Osteoarthritis https://greenmedinfo.com/taxonomy/term/825/all en Lactobacillus casei could act as a potent nutraceutical modulator forosteoarthritis treatment by reducing pain, inflammatory responses, and articular cartilage degradation. https://greenmedinfo.com/article/lactobacillus-casei-could-act-potent-nutraceutical-modulator-forosteoarthritis PMID:  Life Sci. 2010 Dec 16. Epub 2010 Dec 16. PMID: 21167838 Abstract Title:  Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Abstract:  AIMS: We previously reported that Lactobacillus casei (L. casei) has beneficial effects in experimental rheumatoid arthritis (RA) by suppressing inflammatory immune responses. The major purpose of this study was to evaluate therapeutic effects of L. casei on pathological responses in experimental rodent model of osteoarthritis (OA). MAIN METHODS: Experimental OA was induced by intra-articular injection of monosodium iodoacetate (MIA) in Wistar rats. L. casei alone or together with type II collagen (CII) and glucosamine (Gln) was orally administered into OA rats. The pathophysiological aspects of OA were investigated by analyzing mechanical hyperalgesia and histology of articular tissues. Expression of inflammatory molecules was analyzed in CD4(+) T cells, synovial fibroblasts, and chondrocytes by quantitative real-time PCR. KEY FINDINGS: Oral administration of L. casei together with CII and Gln more effectively reduced pain, cartilage destruction, and lymphocyte infiltration than the treatment of Gln or L. casei alone. This co-administration also decreased expression of various pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-2, IL-6, IL-12, IL-17, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ)) and matrix metalloproteinases (MMP1, MMP3, and MMP13), while up-regulating anti-inflammatory cytokines (IL-4 and IL-10). These results are concomitant with reduced translocation of NF-κB into the nucleus and increased expression of the tissue inhibitor of MMP1 (TIMP1) and CII in chondrocytes. SIGNIFICANCE: Our study provides evidence that L. casei could act as a potent nutraceutical modulator for OA treatment by reducing pain, inflammatory responses, and articular cartilage degradation. https://greenmedinfo.com/article/lactobacillus-casei-could-act-potent-nutraceutical-modulator-forosteoarthritis#comments Lactobacillus casei Osteoarthritis Anti-Inflammatory Agents Interleukin-12 downregulation Interleukin-17 downregulation Interleukin-2 Downregulation Matrix Metalloproteinases Inhibitors Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Thu, 30 Dec 2010 19:25:25 +0000 greenmedinfo 59956 at https://greenmedinfo.com Oridonin inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-γ. https://greenmedinfo.com/article/oridonin-inhibits-il-1-induced-inflammation-human-osteoarthritis-chondrocytes- PMID:  Int Immunopharmacol. 2019 Apr ;69:382-388. Epub 2019 Feb 16. PMID: 30776647 Abstract Title:  Oridonin inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-γ. Abstract:  Osteoarthritis (OA), a progressive disease of the joints, affects millions of people worldwide. In the present study, we investigated the effects of oridonin, a diterpenoid isolated from Rabdosia rubescens, on IL-1β-induced inflammation using human osteoarthritis chondrocytes. The results showed that oridonin significantly suppressed IL-1β-induced MMP1, MMP3, and MMP13 production. IL-1β-induced NO and PGEproduction, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin. Western blot analysis demonstrated IL-1β-induced NF-κB activation was reduced by oridonin. Furthermore, the expression of PPAR-γ was increased by oridonin in a concentration-dependent manner. PPAR-γ antagonist could reverse the anti-inflammatory activity of oridonin. The results suggested that oridonin could be a candidate agent forthe treatment of OA. <p><a href="https://greenmedinfo.com/article/oridonin-inhibits-il-1-induced-inflammation-human-osteoarthritis-chondrocytes-" target="_blank">read