Graves Disease https://greenmedinfo.com/taxonomy/term/944/all en Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis https://greenmedinfo.com/article/probiotic-bifidobacterium-longum-supplied-methimazole-improved-thyroid-functio PMID:  Commun Biol. 2021 09 7 ;4(1):1046. Epub 2021 Sep 7. PMID: 34493790 Abstract Title:  Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves&#039; disease patients through the gut-thyroid axis. Abstract:  Graves&#039; disease (GD) is an autoimmune disorder that frequently results in hyperthyroidism and other symptoms. Here, we designed a 6-month study with patients divided into three treatment groups, namely, methimazole (MI, n = 8), MI + black bean (n = 9) and MI + probiotic Bifidobacterium longum (n = 9), to evaluate the curative effects of probiotics supplied with MI on thyroid function of patients with GD through clinical index determination and intestinal microbiota metagenomic sequencing. Unsurprisingly, MI intake significantly improved several thyroid indexes but not the most important thyrotropin receptor antibody (TRAb), which is an indicator of the GD recurrence rate. Furthermore, we observed a dramatic response of indigenous microbiota to MI intake, which was reflected in the ecological and evolutionary scale of the intestinal microbiota. In contrast, we did not observe any significant changes in the microbiome in the MI + black bean group. Similarly, the clinical thyroid indexes of patients with GD in the probiotic supplied with MI treatment group continued to improve. Dramatically, the concentration of TRAb recovered to the healthy level. Further mechanistic exploration implied that the consumed probiotic regulated the intestinal microbiota and metabolites. These metabolites impacted neurotransmitter and blood trace elements through the gut-brain axis and gut-thyroidaxis, which finally improved the host&#039;s thyroid function. <p><a href="https://greenmedinfo.com/article/probiotic-bifidobacterium-longum-supplied-methimazole-improved-thyroid-functio" target="_blank">read more</a></p> https://greenmedinfo.com/article/probiotic-bifidobacterium-longum-supplied-methimazole-improved-thyroid-functio#comments Bifidobacterium Longum Graves Disease Gastrointestinal Agents Natural Substance/Drug Synergy Human Study Sun, 20 Mar 2022 19:01:08 +0000 greenmedinfo 254996 at https://greenmedinfo.com 22 immune diseases diagnosed at hospitalization correlated with obesity https://greenmedinfo.com/article/22-immune-diseases-diagnosed-hospitalization-correlated-obesity PMID:  Ann Med. 2012 May ;44(3):289-95. Epub 2011 Feb 1. PMID: 21284531 Abstract Title:  Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity. Abstract:  Abstract Background. Although there are putative mechanistic links between obesity and autoimmune diseases, obesity is not considered a risk factor for most autoimmune diseases. Methods. Using the nation-wide Hospital Discharge Register we defined a cohort of 29,665 patients hospitalized for obesity since year 1964. The patients were followed for hospitalization for any of 34 autoimmune or related conditions through year 2007. Standardized incidence ratios (SIRs) were calculated for autoimmune diseases in obese individuals compared to those who had not been hospitalized for obesity. Results. Among 22 immune diseases diagnosed after hospitalization for obesity and in at least 5 patients, the overall SIR was 2.05. Of the individual diseases studied, the risk of 16 was significantly increased; none displayed a decreased risk. Psoriasis (4.54) and Behçet&#039;s disease (4.49) exhibited the highest risks, followed by Hashimoto&#039;s disease/hypothyroidism (4.12) and asthma (3.39). Small but significant increases in SIRs were also noted for the common autoimmune diseases Graves&#039;s disease/hyperthyroidism (1.28) and rheumatoid arthritis (1.37). Conclusions.The present population of obese individuals, subsequently diagnosed with a number of autoimmune diseases and related