Overactive Bladder https://greenmedinfo.com/taxonomy/term/8901/all en "Green tea catechins decrease oxidative stress in surgical menopause-induced overactive bladder in a rat model." https://greenmedinfo.com/article/green-tea-catechins-decrease-oxidative-stress-surgical-menopause-induced-overa PMID:  BJU Int. 2012 Sep ;110(6 Pt B):E236-44. Epub 2012 May 28. PMID: 22639915 Abstract Title:  Green tea catechins decrease oxidative stress in surgical menopause-induced overactive bladder in a rat model. Abstract:  UNLABELLED: What&#039;s known on the subject? and What does the study add? Ovary hormone deficiency and the age-related changes in post-menopausal women are subjected to a number of urological dysfunctions, including overactive bladder syndrome. Green tea is a popular healthy drink worldwide and its extract catechin has strong anti-inflammatory and antioxidant properties. EGCG, the major type of catechin, is an antioxidant polyphenol flavonoid isolated from green tea. EGCG supplement could prevent ovariectomy-induced bladder dysfunction in a dose-related manner through its anti-oxidant, anti-fibrosis and anti-apoptosis effects.OBJECTIVE: To evaluate whether green tea extract, epigallocatechin gallate (EGCG), could prevent ovariectomy-induced overactive bladder (OAB) and to investigate its antioxidant, anti-apoptotic and anti-fibrosis effects.MATERIALS AND METHODS: In all, 48 female Sprague-Dawley rats were divided into four groups. After bilateral ovariectomy, the first group served as the ovariectomy control, the second group received EGCG 1µM/kg daily i.p. injection after ovariectomy surgery, and the third group received EGCG 10 µM/kg daily i.p. injection. The fourth group was taken as the sham without ovariectomy surgery. The rats were killed after 6 months after ovariectomy surgery. Cystometrograms were performed for the measure of bladder overactivity. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) assay was used to evaluate apoptotic cells. Western immunoblots were performed to determine the expressions of inflammatory markers, apoptosis-associated proteins and oxidative stress markers.RESULTS: Long-term ovariectomy significantly increased non-voiding contractions and decreased bladder compliance. Treatment with EGCG significantly increased bladder compliance and diminished non-voiding contractions. Ovariectomy significantly increased apoptotic cells and enhanced interstitial fibrosis in bladders. The expression of caspase-3 significantly increased, while that of Bcl-2 notably decreased after ovariectomy. Inflammatory and fibrosis markers, TGF-β, fibronectin and type I collagen expressions were significantly increased after 6 months of ovariectomy surgery. Treatment with EGCG significantly decreased TGF-β and type I collagen expressions. Oxidative stress markers, nitrotyrosine and protein carbonylation levels were significantly increased in the ovariectomy group. EGCG could attenuate this oxidative damage in dose-dependent fashion.CONCLUSIONS: Ovariectomy increased oxidative damage, enhanced voiding frequency and decreased bladder compliance. EGCG could restore ovariectomy-induced bladder dysfunction in a dose-dependent fashion through antioxidant, anti-fibrosis and anti-apoptosis effects. https://greenmedinfo.com/article/green-tea-catechins-decrease-oxidative-stress-surgical-menopause-induced-overa#comments Catechin Overactive Bladder Oxidative Stress Tea Antioxidants Ovariectomy-Induced Changes Plant Extracts Animal Study Wed, 19 Dec 2012 19:15:26 +0000 greenmedinfo 87200 at https://greenmedinfo.com . The use of Lactobacillus-containing feminine products was associated with improved vaginal ecosystem and urogenital health. https://greenmedinfo.com/article/use-lactobacillus-containing-feminine-products-was-associated-improved-vaginal PMID:  PLoS One. 2022 ;17(12):e0270242. Epub 2022 Dec 30. PMID: 36584204 Abstract Title:  Evaluation of the efficacy of Lactobacillus-containing feminine hygiene products on vaginal microbiome and genitourinary symptoms in pre- and postmenopausal women: A pilot randomized controlled trial. Abstract:  As estrogen level decreases with aging, the vaginal mucosa gets thinner, and collagen amount decreases. In addition, the