more</a></p> https://greenmedinfo.com/article/oridonin-inhibits-il-1-induced-inflammation-human-osteoarthritis-chondrocytes-#comments Inflammation Oridonin Osteoarthritis Anti-Inflammatory Agents Cyclooxygenase 2 Inhibitors Interleukin-1 beta downregulation Matrix metalloproteinase-1 (MMP-1) inhibitor Matrix Metalloproteinase-13 (MMP-13) Inhibitor Matrix metalloproteinase-3 (MMP-3) inhibitor NF-kappaB Inhibitor In Vitro Study Sun, 30 Aug 2020 16:05:02 +0000 greenmedinfo 226052 at https://greenmedinfo.com The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study https://greenmedinfo.com/article/protective-effect-hesperetin-osteoarthritis-vitro-and-vivo-study PMID:  Food Funct. 2020 Mar 26 ;11(3):2654-2666. PMID: 32159191 Abstract Title:  The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study. Abstract:  Osteoarthritis (OA), a progressive joint disorder, is principally characterized by the degeneration and destruction of articular cartilage. Previous research studies demonstrated that inflammation and ECM degradation play a major role in OA development. Hesperetin, the aglycone of neohesperidin found in the peel of Citrus aurantium L. (Rutaceae), demonstrated in several studies potential anti-inflammatory activity in a variety of diseases. However, the mechanisms by which hesperetin plays a protective role in osteoarthritis (OA) are not completely understood. In this study, we found the anti-inflammatory effects of hesperetin in the progression of OA in both in vitro and in vivo experiments. In vitro, IL-1β-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) were inhibited by hesperetin. Moreover, hesperetin down-regulated the IL-1β-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) while up-regulating collagen type II and aggrecan. Mechanistically, we revealed that hesperetin suppressed nuclear factor kappa B (NF-κB) signaling by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in IL-1β-induced chondrocytes. Hesperetin-induced repression of OA development is shown using a DMM model. Taken together, our findings suggest that hesperetin may be a novel potential therapeutic agent for repressing the development of OA. <p><a href="https://greenmedinfo.com/article/protective-effect-hesperetin-osteoarthritis-vitro-and-vivo-study" target="_blank">read more</a></p> https://greenmedinfo.com/article/protective-effect-hesperetin-osteoarthritis-vitro-and-vivo-study#comments Hesperidin Osteoarthritis Anti-Inflammatory Agents Antioxidants Cyclooxygenase 2 Inhibitors Matrix Metalloproteinase-13 (MMP-13) Inhibitor Nrf2 activation Postaglandin PGE2 downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study In Vitro Study Thu, 30 Jul 2020 23:18:49 +0000 greenmedinfo 224505 at https://greenmedinfo.com Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes. https://greenmedinfo.com/article/urolithin-attenuates-il-1-induced-inflammatory-responses-and-cartilage-degrada PMID:  J Inflamm (Lond). 2020 ;17:13. Epub 2020 Mar 24. PMID: 32210738 Abstract Title:  Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes. Abstract:  Background: Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties in several chronic diseases. However, the effects of UA on OA remain unclear. The aim of the current study was to investigate the anti-inflammatory effects and mechanism of UA in interleukin-1β (IL-1β)-induced chondrocytes.Results: No marked UA cytotoxicity was noted, and UA protected cartilage from damage following IL-1β stimulation in micromasses. Moreover, UA promoted the expression of anabolic factors including Sox-9, Collagen II, and Aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) in rat chondrocytes. Protective effects of UA were also observed in ex vivo organ culture of articular cartilage. Mechanistically, IL-1β significantly activated and upregulated the expression of p-ERK 1/2, p-JNK, p-P38, and p-P65, while UA protected chondrocytes against IL-1β-induced injury by activating the mitogen-activated kinase (MAPK)/nuclear