conditions, was hospitalized at a relatively young age. Further studies are needed to describe the morbidity in the obese population at large. https://greenmedinfo.com/article/22-immune-diseases-diagnosed-hospitalization-correlated-obesity#comments Asthma Autoimmune Diseases Behcet Disease Graves Disease Hashimoto's thyroiditis Obesity Psoriasis Review Mon, 09 Apr 2012 21:56:22 +0000 greenmedinfo 74078 at https://greenmedinfo.com Alpha-lipoic acid could be a therapeutic agent because of its inhibitory effects on ROS production, inflammation, and adipose tissue expansion https://greenmedinfo.com/article/alpha-lipoic-acid-could-be-therapeutic-agent-because-its-inhibitory-effects-ro PMID:  Medicine (Baltimore). 2016 Jan ;95(2):e2497. PMID: 26765462 Abstract Title:  Inhibitory Effects ofα-Lipoic Acid on Oxidative Stress-Induced Adipogenesis in Orbital Fibroblasts From Patients With Graves Ophthalmopathy. Abstract:  A choice of the optimal treatment for Graves ophthalmopathy (GO) is a challenge due to the complexity of the pathogenesis. Alpha-lipoic acid (ALA) is well known as a multifunctional antioxidant, helping to protect cells against oxidative stress and inflammatory damage.The aim of this study was to investigate the effects of ALA on intracellular production of reactive oxygen species (ROS), inflammation, and adipogenesis using primary cultured orbital fibroblasts from patients with GO.Intracellular ROS levels and mRNA expressions of proinflammatory cytokines and chemokines including intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T cell expressed and presumably secreted (RANTES) were measured. After adipogenesis, the expressions of peroxisome proliferator-activated receptor (PPAR)γ, CCAAT-enhancer-binding proteins (C/EBP)α and β, and heme oxygenase-1 (HO-1) were investigated.H2O2 dose-dependently stimulated ROS production and HO-1 expression. Addition of ALA strongly attenuated ROS production and further increased HO-1 expression. However, by pretreatment of zinc protoporphyrin (ZnPP), HO-1 inhibitor, ALA inhibition of ROS generation by H2O2 was abolished. Tumor necrosis factor (TNF)α-induced mRNA expressions of ICAM-1, IL-6, MCP-1, and RANTES were inhibited by ALA treatment. In this context, TNFα-induced phosphorylation of P65 was also inhibited. In addition, ALAdose-dependently inhibited H2O2-induced intracellular accumulation of lipid droplets. The expression of adipogenic transcription factors, including PPARγ, C/EBPα, and β, was also inhibited.ALA is a potential therapeutic agent for GO because of the inhibitory effects on ROS production and gene expression of proinflammatory cytokines and chemokines, resulting in prevention of adipose-tissue expansion. https://greenmedinfo.com/article/alpha-lipoic-acid-could-be-therapeutic-agent-because-its-inhibitory-effects-ro#comments Alpha-Lipoic Acid Graves Disease Oxidative Stress Anti-Adipogenic Anti-Inflammatory Agents Antioxidants Gene Expression Regulation Human In Vitro Tue, 22 Mar 2016 23:01:00 +0000 greenmedinfo 125111 at https://greenmedinfo.com Antioxidant supplementation improves the effect of methimazole therapy in the treatment of Grave's disease. https://greenmedinfo.com/article/antioxidant-supplementation-improves-effect-methimazole-therapy-treatment-grav PMID:  Clin Chem Lab Med. 2005;43(4):383-8. PMID: 15899653 Abstract Title:  The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves&#039; disease. Abstract:  The effects of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) on superoxide dismutase activity, copper and zinc concentrations, and total antioxidant status were monitored in erythrocytes derived from a group of patients with Graves&#039; disease treated with methimazole, with respect to the rate of achieving euthyroidism. Thyroid-stimulating hormone (TSH), thyroid hormones and the above-mentioned parameters were measured before therapy, and on days 30 and 60 after therapy initiation. The patients receiving antioxidant