Dandelion https://greenmedinfo.com/category/keywords/Dandelion en A leaf extract of Dandelion and its main compound activated nuclear factor erythroid 2-related factor 2 and induced heme oxygenase 1. https://greenmedinfo.com/article/leaf-extract-dandelion-and-its-main-compound-activated-nuclear-factor-erythroi n/a PMID:  J Med Food. 2016 Dec 27. Epub 2016 Dec 27. PMID: 28026992 Abstract Title:  Sesquiterpene Lactone Composition and Cellular Nrf2 Induction of Taraxacum officinale Leaves and Roots and Taraxinic Acidβ-d-Glucopyranosyl Ester. Abstract:  Taraxacum officinale, the common dandelion, is a plant of the Asteraceae family, which is used as a food and medical herb. Various secondary plant metabolites such as sesquiterpene lactones, triterpenoids, flavonoids, phenolic acids, coumarins, and steroids have been described to be present in T. officinale. Dandelion may exhibit various health benefits, including antioxidant, anti-inflammatory, and anticarcinogenic properties. We analyzed the leaves and roots of the common dandelion (T. officinale) using high-performance liquid chromatography/mass spectrometry to determine its sesquiterpene lactone composition. The main compound of the leaf extract taraxinic acidβ-d-glucopyranosyl ester (1), a sesquiterpene lactone, was isolated and the structure elucidation was conducted by nuclear magnetic resonance spectrometry. The leaf extract and its main compound 1 activated the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in human hepatocytes more significantly than the root extract. Furthermore, the leaf extract induced the Nrf2 target gene heme oxygenase 1. Overall, present data suggest that compound 1 may be one of the active principles of T. officinale. https://greenmedinfo.com/article/leaf-extract-dandelion-and-its-main-compound-activated-nuclear-factor-erythroi#comments Dandelion Oxidative Stress Antioxidants Heme oxygenase-1 inducer Nrf2 activation Antioxidants Dandelion Heme oxygenase-1 inducer Nrf2 activation oxidative stress Plant Extracts In Vitro Study Tue, 03 Jan 2017 00:16:53 +0000 greenmedinfo 141323 at https://greenmedinfo.com Dandelion extracts with their antioxidant activity may be beneficial for diseases-associated with oxidative stress, and with changes of hemostasis. https://greenmedinfo.com/article/dandelion-extracts-their-antioxidant-activity-may-be-beneficial-diseases-assoc n/a PMID:  Chem Biol Interact. 2017 Jan 25 ;262:29-37. Epub 2016 Dec 5. PMID: 27923645 Abstract Title:  Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Abstract:  Taraxacum officinale (dandelion) is a widespread perennial of the Asteraceae family. Dandelion is a rich source of different bioactive compounds, including phenolic compounds, terpenes, carbohydrates, proteins, fatty acids, vitamin and minerals. However, the content of phenolics in tested extracts by various authors was not always well described. Dandelion is also a commonly available food with a long history of human use and as such poses little risk of harm. In this study, we focused on four different phenolic fractions from leaves and petals of dandelion, which might be of great interest. The objective was to investigate the antioxidant properties of the phenolic fractions from dandelion leaves and petals in vitro. Effects of four different phenolic fractions from dandelion leaves and petals on the production of thiobarbituric acid reactive substances (TBARS, a marker of lipid peroxidation) in human plasma were studied in vitro. Their antioxidant properties against human plasma protein carbonylationand oxidation of protein thiols induced by a strong biological oxidant - hydrogen peroxide (H2O2) or H2O2/Fe (a donor of hydroxyl radicals) were also examined. The tested fractions of dandelion (0.5-50 μg/mL; the incubation time - 30 min) inhibited plasma lipid peroxidation induced by H2O2 or H2O2/Fe. However, their antioxidant properties were not concentration-dependent. All tested samples also inhibited plasma protein carbonylation and oxidation of thiol groups in plasma proteins stimulated by oxidants (H2O2 and OH(∙)). The obtained results suggest that four tested dandelion fractions,especially phenolic fractions from petals which are recognized as better than leaves source of flavonoids, may be a new and promising source of natural compounds with antioxidant activity beneficial for diseases-associated with oxidative stress, and with changes of hemostasis. https://greenmedinfo.com/article/dandelion-extracts-their-antioxidant-activity-may-be-beneficial-diseases-assoc#comments Dandelion Hydrogen Peroxide Induced Toxicity Lipid Peroxidation Oxidative Stress Antioxidants Antioxidants Dandelion Hydrogen Peroxide Induced Toxicity Lipid Peroxidation oxidative stress Plant Extracts In Vitro Study Tue, 03 Jan 2017 00:26:22 +0000 greenmedinfo 141329 at https://greenmedinfo.com Dietary dandelion extracts promoted intestine health by improving intestine morphology, immunity, antioxidant abilities and intestinal barrier. https://greenmedinfo.com/article/dietary-dandelion-extracts-promoted-intestine-health-improving-intestine-morph n/a PMID:  Fish Shellfish Immunol. 