Myocardial Fibrosis https://greenmedinfo.com/category/keywords/Myocardial%20Fibrosis en Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis. https://greenmedinfo.com/article/neferine-may-have-antifibrogenic-effects-diabetes-related-cardiac-fibrosis n/a PMID:  Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252 Abstract Title:  Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Abstract:  Cardiac fibrosis is a common pathological process accompanying diabetes mellitus. In this report, we studied the effects of neferine (a major bisbenzylisoquinline alkaloid derived from lotus embryos) on cardiac fibrosis induced by diabetes mellitus, as well as the underlying molecular pathways. In vivo, type 1 diabetes mellitus was induced in mice by administering streptozotocin. Diabetic mice were treated with neferine through oral gavage, and cardiac function was assessed using echocardiography. Total collagen deposition was assessed by Masson's trichrome and Picrosirius staining. In vitro, cardiac fibroblasts were cultured in normal or high-glucose medium with or without neferine. Neferine attenuated left ventricular dysfunction and remodeling and reduced collagen deposition in diabetic mice. In vitro, neferine inhibited cardiac fibroblast proliferation, migration, and differentiation into myofibroblasts. In addition, neferine reduced high-glucose-induced collagen production and inhibited TGF-β1-Smad, ERK and p38 MAPK signaling activation in cardiac fibroblasts. These results suggest that neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis. https://greenmedinfo.com/article/neferine-may-have-antifibrogenic-effects-diabetes-related-cardiac-fibrosis#comments Diabetic Complications Lotus Myocardial Fibrosis Anti-Fibrotic Cardioprotective Anti-Fibrotic Cardioprotective Diabetic Complications Lotus Myocardial Fibrosis Animal Study Tue, 21 Feb 2017 18:23:15 +0000 greenmedinfo 143797 at https://greenmedinfo.com Treatment by Nigella sativa reduced myocardial fibrosis in inflammation-induced fibrosis. https://greenmedinfo.com/article/treatment-nigella-sativa-reduced-myocardial-fibrosis-inflammation-induced-fibr n/a PMID:  Res Pharm Sci. 2017 Feb ;12(1):74-81. PMID: 28255317 Abstract Title:  The effect of Nigella sativa on inflammation-induced myocardial fibrosis in male rats. Abstract:  Nigella sativa (NS) (Ranunculaceae) used as a protective and therapeutic traditional medicine. This study evaluates the effect of NS on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. Fifty male Wistar rats were divided into five groups: (1) control; (2) lipopolysaccharide (LPS), 1 mg/kg/day; (3) LPS + NS (hydroalcoholic extract), 100 mg/kg/day; (4) LPS + NS, 200 mg/kg/day; (5) LPS + NS, 400 mg/kg/day (n = 10 in each group). The duration of LPS administration was two weeks. At the end of the experiment, blood samples were taken and ventricles were homogenized and stained for histological evaluation. Serum nitrite levels were lower in LPS group than the control group (22.98± 1.03 vs 28.5 ± 0.93 μmol/L), in which they were significantly increased by NS treatment (P<0.05). Higher levels of heart interlukine-6 (IL-6) and tumor necrosis factor-α (TNF-α) were observed in LPS group compared to the controls (IL-6: 6805 ± 656 vs 4733 ± 691 pg/mL; TNF-α: 6504 ± 501 vs 5309 ± 452 pg/mL), in which they were reduced by NS 400 mg/kg compared to LPS groups (P<0.05). A significant increment of malondialdehyde and reduction in heart total thiol, superoxide dismutase and catalase concentrations were observed in LPS group (p<0.05) which significantly restored with treatment by three doses of NS. Histopathological studies showed higher inflammatory cell infiltrates, cardiac fibrosis, and collagen deposition in LPS group, which were reduced by the administration of NS. Treatment by NS reduced myocardial fibrosis in inflammation-induced fibrosis, possibly through improving oxidative/anti-oxidative balance. https://greenmedinfo.com/article/treatment-nigella-sativa-reduced-myocardial-fibrosis-inflammation-induced-fibr#comments Inflammation Lipopolysaccharide-Induced Toxicity Myocardial Fibrosis Nigella sativa (aka Black Seed) Anti-Fibrotic Anti-Fibrotic Inflammation Lipopolysaccharide-Induced Toxicity Myocardial Fibrosis Nigella sativa (aka Black Seed) Animal Study Wed, 15 Mar 2017 19:58:45 +0000 greenmedinfo 144856 at https://greenmedinfo.com