supplementation along with methimazole therapy (group A, n = 27) achieved euthyroidism at a faster rate than those treated with methimazole alone (group B, n = 28). The activity of superoxide dismutase decreased significantly in both patient groups during the treatment; however, there was no significant difference between the groups. There was no significant change in the erythrocyte concentration of copper, whereas the zinc concentration and total antioxidant status showed significant between-group differences. The study results clearly show that antioxidant supplementation in the treatment of Graves&#039; disease is justified, while zinc and total antioxidant status in erythrocytes seem to be sensitive indicators of the efficacy of supplemental therapy. https://greenmedinfo.com/article/antioxidant-supplementation-improves-effect-methimazole-therapy-treatment-grav#comments Antioxidant formulas Graves Disease Drug-Plant-Vitamin Synergies Human Study Tue, 14 Jul 2009 20:14:48 +0000 greenmedinfo 45494 at https://greenmedinfo.com Basedow's Disease https://greenmedinfo.com/disease/basedows-disease <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="358" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Hyperthyroidism.jpg?1468705070" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_designua&#039;&gt;designua / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Graves Disease Tue, 14 Apr 2009 07:14:31 +0000 greenmedinfo 19140 at https://greenmedinfo.com Celiac disease is far higher in those diagnosed with Grave's disease. https://greenmedinfo.com/article/celiac-disease-far-higher-those-diagnosed-graves-disease PMID:  Endocrine. 2006 Oct;30(2):175-83. PMID: 17322576 Abstract Title:  The effects of royal jelly on autoimmunity in Graves&#039; disease. Abstract:  OBJECTIVE: Graves&#039; disease is an organ-specific autoimmune disease with unknown etiology. TSHR Ab plays the most important role for the pathogenesis of Graves&#039; disease. Recently, the role of cytokines for the pathogenesis of Graves&#039; disease has been studied extensively. Royal jelly (RJ) is a creamy product secreted by young nurse worker bees (Apis mellifera), and it is synthesized in the hypopharyngeal and mandibular glands. RJ has been reported to have such pharmacological characteristics as antitumor, antibacterial, antihypercholesterolemic, antiallergic, antiinflammatory, and immunomodulatory properties. The major aim of the present study is to evaluate the effect of RJ on autoimmunity in peripheral lymphocyte culture and to establish the therapeutic doses. RESEARCH DESIGN AND METHODS: In the first phase, lymphocyte cell isolation from four voluntary healthy subjects was performed to find the effective concentration of RJ on immunity. Serial dilutions of the RJ were prepared (0-5 mg/mL). All isolated lymphocyte cells were treated with the above diluted samples. MTT test was carried out after incubation of 72 h. In the second phase, six patients with Graves&#039; disease, newly diagnosed by clinical and laboratory methods and admitted to my hospital and untreated were identified. RJ samples of 0 and 4 mg/mL were incubated in a culture medium for 72 h with isolated lymphocytes obtained from the patients. After incubation, MTT test in lymphocyte cell culture, Th1 cytokines IFN-gamma, TNF-alpha, and IL-12, and Th2 cytokines IL-4 and IL-10 levels by the enzyme amplified sensitivity immunoassay (EASIA) method and TSHR Ab by the radioreceptor method were determined. RESULTS: The concentration causing lymphocytes to proliferate was found to be 4 mg/mL by MTT test after incubation of 72 h in cell culture medium. Of the cytokines produced and secreted from lymphocytes, IFN-gamma increased, whereas, other cytokines decreased in RJ concentration of 4 mg/mL. Significant differences were found only for IFN-gamma and TNF-alpha. IL-4 concentrations were kept near the level of significancy. Of Th1/Th2 ratios, IFN-gamma/IL-4 and IFN-gamma/IL-10 ratios also