Influenza A https://greenmedinfo.com/category/keywords/Influenza%20A en Chlorogenic acid has potential utility in the treatment of the influenza virus infection. https://greenmedinfo.com/article/chlorogenic-acid-has-potential-utility-treatment-influenza-virus-infection n/a PMID:  Sci Rep. 2017 Apr 10 ;7:45723. Epub 2017 Apr 10. PMID: 28393840 Abstract Title:  Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase. Abstract:  Lonicera japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, ect in China. It was reported that CHA reduced serum hepatitis B virus level and death rate of influenza virus-infected mice. However, the underlying mechanisms of CHA against the influenza A virus have not been fully elucidated. Here, the antiviral effects and potential mechanisms of CHA against influenza A virus were investigated. CHA revealed inhibitory against A/PuertoRico/8/1934(H1N1) (EC50 = 44.87 μM), A/Beijing/32/92(H3N2) (EC50 = 62.33 μM), and oseltamivir-resistant strains. Time-course analysis showed CHA inhibited influenza virus during the late stage of infectious cycle. Indirect immunofluorescence assay indicated CHA down-regulated the NP protein expression. The inhibition of neuraminidase activity confirmed CHA blocked release of newly formed virus particles from infected cells. Intravenous injection of 100 mg/kg/d CHA possessed effective antiviral activity in mice, conferring 60% and 50% protection from death against H1N1 and H3N2, reducing virus titresand alleviating inflammation in the lungs effectively. These results demonstrate that CHA acts as a neuraminidase blocker to inhibit influenza A virus both in cellular and animal models. Thus, CHA has potential utility in the treatment of the influenza virus infection. https://greenmedinfo.com/article/chlorogenic-acid-has-potential-utility-treatment-influenza-virus-infection#comments Chlorogenic Acid Influenza A Antiviral Agents Neurominidase Inhibitor Antiviral Agents Chlorogenic Acid Influenza A Neurominidase Inhibitor In Vitro Study Tue, 30 Jan 2018 22:01:57 +0000 greenmedinfo 159020 at https://greenmedinfo.com The Proof is in the Panic: We Need a New Strategy against Viral Infections https://greenmedinfo.com/blog/proof-panic-we-need-new-strategy-against-viral-infections <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><div> <p class="rtecenter"><img alt="The Proof is in the Panic: We Need a New Strategy against Viral Infections" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/ebola_hazmat_suit.jpg" style="width: 401px; height: 247px;" /></p><p><a href="https://greenmedinfo.com/blog/proof-panic-we-need-new-strategy-against-viral-infections" target="_blank">read more</a></p> https://greenmedinfo.com/blog/proof-panic-we-need-new-strategy-against-viral-infections#comments AIDS Alzheimer's Disease Betaine coenzyme Q-10 Fish Oil Folic Acid Glutamine Glycyrrhiza glabra Hepatitis B Hepatitis C HIV Influenza A SARS Selenium Theanine Vitamin A Zinc AIDS Alzheimer's disease Betaine coenzyme Q-10 Fish Oil folic acid glutamine Glycyrrhiza glabra Hepatitis B hepatitis C HIV Influenza A SARS Selenium Theanine Vitamin A zinc Thu, 11 Dec 2014 00:22:55 +0000 alexvasquez 115437 at https://greenmedinfo.com