factor-κB (NF-κB) signaling pathways.Conclusion: Our results provide the evidence that UA could attenuate IL-1β-induced cell injury in chondrocytes via its anti-inflammatory action. UA may be a promising therapeutic agent in the treatment of OA. <p><a href="https://greenmedinfo.com/article/urolithin-attenuates-il-1-induced-inflammatory-responses-and-cartilage-degrada" target="_blank">read more</a></p> https://greenmedinfo.com/article/urolithin-attenuates-il-1-induced-inflammatory-responses-and-cartilage-degrada#comments Osteoarthritis Urolithin A Anti-Inflammatory Agents Chondroprotective Interleukin-1 beta downregulation In Vitro Study Mon, 24 Aug 2020 21:36:10 +0000 greenmedinfo 225779 at https://greenmedinfo.com 10 Natural Remedies for Arthritis Management Backed By Clinical Studies https://greenmedinfo.com/content/10-natural-remedies-arthritis-management-backed-clinical-studies <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/10_Natural_Remedies_for_Arthritis_Management_Backed_by_Clinical_Studies-GreenMedInfo.jpg" /></p><p><a href="https://greenmedinfo.com/content/10-natural-remedies-arthritis-management-backed-clinical-studies" target="_blank">read more</a></p> https://greenmedinfo.com/content/10-natural-remedies-arthritis-management-backed-clinical-studies#comments Arthritis Bee Venom Curcumin Exercise Fish Oil Flaxseed Lemon Verbena Omega-3 Fatty Acids Osteoarthritis Pomegranate Sesame Seeds arthritis healing foods natural health Mon, 04 Mar 2024 11:00:00 +0000 GMI Research Group 288947 at https://greenmedinfo.com 18 Medicinal Properties of Cucumbers https://greenmedinfo.com/blog/18-medicinal-properties-cucumbers <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/18_Medical_Properties_of_Cucumbers-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p> <p><em style="font-size: 18px; letter-spacing: 0px;"><strong>Marvel over the humble cucumber with these 18 health benefits, which range from keeping your body cool and hydrated to helping prevent diseases such as diabetes</strong></em></p> <p><span style="letter-spacing: 0px;">Eat them raw and you get a juicy crunch. Cucumbers, however, do more than just serve as a refreshing feature of salads, sandwiches, slaws, pickles, noodles, cocktails and more. This popular produce pick, a member of the Cucurbitaceae family along with melon, squash and pumpkins, has been used in traditional medicine since ancient times for its unnumbered health benefits.</span></p><p><a href="https://greenmedinfo.com/blog/18-medicinal-properties-cucumbers" target="_blank">read more</a></p> https://greenmedinfo.com/blog/18-medicinal-properties-cucumbers#comments Atherosclerosis Cancers: All Constipation Cucumber Dehydration Diabetes Inflammation Obesity Osteoarthritis Postmenopausal Disorders Vegetables: All Vitamin K Water Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods fruits and vegetables healing foods natural alternatives Thu, 06 Jul 2023 17:14:09 +0000 GMI Research Group 245758 at https://greenmedinfo.com 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression. https://greenmedinfo.com/article/18-glycyrrhetinic-acid-inhibits-il-1-induced-inflammatory-response-mouse-chond PMID:  Food Funct. 2021 Aug 9. Epub 2021 Aug 9. PMID: 34369548 Abstract Title:  18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. Abstract:  Osteoarthritis (OA) is presently the most prevalent form of chronic degenerative joint disease, which is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis. Accumulating evidence has revealed that 18β-glycyrrhetinic acid (18β-GA), a major bioactive component derived from Glycyrrhiza glabra, exerts anti-inflammatory effects on several diseases. However, the anti-inflammatory effects of 18β-GA on OA remain undetermined. The present study aimed to investigate the anti-inflammatory effects of 18β-GA on chondrocytes and the therapeutic effects on destabilization of the medial meniscus destabilization (DMM) mouse models of OA. For the in vivo study, we randomly