exhibited significant differences between 0 and 4 mg/mL. RJ treatment in lymphocytes from patients with Graves&#039; disease shifted the Th1/Th2 cytokine ratio to the side of Th1 cytokine. Therefore, RJ using the treatment and establishing a remission of Graves&#039; disease may be effective as an antithyroid drug treatment. TSHR Ab levels of lymphocyte cell culture supernatants treated with RJ showed significant decreases. Also, the result may suggest that RJ may exert an effect similar to an antithyroid drug for decreasing TSHR Ab levels. CONCLUSIONS: RJ may be effective as an immunomodulatory agent in Graves&#039; disease. https://greenmedinfo.com/article/celiac-disease-far-higher-those-diagnosed-graves-disease#comments Autoimmune Diseases Celiac Disease Graves Disease Hyperthyroidism Gliadin Gluten Wheat Anti-Gliadin Antibodies Diseases that are Linked Human Study Tue, 29 Jun 2010 20:49:34 +0000 greenmedinfo 55593 at https://greenmedinfo.com Development of Graves' disease after SARS-CoV-2 mRNA vaccination. https://greenmedinfo.com/article/development-graves-disease-after-sars-cov-2-mrna-vaccination PMID:  Front Public Health. 2021 ;9:778964. Epub 2021 Nov 23. PMID: 34888290 Abstract Title:  Development of Graves&#039; Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review. Abstract:  Mounting evidence has revealed the interrelationship between thyroid and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to explain the thyroid dysfunction and autoimmune thyroid disorders observed after coronavirus disease 2019 (COVID-19). There are limited reports of thyroid dysfunction after SARS-CoV-2 vaccination.We report a case of a 40-year-old Chinese woman who developed Graves&#039; disease after BNT162b2 mRNA vaccine. A search of PubMed and Embase databases from 1 September 2019 to 31 August 2021 was performed using the following keywords: &quot;COVID,&quot; &quot;vaccine,&quot; &quot;thyroid,&quot; &quot;thyroiditis,&quot; and &quot;Graves.&quot;A 40-year-old Chinese woman who had 8-year history of hypothyroidism requiring thyroxine replacement. Her anti-thyroid peroxidase and anti-thyroglobulin antibodies were negative at diagnosis. She received her first and second doses of BNT162b2 mRNA vaccine on 6 April and 1 May 2021, respectively. She developed thyrotoxicosis and was diagnosed to have Graves&#039; disease 5 weeks after the second dose of vaccine, with positive thyroid stimulating immunoglobulin level, diffuse goiter with hypervascularity on thyroid ultrasonography and diffusely increased thyroid uptake on technetium thyroid scan. Both anti-thyroid peroxidase and anti-thyroglobulin antibodies became positive. She was treated with carbimazole. Literature search revealed four cases of Graves&#039; disease after SARS-CoV-2 vaccination, all after mRNA vaccines; and nine cases of subacute thyroiditis, after different types of SARS-CoV-2 vaccines.Our case represents the fifth in the literature of Graves&#039; disease after SARS-CoV-2 vaccination, with an unusual presentation on a longstanding history of hypothyroidism. Clinicians should remain vigilant about potential thyroid dysfunction after SARS-CoV-2 vaccination in the current pandemic. <p><a href="https://greenmedinfo.com/article/development-graves-disease-after-sars-cov-2-mrna-vaccination" target="_blank">read more</a></p> https://greenmedinfo.com/article/development-graves-disease-after-sars-cov-2-mrna-vaccination#comments Coronavirus Infection Graves Disease Thyroid Dysfunction Vaccination: COVID-19 Risk Factors Human: Case Report Review Thu, 02 Jun 2022 12:27:05 +0000 greenmedinfo 258429 at https://greenmedinfo.com Diosgenin From Dioscorea nipponica rhizoma against Graves' disease-on network pharmacology and experimental evaluation. https://greenmedinfo.com/article/diosgenin-dioscorea-nipponica-rhizoma-against-graves-disease-network-pharmacol PMID:  Front Pharmacol. 