population of Lactobacillus in the vagina declines, increasing the risk of atrophic vaginitis, bacterial vaginosis, and genitourinary symptoms in the postmenopausal women. In this study, we evaluated the effects of Lactobacillus-containing feminine hygiene products on vaginal microbiome and genitourinary symptoms in pre- and postmenopausal women. This was a pilot randomized controlled trial in 35 premenopausal and 35 postmenopausal healthy women. For 4 weeks, treatment 1 group (14 premenopausal and 16 postmenopausal women) used the Lactobacillus-containing feminine soap and cream, and treatment 2 group (15 premenopausal and 14 postmenopausal women) used Lactobacillus-containing feminine gel in addition to soap and cream. The remaining 6 premenopausal and 5 postmenopausal women served as controls without using any products. We then compared the changes in the vaginal microbiota, genitourinary symptoms, and other related biomarkers after completion of treatment. Vaginal pH and pathogenic flora were reduced in both treatment groups compared to control group, which was more significant in the treatment 2 group of postmenopausal women. Genitourinary symptoms significantly improved in 60% of premenopausal women in treatment 1 group and 81.3% of postmenopausal women in treatment 2 group, compared to control group (0%, p = 0.043 and p<p><a href="https://greenmedinfo.com/article/use-lactobacillus-containing-feminine-products-was-associated-improved-vaginal" target="_blank">read more</a></p> https://greenmedinfo.com/article/use-lactobacillus-containing-feminine-products-was-associated-improved-vaginal#comments Atrophic Vaginitis (Vaginal Atrophy) Lactobacillus Acidophilus Overactive Bladder Human Study Mon, 30 Jan 2023 19:12:02 +0000 greenmedinfo 270320 at https://greenmedinfo.com Acupuncture has significant improvements in bladder capacity, urgency, frequency, and quality-of-life scores in women with overactive bladder. https://greenmedinfo.com/article/acupuncture-has-significant-improvements-bladder-capacity-urgency-frequency-an PMID:  Obstet Gynecol. 2005 Jul;106(1):138-43. PMID: 15994629 Abstract Title:  Acupuncture for overactive bladder: a randomized controlled trial. Abstract:  OBJECTIVE: To compare acupuncture treatment for overactive bladder with urge incontinence with a placebo acupuncture treatment. METHODS: Eighty-five women enrolled in this randomized, placebo-controlled trial. Women were randomly assigned to either receive an acupuncture treatment expected to improve their bladder symptoms, or a placebo acupuncture treatment designed to promote relaxation. They underwent cystometric testing, completed a 3-day voiding diary, and completed the urinary distress inventory and incontinence impact questionnaire, validated quality-of-life inventories, before and after 4 weekly acupuncture treatments. The primary endpoint was number of incontinent episodes over 3 days. Secondary endpoints included voiding frequency and urgency, cystometric bladder capacity, maximum voided volume, and the urinary distress inventory and incontinence impact questionnaire symptom scores. RESULTS: Seventy-four women completed all aspects of the study. Women in both treatment and placebo groups had significant decreases in number of incontinent episodes (59% for treatment, 40% for placebo) without a significant difference in the change between the groups. Women in the treatment group had a 14% reduction in urinary frequency (P = .013), a 30% reduction in the proportion of voids associated with urgency (P = .016), and a 13% increase in both maximum voided volume and maximum cystometric capacity (P = .01). Both groups also had an improvement in the urinary distress inventory and incontinence impact questionnaire scores (54% decrease for treatment, 30% decrease for placebo, P &lt; .001 for the difference in change between the groups). CONCLUSION: Women who received 4 weekly bladder-specific acupuncture treatments had significant improvements in bladder capacity, urgency, frequency, and quality-of-life scores as compared with women who received placebo acupuncture treatments. LEVEL OF EVIDENCE: I. https://greenmedinfo.com/article/acupuncture-has-significant-improvements-bladder-capacity-urgency-frequency-an#comments