divided the mice into three groups: vehicle control (n = 15), sham (n = 15) and 18β-GA (n = 15) groups, and treated them with similar doses (50 mg kg-1 day-1) of 18β-GA or saline. Cartilage tissues were harvested from the mice for histological analyses eight weeks after operation. For the in vitro studies, mouse chondrocytes were administered with 10 ng mL-1 interleukin-1β (IL-1β) after being treated with 18β-GA at variousconcentrations. In vitro assays revealed that treatment with 18β-GA considerably suppressed the expression of pro-inflammatory mediators and cytokines, including prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), nitric oxide (NO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase(iNOS), and interleukin-6 (IL-6), which were induced by IL-1β. Furthermore, 18β-GA decreased the expression of matrix-degrading proteases, including matrix metalloproteinase 13 (MMP13) and A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), in a concentration-dependent manner, which mediated extracellular matrix (ECM) degradation. 18β-GA reversed aggrecan and type II collagen degradation. Furthermore, we observed that 18β-GA significantly suppressed IL-1β-induced nuclear factor kappa B (NF-κB) activation by activating the nuclear factor erythroid-derived 2-like2 (Nrf2)/heme oxygenase 1 (HO-1) pathway in vitro and in vivo. Experiments demonstrated that 18β-GA might alleviate the progression of OA in the DMM mouse model in vivo. The findings demonstrate that 18β-GA reduces inflammation induced by IL-1β in chondrocytes. Therefore, 18β-GA could be a potential therapeutic agent for OA. <p><a href="https://greenmedinfo.com/article/18-glycyrrhetinic-acid-inhibits-il-1-induced-inflammatory-response-mouse-chond" target="_blank">read more</a></p> https://greenmedinfo.com/article/18-glycyrrhetinic-acid-inhibits-il-1-induced-inflammatory-response-mouse-chond#comments 18β-Glycyrrhetinic Acid Osteoarthritis Anti-Inflammatory Agents Antioxidants Interleukin-1 beta downregulation Matrix Metalloproteinase-13 (MMP-13) Inhibitor Nrf2 activation Animal Study Mon, 13 Sep 2021 02:41:41 +0000 greenmedinfo 245661 at https://greenmedinfo.com 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside has anti-inflammatory activity and could be applied as a compound for treatment of osteoarthritis drug. https://greenmedinfo.com/article/2354-tetrahydroxystilbene-2-o-d-glucoside-has-anti-inflammatory-activity-and-c PMID:  Molecules. 2018 Mar 3 ;23(3). Epub 2018 Mar 3. PMID: 29510478 Abstract Title:  In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4&#039;-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum. Abstract:  Thunb. is a traditional herbal medicine that is rich in polyphenols. The major compound, 2,3,5,4&#039;-tetrahydroxystilbene-2--β-d-glucoside (THSG) has many pharmacological activities, such as antioxidative and free radical-scavenging properties, and the abilities to reduce hyperlipidemia, prevent lipid peroxidation, and protect the cardiovascular system. In this study, the anti-osteoarthritis (OA) effects of THSG were explored using in vitro and in vivo models. THSG inhibited nitric oxide (NO) and prostaglandin E₂ (PGE₂) production and inducible NO synthase (iNOS) and cyclooxygenase-2 expressions by lipopolysaccharide-stimulated RAW 264.7 cells. On the other hand, THSG inhibited PGE₂ production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1β-stimulated primary rat chondrocytes. Through a mono-iodoacetate-induced rat OA model assay, THSG reduced paw edema and improved the weight-bearing distribution. Therefore, THSG has anti-inflammatory activity and could be applied as a lead compound for the development as an OA drug. <p><a href="https://greenmedinfo.com/article/2354-tetrahydroxystilbene-2-o-d-glucoside-has-anti-inflammatory-activity-and-c" target="_blank">read more</a></p> https://greenmedinfo.com/article/2354-tetrahydroxystilbene-2-o-d-glucoside-has-anti-inflammatory-activity-and-c#comments Lipopolysaccharide-Induced