2021 ;12:806829. Epub 2022 Jan 24. PMID: 35140607 Abstract Title:  Diosgenin From Dioscorea Nipponica Rhizoma Against Graves&#039; Disease-On Network Pharmacology and Experimental Evaluation. Abstract:  Dioscorea nipponica rhizoma (DNR) is commonly used for the cure of hyperthyroidism resulting from Graves&#039; disease (GD) or thyroid nodules. However, its therapeutic mechanism remains unclear. This study aimed to utilize network pharmacology integrated molecular docking and experimental verification to reveal the potential pharmacological mechanism of DNR against GD. First, the active componds of DNR were collected from the HERB database and a literature search was conducted. Then, according to multisource database, the predicted genes of DNR and GD were collected to generate networks. The analysis of protein-protein interaction and GO enrichment and KEGG pathway were employed to discover main mechanisms associated with therapeutic targets. Moreover, molecular docking simulation was applied in order to verify the interactions between the drug and target. Finally, our experiments validated the ameliorated effects of diosgenin, the main component of DNR, in terms of phosphorylation deactivation in IGF-1R, which in turn inhibited the phosphorylation and activation of PI3K-AKT and Rap1-MEK signaling pathways, promoting cell apoptosis and GD remission. Our present study provided a foundation for further investigation of the in-depth mechanisms of diosgenin in GD and will provide new scientific evidence for clinical application. <p><a href="https://greenmedinfo.com/article/diosgenin-dioscorea-nipponica-rhizoma-against-graves-disease-network-pharmacol" target="_blank">read more</a></p> https://greenmedinfo.com/article/diosgenin-dioscorea-nipponica-rhizoma-against-graves-disease-network-pharmacol#comments Diosgenin Graves Disease Apoptotic In Vitro Study Thu, 23 Jun 2022 23:32:48 +0000 greenmedinfo 259497 at https://greenmedinfo.com Exophthalmic Goiter https://greenmedinfo.com/disease/exophthalmic-goiter <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="322" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Autoimmune_10.jpg?1475865119" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_designua&#039;&gt;designua / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Graves Disease Tue, 14 Apr 2009 07:17:43 +0000 greenmedinfo 19950 at https://greenmedinfo.com Experimental studies in humans have suggested beneficial effects of vitamin D supplementation in reducing the severity of autoimmune diseases. https://greenmedinfo.com/article/experimental-studies-humans-have-suggested-beneficial-effects-vitamin-d-supple PMID:  Rev Endocr Metab Disord. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28070798 Abstract Title:  Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Abstract:  In the last few years, more attention has been given to the&quot;non-calcemic&quot;effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases. In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1α-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties. Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response. These findings are supported by the correlation between the polymorphisms of the VDR or the CYP27B1 gene and the pathogenesis of several autoimmune diseases. Currently, the optimal plasma 25-hydroxyvitamin D concentration that is necessary to prevent or treat autoimmune diseases is still under debate. However, experimental studies in humans have suggested beneficial effects of vitamin D supplementation in reducing the severity of disease activity. In this review, we summarize the evidence regarding the role of vitamin D in the pathogenesis of autoimmune endocrine diseases, including type 1 diabetes mellitus, Addison&#039;s disease, Hashimoto&#039;s thyroiditis, Graves&#039; disease and autoimmune polyendocrine syndromes. Furthermore, we discuss the supplementation with vitamin D to prevent or treat autoimmune diseases. <p><a href="https://greenmedinfo.com/article/experimental-studies-humans-have-suggested-beneficial-effects-vitamin-d-supple" target="_blank">read