Overactive Bladder Acupuncture Human Study Wed, 09 Dec 2009 21:10:04 +0000 greenmedinfo 48200 at https://greenmedinfo.com Catechins prevents experimentally-induced hyperactive bladder in rats. https://greenmedinfo.com/article/catechins-prevents-experimentally-induced-hyperactive-bladder-rats PMID:  Neurosci Lett. 2004 Sep 2;367(2):213-7. PMID: 15331156 Abstract Title:  Catechins prevents substance P-induced hyperactive bladder in rats via the downregulation of ICAM and ROS. Abstract:  We previously reported substance P (SP) via neurokinin type 1 receptor facilitates bladder afferent signaling and reactive oxygen species (ROS) formation in bladder connected with neurogenic inflammation [Am. J. Physiol. Renal Physiol. 284 (2003) F840]. Increased intercellular adhesion molecule expression and subsequent leukocyte adhesion in the inflamed bladder contribute to SP-induced oxidative injury. Here we investigate the effect of green tea extract (catechins) on SP-induced bladder hyperactivity. We evaluated isovolumetric cystometrogram, adhesion molecular expression, and ROS activity in anesthetized rat bladder with SP stimulation. Our results showed that SP increased the amount of leukocyte ROS production in vitro in a dose-dependent manner and the enhanced ROS can be inhibited by catechins treatment. Exogenous SP increased ROS in vivo in the bladder via increased intercellular adhesion molecule expression and subsequent leukocyte adhesion, a primary source of ROS in the inflamed bladder. Two weeks of catechins pretreatment reduced SP-induced bladder intercellular adhesion molecule expression and ROS amount and ameliorated the hyperactive bladder response. These results indicate that catechins pretreatment can ameliorate SP-induced neurogenic inflammation via the action of antioxidant, anti-adhesion, and anti-inflammatory activity. https://greenmedinfo.com/article/catechins-prevents-experimentally-induced-hyperactive-bladder-rats#comments Catechin Overactive Bladder Antioxidants Animal Study Wed, 17 Feb 2010 18:55:02 +0000 greenmedinfo 51668 at https://greenmedinfo.com Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women. https://greenmedinfo.com/article/cucurbita-pepo-rhus-aromatica-humulus-lupulus-combination-reduces-overactive-b PMID:  Planta Med. 2019 Jul 1. Epub 2019 Jul 1. PMID: 31261419 Abstract Title:  Cucurbita pepo-Rhus aromatica-Humulus lupulus Combination Reduces Overactive Bladder Symptoms in Women - A Noninterventional Study. Abstract:  This prospective, noninterventional, multicenter 12-wk study in women with overactive bladder investigated the effectiveness of Granu Fink femina, a herbal combination of seed oil from Uromedic pumpkin (cultivar of),(fragrant sumach) bark extract, and(hop) cone extract in a clinical setting. Patients documented overactive bladder symptoms and quality of life using questionnaires as well as diaries recording day- and nighttime micturition frequencies, urine leakages during physical activity or at sneezing or coughing, and use of incontinence pads. The full analysis set included 117 women (age: 21 - 78 y). Urination frequency decreased significantly with improvement during daytime in 49, 71, and 77 (out of 99) patients and at night in 45, 63, and 70 (out of 100) patients after 1, 6, and 12 wk, respectively. The mean frequency of leakages and used pads decreased significantly from 0.9leakages and 2.0 pads at baseline to 0.4 leakages and 1.4 pads after 12 wk. In all measured aspects of overactive bladder-related quality of life, (coping, concern, sleep, social), statistically significant improvement was reached after 1 wk, with further improvement at 6 and 12 wk. Ninety-nine percent of the physicians and 95.4% of the patients rated tolerability as&quot;very good&quot;or&quot;good&quot;. Treatment with Granu Fink femina progressively improved overactive bladder symptoms and related quality of life with significant improvements already after 1 wk. Based on these effects and the observed excellent tolerability profile, Granu Fink femina may be considered a valuable therapeutic option for overactive bladder. <p><a href="https://greenmedinfo.com/article/cucurbita-pepo-rhus-aromatica-humulus-lupulus-combination-reduces-overactive-b" target="_blank">read more</a></p> https://greenmedinfo.com/article/cucurbita-pepo-rhus-aromatica-humulus-lupulus-combination-reduces-overactive-b#comments Hops Overactive Bladder Pumpkin Plant Extracts Human Study Fri, 02 Aug 2019 02:44:27 +0000 greenmedinfo 192603 at https://greenmedinfo.com Efficacy and safety of a new complementary and alternative medicine (CAM) versus Solifenacin Succinate in women with overactive bladder syndrome. https://greenmedinfo.com/article/efficacy-and-safety-new-complementary-and-alternative-medicine-cam-versus-soli PMID:  Arch Ital Urol Androl. 