Hazelnut https://greenmedinfo.com/category/keywords/Hazelnut en A review of almond, hazelnut and walnuts for neuroprotection in Alzheimer's disease. https://greenmedinfo.com/article/review-almond-hazelnut-and-walnuts-neuroprotection-alzheimers-disease n/a PMID:  Pharmacol Res. 2017 Dec 5. Epub 2017 Dec 5. PMID: 29208493 Abstract Title:  Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents. Abstract:  An increase in the prevalence of Alzheimer's disease (AD) as a multifactorial neurodegenerative disorder is an almost obvious issue in the world. Researches on natural products for finding effective drugs to prevent the disease are in progress. There is special attention to the three types of nuts including almond, hazelnut and walnut in manuscripts of traditional Persian medicine (PM) as the preventive agents against brainatrophy and memory loss. The purpose of this study is a pharmacological review of their bioactive constituents and introducing the value of these nuts as the effective supplements and natural medicinal foods in AD patients. Databases including PubMed and ScienceDirect were searched in title, abstract and keywords from year 2000 to present for AD-related researches on these tree nuts, their major phytochemicals and their mechanisms of action. As result, almond, hazelnut and walnut provide macronutrients, micronutrients, and phytochemicals which affect several pathways in AD pathogenesis such as amyloidogenesis, tau phosphorylation, oxidative stress, cholinergic pathways, and some non-target mechanisms including cholesterol lowering and anti-inflammatory properties, as well as effect on neurogenesis. These nuts are recommended in PM for their brain-protective activity and particularly reversing brain atrophy in case of hazelnut. The therapeutical statements of PM scholars mentioned in their books are based on their clinical observations with support of a long history of experiences. Beyond the molecular activities attributed to the phytochemicals, the use of these tree nuts could be more considered in scientific researches as the effective nutrients for prevention or even management of AD. https://greenmedinfo.com/article/review-almond-hazelnut-and-walnuts-neuroprotection-alzheimers-disease#comments Almond Alzheimer's Disease Hazelnut Walnut Anti-Inflammatory Agents Neuroprotective Agents Almond Alzheimer's disease Anti-Inflammatory Agents Hazelnut Neuroprotective Agents Walnut Review Thu, 18 Jan 2018 15:41:50 +0000 greenmedinfo 158543 at https://greenmedinfo.com Hazelnut-enriched diet is associated with a decrease of LDL and total cholesterol. https://greenmedinfo.com/article/hazelnut-enriched-diet-associated-decrease-ldl-and-total-cholesterol n/a PMID:  Nutrients. 2016 Nov 25 ;8(12). Epub 2016 Nov 25. PMID: 27897978 Abstract Title:  Effects of Hazelnut Consumption on Blood Lipids and Body Weight: A Systematic Review and Bayesian Meta-Analysis. Abstract:  Hazelnuts are rich in monounsaturated fatty acids and antioxidant bioactive substances: their consumption has been associated with a decreased risk of cardiovascular disease events. A systematic review and a meta-analysis was performed to combine the results from several trials and to estimate the pooled (overall) effect of hazelnuts on blood lipids and body weight outcomes. Specifically, a Bayesian random effect meta-analysis of mean differences ofΔ-changes from baseline across treatment (MDΔ) (i.e., hazelnut-enriched diet vs. control diet) has been conducted. Nine studies representing 425 participants were included in the analysis. The intervention diet lasted 28-84 days with a dosage of hazelnuts ranging from 29 to 69 g/day. Out of nine studies, three randomized studies have been meta-analyzed showing a significant reduction in low-density lipoprotein (LDL) cholesterol (pooled MDΔ = -0.150 mmol/L; 95% highest posterior density interval (95%HPD) = -0.308; -0.003) in favor of a hazelnut-enriched diet. Total cholesterol showed a marked trend toward a decrease (pooled MDΔ = -0.127 mmol/L; 95%HPD = -0.284; 0.014) and high-density lipoprotein (HDL) cholesterol remained substantially stable (pooled MDΔ = 0.002 mmol/L; 95%HPD = -0.140; 0.147). No effects on triglycerides (pooled MDΔ = 0.045 mmol/L; 95%HPD = -0.195; 0.269) and bodymass index (BMI) (pooled MDΔ = 0.062 kg/m²; 95%HPD = -0.293; 0.469) were found. Hazelnut-enriched diet is associated with a decrease of LDL and total cholesterol, while HDL cholesterol, triglycerides and BMI remain substantially unchanged. https://greenmedinfo.com/article/hazelnut-enriched-diet-associated-decrease-ldl-and-total-cholesterol#comments Cardiovascular Disease Hazelnut Hypolipidemic Cardiovascular Disease cholesterol Hazelnut High Cholesterol Hypolipidemic Meta Analysis Review Thu, 19 Jan 2017 00:29:46 +0000 greenmedinfo 142195 at https://greenmedinfo.com These results indicate a chemopreventive potential of in vitro fermented hazelnuts. https://greenmedinfo.com/article/these-results-indicate-chemopreventive-potential-vitro-fermented-hazelnuts n/a PMID:  Anticancer Res. 2018 01 ;38(1):83-93. PMID: 29277760 Abstract Title:  Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. Abstract:  BACKGROUND/AIM: Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS: Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180.4°C/21 min) on chemopreventive effects of in vitro fermented hazelnuts was analyzed in LT97 colon adenoma cells. RESULTS: FS (2.5%) of raw and roasted hazelnuts reduced H2O2-induced DNA damage while 5% FS significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold). GPx1 mRNA levels were significantly decreased (0.6-fold) by FS (2.5%). The growth of LT97 cells was significantly reduced by hazelnut FS in a time- and dose-dependent manner. Hazelnut FS (5%) increased the numbers of early apoptotic cells (9.6% on average) and caspase-3 activities (6.4-fold on average). CONCLUSION: These results indicate a chemopreventive potential of in vitro fermented hazelnuts which is largely unaffected by the roasting process. https://greenmedinfo.com/article/these-results-indicate-chemopreventive-potential-vitro-fermented-hazelnuts#comments Colon Cancer DNA damage Fermented Foods and Beverages Hazelnut Anticarcinogenic Agents Antineoplastic Agents Antiproliferative Apoptotic Anticarcinogenic Agents Antineoplastic Agents Antiproliferative Apoptotic COLON CANCER DNA damage Fermented Foods and Beverages Hazelnut In Vitro Study Thu, 18 Jan 2018 15:53:23 +0000 greenmedinfo 158544 at https://greenmedinfo.com