more</a></p> https://greenmedinfo.com/article/experimental-studies-humans-have-suggested-beneficial-effects-vitamin-d-supple#comments Addison's Disease Autoimmune Diseases Endocrine Diseases Graves Disease Hashimoto's thyroiditis Vitamin D Vitamin D Deficiency Risk Factors Risk Reduction Review Fri, 13 Jan 2017 02:53:29 +0000 greenmedinfo 141948 at https://greenmedinfo.com Goiter: Exophthalmic https://greenmedinfo.com/disease/goiter-exophthalmic <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="337" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Goiter.jpg?1476474772" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_rob3000&#039;&gt;rob3000 / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Graves Disease Tue, 14 Apr 2009 07:18:38 +0000 greenmedinfo 20181 at https://greenmedinfo.com Graves Disease may occur following the quadrivalent HPV vaccine. https://greenmedinfo.com/article/graves-disease-may-occur-following-quadrivalent-hpv-vaccine PMID:  Vaccine. 2012 Jun 29 ;30(31):4585-7. Epub 2012 May 11. PMID: 22580356 Abstract Title:  An unmasking phenomenon in an observational post-licensure safety study of adolescent girls and young women. Abstract:  Our recent experience in a post-licensure safety study of autoimmune conditions following the quadrivalent human papillomavirus vaccine in 189,629 girls and young women ages 9-26 years led us to question the adequacy of the exclusion of Day 0 events to prevent the erroneous association of prevalent conditions with vaccination. Of the 18 confirmed cases of Graves&#039; disease diagnosed in days 1-60 following vaccination, only 6 cases appeared to be truly new onset. Among the remaining 12 cases, 2 cases had abnormal thyroid stimulating hormone or thyroxine labs drawn prior to or on Day 0 but had no documented pre-existing symptoms. The other 10 cases had mention of symptoms of hyperthyroidism referencing a period prior to first HPV-4 dose. This &#039;unmasking&#039; phenomenon, due to health care visits that include vaccination and new workups of preexisting symptoms, may not be adequately controlled through the exclusion of Day 0 events. <p><a href="https://greenmedinfo.com/article/graves-disease-may-occur-following-quadrivalent-hpv-vaccine" target="_blank">read more</a></p> https://greenmedinfo.com/article/graves-disease-may-occur-following-quadrivalent-hpv-vaccine#comments Graves Disease Vaccination: All Vaccination: HPV (Gardasil) Human Study Fri, 13 Dec 2019 21:32:08 +0000 greenmedinfo 204754 at https://greenmedinfo.com Graves Disease, an 'Incurable' Thyroid Disorder, Cured Through Lifestyle Changes https://greenmedinfo.com/blog/graves-disease-incurable-thyroid-disorder-cured-through-lifestyle-changes <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Graves_Disease_an_Incurable_Thyroid_Disorder_Cured_Through_Lifestyle_Change-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /><br /> <span style="font-size:12px;"><strong>Originally published on&nbsp;<a href="https://kellybroganmd.com/wp-content/uploads/2016/02/Brogan-GravesCase.pdf" rel="dofollow">www.kellybroganmd.com</a></strong></span></p> <p><span style="font-size:18px;"><strong><em>From incurable to a cure for an autoimmune disease known as Graves' disease -- why not make lifestyle changes today that can improve your life and vitality?</em></strong></span></p><p><a href="https://greenmedinfo.com/blog/graves-disease-incurable-thyroid-disorder-cured-through-lifestyle-changes" target="_blank">read more</a></p> https://greenmedinfo.com/blog/graves-disease-incurable-thyroid-disorder-cured-through-lifestyle-changes#comments Autoimmune Diseases Ayurvedic Formulations Depression Digestive System Diseases Exercise Eye Diseases Graves Disease Hair Loss Hyperthyroidism Iodine Iron Selenium Skin Diseases Vitamin A Vitamin B-5 (Pantothenic Acid) Vitamin B-6 Vitamin C Vitamin D Zinc Chemical and Drug Toxicity Health Guide: Chemical Exposures Health Guide: Corruption in Science Health Guide: Farm/Pharma Face Off Health Guide: Herbs and Traditional Knowledge Health Guides: Healing Foods autoimmune disease hyperthyroidism natural health Wed, 11 Dec 2019 22:24:34 +0000 GMI Research Group 202155 at https://greenmedinfo.com Immunomodulatory function of vitamin D and its role in autoimmune thyroid disease. https://greenmedinfo.com/article/immunomodulatory-function-vitamin-d-and-its-role-autoimmune-thyroid-disease PMID:  Front Immunol. 