2017 Dec 31 ;89(4):296-300. Epub 2017 Dec 31. PMID: 29473382 Abstract Title:  A randomized, multicenter, controlled study, comparing efficacy and safety of a new complementary and alternative medicine (CAM) versus Solifenacin Succinate in women with overactive bladder syndrome. Abstract:  INTRODUCTION: To assess efficacy and tolerability of a new complementary and alternative medicine (CAM) consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum capsicatum) and amino acid L-Glutammina, in the treatment of female Overactive Bladder syndrome (OAB).MATERIALS AND METHODS: 90 consecutive women with OAB symptoms were enrolled in this prospective, randomized, controlled study. Women were divided randomly into two groups of 45 patients each. In group A, women received Solifenacin Succinate (SS), 5 mg. once a day for 12 weeks. In group B, women received CAM, 930 mg, twice daily for 12 weeks. Women were assessed with 3-day micturition diary, Patient Perception of Intensity of Urgency Scale (PPIUS), Overactive Bladder questionnaire Short Form (OAB-q SF) and Patient Global Impression of Improvement questionnaire (PGI-I).RESULTS: 8 patients in group A and 1 patient in group B dropped out from therapy because of side effects. A reduction in the number of daily micturitions, nocturia and episodes of urge incontinence was present with both SS and CAM with statistically highly significant differences, but CAM was significantly more effective than SS. PPIUS and OAB-q SF showed improvements with both SS and CAM with a more significant efficacy of CAM. PGI-I, demonstrated improvements in the two groups of patients with a greater satisfaction expressed by patients treated with CAM.CONCLUSIONS: the small number of patients does not permit definitive conclusions; however, the results of the research showed the greater effectiveness and tolerability of CAM. <p><a href="https://greenmedinfo.com/article/efficacy-and-safety-new-complementary-and-alternative-medicine-cam-versus-soli" target="_blank">read more</a></p> https://greenmedinfo.com/article/efficacy-and-safety-new-complementary-and-alternative-medicine-cam-versus-soli#comments Chili pepper Overactive Bladder Pumpkin Vitamin C Vitamin D Human Study Fri, 02 Feb 2024 22:59:21 +0000 greenmedinfo 287523 at https://greenmedinfo.com Efficacy of cinnamon patch treatment for alleviating symptoms of overactive bladder. https://greenmedinfo.com/article/efficacy-cinnamon-patch-treatment-alleviating-symptoms-overactive-bladder PMID:  Phytomedicine. 2021 Jan ;80:153380. Epub 2020 Oct 12. PMID: 33091856 Abstract Title:  Efficacy of cinnamon patch treatment for alleviating symptoms of overactive bladder: A double-blind, randomized, placebo-controlled trial. Abstract:  BACKGROUND: Current treatments for overactive bladder (OAB) have limited efficacy, low persistence and a high rate of adverse events commonly leading to treatment cessation in clinical practice. Clinicians in Asia commonly use traditional Chinese medicine as an alternative for OAB treatment despite it having uncertain efficacy and safety. To evaluate the efficacy and safety of cinnamon patch (CP) treatment for alleviating symptoms of OAB, a double-blind randomized, placebo-controlled trial was conducted in the present study.MATERIALS AND METHODS: In this 6-week randomized clinical trial conducted in an outpatient setting, 66 subjects diagnosed as having OAB were enrolled and treated with a placebo (n=33) or CP (n=33). The OAB symptom score (OABSS) was selected as the primary end point, and a patient perception of bladder condition (PPBC), an urgency severity scale (USS), and post-voiding residual urine (PVR) volume were selected as secondary end points. Statistical analyses were performed with IBM SPSS Statistics 20. Groups were compared using an independent sample t-test, Fisher exact test, and Chi-squared test.RESULTS: In total, 66 participants (40 women and 26 men), 60.35±12.77 years of age, were included in the intention-to-treat analyses. Baseline characteristics were comparable between the CP (n ==33) and placebo (n ==33) groups. Treatment with a CP showed statistically significant differences in reductions in OABSS scores (9.70±2.20 to 6.33±2.42), PPBC scores (3.36±0.60 to 2.15±0.83), and USS scores (2.67±0.54 to 1.64±0.60).CONCLUSIONS: Compared to a placebo, treatment with CP might be considered an effective and safe complementary therapy for OAB. Further studies employing a positive control, different dosage forms, larger sample sizes, and longer treatment periods are warranted. <p><a href="https://greenmedinfo.com/article/efficacy-cinnamon-patch-treatment-alleviating-symptoms-overactive-bladder" target="_blank">read more</a></p> https://greenmedinfo.com/article/efficacy-cinnamon-patch-treatment-alleviating-symptoms-overactive-bladder#comments Cinnamon Overactive Bladder Human Study Sun, 25 Dec 2022 22:48:47 +0000 greenmedinfo 268339 at https://greenmedinfo.com Electrical stimulation results in subjective improvement in overactive bladder. https://greenmedinfo.com/article/electrical-stimulation-results-subjective-improvement-overactive-bladder PMID:  Urology. 2004 Jan;63(1):61-6. PMID: 14751349 Abstract Title:  Single-blind, randomized trial of pelvic floor muscle training, biofeedback-assisted pelvic floor muscle training, and electrical stimulation in the management of overactive bladder. Abstract:  OBJECTIVES: To compare the efficacy of pelvic floor muscle training (PFMT), biofeedback-assisted PFMT (BAPFMT), and electrical stimulation (ES) in the management of overactive bladder (OAB). METHODS: The interventions for the 12-week treatment period, conducted by the physiotherapist who was unaware of the progress and outcome, included (a) a PFMT program tailored to the subject&#039;s PERFECT (power, endurance, repetitions, and fast [1-second] contractions, with every contraction timed) scheme, used for training at home; (b) an electromyography BAPFMT program and home program tailored to the subject&#039;s PERFECT scheme; and (c) an ES program using biphasic symmetric probe current with 10-Hz frequency, 400-micros pulse width, 10/5 duty cycle, and varying intensity. Identical preintervention and postintervention assessment included King&#039;s Health Questionnaire, as well as outcomes of urge incontinence and other urinary symptoms. RESULTS: Of the 103 women who completed this study, 34 were in the PFMT group, 34 in the BAPFMT group, and 35 in the ES group. The changes in the three parameters of King&#039;s Health Questionnaire revealed statistically significant differences, except for the total score, between ES and BAPFMT (domain 7, P = 0.003; domain 9, P = 0.029; and total score, P = 0.952). These same parameters were significantly different between ES and PFMT (domain 7, P = 0.007; domain 9, P = 0.001; and total score P = 0.004). The change in total score was significantly different between BAPFMT and PFMT (P = 0.003). The subjective improvement/cure rate of OAB was 51.4% for ES, 50.0% for BAPFMT, and 38.2% for PFMT (P = 0.567). CONCLUSIONS: ES had the greatest subjective reduction rate of OAB and was the most effective of the three treatments. BAPFMT was more effective than PFMT. https://greenmedinfo.com/article/electrical-stimulation-results-subjective-improvement-overactive-bladder#comments Overactive Bladder Electric Stimulation Human Study Sat, 30 Jan 2010 01:43:55 +0000 greenmedinfo 50528 at https://greenmedinfo.com Electroacupuncture for post-stroke overactive bladder. https://greenmedinfo.com/article/electroacupuncture-post-stroke-overactive-bladder PMID:  Acupunct Med. 2020 Jul 9:964528420925488. Epub 2020 Jul 9. PMID: 32646228 Abstract Title:  Electroacupuncture for post-stroke overactive bladder: a multi-centre pilot randomized controlled trial. Abstract:  BACKGROUND: Although acupuncture has been shown to be effective at treating overactive bladder (OAB) following stroke, to our knowledge, no randomized controlled trial (RCT) examining the effects of acupuncture on patients with post-stroke OAB has been conducted. The aim of this preliminary study was to explore the effects of electroacupuncture (EA) in the treatment of post-stroke OAB.METHODS: This study was a multi-site randomized, assessor-blind, controlled pilot trial of patients with post-stroke OAB. In all, 34 post-stroke subjects (mean age: 71.0 years; 32.4% female) with OAB symptoms were randomly assigned to the treatment group or control group in a 1:1 ratio. The subjects in the treatment group were treated with six sessions of EA for 4 weeks, while the subjects in the control group received usual care. The primary outcome measure was the overactive bladder symptom scale (OABSS). Secondary outcome measures included a three day bladder diary and the stroke-specific quality-of-life scale (SSQoL).RESULTS: EA showed a moderate effect size (ES) on the perceived severity of OAB symptoms as measured by the OABSS at week 5 (one week post-treatment, ES 0.57; p = 0.034) and week 8 (three weeks post-treatment, ES 0.60; p = 0.021), although the results did not remain statistically significant after Bonferroni correction for multiple testing. No significant differences in bladder diary parameters or SSQoL score were found. The EA treatment was well tolerated by the post-stroke subjects.CONCLUSION: A six-session EA treatment was feasible and appeared to reduce OAB symptoms in post-stroke patients. Further fully powered trials are warranted to confirm the efficacy of EA for those with post-stroke OAB. <p><a href="https://greenmedinfo.com/article/electroacupuncture-post-stroke-overactive-bladder" target="_blank">read more</a></p> https://greenmedinfo.com/article/electroacupuncture-post-stroke-overactive-bladder#comments Overactive Bladder Stroke Electroacupuncture Human Study Wed, 22 Jul 2020 11:32:42 +0000 greenmedinfo 223971 at https://greenmedinfo.com Extracorporeal magnetic stimulation has a beneficial effect on women with overactive bladder. https://greenmedinfo.com/article/extracorporeal-magnetic-stimulation-has-beneficial-effect-women-overactive-bla PMID:  Int Urogynecol J Pelvic Floor Dysfunct. 2007 Aug;18(8):875-80. Epub 2006 Nov 30. PMID: 17136485 Abstract Title:  Symptom change in women with overactive bladder after extracorporeal magnetic stimulation: a prospective trial. Abstract:  The purpose of this study was to prospectively evaluate symptom change after discontinuation of extracorporeal magnetic stimulation (EMS) in women with overactive bladder (OAB). A total of 48 women with OAB were included. We applied 10 Hz of repetitive magnetic stimulation with a &quot;magnetic chair&quot; for 20 min, twice weekly for 8 weeks. Changes in OAB symptoms at 2, 12, and 24 weeks after discontinuing the EMS were evaluated. Twenty-seven (56.3%) patients were cured compared with the baseline at 2 weeks: the cure rate was determined as 68.8% (33/48 patients), 56.3% (27/48), and 50% (8/16) for urgency, frequency, and urge incontinence, respectively. The mean number of voids per 24 h was decreased by 42.8% (from 14.5 +/- 4.3, to 8.3 +/- 1.5, P https://greenmedinfo.com/article/extracorporeal-magnetic-stimulation-has-beneficial-effect-women-overactive-bla#comments Overactive Bladder Magnet Therapy Human Study Sat, 30 Jan 2010 01:26:52 +0000 greenmedinfo 50526 at https://greenmedinfo.com Foot reflexology is therapeutic for patients with symptomatic idiopathic detrusor overactivity. https://greenmedinfo.com/article/foot-reflexology-therapeutic-patients-symptomatic-idiopathic-detrusor-overacti PMID:  Int Urogynecol J Pelvic Floor Dysfunct. 