2017 Dec 16 ;73:197-206. Epub 2017 Dec 16. PMID: 29258755 Abstract Title:  Effects of dietary dandelion extract on intestinal morphology, antioxidant status, immune function and physical barrier function of juvenile golden pompano Trachinotus ovatus. Abstract:  Intestinal morphology, antioxidant status, immune function and tight junction proteins mRNA expression were examined in golden pompano (Trachinotus ovatus) that fed respectively six diets containing dandelion extracts (DE) at 0, 0.5, 1, 2, 4 and 10 g kg-1 after 8 weeks feeding. The study indicated that dietary DE significantly improved intestinal antioxidant abilities by increasing SOD, CAT, T-AOC activities and up-regulating intestinal cat, gpx mRNA levels, but by decreasing MDA content and down-regulating intestinal keap1 mRNA levels ingolden pompano. Meanwhile, dietary DE improved intestinal morphology, suggesting that enhances intestinal digestion and absorption, by increasing muscle thickness, villus length, villus width and villus number in the foregut and hindgut; as well as villus number, villus width and muscle thickness in the midgut (P < .05). Dietary DE enhanced intestinal barrier function by increasing intestinal zo-1 and occludin mRNA levels, but by decreasing the mRNA levels of claudin-12 and claudin-15. Furthermore, dietary DE improved intestinal immunity via increasing goblet cells numbers and regulating expression of immune-related genes. In conclusion, dietary DE supplementation promoted intestine health by improving intestine morphology, immunity, antioxidant abilities and intestinal barrier in golden pompano. https://greenmedinfo.com/article/dietary-dandelion-extracts-promoted-intestine-health-improving-intestine-morph#comments Dandelion Antioxidants Gastrointestinal Agents Immunomodulatory Antioxidants Dandelion Gastrointestinal Agents Gene Expression Regulation Immunomodulatory Animal Study Tue, 02 Jan 2018 23:38:46 +0000 greenmedinfo 157930 at https://greenmedinfo.com These results suggest that dandelion extracts have potential as antibacterial uropathogenic disease agents. https://greenmedinfo.com/article/these-results-suggest-dandelion-extracts-have-potential-antibacterial-uropatho n/a PMID:  Evid Based Complement Alternat Med. 2018 ;2018:2706417. Epub 2018 Jan 1. PMID: 29507587 Abstract Title:  Isolation and Identification of Compounds from Bioactive Extracts ofWeber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents. Abstract:  Currently, the most effective treatment for recurrent urinary tract infections in women is antibiotics. However, the limitation for this treatment is the duration and dosage of antibiotics and the resistance that bacteria develop after a long period of administration. With the aim of identifying mainly novel natural agents with antibacterial activity, the present study was undertaken to investigate the biological and phytochemical properties of extracts from the leavesThe structural identification of compounds present in hexane (Hex) and ethyl acetate (AcOEt) extracts was performed by mass spectrometry (GC-MS) spectroscopic techniques and nuclear magnetic resonance (NMR) with the major compounds corresponding to different sesquiterpene lactones (-santonin, glabellin, arborescin, and estafiatin), monoterpene (9,10-dimethyltricycle [4.2.1.1 (2,5)]decane-9,10-diol), phytosterol (Stigmasta-5,22-dien-3-ol acetate), terpenes (lupeol acetate, pregn-5-en-20-one-3-acetyloxy-17-hydroxy, 2-hydroxy-4-methoxy benzaldehyde), and coumarin (benzofuranone 5,6,7,7-a-tetraaldehyde-4,4,7a-trimethyl). The results obtained show that the Hex extract was highly active againstshowing a MIC of 200 g/mL and moderately active againstandwith MIC values of 400 g/mL and 800 g/mL for the other Gram-negative strains tested withas uropathogens. Therefore, the effective dandelion extracts could be used in the development of future products with industrial application. https://greenmedinfo.com/article/these-results-suggest-dandelion-extracts-have-potential-antibacterial-uropatho#comments Dandelion Escherichia coli Infections Klebsiella Infections Staphylococcus aureus infection Anti-Bacterial Agents Anti-Bacterial Agents Dandelion Escherichia coli Infections Klebsiella Infections Staphylococcus aureus infection Animal Study In Vitro Study Sat, 10 Mar 2018 01:57:03 +0000 greenmedinfo 160996 at https://greenmedinfo.com This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D. https://greenmedinfo.com/article/review-recapitulates-previous-work-dandelion-and-its-potential-treatment-and-p n/a PMID:  Rev Diabet Stud. 2016 Summer-Fall;13(2-3):113-131. Epub 2016 Aug 10. PMID: 28012278 Abstract Title:  The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes. Abstract:  The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonalβ-cell lines (INS-1E), α-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive in-vitro, in-vivo, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D. https://greenmedinfo.com/article/review-recapitulates-previous-work-dandelion-and-its-potential-treatment-and-p#comments Dandelion Diabetes Mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Dandelion Diabetes mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Risk Reduction Review Tue, 03 Jan 2017 00:21:31 +0000 greenmedinfo 141326 at https://greenmedinfo.com