Sleep Apnea: Central https://greenmedinfo.com/taxonomy/term/787/all en Acupuncture has therapeutic value in the treatment of moderate obstructive sleep apnea syndrome. https://greenmedinfo.com/article/acupuncture-has-therapeutic-value-treatment-moderate-obstructive-sleep-apnea-s PMID:  Sleep Med. 2007 Jan;8(1):43-50. Epub 2006 Oct 4. PMID: 17023212 Abstract Title:  Treatment of moderate obstructive sleep apnea syndrome with acupuncture: a randomised, placebo-controlled pilot trial. Abstract:  BACKGROUND AND PURPOSE: To investigate the efficacy of acupuncture in the treatment of moderate obstructive sleep apnea syndrome (OSAS), assessed by polysomnography (PSG) and questionnaires of functional quality of life (SF-36) and excessive daytime sleepiness (Epworth). PATIENTS AND METHODS: We performed a randomised, placebo-controlled, single-blinded study, with blinded evaluation on 36 patients presenting an apnea/hypopnea index (AHI) of 15-30/h, assessed by PSG. The study took place at the Public Hospital of the Universidade Federal de São Paulo, Brazil, in the Division of Sleep Disorders of the Department of Psychobiology, between January, 2002 and August, 2004. Patients were randomly assigned to three groups: the acupuncture group (n=12); the sham group, submitted to needle insertion in non-acupoints (n=12); and the control group, receiving no treatment (n=12). Patients received acupuncture or sham acupuncture once a week for 10 weeks. RESULTS: Twenty-six patients completed the study. The AHI (P=0.005), the apnea index (AI) (P=0.008) and the number of respiratory events (P=0.005) decreased significantly in the acupuncturegroup but not in the sham group. On the other hand, the control group displayed significant deterioration in some of the polysomnographic parameters, with a significant increase in the number of respiratory events (P=0.025). Acupuncture treatment significantly improved (before vs. after treatment) several dimensions of the SF-36 and Epworth questionnaires. There was no significant association between changes in the body mass index (BMI) and AHI. CONCLUSIONS: Acupuncture is more effective than sham acupuncture in ameliorating the respiratory events of patients presenting with moderate OSAS. https://greenmedinfo.com/article/acupuncture-has-therapeutic-value-treatment-moderate-obstructive-sleep-apnea-s#comments Sleep Apnea: Central Acupuncture Human Study Mon, 01 Mar 2010 17:03:54 +0000 greenmedinfo 53070 at https://greenmedinfo.com Antioxidant nutrient intake and supplementation may reduce cognitive decline and cardiovascular disease associated with obstructive sleep apnea. https://greenmedinfo.com/article/antioxidant-nutrient-intake-and-supplementation-may-reduce-cognitive-decline-a PMID:  Sleep Med Rev. 2005 Dec;9(6):459-76. Epub 2005 Oct 20. PMID: 16242980 Abstract Title:  Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea. Abstract:  Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q(10) on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA. https://greenmedinfo.com/article/antioxidant-nutrient-intake-and-supplementation-may-reduce-cognitive-decline-a#comments Antioxidant formulas Sleep Apnea: Central Commentary Fri, 17 Jul 2009 01:00:16 +0000 greenmedinfo 45637 at https://greenmedinfo.com Apnea: Sleep: Central https://greenmedinfo.com/disease/apnea-sleep-central <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="309" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Apnea_0.jpg?1468448821" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_BVDC&#039;&gt;BVDC / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:14:06 +0000 greenmedinfo 19030 at https://greenmedinfo.com Central Sleep Apnea https://greenmedinfo.com/disease/central-sleep-apnea <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="299" alt="" src="//cdn.greenmedinfo.com/sites/default/files/SleepApnea.jpg?1472345041" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_BVDC&#039;&gt;BVDC / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:15:20 +0000 greenmedinfo 19344 at https://greenmedinfo.com Congenital Central Hypoventilation Syndrome https://greenmedinfo.com/disease/congenital-central-hypoventilation-syndrome <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="338" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/LungProblems_16.jpg?1473353148" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_Eraxion&#039;&gt;Eraxion / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:15:55 +0000 greenmedinfo 19500 at https://greenmedinfo.com Green tea polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. https://greenmedinfo.com/article/green-tea-polyphenols-attenuate-behavioral-and-oxidative-responses-intermitten PMID:  Am J Respir Crit Care Med. 2008 May 15;177(10):1135-41. Epub 2008 Feb 14. PMID: 18276944 Abstract Title:  Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. Abstract:  RATIONALE: The intermittent hypoxia (IH) that characterizes sleep-disordered breathing impairs spatial learning and increases NADPH oxidase activity and oxidative stress in rodents. We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation. OBJECTIVES: To assess the effects of GTP administered in drinking water on the cognitive, inflammatory, and oxidative responses to long-term (&gt;14 d) IH during sleep in male Sprague-Dawley rats. METHODS: Cognitive assessments were conducted in the Morris water maze. We measured levels and expression of malondialdehyde (MDA), prostaglandin E(2), p47(phox) subunit of NADPH oxidase, receptor for advanced glycation end products (RAGE), and glial fibrillary acidic protein expression in rodent brain tissue. MEASUREMENTS AND MAIN RESULTS: GTP treatment prevented IH-induced decreases in spatial bias for the hidden platform during the Morris water maze probe trails as well as IH-induced increases in p47phox expression within the hippocampal CA1 region. In untreated animals, IH exposure was associated with doubling of cortical MDA levels in comparison to room air control animals, and GTP-treated animals exposed to IH showed a 40% reduction in MDA levels. Increases in brain RAGE and glial fibrillary acidic protein expression were observed in IH-exposed animals, and these increases were attenuated in animals treated with GTP. CONCLUSIONS: Oral GTP attenuates IH-induced spatial learning deficits and mitigates IH-induced oxidative stress through multiple beneficial effects on oxidant pathways. Because oxidative processes underlie neurocognitive deficits associated with IH, the potential therapeutic role of GTP in sleep-disordered breathing deserves further exploration. https://greenmedinfo.com/article/green-tea-polyphenols-attenuate-behavioral-and-oxidative-responses-intermitten#comments Brain Hypoxia Green Tea Hypoxia Sleep Apnea: Central Animal Study Thu, 16 Jul 2009 19:15:56 +0000 greenmedinfo 45593 at https://greenmedinfo.com Homocysteine levels may be elevated in obstructive sleep apnea. https://greenmedinfo.com/article/homocysteine-levels-may-be-elevated-obstructive-sleep-apnea PMID:  Chest. 2001 Sep;120(3):900-8. PMID: 11555527 Abstract Title:  Plasma homocysteine levels in obstructive sleep apnea: association with cardiovascular morbidity. Abstract:  OBJECTIVES: Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality. Plasma levels of homocysteine are also associated with cardiovascular morbidity and mortality. We therefore investigated homocysteine and conventional cardiovascular risk factors in OSA patients with and without cardiovascular morbidity in comparison with normal control subjects and ischemic heart disease (IHD) patients without OSA. SETTING: Technion Sleep Medicine Center, Haifa, Israel. METHODS AND PARTICIPANTS: Levels of homocysteine, cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, creatinine, vitamins B(12) and B(6), and folic acid were determined in 345 participants after overnight fasting. These included OSA patients with IHD (n = 49), with hypertension (n = 61), or without any cardiovascular disease (n = 127). Two control groups were employed: IHD patients without or with low likelihood for sleep apnea (n = 35), and healthy control subjects (n = 73). RESULTS: After adjustment for age, body mass index, creatinine, and existence of diabetes mellitus, OSA patients with IHD had significantly higher homocysteine levels (14.6 +/- 6.77 micromol/L) than all other groups including the IHD-only patients. Hypertensive OSA patients had comparable homocysteine levels to IHD patients (11.80 +/- 5.28 micromol/L and 11.92 +/- 5.7 micromol/L, respectively), while patients with OSA only had comparable levels to normal control subjects (9.85 +/- 2.99 micromol/L and 9.78 +/- 3.49 micromol/L, respectively). No differences in conventional cardiovascular risk factors or in vitamin levels were found between groups. CONCLUSIONS: Patients with the combination of IHD and OSA have elevated homocysteine levels. We hypothesize