2007 Jun;18(6):653-8. Epub 2006 Sep 27. PMID: 17003953 Abstract Title:  Randomized controlled trial of foot reflexology for patients with symptomatic idiopathic detrusor overactivity. Abstract:  The aim of this study was to examine whether foot reflexology has beneficial effects on patients with idiopathic detrusor overactivity. One hundred and nine women with symptomatic idiopathic detrusor overactivity were randomized into either foot reflexology treatment group or nonspecific foot massage control group. The primary outcome measure was the change in the diurnal micturition frequency. There was significant change in the number of daytime frequency in the reflexology group when compared with the massage group (-1.90 vs -0.55, p = 0.029). There was also a decrease in the 24-h micturition frequency in both groups, but the change was not statistically significant (-2.80 vs -1.04 p = 0.055). In the reflexology group, more patients believed to have received &quot;true&quot; reflexology (88.9 vs 67.4%, p = 0.012). This reflects the difficulty of blinding in trials of reflexology. Larger scale studies with a better-designed control group and an improved blinding are required to examine if reflexology is effective in improving patients&#039; overall outcome. https://greenmedinfo.com/article/foot-reflexology-therapeutic-patients-symptomatic-idiopathic-detrusor-overacti#comments Overactive Bladder Massage/Therapeutic Touch Reflexology Human Study Wed, 17 Feb 2010 17:35:19 +0000 greenmedinfo 51660 at https://greenmedinfo.com Gosha-jinki-gan (GJG), a traditional Chinese medicine, may have therapeutic action in overactive bladder https://greenmedinfo.com/article/gosha-jinki-gan-gjg-traditional-chinese-medicine-may-have-therapeutic-action-o PMID:  Hinyokika Kiyo. 2007 Dec;53(12):857-62. PMID: 18203522 Abstract Title:  Effect of Chinese herbal medicine on overactive bladder. Abstract:  Gosha-jinki-gan (GJG), a traditional Chinese medicine, is known to be potentially effective for urinary disturbance. For the clinical evaluation of Gosha-jinki-gan, we administered GJG for 6 weeks to elderly male patients with overactive bladder (OAB) and assessed its efficacy and tolerability. In this study, 30 male patients with over 6 months of OAB symptoms had received 2.5 g GJG mixture x 3/day. After 6 weeks of treatment, the efficacy, safety, and tolerability were assessed. We evaluated International Prostate Symptom Score (I-PSS), Overactive Bladder Symptom Score (OABSS), quality of life (QOL), maximal urinary flow rate (Qmax), average urinary flow rate (Qave), incidence of urinary incontinence, and post-void residual before and after treatment. We observed significant improvements in I-PSS (15.2 +/- 1.0 vs. 12.0 +/- 0.9, p https://greenmedinfo.com/article/gosha-jinki-gan-gjg-traditional-chinese-medicine-may-have-therapeutic-action-o#comments Japanese traditional herbal formula: gosha-jinki-gan Overactive Bladder Voiding dysfunction Human Study Sat, 30 Jan 2010 01:22:58 +0000 greenmedinfo 50524 at https://greenmedinfo.com Higher intakes of vitamin D, protein and potassium are significantly associated with decreased risks of onset of overactive bladder. https://greenmedinfo.com/article/higher-intakes-vitamin-d-protein-and-potassium-are-significantly-associated-de PMID:  Neurourol Urodyn. 2004;23(3):204-10. PMID: 15098215 Abstract Title:  Nutrient composition of the diet and the development of overactive bladder: a longitudinal study in women. Abstract:  AIMS: Evidence for an association between diet and the symptom syndrome overactive bladder (OAB) would be valuable in understanding its aetiology. The present study investigates prospectively the association between the nutrient composition of the diet and the onset of OAB.METHODS: A random sample of community dwelling women aged 40 years or over was studied. Baseline data on urinary symptoms and diet were collected from 6,371 women using a postal questionnaire and food frequency questionnaire. Follow-up data on urinary symptoms were collected from 5,816 of the women in a postal survey 1 year later. Logistic regression was used to investigate the association of diet (daily intakes of energy, macro and micronutrients) with 1 year incidence of OAB.RESULTS: There was evidence that three nutrients may be associated with OAB onset. Higher intakes of vitamin D (P = 0.008), protein (P = 0.03), and potassium (P = 0.05) were significantly associated with decreased risks of onset. Although overall the associations with vitamin B6 and niacin were not significant (P = 0.08 and P = 0.13), there was some evidence of a decreased risk of onset with higher intakes.CONCLUSIONS: The results from this prospective study suggest possible aetiological associations between certain nutrients and OAB onset. The