Ocular Hypertension https://greenmedinfo.com/taxonomy/term/9251/all en A water extract of fennel possesses significant oculohypotensive activity, comparable to that of timolol. https://greenmedinfo.com/article/water-extract-fennel-possesses-significant-oculohypotensive-activity-comparabl PMID:  J Altern Complement Med. 2009 Jan;15(1):53-7. PMID: 18831355 Abstract Title:  Oculohypotensive effects of foeniculum vulgare in experimental models of glaucoma. Abstract:  PURPOSE: Evaluation of oculohypotensive activity of single drop application of aqueous extract of Foeniculum vulgare in experimental models of glaucoma. METHODS: The evaluation of oculohypotensive activity of Foeniculum vulgare was done in rabbits with normal intraocular pressure (IOP) and with experimentally elevated IOP. The experimental increase in IOP was achieved using water loading and steroid induced glaucoma models. RESULTS: The aqueous seed extract of Foeniculum vulgare exhibited 17.49, 21.16 and 22.03% reduction of intraocular pressure (IOP) in normotensive rabbits at 0.3%, 0.6% and 1.2% (w/v) concentrations respectively. The 0.6% concentration was further evaluated in acute and chronic models of glaucoma. A maximum mean difference of 31.20% was observed between vehicle treated and extract treated eyes in water loading model while a maximum mean IOP lowering of 31.29% was observed in steroid induced model of glaucoma. CONCLUSIONS: The aqueous extract of Foeniculum vulgare possesses significant oculohypotensive activity, which was found to be comparable to that of timolol. Further investigations into the mechanism of action, possible toxicity and human clinical trials are warranted before the Foeniculum vulgare finds place in the arsenal of antiglaucoma drugs prescribed by physicians. https://greenmedinfo.com/article/water-extract-fennel-possesses-significant-oculohypotensive-activity-comparabl#comments Fennel Glaucoma Ocular Hypertension Natural Substances Versus Drugs Plant Extracts Animal Study Tue, 26 Jan 2010 15:22:54 +0000 greenmedinfo 50121 at https://greenmedinfo.com Bael (A. marmelos) fruit extract showed significant Intraocular pressure-lowering activity in experimental animal models. https://greenmedinfo.com/article/bael-marmelos-fruit-extract-showed-significant-intraocular-pressure-lowering-a PMID:  Ophthalmic Res. 2009;42(2):112-6. Epub 2009 Jun 26. PMID: 19556826 Abstract Title:  Intraocular pressure-lowering activity of topical application of Aegle marmelos fruit extract in experimental animal models. Abstract:  AIM: The present study was designed to evaluate the intraocular pressure (IOP)-lowering activity of topical application of the aqueous extract of Aegle marmelos fruit in experimental animal models. MATERIALS AND METHODS: New Zealand white rabbits with normal and experimentally elevated IOP using water loading and steroid-induced models were included in this study. The IOP-lowering effect of A. marmelos fruit extract in rabbits with experimentally elevated IOP was also compared with that of timolol 0.25%. RESULTS: In rabbits with normal IOP, the A. marmelos fruit extract at a concentration of 1% showed the maximum IOP-lowering effect with 22.81% reduction from baseline IOP. The maximum IOP reduction achieved in water loading and steroid-induced models with the same concentration of A. marmelos was 27.57 and 28.41% from baseline, respectively. The efficacy was comparable to that of timolol after 45 min of water loading in the water loading model, and during the first 2 h of treatment in the steroid-induced model. CONCLUSION: A. marmelos fruit extract showed significant IOP-lowering activity in experimental animal models. https://greenmedinfo.com/article/bael-marmelos-fruit-extract-showed-significant-intraocular-pressure-lowering-a#comments Bael Ocular Hypertension Antihypertensive Agents Plant Extracts Animal Study Tue, 26 Jan 2010 15:21:27 +0000 greenmedinfo 50120 at https://greenmedinfo.com Flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension. https://greenmedinfo.com/article/flavonoids-have-promising-role-improving-visual-function-patients-glaucoma-and PMID:  Graefes Arch Clin Exp Ophthalmol. 2015 Sep 4. Epub 2015 Sep 4. PMID: 26340868 Abstract Title:  The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis. Abstract:  BACKGROUND: Glaucoma is a leading cause of irreversible blindness worldwide. A major symptom of this pathology is the loss to the visual field in a peripheral to central pattern. Flavonoids are polyphenol compounds sourced from plants, commonly found in green tea, red wine and cocoa, and they have neuroprotective and antioxidant characteristics proposed to be advantageous within the context of glaucoma. Currently, the literature presents conflicting evidence regarding the effect of flavonoids on patients with glaucoma and ocular hypertension; hence a systematic review and meta-analysis was conducted.METHOD: Databases included in our literature search were EMBASE (1980-present), MEDLINE Ovid, Alternative and Complementary Medicine Database (AMED), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Cochrane Central Register of Controlled Trials (CENTRAL). Meta-analysis was performed using RevMan 5 (Review Manager) 5 software, version 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen). The primary outcomes were visual field mean deviation (MD) and intraocular pressure (IOP). Secondary outcomes were ocular blood flow and blood pressure (BP).CONCLUSION: Meta-analyses showed that flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension (OHT), and appear to play a part in both improving and slowing the progression of visual field loss. https://greenmedinfo.com/article/flavonoids-have-promising-role-improving-visual-function-patients-glaucoma-and#comments Cocoa Flavonoids Glaucoma Green Tea Ocular Hypertension Red Wine Extract Meta Analysis Review Wed, 23 Sep 2015 20:53:14 +0000 greenmedinfo 120596 at https://greenmedinfo.com Garcinia kola 0.5% aqueous eye drops were comparable to Timolol 0.5% eye drops in lowering intraocular pressure. https://greenmedinfo.com/article/garcinia-kola-05-aqueous-eye-drops-were-comparable-timolol-05-eye-drops-loweri PMID:  Middle East Afr J Ophthalmol. 