preeclampsia https://greenmedinfo.com/taxonomy/term/76260/all en Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice. https://greenmedinfo.com/article/bisphenol-exposure-alters-placentation-and-causes-preeclampsia-features-pregna PMID:  FASEB J. 2018 Oct 10:fj201800934RRR. Epub 2018 Oct 10. PMID: 30303745 Abstract Title:  Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. Abstract:  Preeclampsia leads to adverse outcomes for pregnant women. Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies. We investigated whether BPA exposure causes preeclampsia-like features in pregnant mice and the associated underlying mechanisms. Experiments were performed in animal models and cell cultures. In pregnant mice, BPA-exposed mice exhibited preeclampsia-like features including hypertension, disruption of the circulation, and the placental angiogenesis biomarkers fms-related tyrosine kinase 1 and placenta growth factor, and glomerular atrophy; urinary protein was not affected. These preeclampsia-like features correlated with increased retention of smooth muscle cells and reduced vessel areas at the junctional zone of the placenta. In addition, there were disrupted expression of invasion-related genes including increased tissue inhibitors of metalloproteinases, decreased metalloproteinases, and Wnt family member WNT2/β-catenin, which correlated with increased DNA methylation in its promoter region and upregulation of DNA methyltransferase (Dnmt)1. BPA exposure impeded the interaction between the human cytotrophoblast cell line, HTR-8/SVneo, and endothelium cells. BPA exposure down-regulated WNT2 expression, andelevated the DNA methylation of WNT2; these results were consistent with in vivo observations. Inhibition of DNMT in HTR-8/SVneo cells resulted in reduced DNA methylation and increased expression of WNT2. Taken together, these data demonstrate that BPA exposure alters trophoblast cell invasion andcauses abnormal placental vessel remodeling, both of which lead to the development of preeclampsia-like features in pregnant mice. Our results suggest that this phenomenon involves the epigenetic reprogramming and down-regulation of WNT2 mediated by DNMT1.-Ye, Y., Tang, Y., Xiong, Y., Feng, L., Li,X. Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. <p><a href="https://greenmedinfo.com/article/bisphenol-exposure-alters-placentation-and-causes-preeclampsia-features-pregna" target="_blank">read more</a></p> https://greenmedinfo.com/article/bisphenol-exposure-alters-placentation-and-causes-preeclampsia-features-pregna#comments Bisphenol Toxicity preeclampsia Bisphenol A Risk Factors Animal Study Sat, 13 Oct 2018 22:48:17 +0000 greenmedinfo 172429 at https://greenmedinfo.com calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. https://greenmedinfo.com/article/calcium-magnesium-and-zinc-supplements-have-significant-effect-prevention-pree PMID:  Int J Reprod Biomed (Yazd). 2017 May ;15(5):273-278. PMID: 28744522 Abstract Title:  The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT. Abstract:  BACKGROUND: Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia.OBJECTIVE: The present study aims to investigate the effect of multimineral-vitamin D supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in the prevention of preeclampsia.MATERIALS AND METHODS: In this randomized clinical trial, 90 pregnant women were divided into three groups: group A received Ferrous sulfate (1 tablet/day) + one tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous sulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily.RESULTS: The incidence of preeclampsia in group A was significantly lower than the control group (p=0.03), while there was no significant difference between group B and controls (p=0.50), as well as groups A and B (p=0.063). The incidence of neonatal complications in the group A was significantly lower than the control group (p=0.01), while there was no significant difference between group B and control (p=0.48).CONCLUSION: According to the results, calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia. <p><a href="https://greenmedinfo.com/article/calcium-magnesium-and-zinc-supplements-have-significant-effect-prevention-pree" target="_blank">read more</a></p> https://greenmedinfo.com/article/calcium-magnesium-and-zinc-supplements-have-significant-effect-prevention-pree#comments