Toxicity Osteoarthritis Anti-Inflammatory Agents Cyclooxygenase 2 Inhibitors Matrix Metalloproteinase-13 (MMP-13) Inhibitor Postaglandin PGE2 downregulation In Vitro Study Mon, 14 Jan 2019 23:46:41 +0000 greenmedinfo 177532 at https://greenmedinfo.com 2-butoxyethanol may contribute to the pathogenesis of osteoarthritis. https://greenmedinfo.com/article/2-butoxyethanol-may-contribute-pathogenesis-osteoarthritis PMID:  Br J Oral Maxillofac Surg. 2009 Dec 22. Epub 2009 Dec 22. PMID: 20034712 Abstract Title:  2-Butoxyethanol model of haemolysis and disseminated thrombosis in female rats: a preliminary study of the vascular mechanism of osteoarthritis in the temporomandibular joint. Abstract:  Female rats develop haemolytic anaemia and disseminated thrombosis and infarction in multiple organs, including bone, when exposed to 2-butoxyethanol (BE). There is growing evidence that vascular occlusion of the subchondral bone may play a part in some cases of osteoarthritis. The subchondral bone is the main weight bearer as well as the source of the blood supply to the mandibular articular cartilage. Vascular occlusion is thought to be linked to sclerosis of the subchondral bone associated with disintegration of the articular cartilage. The aim of this study was to find out whether this model of haemolysis and disseminated thrombosis supports the vascular hypothesis of osteoarthritis. Six female rats were given BE orally for 4 consecutive days and the two control rats were given tap water alone. The rats were killed 26 days after the final dose. The mandibular condyles showed histological and radiological features consistent with osteoarthritis in three of the four experimental rats and in neither of the control rats. These results may support the need to explore the vascular mechanism of osteoarthritis further. https://greenmedinfo.com/article/2-butoxyethanol-may-contribute-pathogenesis-osteoarthritis#comments Osteoarthritis 2-Butoxyethanol Animal Study Wed, 05 May 2010 19:01:36 +0000 greenmedinfo 55086 at https://greenmedinfo.com 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation. https://greenmedinfo.com/article/33-diindolylmethane-inhibits-lps-induced-human-chondrocytes-apoptosis-and-extr PMID:  Front Pharmacol. 2022 ;13:999851. Epub 2022 Nov 10. PMID: 36438802 Abstract Title:  3,3&#039;-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Abstract:  Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylmethane (DIM), a phytoconstituent extracted from cruciferous vegetables, has various effects such as anti-inflammatory, antioxidant and anti-apoptotic. However, the effects of DIM on osteoarthritic chondrocytes remain undetermined. In this study, we simulated a lipopolysaccharide (LPS)-induced osteoarthritis model in human primary chondrocytes. We found that LPS stimulation significantly inhibited autophagy, induced chondrocyte apoptosis and extracellular matrix (ECM) degradation, which could be ameliorated by DIM. DIM inhibited the expression of a disintegrin and metalloproteinase with thrombospondin motif 5 (ADAMTS-5), matrix metalloproteinase 13 (MMP13), cleaved caspase-3, Bax, and p62, and increased the expression level of collagen II, aggrecan, Bcl-2, light chain 3Ⅱ(LC3Ⅱ), and beclin-1. Mechanistic studies showed that DIM increased chondrocyte autophagy levels by inhibiting the activation of PI3K/AKT/mTOR pathway. In mice destabilization of the medial meniscus (DMM) model, immunohistochemical analysis showed that DIM inhibited the expression of p-PI3K and cleaved caspase-3, increased the expression of LC3Ⅱ. Furthermore, DIM relieved joint cartilage degeneration. In conclusion, our findings demonstrate for the first time that DIM inhibits LPS-induced chondrocyte apoptosis and ECM degradation by regulating the PI3K/AKT/mTOR-autophagy axis and delays OA progression. <p><a href="https://greenmedinfo.com/article/33-diindolylmethane-inhibits-lps-induced-human-chondrocytes-apoptosis-and-extr" target="_blank">read