Sea buckthorn https://greenmedinfo.com/category/keywords/Sea%20buckthorn en Hippophae extract counters neuronal tissue injuries and changes in neurotransmitters: implications in radiation protection. https://greenmedinfo.com/article/hippophae-extract-counters-neuronal-tissue-injuries-and-changes-neurotransmitt n/a PMID:  Pharm Biol. 2017 Dec ;55(1):1833-1842. PMID: 28552029 Abstract Title:  A standardized Hippophae extract (SBL-1) counters neuronal tissue injuries and changes in neurotransmitters: implications in radiation protection. Abstract:  CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. Understanding CTA in rats is important because its process is considered parallel to nausea and vomiting in humans. OBJECTIVE: This study investigated the levels of neurotransmitters, antioxidant defences and histological changes in rats showing radiation CTA, and their modification by SBL-1. MATERIALS AND METHODS: The inbred male Sprague-Dawley rats (age 65 days, weighing 190 ± 10 g) were used. Saccharin-preferring rats were selected using standard procedure and divided into groups. Group I (untreated control) was administered sterile water, group II wasCo-γ-irradiated (2 Gy), and group III was administered SBL-1 before irradiation. Observations were recorded up to day 5. RESULTS: Irradiation (2 Gy) caused (i) non-recoverable CTA (≥ 64.7 ± 5.0%); (ii) degenerative changes in cerebral cortex, amygdala and hippocampus; (iii) increases in brain dopamine (DA, 63.4%), norepinephrine (NE, 157%), epinephrine (E, 233%), plasma NE (103%) and E (160%); and (iv) decreases in brain superoxide dismutase (67%), catalase (60%) and glutathione (51%). SBL-1 treatment (12 mg/kg body weight) 30 min before irradiation (i) countered brain injuries, (ii) reduced CTA (38.7 ± 3.0%, day 1) and (iii) normalized brain DA, NE, E, superoxide dismutase, catalase and CTA from day 3 onwards. DISCUSSION AND CONCLUSION: Radiation CTA was coupled with brain injuries, disturbances in neurotransmitters and antioxidant defences. SBL-1 pretreatment countered these disturbances, indicating neuroprotective action. https://greenmedinfo.com/article/hippophae-extract-counters-neuronal-tissue-injuries-and-changes-neurotransmitt#comments Chemotherapy and Radiation Toxicity Oxidative Stress Sea buckthorn Antioxidants Neuroprotective Agents Radioprotective Antioxidants Chemotherapy and Radiation Toxicity Neuroprotective Agents oxidative stress Plant Extracts Radioprotective Sea buckthorn Animal Study Sat, 07 Apr 2018 16:03:58 +0000 greenmedinfo 162347 at https://greenmedinfo.com Sea buckthorn twig and leaf extracts targeted some of Candida spp. virulence factors essential for the establishment of the infection.. https://greenmedinfo.com/article/sea-buckthorn-twig-and-leaf-extracts-targeted-some-candida-spp-virulence-facto n/a PMID:  Microb Pathog. 2017 Jun ;107:372-379. Epub 2017 Apr 18. PMID: 28428132 Abstract Title:  Novel properties of Hippophae rhamnoides L. twig and leaf extracts - anti-virulence action and synergy with antifungals studied in vitro on Candida spp. model. Abstract:  Original, chemically characterized Sea buckthorn (SBT) twig and leaf extracts were in vitro studied in terms of anti-Candida activity. Minimum inhibitory concentrations (MICs) of the extracts against C. albicans ATCC 10231 ranged: 250 μg/ml (twig), 31.5 μg/ml (leaf), and against C. glabrata G1 (clinical isolate) - 15.6 μg/ml (twig), 3.9 μg/ml (leaf). Next the extracts have been used at their subMIC. Both extracts significantly enhanced activity of fluconazole (FLC) and caspofungin (CAS) against C. albicans and increased their efficacy against C. glabrata, measured by an agar dilution assay combined with the E-test. The extracts inhibited C. albicans morphogenesissuch as germ tube and hyphae formation as well as invasion to the"Spider"Agar. Antiadhesive and anti-biofilm activities of the extracts were evaluated by Alamar Blue reduction assay. It showed not significant reduction in the degree of cell adhesion (by 10-15%) but noticeable decrease of biofilm formation (by 80% in the case of SBT-twig extract). In conclusion, this study provided the evidence that SBT extracts, used at non-cytotoxic concentrations for the fibroblasts (ICfrom 664.8 μg/ml to 1060.4 μg/ml), targeted some of Candida spp. virulence factors essential for the establishment of the infection. SBT twigs, previously regarded as waste material, were shown to be also a valuable source of the substances with promising antimicrobial activity. https://greenmedinfo.com/article/sea-buckthorn-twig-and-leaf-extracts-targeted-some-candida-spp-virulence-facto#comments Candida Albicans Candida Infection Sea buckthorn Antifungal Agents Antifungal Agents Candida Albicans Candida Infection Natural Substance/Drug Synergy Plant Extracts Sea buckthorn In Vitro Study Sat, 07 Apr 2018 15:52:11 +0000 greenmedinfo 162345 at https://greenmedinfo.com