Insulin Sensitizers https://greenmedinfo.com/category/keywords/Insulin%20Sensitizers en Litchi semen constituents can improve glycolipid metabolism and insulin resistance, and increase insulin sensitivity to cure T2DM. https://greenmedinfo.com/article/litchi-semen-constituents-can-improve-glycolipid-metabolism-and-insulin-resist n/a PMID:  Zhong Yao Cai. 2015 Jul ;38(7):1466-71. PMID: 26946845 Abstract Title:  [Effect and Mechanism of Litchi Semen Effective Constituents on Insulin Resistance in Rats with Type 2 Diabetes Mellitus]. Abstract:  OBJECTIVE: To observe the effect of Litchi Semen Effective Constituents (LSEC) on insulin resistance (IR) in rats with Type 2 Diabetes Mellitus(T2DM), and to explore its mechanism. METHOD: T2DM models in rats with IR were induced by high-fat feeding combined with streptozocin, then the rats were randomly divided into four groups: model group, LSEC high-dose group (1. 87 g/kg), LSEC low-dose group(0. 47 g/kg) and rosiglitazone group(3. 87 x 10(-3) g/kg), blank group was established as control. After medication for four weeks, effects of LSEC on glucose or lipid metabolism and insulin resistance were investigated, histopathology and ultrastructure changes of pancreatic tissues were observed,Stem-loop Real-time fluorescence quantitative RT-PCR was used for evaluation of GRP78 mRNA and CHOP mRNA levels in pancreatic tissue of rats. RESULT: LSEC of high-dose group obviously improved fasting blood glucose, serum TG level and glucose tolerance in T2DM rats (P<0. 05 or P<0. 01). ISI was increased, HOMA-IR index was decreased, histopathology change of pancreatic tissue were alleviated, damaged organelle, such as endoplasmic reticulum and mitochondria were repaired in both groups of LSEC. Expression levels of GRP78 mRNA of both groups of LSEC and CHOP mRNA of high-dose group in pancreatic tissue were obviously lower than those of model group (P<0. 01). CONCLUSION: LSEC can improve glycolipid metabolism and IR, increase insulin sensitivity to cure T2DM, its effects may be attributed, at least in part, to inhibit the expression of GRP78 mRNA and CHOP mRNA. https://greenmedinfo.com/article/litchi-semen-constituents-can-improve-glycolipid-metabolism-and-insulin-resist#comments Diabetes Mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Insulin Resistance Litchi Insulin Sensitizers MicroRNA modulator Pancreato Protective Agents Diabetes mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Insulin Resistance Insulin Sensitizers Litchi Plant Extracts Animal Study Tue, 31 Jan 2017 16:54:58 +0000 greenmedinfo 142805 at https://greenmedinfo.com Vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among gestational diabetes patients had beneficial effects. https://greenmedinfo.com/article/vitamin-d-and-omega-3-fatty-acids-co-supplementation-6-weeks-among-gestational n/a PMID:  J Clin Lipidol. 2017 Mar - Apr;11(2):459-468. Epub 2017 Feb 2. PMID: 28502503 Abstract Title:  The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes. Abstract:  OBJECTIVE: This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on glucose metabolism and lipid concentrations in gestational diabetes (GDM) patients. METHODS: This randomized double-blind placebo-controlled clinical trial was done among 140 GDM patients. Participants were randomly divided into 4 groups to receive: (1) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid and 240 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 35); (2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 35); (3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fattyacids twice a day (n = 35), and (4) vitamin D placebo + omega-3 fatty acids placebo (n = 35) for 6 weeks. RESULTS: After 6 weeks of intervention, patients who received combined vitamin D and omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids, and placebo had significantly decreased fasting plasma glucose (-7.3 ± 7.8, -6.9 ± 6.6, -4.0 ± 2.5, and +1.0 ± 11.4 mg/dL, respectively, P < .001), serum insulin levels (-1.9 ± 1.9, -1.3 ± 6.3, -0.4 ± 6.3, and +2.6 ± 6.5 μIU/mL, respectively, P = .005), homeostatic model of assessment for insulin resistance (-0.7 ± 0.6, -0.5 ± 1.4, -0.2 ± 1.5, and +0.6 ± 1.5, respectively, P < .001) and increased quantitative insulin sensitivity check index (+0.01 ± 0.01, +0.008 ± 0.02, +0.002 ± 0.02, and -0.005 ± 0.02, respectively, P = .001). In addition, changes in serum triglycerides (-8.2 ± 41.0, +7.6 ± 31.5, +3.6 ± 29.9, and +20.1 ± 29.6 mg/dL, respectively, P = .006) and very low-density lipoprotein cholesterol (-1.6 ± 8.2, +1.5 ± 6.3, +0.8 ± 6.0, and +4.0 ± 5.9 mg/dL, respectively, P = .006) in the vitamin D plus omega-3 fatty acids group were significantly different from the changes in these indicators in the vitamin D,omega-3 fatty acids, and placebo groups. CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels. https://greenmedinfo.com/article/vitamin-d-and-omega-3-fatty-acids-co-supplementation-6-weeks-among-gestational#comments Gestational Diabetes Omega-3 Fatty Acids Vitamin D Hypoglycemic Agents Insulin Sensitizers Gestational Diabetes Hypoglycemic Agents Insulin Sensitizers omega-3 fatty acids VITAMIN D Human Study Tue, 16 May 2017 20:34:23 +0000 greenmedinfo 147813 at https://greenmedinfo.com