more</a></p> https://greenmedinfo.com/article/33-diindolylmethane-inhibits-lps-induced-human-chondrocytes-apoptosis-and-extr#comments Lipopolysaccharide-Induced Toxicity Osteoarthritis Anti-Apoptotic Chondroprotective In Vitro Study Thu, 08 Jun 2023 18:15:23 +0000 greenmedinfo 274116 at https://greenmedinfo.com 5 Common Kitchen Foods to Reduce Inflammation Naturally https://greenmedinfo.com/blog/5-common-kitchen-foods-reduce-inflammation-naturally <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Purple%20Yellow%20Blue%20Rainbow%20Pastel%20Gradient%20Beauty%20Vlogger%20-%20Youtube%20Channel%20Art.png" style="width: 1280px; height: 720px;" /></p> <p><span style="font-size:22px;"><em><strong>Our kitchens may hold the keys to combatting inflammation in a safe, natural, and effective way.</strong></em></span></p> <p><span style="font-size:16px;"><span style="letter-spacing: 0px;">It has been established that inflammation is an underlying contributing factor in multiple diseases that afflict Western society. Unfortunately, the Standard American Diet, as well as poor lifestyle choices such as inactivity, contribute to the wide-spread presence of inflammation in the population. </span></span></p><p><a href="https://greenmedinfo.com/blog/5-common-kitchen-foods-reduce-inflammation-naturally" target="_blank">read more</a></p> https://greenmedinfo.com/blog/5-common-kitchen-foods-reduce-inflammation-naturally#comments Arthritis: Rheumatoid Blueberry Curcumin Diabetes Ginger Green Tea Inflammation Kidney Damage Metabolic Syndrome X Osteoarthritis Pomegranate Post-Traumatic Stress Disorders (PTSD) Turmeric anti-diabetic anti-inflammatory Health Guide: Turmeric Health Guides: Healing Foods anti-diabetic anti-inflammatory Arthritis: Rheumatoid Blueberry CURCUMIN Diabetes Ginger GREEN TEA Inflammation pomegranate Turmeric Wed, 08 Jun 2022 01:24:47 +0000 tara@tarathornenutrition.com 151038 at https://greenmedinfo.com 6 Bodily Tissues That Can Be Regenerated Through Nutrition https://greenmedinfo.com/blog/6-bodily-tissues-can-be-regenerated-through-nutrition2 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="6 Bodily Tissues That Can Be Regenerated Through Nutrition" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/greenmedinfo/images/tissue_regeneration(1).jpg" style="width: 300px; height: 400px;" title="6 Bodily Tissues That Can Be Regenerated Through Nutrition" /></p> <p><span style="font-size:20px;"><em><strong>It may come as a surprise to some, especially those with conventional medical training, but the default state of the body is one of ceaseless <a href="/blog/flame-cell-life-death-miracle-regeneration" rel="dofollow" target="_blank">regeneration</a>. Without the flame-like process of continual cell turnover within the body - life and death ceaselessly intertwined - the miracle of the human body would not exist</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/6-bodily-tissues-can-be-regenerated-through-nutrition2" target="_blank">read more</a></p> https://greenmedinfo.com/blog/6-bodily-tissues-can-be-regenerated-through-nutrition2#comments Brain Damage Curcumin Demyelinating Diseases Glycyrrhizin Neurodegenerative Diseases Osteoarthritis Resveratrol Spinal Cord Injuries Stevia Trigonelline Vitamin C Blood Sugar Problems Health Guide: Aging Heart Health Neuritogenic Secretagogue Beta Cell Regeneration Bodily Tissue Regeneration Bone Regeneration Hormone Regeneration Liver Regeneration Myocardial Regeneration natural Bodily Tissue Regeneration Regenerative Actions Regenerative Substances Remyelination Sat, 29 Oct 2022 00:03:34 +0000 Sayer Ji 75902 at https://greenmedinfo.com 7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis. https://greenmedinfo.com/article/78-dihydroxyflavone-activates-nrf2ho-1-signaling-pathways-and-protects-against PMID:  Exp Ther Med. 2019 Sep ;18(3):1677-1684. Epub 2019 Jul 8. PMID: 31410125 Abstract Title:  7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis. Abstract:  The aim