findings need confirmation and possible mechanisms to explain these associations need further investigation. https://greenmedinfo.com/article/higher-intakes-vitamin-d-protein-and-potassium-are-significantly-associated-de#comments Overactive Bladder Potassium Protein Supplement Vitamin D Meta Analysis Mon, 03 Jan 2011 18:12:56 +0000 greenmedinfo 60044 at https://greenmedinfo.com Hydrogen water could ameliorate bladder dysfunction secondary to bladder outlet obstruction by attenuating oxidative stress. https://greenmedinfo.com/article/hydrogen-water-could-ameliorate-bladder-dysfunction-secondary-bladder-outlet-o PMID:  J Urol. 2016 Mar ;195(3):780-7. Epub 2015 Oct 27. PMID: 26518110 Abstract Title:  Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction. Abstract:  PURPOSE: Bladder ischemia and oxidative stress contribute to the pathogenesis of bladder dysfunction caused by bladder outlet obstruction. H2 reportedly acts as an effective antioxidant. We investigated whether oral ingestion of H2 water would have a beneficial effect on bladder function in a rat model of bladder outlet obstruction.MATERIALS AND METHODS: H2 water was made by dissolving H2 gas in ordinary drinking water using a hydrogen water producing apparatus. The bladder outlet obstruction model was surgically induced in male rats. Rats with obstruction were fed H2 water or ordinary drinking water. On week 4 postoperatively cystometry was performed. Oxidative stress markers and the bladder nerve growth factor level were determined. Bladder tissues were processed for pharmacological studies and histological analysis.RESULTS: The micturition interval and micturition volume significantly decreased in obstructed rats given ordinary drinking water. These decreases were significantly suppressed by oral ingestion of H2 water. Increased post-void residual volume in obstructed rats was significantly reduced by H2 water. Obstruction led to a significant increase in bladder weight, oxidative stress markers and nerve growth factor. H2 water significantly suppressed these increases without affecting bladder weight. There was no significant difference in histological findings between rats with bladder obstruction given H2 water and ordinary drinking water. Decreased responses of detrusor muscle strips from obstructed bladders to KCl, carbachol and electrical field stimulation were reversed by H2 water ingestion.CONCLUSIONS: Results suggest that H2 water could ameliorate bladder dysfunction secondary to bladder outlet obstruction by attenuating oxidative stress. <p><a href="https://greenmedinfo.com/article/hydrogen-water-could-ameliorate-bladder-dysfunction-secondary-bladder-outlet-o" target="_blank">read more</a></p> https://greenmedinfo.com/article/hydrogen-water-could-ameliorate-bladder-dysfunction-secondary-bladder-outlet-o#comments Hydrogen Water Overactive Bladder Oxidative Stress Antioxidants Animal Study Wed, 10 Oct 2018 21:45:39 +0000 greenmedinfo 172149 at https://greenmedinfo.com Industry-Sponsored Doctors: New Study Shows Depth of Commercial Influence https://greenmedinfo.com/blog/industry-sponsored-doctors-new-study-shows-depth-commercial-influence <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/IndustySponsoredDoctorsNewStudyShowsDepthofCommercialInfluence.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:24px;"><em><strong>Professional education events are heavily sponsored by drug companies promoting their products as the solution. This widely used coercive and misinformation technique where drug benefits are exaggerated and side effects minimized was exposed in a recent BMJ Open study.&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/industry-sponsored-doctors-new-study-shows-depth-commercial-influence" target="_blank">read more</a></p> https://greenmedinfo.com/blog/industry-sponsored-doctors-new-study-shows-depth-commercial-influence#comments Depression Osteoporosis Overactive Bladder Antidepressants Chemical and Drug Toxicity Health Guide: Corruption in Science Osteoporosis Drugs Osteoporosis/Osteopenia Overdiagnosis cancer overtreatment corruption in science medical errors Overdiagnosis Overtreatment Thu, 07 Feb 2019 21:19:02 +0000 jeffereyjaxen 179217 at https://greenmedinfo.com