-pharmacological-properties-nigella-sativa#comments Asthma Cancers: All Hyperlipidemia Hypertension Inflammation Nigella sativa (aka Black Seed) Pain Ulcers Analgesics Anti-Asthmatic Agents Anti-Inflammatory Agents Anti-Ulcer Agents Anticonvulsants Antihypertensive Agents Antimicrobial Antioxidants Hypolipidemic Immunomodulatory Asthma Cancers: All hyperlipidemia hypertension Inflammation Nigella sativa (aka Black Seed) pain Ulcers Review Wed, 15 Mar 2017 20:59:53 +0000 greenmedinfo 144870 at https://greenmedinfo.com Avocado fruit extract can act as hypolipidemic agent. https://greenmedinfo.com/article/avocado-fruit-extract-can-act-hypolipidemic-agent n/a PMID:  Indian J Exp Biol. 2016 Jun ;54(6):370-8. PMID: 27468463 Abstract Title:  Effect of hydroalcoholic fruit extract of Persea americana Mill. on high fat diet induced obesity: A dose response study in rats. Abstract:  The fruits of Persea Americana Mill., commonly known as Avocado, are traditionally consumed for various health benefits including weight reduction. Here, we studied the effect of hydroalcoholic fruit extract of Persea americana (HAEPA) on high fat diet (HFD) induced obesity in rats. Obesity was induced in male Sprague Dawley rats by feeding HFD for 14 wk. The hypolipidemic effect was evaluated by co-administering 25, 50, 100 and 200 mg/kg body wt. of HAEPA. There was a significant increase in weight gain, body mass index (BMI), blood lipids, low density lipoproteins (LDL), lipid peroxides (LPO) and serum transaminases in HFD fed rats. HFD+HAEPA fed rats showed a significant decrease in blood lipids, LPO, liver lipids and increase in antioxidant status when compared to HFD control rats. The activity of lipid metabolic key enzymes such as fatty acid synthase and HMG CoA reductase in liver were also found to be decreased significantly in HAEPA co-administered rats. Lipoprotein lipase activity was found increased in HFD+HAEPA rats. Among the 4 doses studied, 100 mg of HAEPA/kg body wt. exhibited optimum hypolipidemic activity. Histopathological observations in liver and visceral adipose tissue added more evidence for the lipid lowering effect of HAEPA. It can be concluded that avocado fruit extract can act as hypolipidemic agent probably by modulating the activities of HMG CoA reductase and fatty acid synthase in liver. https://greenmedinfo.com/article/avocado-fruit-extract-can-act-hypolipidemic-agent#comments Avocado Hyperlipidemia Obesity Hypolipidemic Anti-Obesity Agents Avocado hyperlipidemia Hypolipidemic obesity Plant Extracts Animal Study Tue, 07 Feb 2017 17:38:34 +0000 greenmedinfo 143105 at https://greenmedinfo.com Krill oil supplementation can reduce low-density lipoprotein cholesterol and triglycerides https://greenmedinfo.com/article/krill-oil-supplementation-can-reduce-low-density-lipoprotein-cholesterol-and-t n/a PMID:  Nutr Rev. 2017 May 1 ;75(5):361-373. PMID: 28371906 Abstract Title:  Lipid-modifying effects of krill oil in humans: systematic review and meta-analysis of randomized controlled trials. Abstract:  Context: Some experimental and clinical trials have shown that krill oil, extracted from small red crustaceans, might be an effective lipid-modifying agent, but the evidence is not conclusive. Objective: The effect of krill oil supplements on plasma lipid concentrations was assessed through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Data sources: PubMed and Scopus were searched up to March 25, 2016, to identify RCTs investigating the effect of krill oil supplements on plasma lipids. Study selection: Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with krill oil on plasma/serum concentrations of at least one of the main lipid parameters (ie, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or triglycerides) and that reported sufficient information on plasma/serum lipid levels at baseline and at the end of study in both krill oil and control groups were eligible for inclusion. Data extraction: Two reviewers independently extracted the following data: first author&#039;s name, year of publication, study location, study design, number of participants in the krill oil and control groups, dosage of krill oil, type of control allocation, treatment duration, demographic characteristics of study participants, and baseline and follow-up plasma concentrations of lipids. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95%CI). Results: Meta-analysis of data from 7 eligible trials (14 treatment arms) with 662 participants showed a significant reduction in plasma concentrations of low-density lipoprotein cholesterol (WMD, -15.52 mg/dL; 95%CI, -28.43 to -2.61; P = 0.018) and triglycerides (WMD, -14.03 mg/dL; 95%CI, -21.38 to -6.67; P &lt; 0.001) following supplementation with krill oil. A significant elevation in plasma concentrations of high-density lipoprotein cholesterol was also observed (WMD, 6.65 mg/dL; 95%CI, 2.30 to 10.99; P = 0.003), while a reduction in plasma concentrations of total cholesterol did not reach statistical significance (WMD, -7.50 mg/dL; 95%CI, -17.94 to 2.93; P = 0.159). Conclusion: Krill oil supplementation can reduce low-density lipoprotein cholesterol and triglycerides. Additional clinical studies with more participants are needed to assess the impact of krill oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes. https://greenmedinfo.com/article/krill-oil-supplementation-can-reduce-low-density-lipoprotein-cholesterol-and-t#comments Hypercholesterolemia Hyperlipidemia Krill Triglycerides: Elevated Anticholesteremic Agents Hypolipidemic Anticholesteremic Agents Hypercholesterolemia hyperlipidemia Hypolipidemic Krill Meta Analysis Triglycerides: Elevated Review Fri, 01 Sep 2017 20:48:52 +0000 greenmedinfo 152592 at https://greenmedinfo.com Krill oil treatment was associated with the alleviation of hyperlipidemia in animals. https://greenmedinfo.com/article/krill-oil-treatment-was-associated-alleviation-hyperlipidemia-animals n/a PMID:  Front Microbiol. 2017 ;8:905. Epub 2017 May 17. PMID: 28567037 Abstract Title:  Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet. Abstract:  Multiple lines of evidence suggest that the gut microbiota plays vital roles in metabolic diseases such as hyperlipidemia. Previous studies have confirmed that krill oil can alleviate hyperlipidemia, but the underlying mechanism remains unclear. To discern whether krill oil changes the structure of the gut microbiota during the hyperlipidemia treatment, 72 mice were acclimatized with a standard chow diet for 2 weeks and then randomly allocated to receive a standard chow diet (control group, n = 12) or a high-sugar-high-fat (HSHF) diet supplemented with a low (100μg/g·d, HSHF+LD group, n = 12), moderate (200 μg/g·d, HSHF+MD group, n = 12) or high dosage of krill oil (600 μg/g·d, HSHF+HD group, n = 12), simvastatin (HSHF+S group, n = 12) or saline (HSHF group, n = 12) continuously for 12 weeks. The resulting weight gains were attenuated, the liver indexand the low-density lipoprotein, total cholesterol and triglyceride concentrations showed a stepwise reduction in the treated groups compared with those of the control group. A dose-dependent modulation of the gut microbiota was observed after treatment with krill oil. Low- and moderate- doses of krill oil increased the similarity between the composition of the HSHF diet-induced gut microbiota and that of the control, whereas the mice fed the high-dose exhibited a unique gut microbiota structure that was different from that of the control and HSHF groups. Sixty-five key operational taxonomicunits (OTUs) that responded to the krill oil treatment were identified using redundancy analysis, of which 26 OTUs were increased and 39 OTUs were decreased compared with those of the HSHF group. In conclusion, the results obtained in this study suggest that the structural alterations in the gut microbiota induced by krill oil treatment were dose-dependent and associated with the alleviation of hyperlipidemia. Additionally, the high-dose krill oil treatment showed combined effects on the alleviation of hyperlipidemia and obesity. https://greenmedinfo.com/article/krill-oil-treatment-was-associated-alleviation-hyperlipidemia-animals#comments High Fat Diet High Sugar Diet Hyperlipidemia Krill Obesity Gastrointestinal Agents Hypolipidemic Anti-Obesity Agents Gastrointestinal Agents high fat diet High Sugar Diet hyperlipidemia Hypolipidemic Krill obesity Animal Study Fri, 01 Sep 2017 20:28:52 +0000 