of the present study was to investigate the effect of 7,8-dihydroxyflavone (7,8-DHF) against osteoarthritis (OA) and examine its regulatory role in the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway in chondrocytes. Primary mouse chondrocytes were treated with 7,8-DHF to examine the expression of Nrf2 and downstream heme oxygenase 1 (HO-1). The surgical destabilization of the medial meniscus model was used to assess the effectiveness of 7,8-DHF in protecting the cartilage from damage, with knee cartilage harvested from mice for histological analysis. The results revealed that 7,8-DHF activated the Nrf2 signaling pathway in primary chondrocytes. Cartilage degradation in the 7,8-DHF-treated group was reduced significantly compared with that in the vehicle-treated group, according to histological evaluation. The gene expression of matrix metalloproteinase (MMP)1, MMP3, MMP13, interleukin (IL)-1β, IL-6 and tumor necrosis factor-α were reduced in the cartilage of OA mice following 7,8-DHF treatment. Genetic and protein analyses indicated that the expression levels of HO-1 were upregulated in the cartilage of the knee with OA, and 7,8-DHF treatment further promoted the induction of HO-1. These results suggest that 7,8-DHF may serve as a potential therapeutic agent in OA. <p><a href="https://greenmedinfo.com/article/78-dihydroxyflavone-activates-nrf2ho-1-signaling-pathways-and-protects-against" target="_blank">read more</a></p> https://greenmedinfo.com/article/78-dihydroxyflavone-activates-nrf2ho-1-signaling-pathways-and-protects-against#comments Osteoarthritis Antioxidants Heme oxygenase-1 up-regulation Nrf2 activation In Vitro Study Tue, 12 Oct 2021 01:39:02 +0000 greenmedinfo 247170 at https://greenmedinfo.com 8 Prescriptions Sabotaging Your Bone Density & Increasing Fracture Risk https://greenmedinfo.com/content/8-prescriptions-sabotaging-your-bone-density-increasing-fracture-risk <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Untitled%20design-5(16).png" style="width: 600px; height: 600px;" /></p> <p><span style="font-size:18px;"><em><strong><span style="font-family:verdana,geneva,sans-serif;"><span style="letter-spacing: 0px;">Trusted treatments you'd never suspect could be stealthily chipping away at your bone health. A 2021 review compiles extensive data on 7 drug classes that studies connect to a significant deterioration of skeletal integrity, density, and shockingly higher fracture rates.</span></span></strong></em></span></p><p><a href="https://greenmedinfo.com/content/8-prescriptions-sabotaging-your-bone-density-increasing-fracture-risk" target="_blank">read more</a></p> https://greenmedinfo.com/content/8-prescriptions-sabotaging-your-bone-density-increasing-fracture-risk#comments Acid Reflux antidepressants Drug-Induced Toxicity: Aromatase Inhibitors NSAIDs Osteoarthritis Arthritic High Bone Density arthritis NSAIDs Osteoporosis Thu, 22 Feb 2024 16:32:00 +0000 GMI reporter 288811 at https://greenmedinfo.com 9 Health Benefits of Garlic https://greenmedinfo.com/blog/9-health-benefits-garlic <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/9_Health_Benefits_of_Garlic-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /><br /> <span style="font-size:12px;"><strong>Originally published on <a href="http://www.mercola.com" rel="dofollow" target="_blank">www.mercola.com</a></strong></span></p> <p><strong style="letter-spacing: 0px;">STORY AT-A-GLANCE</strong></p><p><a href="https://greenmedinfo.com/blog/9-health-benefits-garlic" target="_blank">read more</a></p> https://greenmedinfo.com/blog/9-health-benefits-garlic#comments Atherosclerosis Blood Pressure: High Cancers Fungal Infection Garlic Metabolic Syndrome X Osteoarthritis Potassium Zinc Health Guide: Farm/Pharma Face Off Health Guide: Herbs and Traditional Knowledge Health Guides: Healing Foods Heart Health Osteoporosis/Osteopenia aged garlic healing foods natural health Tue, 28 Nov 2023 22:03:13 +0000 mercola 283984 at https://greenmedinfo.com