2010 Jan ;17(1):88-93. PMID: 20543944 Abstract Title:  Efficacy of Garcinia kola 0.5% Aqueous Eye Drops in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension. Abstract:  PURPOSE: To evaluate the intraocular pressure (IOP) lowering efficacy of Garcinia kola 0.5% aqueous solution eye drops in patients with newly diagnosed primary open-angle glaucoma or ocular hypertension (POAG/OH).MATERIALS AND METHODS: A randomized, double-masked, multicenter, active-controlled prospective study. Patients who met the inclusion criteria were randomly assigned in equal numbers to receive Timolol 0.5% eye drops as a control medication (A = Group 1 eyes) or Garcinia kola 0.5% eye drops as the study medication (B = Group 2 eyes). All drops were instilled at 6 am and 6 pm daily. Goldman applanation tonometry was performed at 9 am, 12 pm and 3 pm at baseline, week-6, week-12 and week-24 visits. Voluntary and actively elicited reports of adverse events were documented. The mean change in IOP over 24 weeks was the primary outcome measure. Both groups were compared for statistically significant differences at all visits. A P0.05). Adverse events were mild in nature with no statistically significant differences between groups (P&gt;0.05).CONCLUSIONS: Garcinia kola ophthalmic solution significantly reduces IOP as compared to baseline. The IOP lowering effect of both treatments was equivalent. https://greenmedinfo.com/article/garcinia-kola-05-aqueous-eye-drops-were-comparable-timolol-05-eye-drops-loweri#comments Garcinia kola Glaucoma Intraocular hypertension Ocular Hypertension Natural Substances Versus Drugs Human Study Sun, 08 Feb 2015 14:46:53 +0000 greenmedinfo 116244 at https://greenmedinfo.com The oxidative stress associated with intraocular hypertension in rats may be ameliorated by n-acetyl cysteine supplementation. https://greenmedinfo.com/article/oxidative-stress-associated-intraocular-hypertension-rats-may-be-ameliorated-n PMID:  Dig Dis Sci. 2008 Jul 10. PMID: 20010244 Abstract Title:  Retinal oxidative stress induced by intraocular hypertension in rats may be ameliorated by brimonidine treatment and N-acetyl cysteine supplementation. Abstract:  PURPOSE: To investigate the effect of brimonidine and N-acetyl cysteine (NAC) on retinal oxidative status under ocular hypertension. MATERIALS AND METHODS: Ocular hypertension is produced in right eyes of 60 rats through intraocular injection of sodium hyaluronate. The left eyes received intracameral saline as sham. Twenty right eyes (brimonidine group) received topical brimonidine twice a day for a week. Other 20 eyes received intraperitoneal NAC (NAC group) once a day. Another group of 20 eyes were followed without any drugs but only intracameral sodium hyaluronate (sodium hyaluronate group) into right eyes. RESULTS: Intraocular injection of sodium hyaluronate increased intraocular pressure for a week and caused retinal peroxidation and decreased glutathione peroxidase and catalase levels. Brimonidine and NAC treatment reversed the retinal oxidative stress created by high intraocular pressure. CONCLUSIONS: Brimonidine and NAC supplementation provide antioxidative properties to retina and decrease retinal damage induced by ocular hypertension. https://greenmedinfo.com/article/oxidative-stress-associated-intraocular-hypertension-rats-may-be-ameliorated-n#comments NAC (N-acetyl-L-cysteine) Ocular Hypertension Animal Study Wed, 23 Dec 2009 02:40:51 +0000 greenmedinfo 48308 at https://greenmedinfo.com Topical CoQ10 appears an effective therapy preventing retinal ganglion cell apoptosis and loss in glaucoma-related models. https://greenmedinfo.com/article/topical-coq10-appears-effective-therapy-preventing-retinal-ganglion-cell-apopt PMID:  Mitochondrion. 2017 May 24. Epub 2017 May 24. PMID: 28549843 Abstract Title:  Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension. Abstract:  Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known neuroprotective activity. Its ocular effects when co-solubilised withα-tocopherol polyethylene glycol succinate (TPGS) were evaluated. In vitro studies confirmed that CoQ10 was significantly protective in different retinal ganglion cell (RGC) models. In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts. CoQ10/TPGS showed a significant neuroprotective effect compared to control with DARC (p<p><a href="https://greenmedinfo.com/article/topical-coq10-appears-effective-therapy-preventing-retinal-ganglion-cell-apopt" target="_blank">read more</a></p> https://greenmedinfo.com/article/topical-coq10-appears-effective-therapy-preventing-retinal-ganglion-cell-apopt#comments Coenzyme Q10 Ocular Hypertension Anti-Apoptotic Neuroprotective Agents Animal Study Tue, 04 Jul 2017 01:12:44 +0000 greenmedinfo 149990 at https://greenmedinfo.com