greenmedinfo 152590 at https://greenmedinfo.com Lipid Lowering Effects of Black Seed https://greenmedinfo.com/blog/lipid-lowering-effects-black-seed <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Lipid Lowering Effects of Black Seed" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Black_Seed_Oil.jpg" style="height: 342px; width: 500px;" /></p> <p><strong><a href="/substance/cholesterol" rel="dofollow" target="_blank">Cholesterol</a></strong> is a lipid molecule vital for life. It is required to build the membrane of each cell in our bodies and also for the synthesis of <strong><a href="/substance/vitamin-d" rel="dofollow" target="_blank">vitamin D</a></strong>&nbsp;and a number of very important steroid hormones.</p><p><a href="https://greenmedinfo.com/blog/lipid-lowering-effects-black-seed" target="_blank">read more</a></p> https://greenmedinfo.com/blog/lipid-lowering-effects-black-seed#comments Cholesterol: LDL/HDL ratio Dyslipidemias Hypercholesterolemia Nigella sativa (aka Black Seed) Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Hypolipidemic Metformin Black Seed Cardiovascular Disease cholestrol Hypercholesterolemia hyperlipidemia Lipid VITAMIN D Fri, 23 May 2014 01:26:34 +0000 nabiblackseed 112525 at https://greenmedinfo.com The high reactivity of bisphenol A with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives. https://greenmedinfo.com/article/high-reactivity-bisphenol-disinfectant-chlorine-evident-instantaneous-formatio n/a PMID:  Environ Int. 2015 Dec ;85:352-79. Epub 2015 Oct 30. PMID: 26521216 Abstract Title:  Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Abstract:  The high reactivity of bisphenol A (BPA) with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives (ClxBPA) in various environmental media that show increased estrogen-activity when compared with that of BPA. The documented health risks associated with BPA exposures have led to the gradual market entry of BPA structural analogs, such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), etc. A suite of exposure sources to ClxBPA and BPA analogs in the domestic environment is anticipated to drive the nature and range of halogenated BPA derivatives that can form when residual BPA comes in contact with disinfectant in tap water and/or consumer products. The primary objective of this review was to survey all available studies reporting biomonitoring protocols of ClxBPA and structural BPA analogs (BPS, BPF, BPB, etc.) in human matrices. Focus was paid on describing the analytical methodologies practiced for the analysis of ClxBPA and BPA analogs using hyphenated chromatography and mass spectrometry techniques, because current methodologies for human matrices are complex. During the last decade, an increasing number of ecotoxicological, cell-culture and animal-based and human studies dealing with ClxBPA exposure sources and routes of exposure, metabolism and toxicity have been published. Up to date findings indicated the association of ClxBPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly in in-vitro and in-vivo studies. We critically discuss the limitations, research needs and future opportunities linked with the inclusion of ClxBPA and BPA analogs into exposure assessment protocols of relevant epidemiological studies. https://greenmedinfo.com/article/high-reactivity-bisphenol-disinfectant-chlorine-evident-instantaneous-formatio#comments Diabetes Mellitus: Type 2 Hyperlipidemia Obesity Bisphenol A Chlorine Disinfection by-products: In Drinking Water Bisphenol A Chlorine Diabetes mellitus: Type 2 Disinfection by-products: In Drinking Water hyperlipidemia obesity Risk Factors Review Wed, 04 Jan 2017 18:25:59 +0000 greenmedinfo 141408 at https://greenmedinfo.com The lipid metabolism of hyperlipidemic rats was improved by regulating the gut microbiota with supplementation of L.rhamnosus hsryfm. https://greenmedinfo.com/article/lipid-metabolism-hyperlipidemic-rats-was-improved-regulating-gut-microbiota-su n/a PMID:  BMC Complement Altern Med. 2014 Oct 10 ;14:386. Epub 2014 Oct 10. PMID: 25300818 Abstract Title:  The effect of Lactobacillus rhamnosus hsryfm 1301 on the intestinal microbiota of a hyperlipidemic rat model. Abstract:  BACKGROUND: Growing evidence