2021 ;12:574967. Epub 2021 Feb 19. PMID: 33679732 Abstract Title:  Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Abstract:  Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D. <p><a href="https://greenmedinfo.com/article/immunomodulatory-function-vitamin-d-and-its-role-autoimmune-thyroid-disease" target="_blank">read more</a></p> https://greenmedinfo.com/article/immunomodulatory-function-vitamin-d-and-its-role-autoimmune-thyroid-disease#comments Graves Disease Hashimoto's thyroiditis Thyroid Diseases Vitamin D Vitamin D Deficiency Immunomodulatory In Vitro Study Thu, 25 Nov 2021 02:09:22 +0000 greenmedinfo 249213 at https://greenmedinfo.com Lower serum 25-hydroxyvitamin D levels were associated with a higher incidence of Graves disease recurrence. https://greenmedinfo.com/article/lower-serum-25-hydroxyvitamin-d-levels-were-associated-higher-incidence-graves PMID:  Medicine (Baltimore). 2017 Aug ;96(31):e7700. PMID: 28767604 Abstract Title:  Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence. Abstract:  Graves disease is the most common cause of thyrotoxicosis. Although medical intervention with antithyroid drugs (ATDs) is commonly the first choice of treatment in Korea, the remission rate associated with this approach is not satisfactory. During ATD therapy, low or undetectable serum levels of thyroid-stimulating hormone (TSH) receptor antibodies (TRAbs) have been reported to affect the incidence of Graves disease remission. This study evaluated the correlation between serum 25-hydroxyvitamin D levels and TRAb levels, as well as the effect of 25-hydroxyvitamin D on the recurrence of Graves disease.A total of 143 patients, who were diagnosed with Graves disease and treated with ATDs, were retrospectively included in our observational study. These patients were followed for more than 1 year after ATD discontinuation. The levels of serum 25-hydroxyvitamin D and TRAb (ie, thyroid-stimulating antibody [TSAb], as detected by bioassay, and TSH-binding inhibitory immunoglobulins [TBIIs]) were measured, and a thyroid function test was performed upon ATD discontinuation. Recurrence was evaluated every 3 months, and was defined as an occurrence of overt thyrotoxicosis during the follow-up period.A total of 95 patients (66.4%) experienced recurrence with a median latency period of 182 days (ranging 28-1219 days). The serum 25-hydroxyvitamin D levels at the time of ATD discontinuation were not correlated with either TBII or TSAb. In the Cox proportional hazard regression analysis, higher free T4 levels (&gt;1.4 ng/dL; hazard ratio [HR], 3.252; 95% confidence interval [CI], 1.022-10.347) and low levels of 25-hydroxyvitamin D (≤14.23 ng/mL) were associated with a higher probability of Graves disease recurrence (HR, 3.016; 95% CI, 1.163-7.819).Lower serum 25-hydroxyvitamin D levels were associated witha higher incidence of Graves disease recurrence. Therefore, serum 25-hydroxyvitamin D might be an independent risk factor for predicting Graves disease recurrence after ATD discontinuation. <p><a href="https://greenmedinfo.com/article/lower-serum-25-hydroxyvitamin-d-levels-were-associated-higher-incidence-graves" target="_blank">read more</a></p> https://greenmedinfo.com/article/lower-serum-25-hydroxyvitamin-d-levels-were-associated-higher-incidence-graves#comments Graves Disease Graves Disease: Prevention Vitamin D Vitamin D Deficiency Risk Factors Human Study Fri, 29 Sep 2017 21:29:19 +0000 greenmedinfo 153588 at https://greenmedinfo.com