Calcium Magnesium preeclampsia Zinc Risk Reduction Human Study Fri, 27 Oct 2017 22:18:30 +0000 greenmedinfo 154991 at https://greenmedinfo.com Perinatal mortality and preeclampsia increased after paternal acute increased estimated radiofrequency exposure from fast patrol boats. https://greenmedinfo.com/article/perinatal-mortality-and-preeclampsia-increased-after-paternal-acute-increased- PMID:  J Occup Environ Med. 2012 Apr ;54(4):431-8. PMID: 22354128 Abstract Title:  Pregnancy outcomes after paternal radiofrequency field exposure aboard fast patrol boats. Abstract:  OBJECTIVES: To investigate adverse reproductive outcomes among male employees in the Royal Norwegian Navy exposed to radiofrequency electromagnetic fields aboard fast patrol boats.METHODS: Cohort study of Royal Norwegian Navy servicemen linked to the Medical Birth Registry of Norway, including singleton offspring born between 1967 and 2008 (n = 37,920). Exposure during the last 3 months before conception (acute) and exposure more than 3 months before conception (nonacute) were analyzed.RESULTS: Perinatal mortality and preeclampsia increased after service aboard fast patrol boats during an acute period and also after increased estimated radiofrequency exposure during an acute period, compared with service aboard other vessels. No associations were found between nonacute exposure and any of the reproductive outcomes.CONCLUSIONS: Paternal work aboard fast patrol boats during an acute period was associated with perinatal mortality and preeclampsia, but the cause is not clear. <p><a href="https://greenmedinfo.com/article/perinatal-mortality-and-preeclampsia-increased-after-paternal-acute-increased-" target="_blank">read more</a></p> https://greenmedinfo.com/article/perinatal-mortality-and-preeclampsia-increased-after-paternal-acute-increased-#comments Perinatal Mortality preeclampsia Electromagnetic Field Harms Electromagnetic Radiation EMF Human Study Wed, 07 Aug 2019 22:50:24 +0000 greenmedinfo 193156 at https://greenmedinfo.com These results showed that vitamin D deficiency has a statistically significant relationship with preeclampsia. https://greenmedinfo.com/article/these-results-showed-vitamin-d-deficiency-has-statistically-significant-relati PMID:  Pregnancy Hypertens. 2019 Jan ;15:161-165. Epub 2019 Jan 17. PMID: 30825915 Abstract Title:  Relationship between low maternal vitamin D status and the risk of severe preeclampsia: A case control study. Abstract:  BACKGROUND: Low maternal vitamin D status has been associated with several adverse outcomes during pregnancy. The aim of the study was to evaluate the vitamin D levels in preeclamptic and healthy pregnant women and the role of vitamin D deficiency in the etiology of preeclampsia.METHODS: In this case-control study, 80 preeclamptic women and 80 healthy pregnant women were selected from Motahari hospital in Urmia, Iran. 2 ml of venous blood sample was collected from each pregnant woman and the serum 25-OH-D level was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and reported in nanograms per milliliter. levels of 25-OH-D less than 10 ng mL, between 10 ng mLand 29 ng mLand more than 30 ng mL, were considered as deficient, insufficient and normal 25-OH-D concentrations, respectively. Results were analyzed by independent t-test, Mann-Whitney U test, and logistic regression.RESULTS: Preeclamptic women (n = 80) were noted to have decreased total 25-OH-D levels relative to healthy control women (n = 80; P = 0.01). This difference in total 25-OH-D remained significant after control for potential confounders [odds ratio (OR) = 4.79, confidence interval (CI) = 1.45-9.87, P = 0.01].CONCLUSION: These results showed that vitamin D deficiency has a statistically significant relationship with preeclampsia and support the hypothesis that vitamin D deficiency may be a risk factor for preeclampsia. <p><a href="https://greenmedinfo.com/article/these-results-showed-vitamin-d-deficiency-has-statistically-significant-relati" target="_blank">read more</a></p> https://greenmedinfo.com/article/these-results-showed-vitamin-d-deficiency-has-statistically-significant-relati#comments preeclampsia Vitamin D Vitamin D Deficiency Increased Risk Human Study Tue, 05 Mar 2019 01:02:50 +0000 greenmedinfo 180721 at https://greenmedinfo.com