indicates that intestinal microbiota regulate our metabolism. Probiotics confer health benefits that may depend on their ability to affect the gut microbiota. The objective of this study was to examine the effect of supplementation with the probiotic strain, Lactobacillus rhamnosus hsryfm 1301, on the gut microbiota in a hyperlipidemic rat model, and to explore the associations between the gut microbiota and the serum lipids. METHODS: The hyperlipidemic rat model was established by feeding rats a high-fat diet for 28 d. The rats&#039; gut microbiota were analyzed using high-throughput sequencing before and after L. rhamnosus hsryfm 1301 supplementation or its fermented milk for 28 d. The serum lipids level was also tested. RESULTS: The rats&#039; primary gut microbiota were composed of Bacteroidetes, Firmicutes, Proteobacteria, Spirochaetes and Verrucomicrobia. The abundance and diversity of the gut microbiota generally decreased after feeding with a high-fat diet, with a significant decrease in the relative abundance of Bacteroidetes, but with an increase in that of Firmicutes (P&lt;0.05). Administration of L. rhamnosus hsryfm 1301 or its fermented milk for 28 d, could recover the Bacteroidetes and Verrucomicrobia abundance and could decrease the Firmicutes abundance, which was associated with a significant reduction in the serum lipids&#039; level in the hyperlipidemic rats with high-fat diet induced. The abundance of 22 genera of gut bacteria was changed significantly after probiotic intervention for 28 d (P&lt;0.05). A positive correlation was observed between Ruminococcus spp. and serum triglycerides, Dorea spp. and serum cholesterol (TC) and low-density lipoprotein (LDL-C), and Enterococcus spp. and high-density lipoprotein. The Butyrivibrio spp. negatively correlated with TC and LDL-C. CONCLUSIONS: Our results suggest that the lipid metabolism of hyperlipidemic rats was improved by regulating the gut microbiota with supplementation of L.rhamnosus hsryfm 1301 or its fermented milk for 28 d. https://greenmedinfo.com/article/lipid-metabolism-hyperlipidemic-rats-was-improved-regulating-gut-microbiota-su#comments Hyperlipidemia Lactobacillus rhamnosus Hypolipidemic hyperlipidemia Hypolipidemic Lactobacillus rhamnosus Animal Study Thu, 08 Jun 2017 01:57:26 +0000 greenmedinfo 148842 at https://greenmedinfo.com The results showed that adlay seed oil had blood lipid-reducing and antioxidant effects. https://greenmedinfo.com/article/results-showed-adlay-seed-oil-had-blood-lipid-reducing-and-antioxidant-effects n/a PMID:  J Sci Food Agric. 2011 Aug 15 ;91(10):1843-8. Epub 2011 Mar 30. PMID: 21452173 Abstract Title:  Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. Abstract:  BACKGROUND: Adlay (Coix lacryma-jobi L. subsp. ma-yuen (Romanet) T. Koyama (family Poaceae)) seed has been used as a dietary supplement for its therapeutic effects for thousands of years. This study was designed to investigate the effects of adlay seed oil, obtained by supercritical CO₂ extraction, on blood lipids and antioxidant capacity in hyperlipidemic rats. RESULTS: Adlay seed oil could reduce the abdominal fat tissue and low-density lipoprotein concentration, and increase the total antioxidant capacity in hyperlipidemic rats. Adlay seed oil also significantly decreased the malondialdehyde content in serum, and increased serum total superoxide dismutase activity in hyperlipidemic rats. Therefore, the antioxidant mechanism might be related to the scavenging effects of adlay seed oil on reactive oxidative species, especially on the superoxide anion free radical. CONCLUSION: The results showed that adlay seed oil had blood lipid-reducing and antioxidant effects, and could be used as a supplement in healthcare food and drugs for the prevention of chronic diseases (especially artherosclerosis and coronary artery disease). https://greenmedinfo.com/article/results-showed-adlay-seed-oil-had-blood-lipid-reducing-and-antioxidant-effects#comments Adlay Hyperlipidemia Antioxidants Malondialdehyde Down-regulation Superoxide Dismutase Up-regulation Adlay Antioxidants hyperlipidemia Phytotherapy Plant Extracts Animal Study Sat, 21 Apr 2018 00:40:57 +0000 greenmedinfo 163112 at https://greenmedinfo.com