that these results may be explained by endothelial dysfunction combined with excess free-radical formation in OSA patients. https://greenmedinfo.com/article/homocysteine-levels-may-be-elevated-obstructive-sleep-apnea#comments Folic Acid High Homocysteine Sleep Apnea: Central Vitamin B-6 Diseases that are Linked Human Study Mon, 01 Mar 2010 17:32:49 +0000 greenmedinfo 53074 at https://greenmedinfo.com Hypoventilation: Central Alveolar https://greenmedinfo.com/disease/hypoventilation-central-alveolar <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="338" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/LungProblems_27.jpg?1478113667" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_Eraxion&#039;&gt;Eraxion / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:20:03 +0000 greenmedinfo 20533 at https://greenmedinfo.com Melatonin may protect against neurological injury associated with intermittent hypoxia (low oxygen) in patients with obstructive sleep apnea. https://greenmedinfo.com/article/melatonin-may-protect-against-neurological-injury-associated-intermittent-hypo PMID:  J Pineal Res. 2008 Mar;44(2):214-21. PMID: 18289174 Abstract Title:  Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. Abstract:  Obstructive sleep apnea (OSA) patients suffer from intermittent hypoxia (IH) and neuropsychologic impairments. Oxidative stress is involved in the pathogenesis of OSA, so the application of an antioxidant may be useful. We evaluated the hypothesis that melatonin would reduce IH-induced hippocampal injury via an increased expression of antioxidant enzymes. Adult Sprague-Dawley rats that had received a daily injection of melatonin or vehicle were exposed to IH for 8 hr/day for 7 or 14 days. The serum and hippocampus were harvested for the measurement of malondialdehyde (MDA). Apoptotic cell death was studied histologically in hippocampal sections. The mRNA expression of inflammatory mediators including tumor necrosis factor-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and antioxidant enzymes including glutathione peroxidase, catalase and copper/zinc superoxide dismutase were examined in the hippocampus by RT-PCR. The results show significant increases in levels of serum and hippocampal MDA, apoptotic cell death and mRNA levels of inflammatory mediators in hypoxic rats when compared with the normoxic controls. Also, mRNA levels of the antioxidant enzymes were decreased in hypoxic animals. In the melatonin-treated hypoxic rats, serum MDA levels were comparable with those in normoxic control rats. Also, melatonin treatment significantly reduced hippocampal MDA levels and totally prevented apoptosis. Moreover, there were a decreased expression of the inflammatory mediators and an elevated expression of antioxidant enzymes in the melatonin injected rats when compared with vehicle-treated animals. These results indicate that melatonin mitigates oxidative stress and the pathogenesis of IH-induced hippocampal injury via its antioxidant and anti-inflammatory properties which includes stimulation of transcriptional regulation of antioxidant enzymes. https://greenmedinfo.com/article/melatonin-may-protect-against-neurological-injury-associated-intermittent-hypo#comments Melatonin Sleep Apnea: Central Animal Study Fri, 17 Jul 2009 01:02:32 +0000 greenmedinfo 45638 at https://greenmedinfo.com Oncology Oncology Ondine Curse https://greenmedinfo.com/disease/oncology-oncology-ondine-curse <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="292" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Cancer_92.jpg?1483483932" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_vitanovski&#039;&gt;vitanovski / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:23:24 +0000 greenmedinfo 21301 at https://greenmedinfo.com Ondine Syndrome https://greenmedinfo.com/disease/ondine-syndrome <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="246" alt="" src="//cdn.greenmedinfo.com/sites/default/files/LungAnatomy_0.jpg?1483484610" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_vonuk&#039;&gt;vonuk / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:23:24 +0000 greenmedinfo 21302 at https://greenmedinfo.com Sleep-Disordered Breathing: Central https://greenmedinfo.com/disease/sleep-disordered-breathing-central <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="300" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Sleep_2.jpg?1486686248" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_ruigsantos&#039;&gt;ruigsantos / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Sleep Apnea: Central Tue, 14 Apr 2009 07:26:22 +0000 greenmedinfo 22041 at https://greenmedinfo.com Vitamin C improves endothelial function in obstructive sleep apnea. https://greenmedinfo.com/article/vitamin-c-improves-endothelial-function-obstructive-sleep-apnea PMID:  Am J Respir Crit Care Med. 2006 Apr 15;173(8):897-901. Epub 2006 Jan 26. PMID: 16439717 Abstract Title:  Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Abstract:  RATIONALE: Obstructive sleep apnea (OSA) is associated with oxidative stress, endothelial dysfunction, and increased cardiovascular morbidity and mortality. OBJECTIVE: We tested the hypothesis that endothelial dysfunction in patients with OSA is linked to oxidative stress. METHODS: In the present study, we measured flow-mediated dilation (FMD) of the brachial artery by ultrasound in 10 otherwise healthy, untreated patients with OSA and 10 age-and sex-matched control subjects without sleep-disordered breathing before and after intravenous injection of the antioxidant vitamin C. The investigator performing the FMD measurements was blinded to the status of the patients. RESULTS: When compared with control subjects, baseline FMD was significantly reduced in the patients with OSA. After intravenous injection of 0.5 g vitamin C, vasoreactivity remained unchanged in the control subjects. In the patients with OSA, ascorbate led to an increase in FMD to a level comparable to that observed in the control group. CONCLUSION: The reduced endothelial-dependent vasodilation in untreated patients with OSA acutely improves by the free radical scavenger vitamin C. These results are in favor of oxidative stress being responsible for the endothelial dysfunction in OSA. Antioxidant strategies should be explored for the treatment of OSA-related cardiovascular disease. https://greenmedinfo.com/article/vitamin-c-improves-endothelial-function-obstructive-sleep-apnea#comments Sleep Apnea: Central Vitamin C Human Study Fri, 17 Jul 2009 00:57:49 +0000 greenmedinfo 45636 at https://greenmedinfo.com Weight loss has a therapeutic effect on upper airway collapsibility in obstructive sleep apnea. https://greenmedinfo.com/article/weight-loss-has-therapeutic-effect-upper-airway-collapsibility-obstructive-sle PMID:  Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):494-8. PMID: 1892285 Abstract Title:  Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Abstract:  Previous investigators have demonstrated in patients with obstructive sleep apnea that weight reduction results in a decrease in apnea severity. Although the mechanism for this decrease is not clear, we hypothesize that decreases in upper airway collapsibility account for decreases in apnea severity with weight loss. To determine whether weight loss causes decreases in collapsibility, we measured the upper airway critical pressure (Pcrit) before and after a 17.4 +/- 3.4% (mean +/- SD) reduction in body mass index in 13 patients with obstructive sleep apnea. Thirteen weight-stable control subjects matched for age, body mass index, gender (all men), and non-REM disordered breathing rate (DBR) also were studied before and after usual care intervention. During non-REM sleep, maximal inspiratory airflow was measured by varying the level of nasal pressure and Pcrit was determined by the level of nasal pressure below which maximal inspiratory airflow ceased. In the weight loss group, a significant decrease in DBR from 83.3 +/- 31.0 to 32.5 +/- 35.9 episodes/h and in Pcrit from 3.1 +/- 4.2 to -2.4 +/- 4.4 cm H2O (p less than 0.00001) was demonstrated. Moreover, decreases in Pcrit were associated with nearly complete elimination of apnea in each patient whose Pcrit fell below -4 cm H2O. In contrast, no significant change in DBR and a minimal reduction in Pcrit from 5.2 +/- 2.3 to 4.2 +/- 1.8 cm H2O (p = 0.031) was observed in the &quot;usual care&quot; group. We conclude that (1) weight loss is associated with decreases in upper airway collapsibility in obstructive sleep apnea, and that (2) the resolution of sleep apnea depends on the absolute level to which Pcrit falls. https://greenmedinfo.com/article/weight-loss-has-therapeutic-effect-upper-airway-collapsibility-obstructive-sle#comments Sleep Apnea: Central Weight Reduction Human Study Mon, 01 Mar 2010 17:08:25 +0000 greenmedinfo 53072 at https://greenmedinfo.com