Chlamydia pneumoniae https://greenmedinfo.com/taxonomy/term/75403/all en An extract from schisandra chinensis berries inhibited the growth of both C. pneumoniae and C. trachomatis. https://greenmedinfo.com/article/extract-schisandra-chinensis-berries-inhibited-growth-both-c-pneumoniae-and-c- PMID:  Nat Prod Commun. 2015 Jun ;10(6):1001-4. PMID: 26197536 Abstract Title:  The Lignan-containing Extract of Schisandra chinensis Berries Inhibits the Growth of Chlamydia pneumonia. Abstract:  The purpose of this study was to investigate the effect and selectivity of an extract of Schisandra chinensis berries against Chlamydia pneumoniae and C. trachomatis. Among the ethnopharmacological uses of the extract from Schisandrae fructus are cough and pneumonia. Therefore we focused on respiratory pathogens. The extract completely inhibited the growth of C. pneumoniae strain CV6 at 250μg/mL concentration. The inhibition of C. pneumoniae and C. trachomatis growth was dose dependent and established with three different strains. The extract inhibited C. pneumoniae production of infectious progeny in a dose dependent manner. Chlamydia selectivity was elucidated with growth inhibition measurements of three other respiratory bacterial species. A pure compound found in Schisandra chinensis berries, schisandrin B at 20.0 μg/mL concentration inhibited the growth of both C. pneumoniae and C. trachomatis. The extract was found to be non-toxic to the human host cells. These findingshighlight the potential of the extract from Schisandra chinensis berries as a source for antichlamydial compounds. https://greenmedinfo.com/article/extract-schisandra-chinensis-berries-inhibited-growth-both-c-pneumoniae-and-c-#comments Chlamydia pneumoniae Chlamydia trachomatis Lignans Pneumonia Schisandra Anti-Bacterial Agents Antimicrobial Dose Response Plant Extracts In Vitro Study Mon, 24 Aug 2015 00:25:48 +0000 greenmedinfo 119961 at https://greenmedinfo.com Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses. https://greenmedinfo.com/article/epigallocatechin-gallate-suppresses-chlamydia-pneumoniae-mediated-ige-response PMID:  Minerva Med. 2016 Jun 16. Epub 2016 Jun 16. PMID: 27309037 Abstract Title:  Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses in peripheral blood mononuclear cells: a pilot study. Abstract:  BACKGROUND: Chlamydia pneumoniae causes respiratory infection in children and adults and is associated with asthma and induction of immunoglobulin E (IgE) responses. Previous studies in our laboratory reported that green tea extract (GTE) and its catechin, epigallocatechin gallate (EGCG) have immunoregulatory effects on IgE responses. Whereas tea polyphenols have in vitro inhibitory effects on the proliferation of C. pneumoniae, the in vitro effects of EGCG on C. pneumoniae- mediated IgE responses haven't been studied. We sought to clarify the in vitro effect of EGCG on C. pneumoniae mediated IgE responses by peripheral blood mononuclear cells (PBMC) in asthma.METHODS: PBMC from subjects with asthma and non-asthmatic controls were incubated with C. pneumoniae and cultured for 10 days +/- EGCG (0.5, 5.0, 50 ng/mL). IgE levels in supernatants were determined (ELISA).RESULTS: Elevated IgE levels were detected in supernatants of PBMC from an asthma patient (2.6 ng/mL), whereas IgE levels of PBMC from non-asthmatics were low ( https://greenmedinfo.com/article/epigallocatechin-gallate-suppresses-chlamydia-pneumoniae-mediated-ige-response#comments Chlamydia pneumoniae EGCG (Epigallocatechin gallate) Immunomodulatory Human In Vitro Tue, 21 Jun 2016 04:14:49 +0000 greenmedinfo 128902 at https://greenmedinfo.com This study shows a strongly positive association between bacterial infection and Alzheimer's disease. https://greenmedinfo.com/article/study-shows-strongly-positive-association-between-bacterial-infection-and-alzh PMID:  J Alzheimers Dis. 2015 ;43(3):957-66. PMID: 25182736 Abstract Title:  Bacterial infection and Alzheimer's disease: a meta-analysis. Abstract:  The possibility of an infectious etiology for Alzheimer's disease (AD) has been repeatedly postulated over the past three decades. We provide the first meta-analysis to address the relationship between bacterial infection and AD. Studies examining the association between AD and spirochetal bacteria or Chlamydophila pneumoniae (Cpn) were identified through a systematic search of the databases MEDLINE, EMBASE, PubMed, and Google Scholar. Data combined from 25 relevant, primarily case-control studies demonstrated a statistically significant association between AD and detectable evidence of infection of either bacterial group. We found over a ten-fold increased occurrence of AD when there is detectable evidence of spirochetal infection (OR: 10.61; 95% CI: 3.38-33.29) and over a four-fold increased occurrence of AD in a conservative risk estimate (OR: 4.45; 95% CI: 2.33-8.52). We found over a five-fold increased occurrence of AD with Cpn infection (OR: 5.66; 95% CI: 1.83-17.51). This study shows a strongly positive association between bacterial infection and AD. Further detailed investigation of the role of bacterial infection is warranted. https://greenmedinfo.com/article/study-shows-strongly-positive-association-between-bacterial-infection-and-alzh#comments Alzheimer's Disease Bacterial Infections Chlamydia pneumoniae Increased Risk Meta Analysis Thu, 07 Jan 2016 22:06:10 +0000 greenmedinfo 122986 at https://greenmedinfo.com